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Drug: Melatonin

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Total 139 results found since Jan 2013.

Melatonin reduces OGD/R-induced neuron injury by regulating redox/inflammation/apoptosis signaling.
CONCLUSIONS: Melatonin protected SH SY5Y cells from OGD/R induced oxidative stress, inflammation, apoptosis, and autophagy by blocking NF-κB signaling and activating Nrf2/HO-1, Akt, and mTOR/p70S6K/4E-BP-1 pathways, thereby indicating that melatonin is a potential and novel therapeutic drug for ischemic stroke. PMID: 32096202 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 26, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Melatonin's efficacy in stroke patients; a matter of dose? A systematic review.
Abstract There is a lack of effective therapies for stroke patients; its treatment is even more difficult considering the unexpected onset of the disease. In the last decade, melatonin has emerged as a promising neuroprotective agent which is able to cross the blood-brain-barrier (BBB) and with a low toxicity profile. The aim of this systematic review was to summarize and critically review clinical and pre-clinical evidence related to melatonin's effectiveness as a stroke treatment. Together with a comparative dose extrapolation with those used in the selected randomized controlled trials (RCTs), and based on thes...
Source: Toxicology and Applied Pharmacology - February 25, 2020 Category: Toxicology Authors: Ramos E, Farré-Alins V, Egea J, López-Muñoz F, Reiter RJ, Romero A Tags: Toxicol Appl Pharmacol Source Type: research

Agomelatine protects against permanent cerebral ischaemia via the Nrf2-HO-1 pathway.
In this study, we focused on the effect of agomelatine on permanent cerebral ischaemia in a rat model. Male Wistar rats were randomly divided into the following four groups (n = 6/group): sham operating group, permanent ischaemic model group, permanent ischaemic model plus agomelatine (40 mg/kg, i.p) group and permanent ischaemic model plus melatonin (10 mg/kg, i.p) group. Twenty-four h after ischaemic onset, we investigated the neurological deficits and infarct volume using neurological deficit scores, 2,3,5-triphenyltetrazolium chloride (TTC) and transmission electron microscopy (Kochanski et al.). Moreover, we a...
Source: European Journal of Pharmacology - February 17, 2020 Category: Drugs & Pharmacology Authors: Chumboatong W, Khamchai S, Tocharus C, Govitrapong P, Tocharus J Tags: Eur J Pharmacol Source Type: research

Gen X Women Get Less Sleep Than Any Other Generation. What ’s Keeping Them Up?
In the middle of the night, I wake up feeling warm. I open the window and pull my hair back into a ponytail and drink some water. Then I glance at my phone, delete a few things, and see some spam. I hit unsubscribe and go back to bed. Then I lie there thinking, What if by opening that spam email I got myself hacked? What if I just sent everyone in my contact list a Burger King ad at two in the morning? Now wide awake, I move on to other concerns: my parents’ health, my stepson’s college tuition, pending deadlines. Hours roll by. I tackle real-life math problems: how many weeks I have before getting my next free...
Source: TIME: Health - January 6, 2020 Category: Consumer Health News Authors: Ada Calhoun Tags: Uncategorized Gen X healthy sleep insomnia Source Type: news

Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway.
CONCLUSION: Melatonin treatment ameliorates brain damage at least partially through shifting microglia phenotype from pro-inflammatory to anti-inflammatory polarity in a STAT3-dependent manner. PMID: 31793209 [PubMed - in process]
Source: CNS Neuroscience and Therapeutics - November 30, 2019 Category: Neuroscience Authors: Liu ZJ, Ran YY, Qie SY, Gong WJ, Gao FH, Ding ZT, Xi JN Tags: CNS Neurosci Ther Source Type: research

Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation
This study provides novel therapeutic targets and mechanisms for the treatment of ischemic stroke in the clinic, especially during cerebrovascular reperfusion.
Source: Life Sciences - November 6, 2019 Category: Biology Source Type: research

How You Should Spend That Extra Hour As Daylight Saving Time Ends
(CNN) — It’s Sunday morning, and you open your eyes to discover it’s still incredibly early because — huzzah! — we’ve reached the end of the seasonal practice known as Daylight Saving Time. Do you: A) Immediately roll over and go back to sleep? or B) Tell yourself that you shouldn’t be lazy, and get up to make the most of this “extra” hour? It’s a trick question, because there isn’t a perfectly right answer that would be the same for everyone. But in general, experts say, most should use the fall time change to squeeze in more sleep — and with zero gu...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - October 31, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Offbeat CNN Daylight saving time Source Type: news

