Antivirals for HCV improve kidney and cardiovascular diseases in diabetic patients
(Wiley) Researchers from Taiwan reveal that antiviral therapy for hepatitis C virus (HCV) improves kidney and cardiovascular outcomes for patients with diabetes. Results of the study published in Hepatology, a journal of the American Association for the Study of Liver Diseases, show that incidences of kidney disease, stroke, and heart attack were lower in patients treated with pegylated interferon and ribavirin compared to HCV patients not treated with antivirals or diabetic patients not infected with the virus.
ConclusionExndin-4 can alleviate diabetes-caused damage to mice, moreover, it reduced endoplasmic reticulum stress and ROS through inhibiting p38 MAPK pathway in MPCs cells under high-glucose condition, thus increasing cell viability and reducing cell apoptosis.
BACKGROUND: Heat stroke is an emergent condition characterized by hyperthermia (>40 °C/>104 °F) and nervous system dysregulation. There are two primary etiologies: exertional which occurs during physical activity and non-exertional which occurs durin...
Certain apps can provide a high-quality data record and give patients access to a social support network, but they also have privacy issues, inappropriate disclaimers, and lack good evidence of efficacy.Medscape Medical News
ConclusionWe herein reported a subphrenic abscess due to Clostridium perfringens after hepatic resection for hepatocellular carcinoma following emphysematous cholecystitis.
This study aimed to compare the therapeutic efficacy of metformin and other anti-hyperglycemic agents in hepatocellular carcinoma (HCC) patients with type 2 diabetes (T2D). MATERIALS: A systematic electronic search on keywords including HCC and different anti-hyperglycemic agents was performed through electronic databases including Medline and EMBASE. The primary outcome was the overall survival (OS). The secondary outcomes were the recurrence-free survival (RFS) and progression-free survival (PFS). RESULTS: Six retrospective cohort studies were included for analysis: Four studies with curative treatment for HCC (6...
Find out how the lymphocyte-to-monocyte ratio may aid in the prognosis of patients with progressive radioiodine-refractory differentiated thyroid carcinoma.Clinical Endocrinology
This study demonstrates that successful DAA therapy for HCV provides an initial rapid resolution of liver inflammation followed by a steady improvement in liver fibrosis and metabolic liver function.Journal of Viral Hepatitis
An ultrasensitive AMH blood test predicts final menstrual period to within 1 to 2 years, which is more accurate than current methods; expert notes results do not apply to women younger than 42 years.Medscape Medical News
Undergoing earlier menopause is a sign of a greater burden of age-related damage and dysfunction, so it should not be surprising to see that this correlates with a greater incidence of chronic disease in the years thereafter. People with a greater burden of cell and tissue damage tend to exhibit all of the manifestations of aging earlier than their less damaged peers. These variations in damage burden and consequences from individual to individual are near all the results of lifestyle choices, particularly smoking, weight, and exercise, and environmental factors such as exposure to chronic viral infection. Genetics plays o...