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Drug: Melatonin

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Total 139 results found since Jan 2013.

Melatonin improves vascular cognitive impairment induced by ischemic stroke by remyelination via activation of ERK1/2 signaling and restoration of glutamatergic synapses in the gerbil hippocampus
In this study, effects of melatonin on cognitive impairment and related mechanisms were investigated in an animal model of ischemic vascular dementia (IVD). Melatonin was intraperitoneally administered to adult gerbils after transient global cerebral ischemia (tGCI) for 25 days beginning 5 days after tGCI. Cognitive impairment was examined using a passive avoidance test and the Barnes maze test. To investigate mechanisms of restorative effects by melatonin, neuronal damage/death, myelin basic protein (MBP, a marker for myelin), Rip (a marker for oligodendrocyte), extracellular signal-regulated protein kinase1/2 (ERK1/2) an...
Source: Biomedicine and Pharmacotherapy - September 21, 2018 Category: Drugs & Pharmacology Source Type: research

Co-Administration of Progesterone and Melatonin Attenuates Ischemia-Induced Hippocampal Damage in Rats
AbstractStroke is the second leading reason for death worldwide and is one of the fundamental causes of long-term disabilities. The aim of this investigation was to assess the impact of combined administration progesterone (PROG) and melatonin (MEL) on stroke complications. Male Wistar rats (9 –10 weeks) weighing 250–300 g were used as a part of this examination. They were randomly separated into eight groups (nine rats for every group). Common carotid arteries on the two sides clamped (BCCAO model) with non-traumatic clips for 20 min. At that point, the rats were treated with 8 m g/kg PROG, 10 mg/kg MEL, and vehi...
Source: Journal of Molecular Neuroscience - September 4, 2018 Category: Neuroscience Source Type: research

Daylight Saving Time Starts Sunday. Here ’s What Losing An Hour of Sleep Really Does to Your Body
The start of Daylight Saving Time, when the clocks spring forward by an hour, is among the most hated days of the year. Aside from the obvious reason — losing an hour of sleep — research has shown that the time change, which this year falls on March 11, may contribute to everything from lost productivity to a heightened risk of heart attack and stroke. How can resetting your clocks do all that? TIME asked Dr. Cathy Goldstein, an assistant professor of neurology at the University of Michigan School of Medicine Sleep Disorders Center, what really happens to your body when you lose an hour of sleep for Daylight Sa...
Source: TIME: Health - March 9, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime onetime sleep Source Type: news

Daylight Saving Time Starts Today. Here ’s What Losing An Hour of Sleep Really Does to Your Body
The start of Daylight Saving Time, when the clocks spring forward by an hour, is among the most hated days of the year. Aside from the obvious reason — losing an hour of sleep — research has shown that the time change, which this year falls on March 11, may contribute to everything from lost productivity to a heightened risk of heart attack and stroke. How can resetting your clocks do all that? TIME asked Dr. Cathy Goldstein, an assistant professor of neurology at the University of Michigan School of Medicine Sleep Disorders Center, what really happens to your body when you lose an hour of sleep for Daylight Sa...
Source: TIME: Health - March 9, 2018 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized healthytime onetime sleep Source Type: news

The neuroprotective role of melatonin in neurological disorders
Abstract Melatonin is a neurohormone secreted from the pineal gland and has a wide‐ranging regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in some neurological conditions such as stroke, Alzheimer's disease, and Parkinson's disease, which indicates its involvement in the pathophysiology of these diseases. Its properties qualify it to be a promising potential therapeutic neuroprotective agent, with no side effects, for some neurological disorders. This review discusses and localizes the effect of melatonin in the pathophysiology of some diseases.
Source: Journal of Neuroscience Research - March 2, 2018 Category: Neuroscience Authors: B. S. Alghamdi Tags: REVIEW Source Type: research

Melatonin provides protection against heat stroke ‐induced myocardial injury in male rats
ConclusionsMelatonin may protect against HS‐induced myocardial injury in male rats by mitigating oxidative stress and inflammation.
Source: Journal of Pharmacy and Pharmacology - February 27, 2018 Category: Drugs & Pharmacology Authors: Xiaojing Lin, Tingbao Zhao, Cheng ‐Hsien Lin, Dan Zuo, Zhujun Ye, Shide Lin, Shaonan Wen, Lin Liu, Mao‐Tsun Lin, Ching‐Ping Chang, Chien‐Ming Chao Tags: Research Paper Source Type: research

