Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study

Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. Methods: Using the Veterans Aging Cohort Study Survey Cohort, insomnia symptoms were measured and dummy coded with the item, “Difficulty falling or staying asleep?” (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with the Department of Veterans Affairs (VA) and Medicare administrative data and VA fee-for-service data. Those with baseline CVD were excluded. Results: HIV-infected (N = 3108) veterans had a median follow-up time of 10.8 years, during which 267 CVD events occurred. Compared to HIV-infected veterans with no difficulty falling or staying asleep, HIV-infected veterans bothered a lot by insomnia symptoms had an increased risk of incident CVD after adjusting for demographics [hazard ratio (HR) = 1.64, 95% confidence interval (CI): 1.16 to 2.31, P = 0.005], CVD risk factors (HR = 1.62, 95% CI: 1.14 to 2.30, P = 0.007), additional potential confounders (hepatitis C infection, renal disease, anemia, alcohol use, and cocaine use; HR = 1.70, 95% CI: 1.19 to 2.43, P = 0.003), and HIV-specific factors (HIV-1 RNA, CD4+ T-cell count, and antiretroviral therapy; HR = 1.66, 95% CI: 1.16 to 2.37, P = 0.005). Addition...
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Clinical Science Source Type: research

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Resumen A pesar de que son ampliamente conocidos los perfiles de utilizaci ón de las benzodiazepinas (BZD) y los riesgos asociados, este conocimiento no ha conducido a visibles transformaciones que mejoren la seguridad de los tratamientos y la salud de los pacientes. Por tanto, es necesaria una mejor compresión del contexto de su utilización, con el fin de implementar a cciones educativas eficaces, tomar decisiones clínicas pertinentes y perfeccionar su regulación en los servicios de salud. Este artículo se propone caracterizar el perfil de utilización de benzodiazepinas en ...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
Resumo Este artigo tem por base uma investiga ção realizada entre novembro de 2013 e janeiro de 2017, na Universidade do Minho (Portugal), sobre os docentes da Universidade Óscar Ribas (UOR) (Angola). Foi alicerçado num referencial teórico, a Psicodinâmica do Trabalho de Christophe Dejours, e teve como objetivos analisar os sintomas biops icossociais e os sentimentos de prazer e/ou de sofrimento relacionados com o trabalho docente. Foi utilizada a metodologia quantitativa, que teve por base a aplicação de um questionário e duas escalas a 56 docentes da UOR. Veri...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
ConclusionsFurther research exploring concurrent changes in all movement behaviours (PA, SB and sleep) and associated factors is warranted to inform future behavioural interventions and policies for promoting an optimal 24-h movement behaviour pattern during this critical developmental period.
Source: Journal of Science and Medicine in Sport - Category: Sports Medicine Source Type: research
Publication date: Available online 9 December 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): I Laffont, J Froger, C Jourdan, K Bakhti, LEH Van Dokkum, A Gouaich, HY Bonnin, P Armingaud, A Jaussent, MC Picot, E Le Bars, A Dupeyron, C Arquizan, A Gelis, D MottetAbstractBackground. Few rehabilitation methods have proven their efficacy in increasing sensori-motor recovery and/or function of the upper limb (UL) after stroke. Video games (VGs) are promising tools in this indication.Objective. To compare UL rehabilitation by using VGs and conventional rehabilitation (CR) in patients with sub-acute stroke.Des...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Insomnia and co-existing sleeplessness and musculoskeletal pain were inversely related to long-term recovery from chronic low back pain, a study found; relieving sleep problems may improve recovery.Medscape Medical News
Source: Medscape FamilyMedicine Headlines - Category: Primary Care Tags: Internal Medicine News Source Type: news
ConclusionNewly available evidence supports earlier findings that cannabidiol probably reduces the frequency of seizures among children with drug-resistant epilepsy.PROSPEROCRD42018084755
Source: Seizure - Category: Neurology Source Type: research
Publication date: Available online 9 December 2019Source: NeuropsychologiaAuthor(s): Fang Wang, Urs MaurerAbstractHow and when top-down information modulates visual-orthographic processing is an essential question in reading research. In a previous study, we showed that task modulation of print-tuning started at around 170 ms after stimulus presentation in the N1 offset of the ERP, while the N1 onset was yet unaffected. Here we test how prior category-level expectation affects visual-orthographic processing. Familiar, left/right-structured Chinese characters and stroke number matched, unfamiliar Korean characters were pr...
Source: Neuropsychologia - Category: Neurology Source Type: research
BOSTON (CBS) — According to a new study published in the journal Cancer, even light to moderate alcohol intake has been linked to a higher risk of cancer. Researchers at the University of Tokyo and the Harvard T.H. Chan School of Public Health looked at data on over 60,000 cancer patients in Japan. They found drinking as little as one drink a day for 10 years or two drinks a year for five years, was associated would increase overall cancer risk by five percent, such as cancers of the colon, stomach, breast, prostate, and esophagus. Cancer risk was lowest with no alcohol consumption.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated Local Cancer Dr. Mallika Marshall Drinking Source Type: news
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Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
Abstract Anoectochilus roxburghii (Wall.) Lindl., Orchidaceae, is a Chinese medicinal plant which can be effective for some diseases such as hepatitis, nephritis, pneumonia. Its active ingredient is kinsenoside. The mechanisms of kinsenoside on the liver-protective effect have not been fully explored until today. The present study was aimed to investigate the protective effect and mechanism of kinsenoside on acute alcoholic liver injury. The protected activity of kinsenoside (10, 20 and 40 mg/kg) were investigated on acute alcoholic liver injury in mice. Male C57BL/6 J mice were fed with non-fat feed for 30 days and oral a...
Source: Revista Brasileira de Farmacognosia - Category: Drugs & Pharmacology Source Type: research
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