What Causes Ataxia?
Discussion Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy walking. Sometimes can be difficult with an uncooperative or scared young child to determine if there are sensation changes or weakness particularly early in the disease process. Therefore the child may be misclassified as having ataxia. Acute cerebellar ataxia was first described in 1868 by Shepherd. It has an acute onset that is usually followed by a complete recovery and good long-term prognosis. It is thought to be caused by an transient para- or post-infectious process but has not been specifically identified. Organisms that have been associated with acute cerebellar ataxia include: Bacterial Bordetella pertussis Streptococcus, group A beta-hemolytic Legionella Mycoplasma Viral Epstein-Barr virus Influenza Hepatitis A and B Herpes simplex Measles Mumps Parvovirus B19 Polio Varicella Patients present with acute ataxia with gross and fine motor p...
CONCLUSIONS Our ﬁndings in mice are the first to suggest the involvement of the NKG2D/RAE-1 interaction and cytokines in the synergistic effects of NK and Kupffer cells in PBC. PMID: 32599603 [PubMed - in process]
CONCLUSION: Seropositivity for IgG antibodies correlate with TORCH-associated pregnancy complications in Abha, KSA; however, IgM positive CMV pregnant cases warrant further systematic investigation to understand the implications of CMV on outcomes during pregnancy. PMID: 32601646 [PubMed - in process]
Authors: Barnawi AI, Kordy FN, Almuwallad OK, Kassarah KA Abstract Elizabethkingia meningoseptica (E. meningoseptica ) are Gram-negative bacteria commonly associated with nosocomial infections in neonates. This is a case study of E. meningoseptica, presented as meningitis and sepsis in a term baby. The female infant was born by vaginal delivery at 37 weeks gestational age. The case was peculiar because the baby was neither premature nor immuno-compromised, which are known risk factors for E. meningoseptica infection. The onset began on the second day of the neonate's life. On day 3, peripheral blood culture and cer...
CONCLUSION: A clinical assessment of female patients with FM requires a multidisciplinary approach, and patients with excessive daytime sleepiness in particular are recommended to undergo polysomnography. The authors believe that the early detection and treatment of accompanying OSA will contribute not only to the quality of life, but also to the survival of patients with FM. PMID: 32601643 [PubMed - in process]
CONCLUSION: The NBS coverage rate at our facility was 100%. Congenital hypothyroidism was the most frequently detected disorder with an incidence that matches worldwide figures. The incidence of other inherited disorders was consistent with regional figures. PMID: 32601637 [PubMed - in process]
Publication date: Available online 30 June 2020Source: European Journal of RadiologyAuthor(s): Hannah du Preez, Imran Lasker, Ramanan Rajakulasingam, Asif Saifuddin
Publication date: Available online 30 June 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Fábio P. Sellera, Ralf Lopes, Daniel F. Monte, Brenda Cardoso, Fernanda Esposito, Carolina dos Anjos, Luciano C.B.A. da Silva, Nilton Lincopan
Conclusions: A significant number of patients with MINOCA have ischaemic LGE changes or myocardial wall oedema. The patients with CMR abnormalities have similar ECG and echocardiographic features except higher biomarker, highlighting the role of CMR in patients with MINOCA. PMID: 32594904 [PubMed - as supplied by publisher]
Authors: Biniwale N, Kibe R, Biniwale A Abstract Neuro-Behcet's disease (NBD) is a rare neurological manifestation of the systemic small vessel vasculitis called Behcet's disease. It can present in various ways with predilection for the brain stem, thalamo- hypothalamic regions, cerebellum and basal ganglia. In this case, we describe a case of young stroke that was later attributed to NBD. PMID: 32602687 [PubMed - in process]
Conclusion: The varied spectra of COVID-19 presentation included fever, cough, shortness of breath, sore throat etc. Diabetes mellitus, hypertension, COPD/K-Chest and CAD were found as major comorbid conditions. Symptomatic presentation of COVID-19 was observed to be higher in patients with co morbid disease, especially if multiple. HRCT chest in COVID-19 patients had a major diagnostic and prognostic importance as positive CT findings were more prominent in symptomatic patients and co-morbid patients. Clinical symptoms of patients directly correlated with CT severity index. CT imaging was found to be useful in predicting ...
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