Melatonin Regulates Neuroinflammation Ischemic Stroke Damage through Interactions with Microglia in Reperfusion phase.
In this study, we initially aimed to evaluate the therapeutic efficacy of melatonin intra-arterially and to clarify the underlying mechanisms. After that by using an in vitro approach, we evaluated the protective effects of melatonin on microglial cells following the hypoxia condition. Our results proved that a single dose of melatonin at the beginning of reperfusion phase improved structural and behavioral outcomes. Melatonin increased NeuN and decreased GFAP, Iba1 and active caspase-3 at protein level. Furthermore, melatonin elevated BDNF, MAP2, HSPA1A and reduced VEGF at mRNA level. We also showed that melatonin recepto...
Source: Brain Research - August 20, 2019 Category: Neurology Authors: Azedi F, Mehrpour M, Talebi S, Zendedel A, Kazemnejad S, Mousavizadeh K, Beyer C, Hassan Zarnani A, Taghi Joghataei M Tags: Brain Res Source Type: research

Effects of Melatonin on the Defense to Acute Hypoxia in Newborn Lambs
Neonatal lambs, as other neonates, have physiologically a very low plasma melatonin concentration throughout the 24-h. Previously, we found that melatonin given for 5 days decreased heart’s weight, changed plasma cortisol and gene expression in the adrenal and heart. Whether these changes could compromise the responses to life challenges is not known. Therefore, firstly we studied acute effects of melatonin on the defense mechanisms to acute hypoxia in the neonate. Eleven lambs, 2 weeks old were instrumented and submitted to an episode of acute isocapnic hypoxia, consisting of four 30 min periods: normoxia (room air); no...
Source: Frontiers in Endocrinology - July 11, 2019 Category: Endocrinology Source Type: research

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research

10 Biggest Myths About Sleeping, According To Researchers
(CNN) — Hey, sleepyheads. What you believe about sleep may be nothing but a pipe dream. Many of us have notions about sleep that have little basis in fact and may even be harmful to our health, according to researchers at NYU Langone Health’s School of Medicine, who conducted a study published Tuesday in the journal Sleep Health. “There’s such a link between good sleep and our waking success,” said lead study investigator Rebecca Robbins, a postdoctoral research fellow in the Department of Population Health at NYU Langone Health. “And yet we often find ourselves debunking myths, whether ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 16, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Healthwatch News CNN Sleep Source Type: news

Light-Induced Pupillary Responses in Alzheimer's Disease
Light-Induced Pupillary Responses in Alzheimer's Disease Pratik S. Chougule1, Raymond P. Najjar1,2, Maxwell T. Finkelstein1, Nagaendran Kandiah3,4 and Dan Milea1,2,5* 1Department of Visual Neurosciences, Singapore Eye Research Institute, Singapore, Singapore 2The Ophthalmology & Visual Sciences ACP, Duke-National University of Singapore (NUS) Medical School, Singapore, Singapore 3Department of Neurology, National Neuroscience Institute, Singapore, Singapore 4Duke-National University of Singapore (NUS), Singapore, Singapore 5Singapore National Eye Centre, Singapore, Singapore The impact of Alzhe...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

The Effects of Naturalistic Light on Diurnal Plasma Melatonin and Serum Cortisol Levels in Stroke Patients during Admission for Rehabilitation: A Randomized Controlled Trial.
Conclusions: This study is the first to demonstrate elevated melatonin plasma levels and evolved rhythmicity due to stimulation with naturalistic light. PMID: 30662336 [PubMed - in process]
Source: International Journal of Medical Sciences - January 22, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Co-Administration of Progesterone and Melatonin Attenuates Ischemia-Induced Hippocampal Damage in Rats
AbstractStroke is the second leading reason for death worldwide and is one of the fundamental causes of long-term disabilities. The aim of this investigation was to assess the impact of combined administration progesterone (PROG) and melatonin (MEL) on stroke complications. Male Wistar rats (9 –10 weeks) weighing 250–300 g were used as a part of this examination. They were randomly separated into eight groups (nine rats for every group). Common carotid arteries on the two sides clamped (BCCAO model) with non-traumatic clips for 20 min. At that point, the rats were treated with 8 m g/kg PROG, 10 mg/kg MEL, and vehi...
Source: Journal of Molecular Neuroscience - October 1, 2018 Category: Neuroscience Source Type: research