Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti-inflammatory phenotype through STAT3 pathway.

CONCLUSION: Melatonin treatment ameliorates brain damage at least partially through shifting microglia phenotype from pro-inflammatory to anti-inflammatory polarity in a STAT3-dependent manner. PMID: 31793209 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31793209?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - November 30, 2019 Category: Neuroscience Authors: Liu ZJ, Ran YY, Qie SY, Gong WJ, Gao FH, Ding ZT, Xi JN Tags: CNS Neurosci Ther Source Type: research