Circadian rhythms of melatonin and cortisol in manifest Huntington's disease and in acute cortical ischemic stroke.
In conclusion, 1) abnormal pattern of melatonin release in the late stages of HD and in moderate AIS occurs in conjunction with phase-advanced rhythm of cortisol; 2) changes observed in late stages of HD are similar to those that occur with ageing; 3) brain regions other than the presumptive retinopineal neural pathway may play an important role in the pineal production of melatonin in humans; 4) lesion in extrahypothalamic region is related to the strong adrenal stimulation in response to AIS. PMID: 29151070 [PubMed - in process]
Source: Journal of Physiology and Pharmacology - November 22, 2017 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Associations between Greenness, Impervious Surface Area, and Nighttime Lights on Biomarkers of Vascular Aging in Chennai, India
Conclusion: Greenness, ISA, and NTL were associated with increased SBP, DBP, and cPP, and with reduced FMD, suggesting a possible additional EVA pathway for the relationship between urbanization and increased CVD prevalence in urban India. https://doi.org/10.1289/EHP541 Received: 20 May 2016 Revised: 03 January 2017 Accepted: 23 January 2017 Published: 02 August 2017 Address correspondence to K.J. Lane, Yale School of Forestry and Environmental Studies, 195 Prospect Street, New Haven, CT 06511 USA. Telephone: (781) 696-4537; Email: kevin.lane@yale.edu Supplemental Material is available online (https://doi.org/10.1289...
Source: EHP Research - August 2, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Melatonin Alleviates Intracerebral Hemorrhage-Induced Secondary Brain Injury in Rats via Suppressing Apoptosis, Inflammation, Oxidative Stress, DNA Damage, and Mitochondria Injury
AbstractIntracerebral hemorrhage (ICH) is a cerebrovascular disease with high mortality and morbidity, and the effective treatment is still lacking. We designed this study to investigate the therapeutic effects and mechanisms of melatonin on the secondary brain injury (SBI) after ICH. An in vivo ICH model was induced via autologous whole blood injection into the right basal ganglia in Sprague-Dawley (SD) rats. Primary rat cortical neurons were treated with oxygen hemoglobin (OxyHb) as an in vitro ICH model. The results of the in vivo study showed that melatonin alleviated severe brain edema and behavior disorders induced b...
Source: Translational Stroke Research - August 1, 2017 Category: Neurology Source Type: research

Sleep Deprivation Is Killing You (And Making You Fat In The Process)
The next time you tell yourself that you'll sleep when you're dead, realize that you're making a decision that can make that day come much sooner. Pushing late into the night is a health and productivity killer. According to the Division of Sleep Medicine at the Harvard Medical School, the short-term productivity gains from skipping sleep to work are quickly washed away by the detrimental effects of sleep deprivation on your mood, ability to focus, and access to higher-level brain functions for days to come. The negative effects of sleep deprivation are so great that people who are drunk outperform those lacking sleep. Why...
Source: Healthy Living - The Huffington Post - June 24, 2017 Category: Consumer Health News Source Type: news

Poor Sleep Hygiene Is Killing You And Your Career
The next time you tell yourself that you'll sleep when you're dead, realize that you're making a decision that can make that day come much sooner. Pushing late into the night is a health and productivity killer. According to the Division of Sleep Medicine at the Harvard Medical School, the short-term productivity gains from skipping sleep to work are quickly washed away by the detrimental effects of sleep deprivation on your mood, ability to focus, and access to higher-level brain functions for days to come. The negative effects of sleep deprivation are so great that people who are drunk outperform those lacking sleep. Why...
Source: Healthy Living - The Huffington Post - April 22, 2017 Category: Consumer Health News Source Type: news

Pre ‐ischemia melatonin treatment alleviated acute neuronal injury after ischemic stroke by inhibiting ER stress‐dependent autophagy via PERK and IRE1 signalings
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - February 7, 2017 Category: Research Authors: Dayun Feng, Bao Wang, Lei Wang, Neeta Abraham, Kai Tao, Lu Huang, Wei Shi, Yushu Dong, Yan Qu Tags: Original Article Source Type: research

Neuroprotective Mechanisms of Melatonin in Hemorrhagic Stroke.
Abstract Hemorrhagic stroke which consists of subarachnoid hemorrhage and intracerebral hemorrhage is a dominant cause of death and disability worldwide. Although great efforts have been made, the physiological mechanisms of these diseases are not fully understood and effective pharmacological interventions are still lacking. Melatonin (N-acetyl-5-methoxytryptamine), a neurohormone produced by the pineal gland, is a broad-spectrum antioxidant and potent free radical scavenger. More importantly, there is extensive evidence demonstrating that melatonin confers neuroprotective effects in experimental models of hemorr...
Source: Cellular and Molecular Neurobiology - January 27, 2017 Category: Cytology Authors: Wu HJ, Wu C, Niu HJ, Wang K, Mo LJ, Shao AW, Dixon BJ, Zhang JM, Yang SX, Wang YR Tags: Cell Mol Neurobiol Source Type: research

Mortality of Shift Workers
This study strengthens the evidence of a connection between shift work and all-cause mortality. It also provides support for an association between shift work and mortality of cardiovascular disease. The mechanisms responsible for the association between shift work and disease are probably co mplex and influenced by genetics, lifestyle, sleep, social stress, and disturbed circadian rhythms (7). Further epidemiological studies and experimental studies are needed to explain the causal pathways. One issue would be to find a better variable measuring the circadian phase. Shift work is not a valid proxy since previous studies...
Source: Scandinavian Journal of Work, Environment and Health - January 25, 2017 Category: Occupational Health Tags: Editorial Source Type: research