Melatonin Offers Dual-Phase Protection to Brain Vessel Endothelial Cells in Prolonged Cerebral Ischemia-Recanalization Through Ameliorating ER Stress and Resolving Refractory Stress Granule

We report that melatonin treatment downregulates ER stress in the ischemic period and enhances dissociation of the refractory SGs during reperfusion, thus offering dual-phase protection to BVECs in prolonged cerebral stroke. Mechanistically, melatonin enhances autophagy in BVECs, which preserves ER function and resolves refractory SGs. We, therefore, propose that melatonin is a potential treatment to extend the time window of delayed recanalization therapy in AIS.PMID:36181629 | DOI:10.1007/s12975-022-01084-7

Source: Cell Research - October 1, 2022 Category: Cytology Authors: Danli Lu Yuxin Liu Huipeng Huang Mengyan Hu Tiemei Li Shisi Wang Shishi Shen Ruizhen Wu Wei Cai Tingting Lu Zhengqi Lu Source Type: research