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Drug: Melatonin
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Total 139 results found since Jan 2013.
Too Little Sleep Destroys DNA?
I talk to my patients about the danger of not sleeping all the time. Unfortunately, it’s a common problem that affects 75 million Americans.
People who don’t sleep, or sleep poorly, have up to 400% more accidents that those who get a good night’s rest. Not getting enough sleep also increases your risk of developing chronic diseases.
Studies, including a large meta-analysis of 470,000 adults, found that those who slept less than six hours developed a:1,2,3,4,5
48% increase in the incidence of coronary heart disease
30% increased risk of dementia
15% increase in the incidence of stroke
50% cancer risk
17% higher risk ...
Source: Al Sears, MD Natural Remedies - August 25, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news
Melatonin mitigates type 1 diabetes ‐aggravated cerebral ischemia‐reperfusion injury through anti‐inflammatory and anti‐apoptotic effects
ConclusionsT1DM aggravates CIRI. Melatonin treatment is neuroprotective against CIRI in T1DM rats via anti-inflammatory and anti-apoptotic effects.
Source: Brain and Behavior - June 16, 2023 Category: Neurology Authors: Qian Xu,
Raymond Tak Fai Cheung Tags: ORIGINAL ARTICLE Source Type: research
Melatonin modulates the aggravation of pyroptosis, necroptosis, and neuroinflammation following cerebral ischemia and reperfusion injury in obese rats
This study aimed to investigate the roles of melatonin on pyroptosis, necroptosis, and pro-inflammatory pathways occurring in the I/R brain of obese rats. Male Wistar rats were given a high-fat diet for 16 weeks to induce the obese condition, and then were divided into 4 groups: Sham-operated, I/R treated with vehicle, I/R treated with melatonin (10 mg/kg), and I/R treated with glycyrrhizic acid (10 mg/kg). All drugs were administered via intraperitoneal injection at the onset of reperfusion. The development of neurological deficits, cerebral infarction, histological changes, neuronal death, and glial cell hyperactivation ...
Source: Biochimica et Biophysica Acta - June 11, 2023 Category: Biochemistry Authors: Nuttapong Yawoot Jirakhamon Sengking Piyarat Govitrapong Chainarong Tocharus Jiraporn Tocharus Source Type: research
Melatonin regulates microglial polarization and protects against ischemic stroke-induced brain injury in mice
Exp Neurol. 2023 Jun 8:114464. doi: 10.1016/j.expneurol.2023.114464. Online ahead of print.ABSTRACTIschemic stroke is a leading cause of mortality and morbidity worldwide, with neuroinflammation playing a key role in its pathophysiology. Microglia, the primary immune cells in the brain, undergo rapid activation and phenotypic polarization, which are crucial for regulating neuroinflammatory responses following ischemic stroke. Melatonin is a promising neuroprotective agent that can regulate microglial polarization in central nervous system (CNS) diseases. However, the specific mechanism underlying the neuroprotective effect...
Source: Experimental Neurology - June 10, 2023 Category: Neurology Authors: Donghai Li Tianpeng He Yue Zhang Junru Liu Haiyu Zhao Dongliang Wang Quanchao Wang Yuan Yuan Shengxiang Zhang Source Type: research
Circadian Factors in Stroke: A Clinician ’s Perspective
AbstractStroke remains one of the leading causes of mortality and long-term and permanent disability worldwide despite technological innovations and developments in pharmacotherapy. In the last few decades, the growing data have evidenced the role of the circadian system in brain vulnerability to damage, the development and evolution of stroke, and short-term and long-term recovery. On the other hand, the stroke itself can affect the circadian system via direct injury of specific brain structures involved in circadian regulation (i.e., hypothalamus, retinohypothalamic tracts, etc.) and impairment of endogenous regulatory m...
Source: Cardiology and Therapy - May 16, 2023 Category: Cardiology Source Type: research
How People With Diabetes Can Lower Stroke Risk
After spending nearly two decades trying to manage her Type 2 diabetes, Agnes Czuchlewski landed in the emergency room in 2015, with news that she’d just experienced a heart attack. She also learned that she had metabolic syndrome, a cluster of conditions that includes diabetes but also brings higher risk of heart disease and stroke.
“Because I needed to lose quite a bit of weight when I was first diagnosed, I was focused on the number I saw on the scale, and then on my blood-sugar numbers,” recalls Czuchlewski, 68, who lives in New York City. “I didn’t realize other numbers came into play, li...
