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Drug: Melatonin

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Total 139 results found since Jan 2013.

Melatonin and Ischemic Stroke: Mechanistic Roles and Action.
Authors: Andrabi SS, Parvez S, Tabassum H Abstract Stroke is one of the most devastating neurological disabilities and brain's vulnerability towards it proves to be fatal and socio-economic loss of millions of people worldwide. Ischemic stroke remains at the center stage of it, because of its prevalence amongst the several other types attacking the brain. The various cascades of events that have been associated with stroke involve oxidative stress, excitotoxicity, mitochondrial dysfunction, upregulation of Ca(2+) level, and so forth. Melatonin is a neurohormone secreted by pineal and extra pineal tissues responsibl...
Source: Advances in Pharmacological Sciences - October 6, 2015 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

Neuroprotective mechanism of the novel melatonin derivative Neu-P11 in brain ischemia related models.
In conclusion, Neu-P11 affords neuroprotection against brain ischemia in in vitro and in vivo models by activating a pro-survival signaling pathway that involves melatonin receptors, JAK/STAT, PI3K/Akt and MEK/ERK1/2. PMID: 26188145 [PubMed - as supplied by publisher]
Source: Neuropharmacology - July 15, 2015 Category: Drugs & Pharmacology Authors: Buendia I, Gómez-Rangel V, González-Lafuente L, Parada E, León R, Gameiro I, Michalska P, Laudon M, Egea J, López MG Tags: Neuropharmacology Source Type: research

Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats
Melatonin, N-aceyl-5-methoxytryptamine, is the main secretory product of the pineal gland and has neuroprotective effects on several brain injuries including ischemic stroke. In the present study, we hypothesized that exogenous melatonin may decrease hypoglycemia-induced neuronal death through prevention of superoxide generation. To test our hypothesis, hypoglycemia was induced by injecting human insulin (10 U/kg, ip) in rats. Melatonin injection was started immediately after hypoglycemia (10 mg/kg, ip). The first melatonin injection was performed at the end of a 30-min isoelectric EEG period. The second and third injectio...
Source: Neuroendocrinology - June 10, 2015 Category: Endocrinology Source Type: research

7 Big Things We Learned About Sleep In The Past Decade
It's no secret that here at The Huffington Post, we love sleep -- and for good reason. Sleep has been called the "third pillar" of health, along with nutrition and exercise. Getting the quality sleep that you need has the power to protect your physical and mental health, while skipping out on sleep can seriously hurt your health, cognition and well-being over time. Over the past 10 years, sleep has finally become widely recognized as a critical aspect of good health, and new research has shed more light on its importance in our lives. Here's what we've learned. 1. A sleeping brain is an active brain. While you're re...
Source: Science - The Huffington Post - May 25, 2015 Category: Science Source Type: news

The effect of blue-blocking intraocular lenses on circadian biological rhythm: protocol for a randomised controlled trial (CLOCK-IOL colour study)
Introduction Blue light information plays an important role in synchronising internal biological rhythm within the external environment. Circadian misalignment is associated with the increased risk of sleep disturbance, obesity, diabetes mellitus, depression, ischaemic heart disease, stroke and cancer. Meanwhile, blue light causes photochemical damage to the retina, and may be associated with age-related macular degeneration (AMD). At present, clear intraocular lenses (IOLs) and blue-blocking IOLs are both widely used for cataract surgery; there is currently a lack of randomised controlled trials to determine whether clear...
Source: BMJ Open - May 12, 2015 Category: Journals (General) Authors: Nishi, T., Saeki, K., Obayashi, K., Miyata, K., Tone, N., Tsujinaka, H., Yamashita, M., Masuda, N., Mizusawa, Y., Okamoto, M., Hasegawa, T., Maruoka, S., Ueda, T., Kojima, M., Matsuura, T., Kurumatani, N., Ogata, N. Tags: Open access, Epidemiology, Ophthalmology Protocol Source Type: research

Stroke and pineal gland calcification: Lack of association. Results from a population-based study (The Atahualpa Project)
The pineal gland has been the subject of myths and misconceptions over the years. These ranged from the ancient belief that it is the “seat of the soul” (René Descartes, 1596-1650), to more recent hypotheses suggesting that pineal dysfunction is associated with sense of direction loss [1] or that calcifications of the gland are less prevalent in underdeveloped societies [2]. Current knowledge indicates that the main function of the pineal gland is to secrete melatonin, a hormone primarily associated with timing of circadian rhythms and control of the sleep-wake cycle [3].
Source: Clinical Neurology and Neurosurgery - January 5, 2015 Category: Neurosurgery Authors: Oscar H. Del Brutto, Robertino M. Mera, Julio Lama, Mauricio Zambrano Source Type: research

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1‐dependent mechanism during ischemic‐stroke in mice
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - November 17, 2014 Category: Research Authors: Yang Yang, Shuai Jiang, Yushu Dong, Chongxi Fan, Lei Zhao, Xiangmin Yang, Juan Li, Shouyin Di, Liang Yue, Guobiao Liang, Russel J Reiter, Yan Qu Tags: Original Article Source Type: research

The Role of Melatonin in Multiple Sclerosis, Huntington's Disease and Cerebral Ischemia.
Abstract Melatonin is produced and released by the pineal gland in a circadian rhythm. This neurohormone has proven to be an antioxidant and anti-inflammatory molecule able to reduce or mitigate cell damage associated with oxidative stress and inflammation, and this phenomenon underlies neurodegenerative disorders. These facts have drawn attention to this indole,triggering interest in evaluating its changes and in its relationship to the processes indicated, and analyzing its role in the mechanisms involved at the onset and development of neurodegenerative diseases, as well as its therapeutic potential. Multiple s...
Source: CNS and Neurological Disorders Drug Targets - August 6, 2014 Category: Drugs & Pharmacology Authors: Escribano BM, Colín-González AL, Santamaría A, Tunez I Tags: CNS Neurol Disord Drug Targets Source Type: research

