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Drug: Melatonin
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Total 139 results found since Jan 2013.
Agomelatine Exerts an Anti-inflammatory Effect by Inhibiting Microglial Activation Through TLR4/NLRP3 Pathway in pMCAO Rats
In this study, we aimed to investigate the anti-inflammatory effect of agomelatine in a permanent middle cerebral artery occlusion (pMCAO) model. Forty-eight male Wistar rats were randomly divided into four groups: sham, pMCAO + vehicle, pMCAO + agomelatine (40 mg/kg, i.p.), and pMCAO + melatonin (10 mg/kg, i.p.) groups. On day 1 after permanent cerebral ischemia, the animals were sacrificed, and brain tissues were collected for western blot analysis, and immunohistochemistry. Agomelatine treatment ameliorated inflammatory responses by decreasing the protein levels of trigger Toll-like receptor (TLR4)/nuclear factor kappa-...
Source: Cell Research - November 29, 2021 Category: Cytology Authors: Wijitra Chumboatong Satchakorn Khamchai Chainarong Tocharus Piyarat Govitrapong Jiraporn Tocharus Source Type: research
Ramelteon Mitigates Free Fatty Acid (FFA)-Induced Attachment of Monocytes to Brain Vascular Endothelial Cells
In conclusion, Ramelteon mitigated FFA-induced attachment of monocytes to brain vascular endothelial cells by increasing the expression of KLF2 and reducing the expression of E-selectin.PMID:34792763 | DOI:10.1007/s12640-021-00422-1
Source: Cell Research - November 18, 2021 Category: Cytology Authors: Guijie Wang Fang Tian Yu Li Yang Liu Chunfeng Liu Source Type: research
Inflammatory Cytokines are in Action: Brain Plasticity and Recovery after Brain Ischemia Due to Delayed Melatonin Administration
Brain ischemia is a critical condition which starts because of a decrease in blood circulation to brain. This insufficient blood flow leads to inability to do metabolic functions and to the death of brain tissue. In the acute phase of the stroke, inflammation occurs in the ischemic hemisphere due to the infiltration of blood immune cells from damaged blood-brain barrier (BBB). Infiltrating immune cells because the secretion of various inflammatory mediators, and a secondary damage occurs in the place of stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - September 18, 2021 Category: Neurology Authors: Ulkan Kilic, Birsen Elibol, Merve Beker, Burcugul Altug-Tasa, Ahmet Burak Caglayan, Mustafa Caglar Beker, Bayram Yilmaz, Ertugrul Kilic Source Type: research
Melatonin supplementation in the subacute phase after ischemia alleviates postischemic sleep disturbances in rats
ConclusionsMelatonin promptly reversed ischemia-induced sleep disturbances. The neuroprotective effects of melatonin on ischemic injury may be partially associated with its role in sleep modulation.
Source: Brain and Behavior - September 14, 2021 Category: Neurology Authors: Shu ‐Mei Hao,
Zhi‐Gang Zhong,
Wei‐Min Qu,
Zhi‐Li Huang,
Feng‐Yan Sun,
Mei‐Hong Qiu Tags: ORIGINAL ARTICLE Source Type: research
Modulation of α7nAchR by Melatonin Alleviates Ischemia and Reperfusion-Compromised Integrity of Blood-Brain Barrier Through Inhibiting HMGB1-Mediated Microglia Activation and CRTC1-Mediated Neuronal Loss
Cell Mol Neurobiol. 2021 Jul 1. doi: 10.1007/s10571-021-01122-2. Online ahead of print.ABSTRACTThe only food and drug administration (FDA)-approved drug currently available for the treatment of acute ischemic stroke is tissue plasminogen activator (tPA), yet the therapeutic benefits of this drug are partially outweighed by the increased risk of hemorrhagic transformation (HT). Analysis of the NIH trial has shown that cigarette smoking protected tPA-treated patients from HT; however, the underlying mechanism is not clear. Nicotinic acetylcholine receptors (nAChR) has shown anti-inflammatory effect and modulation nAChR could...
Source: Cellular and Molecular Neurobiology - July 1, 2021 Category: Cytology Authors: Shuang Chen Yanyun Sun Fei Li Xinyu Zhang Xiaoyan Hu Xiaoyun Zhao Yixuan Li Hui Li Jianliang Zhang Wenlan Liu Guo-Qing Zheng Xinchun Jin Source Type: research
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway
Aging (Albany NY). 2021 Jun 11;13. doi: 10.18632/aging.203137. Online ahead of print.ABSTRACTDiabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, cerebral infarct volume, brain edema, and cell viability, reduced mitochondrial swelli...
Source: Aging - June 12, 2021 Category: Biomedical Science Authors: Lian Liu Quan Cao Wenwei Gao Bingyu Li Zhongyuan Xia Bo Zhao Source Type: research
Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain
CONCLUSION: Conclusively, Mel is a potent biomaterial which could potentially impart neurogenesis through repairing impaired metabolic-redox circuit via enhanced TNT-mediated mitochondrial transfer, anti-oxidation, and anti-apoptotic activities in ischemia.PMID:33865018 | DOI:10.1016/j.biopha.2021.111593
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2021 Category: Drugs & Pharmacology Authors: Hon-Kan Yip Navneet Kumar Dubey Kun-Chen Lin Pei-Hsun Sung John Y Chiang Yi-Ching Chu Chi-Ruei Huang Yi-Ling Chen Yue-Hua Deng Hsin-Chung Cheng Win-Ping Deng Source Type: research
Analysis of Evolution and Ethnic Diversity at Glucose-Associated SNPs of Circadian Clock-Related Loci with Cryptochrome 1, Cryptochrome 2, and Melatonin receptor 1B
Biochem Genet. 2021 Mar 11. doi: 10.1007/s10528-021-10045-y. Online ahead of print.ABSTRACTDiabetes shows high heritability and, worldwide, causes significant health problems including cardiovascular disease and stroke. There is significant variation in the frequency of diabetes between different populations. Both Cryptochromes and Melatonin have a major role to regulate the circadian clock. Circadian clock failure causes metabolic dysfunctions including diabetes and obesity. Variations in the Cryptochrome 1, the Cryptochrome 2, and the Melatonin receptor 1B (MTNR1B) genes show associations with fasting glucose, and are al...
Source: Biochemical Genetics - March 12, 2021 Category: Genetics & Stem Cells Authors: Issei Yoshiuchi Source Type: research
Prevention of depression in adults with long-term physical conditions
CONCLUSIONS: Based on evidence of very low certainty, our results may indicate the benefit of pharmacological interventions, during or directly after preventive treatment. Few trials examined short-term outcomes up to six months, nor the follow-up effects at six to 12 months, with studies suffering from great numbers of drop-outs and inconclusive results. Generalisation of results is limited as study populations and treatment regimes were very heterogeneous. Based on the results of this review, we conclude that for adults with long-term physical conditions, there is only very uncertain evidence regarding the implementation...
Source: Cochrane Database of Systematic Reviews - March 5, 2021 Category: General Medicine Authors: Hanna Kampling Harald Baumeister J ürgen Bengel Oskar Mittag Source Type: research