Source: TIME: Health - November 10, 2022 Category: Consumer Health News Authors: Elizabeth Millard Tags: Uncategorized Disease healthscienceclimate Source Type: news
Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule
We report that melatonin treatment downregulates ER stress in the ischemic period and enhances dissociation of the refractory SGs during reperfusion, thus offering dual-phase protection to BVECs in prolonged cerebral stroke. Mechanistically, melatonin enhances autophagy in BVECs, which preserves ER function and resolves refractory SGs. We, therefore, propose that melatonin is a potential treatment to extend the time window of delayed recanalization therapy in AIS.PMID:36181629 | DOI:10.1007/s12975-022-01084-7
Source: Cell Research - October 1, 2022 Category: Cytology Authors: Danli Lu Yuxin Liu Huipeng Huang Mengyan Hu Tiemei Li Shisi Wang Shishi Shen Ruizhen Wu Wei Cai Tingting Lu Zhengqi Lu Source Type: research
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality
Drug Deliv. 2022 Dec;29(1):2469-2480. doi: 10.1080/10717544.2022.2104405.ABSTRACTIschemic stroke accounts for about 87% of all strokes, causing long-term disability in adults, and is the second leading cause of death worldwide. In search of new therapeutic modalities, the use of neuroprotective agents loaded in nanocarriers to be delivered by noninvasive means (i.e. via intranasal route) became a popular approach. In the current study, melatonin (MEL) was loaded in lipidic nanocapsules (LNCs) prepared using the phase inversion method, and characterized in terms of size, polydispersity, zeta potential, in vitro drug release...
Source: Drug Delivery - July 27, 2022 Category: Drugs & Pharmacology Authors: Eman A Bseiso Sarah A AbdEl-Aal Maha Nasr Omaima A Sammour Nabaweya A Abd El Gawad Source Type: research
What Medications Prevent Delirium in Elderly Medical Inpatients?
This study demonstrated lower rates of delirium in the melatonin arm, with an impressive number needed to treat (NNT) below six patients; mortality and length of hospital stay were unaffected.3 A delirium-prevention effect of melatonin has not been reproduced in other studies, notably Jaiswal et al, which randomized patients to a placebo or 3 mg of melatonin and found no difference in rates of delirium prevention.7
The melatonin receptor agonist ramelteon also has small but favorable evidence for preventing non-ICU hospitalized delirium. This comes from a study of 67 patients aged 65 years or older who were randomized to...
Source: The Hospitalist - May 2, 2022 Category: Hospital Management Authors: Ronda Whitaker Tags: Drug Therapy Geriatrics Key Clinical Questions Medication Source Type: research
What the Science Says About the Health Benefits of Vitamins and Supplements
From multivitamins and melatonin to fiber and fish oil, Americans who are trying to boost their health and immunity have a plethora of supplements to choose from. An estimated 58% of U.S. adults ages 20 and over take dietary supplements, according to the U.S. Centers for Disease Control and Prevention, and the supplement industry is valued at more than $30 billion a year. Supplement use has been growing rapidly over the past few decades along with the wellness industry.
“The popular belief is that a supplement is going to be helpful for promoting health,” says Fang Fang Zhang, a professor at Tufts University&rs...
Source: TIME: Health - April 28, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news
Gut Flora Mediates the Rapid Tolerance of Electroacupuncture on Ischemic Stroke by Activating Melatonin Receptor through Regulating Indole-3-Propionic Acid
This study aimed to clarify the mechanisms of action of treatments of cerebral ischemic stroke from the perspective of gut microecology. We used a mouse model and cell cultures to investigate the effects of EA on the intestinal microflora in mice models of middle cerebral artery occlusion (MCAO) and the mechanisms underlying the antioxidant activities of metabolites. Fecal microbiota transplantation (FMT) was used to validate the roles of gut microbiota. Metabolomic analysis was performed to characterize the metabolic profile differences between the mice in the EA + MCAO and MCAO groups. Gavaging with feces relieved brain ...
Source: The American Journal of Chinese Medicine - April 27, 2022 Category: Complementary Medicine Authors: Shan Li Xiaoyong Zhao Feihong Lin Xuqing Ni Xia Liu Chang Kong Xinyu Yao Yunchang Mo Qinxue Dai Junlu Wang Source Type: research