Preconditioned Stem Cells: a Promising Strategy for Cell-Based Ischemic Stroke Therapy.
Abstract Ischemic stroke is a leading cause of mortality and morbidity worldwide. Numerous therapeutic studies, including stem cell therapy, have been explored in order to find the possible approach treating cerebral ischemia effectively. However, massive grafted-cell death and low survival rate made us pessimistic about the widespread application of stem cell therapy. The approach of preconditioning stem cells became an attractive option due to its high cell viability after transplantation. In this review, we focused on preconditioning stem cells via cytokines, chemical drugs and other factors including interleuk...
Source: Current Drug Targets - June 23, 2014 Category: Drugs & Pharmacology Authors: Cai H, Zhang Z, Yang GY Tags: Curr Drug Targets Source Type: research

Alterations in the time course of expression of the Nox family in the brain in a rat experimental cerebral ischemia and reperfusion model: effects of melatonin
This study was designed to evaluate the time course of expression of the Nox family, a major source of ROS, and whether melatonin, a potent scavenger of ROS, influences these parameters in a rat model of cerebral I/R caused by middle cerebral artery occlusion (MCAO). After 2 h occlusion, the filament was withdrawn to allow reperfusion. At 0 h, 3 h, 6 h, 12 h, 24 h and 48 h after reperfusion, brain tissue samples were obtained for assays. Among the Nox family, the mRNA and protein levels of Nox2 and Nox4 were increased both in the ischemic hemisphere and contralateral counterpart in the experimental I/R rats at 0 h after ...
Source: Journal of Pineal Research - May 1, 2014 Category: Research Authors: Haiying Li, Yang Wang, Dongxia Feng, Yin Liu, Min Xu, Anju Gao, Fengxuan Tian, Li Zhang, Yonghua Cui, Zhong Wang, Gang Chen Tags: Original Article Source Type: research

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha‐7 nicotinic receptor modulation and HO‐1 overexpression
In this study, we evaluated the neuroprotective/antioxidant mechanism of action of melatonin in organotypic hippocampal cultures (OHCs) as well as in photothrombotic stroke model in vivo. Melatonin (0.1, 1, and 10 μm) incubated postoxygen and glucose deprivation (OGD) showed a concentration‐dependent protection; maximum protection was achieved at 10 μm (90% protection). Next, OHCs were exposed to 10 μm melatonin at different post‐OGD times; the protective effect of melatonin was maintained at 0, 1, and 2 hr post‐OGD treatment, but it was lost at 6 hr post‐OGD. The protective effect of melatonin and the redu...
Source: Journal of Pineal Research - January 16, 2014 Category: Research Authors: Esther Parada, Izaskun Buendia, Rafael León, Pilar Negredo, Alejandro Romero, Antonio Cuadrado, Manuela G. López, Javier Egea Tags: Original Article Source Type: research

Melatonin improves neuroplasticity by upregulating the growth‐associated protein‐43 (GAP‐43) and NMDAR postsynaptic density‐95 (PSD‐95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long‐term recovery period
Abstract Recent evidence shows that the NMDAR postsynaptic density‐95 (PSD‐95), growth‐associated protein‐43 (GAP‐43), and matrix metalloproteinase‐9 (MMP‐9) protein enhance neuroplasticity at the subacute stage of stroke. Here, we evaluated whether melatonin would modulate the PSD‐95, GAP‐43, and MMP‐9 proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to experimental stroke. Adult male Sprague–Dawley rats were treated with melatonin (5 mg/kg) or vehicle at reperfusion onset after transient occlusion of the right middle cerebral artery (tMCAO) for 90 min. Animals...
Source: Journal of Pineal Research - January 13, 2014 Category: Research Authors: Wei‐Sheng Juan, Sheng‐Yang Huang, Che‐Chao Chang, Yu‐Chang Hung, Yu‐Wen Lin, Tsung‐Ying Chen, Ai‐Hua Lee, Ai‐Chiang Lee, Tian‐Shung Wu, E‐Jian Lee Tags: Original Article Source Type: research

Melatonin improves neuroplasticity by upregulating the growth‐associated protein 43 (GAP‐43) and NMDAR‐post‐synaptic density‐95 (PSD95) proteins in cultured neurons exposed to glutamate excitotoxicity and in rats subjected to transient focal cerebral ischemia even during a long‐term recovery period
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - December 18, 2013 Category: Research Authors: Wei‐Sheng Juan, Sheng‐Yang Huang, Che‐Chao Chang, Yu‐Chang Hung, Yu‐Wen Lin, Tsung‐Ying Chen, Ai‐Hua Lee, Ai‐Chiang Lee, Tian‐Shung Wu, E‐Jian Lee Tags: Original Article Source Type: research

Neuroprotective effect of melatonin against ischemia is partially mediated by alfa‐7 nicotinic receptor modulation and HO‐1 overexpression
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - December 18, 2013 Category: Research Authors: Esther Parada, Izaskun Buendia, Rafael León, Pilar Negredo, Alejandro Romero, Antonio Cuadrado, Manuela G. López, Javier Egea Tags: Original Article Source Type: research