Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain

CONCLUSION: Conclusively, Mel is a potent biomaterial which could potentially impart neurogenesis through repairing impaired metabolic-redox circuit via enhanced TNT-mediated mitochondrial transfer, anti-oxidation, and anti-apoptotic activities in ischemia.PMID:33865018 | DOI:10.1016/j.biopha.2021.111593

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 17, 2021 Category: Drugs & Pharmacology Authors: Hon-Kan Yip Navneet Kumar Dubey Kun-Chen Lin Pei-Hsun Sung John Y Chiang Yi-Ching Chu Chi-Ruei Huang Yi-Ling Chen Yue-Hua Deng Hsin-Chung Cheng Win-Ping Deng Source Type: research