Platelet-Secreted MicroRNA-223 Promotes Endothelial Cell Apoptosis Induced by Advanced Glycation End Products via Targeting the Insulin-like Growth Factor 1 Receptor.

In conclusion, our study presents the first evidence, to our knowledge, that platelet-released miR-223 promotes advanced glycation end product-induced vascular endothelial cell apoptosis via targeting insulin-like growth factor 1 receptor. PMID: 24307738 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24307738?dopt=Abstract

Source: Journal of Immunology - December 4, 2013 Category: Allergy & Immunology Authors: Pan Y, Liang H, Liu H, Li D, Chen X, Li L, Zhang CY, Zen K Tags: J Immunol Source Type: research