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Condition: Osteoarthritis

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Total 270 results found since Jan 2013.

Real-world retrospective cohort study ARCTIC shows burden of comorbidities in Swedish COPD versus non-COPD patients.
This study aimed to generate real-world evidence to assess the burden of comorbidities in COPD patients, to effectively manage these patients and optimize the associated healthcare resource allocation. ARCTIC is a large, real-world, retrospective cohort study conducted in Swedish COPD patients using electronic medical record data collected between 2000 and 2014. These patients were studied for prevalence of various comorbidities and for association of these comorbidities with exacerbations, mortality, and healthcare costs compared with an age-, sex-, and comorbidities-matched non-COPD reference population. A total of 17,47...
Source: Primary Care - September 10, 2018 Category: Primary Care Authors: Ställberg B, Janson C, Larsson K, Johansson G, Kostikas K, Gruenberger JB, Gutzwiller FS, Jorgensen L, Uhde M, Lisspers K Tags: NPJ Prim Care Respir Med Source Type: research

To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans.
Abstract Bee venom acupuncture is a form of acupuncture in which bee venom is applied to the tips of acupuncture needles, stingers are extracted from bees, or bees are held with an instrument exposing the stinger, and applied to acupoints on the skin. Bee venom is a complex substance consisting of multiple anti-inflammatory compounds such as melittin, adolapin, apamin. Other substances such as phospholipase A2 can be anti-inflammatory in low concentrations and pro-inflammatory in others. However, bee venom also contains proinflammatory substances, melittin, mast cell degranulation peptide 401, and histamine. Never...
Source: Toxicon - September 27, 2018 Category: Toxicology Authors: Cherniack EP, Govorushko S Tags: Toxicon Source Type: research

Wearable Movement Sensors for Rehabilitation: A Focused Review of Technological and Clinical Advances
This article presents state-of-the-art and next-generation wearable movement sensors, ranging from inertial measurement units to soft sensors. An overview of clinical applications is presented across a wide spectrum of conditions that have potential to benefit from wearable sensors, including stroke, movement disorders, knee osteoarthritis, and running injuries. Complementary applications enabled by next-generation sensors that will enable point-of-care monitoring of neural activity and muscle dynamics during movement also are discussed.
Source: PMandR - October 5, 2018 Category: Rehabilitation Source Type: research

Side does not matter in healthy young and older individuals - Examining the importance of how we match limbs during gait studies
Gait is a basic requirement of daily life, and a major determinant of independence and quality of life [1]. However, gait is frequently impaired by a variety of musculoskeletal and neurological conditions, or surgical intervention (e.g. osteoarthritis, Parkinson ’s, stroke, total knee arthroplasty, etc.). In rehabilitation, gait receives a lot of attention due to its importance on restoring patients’ independence [2]. To understand how gait changes from impairment to rehabilitation, it is often necessary to use healthy individuals as a comparison.
Source: Gait and Posture - October 9, 2018 Category: Orthopaedics Authors: Erik Kowalski, Danilo S. Catelli, Mario Lamontagne Source Type: research

Downregulation of growth arrest ‑specific transcript 5 alleviates palmitic acid‑induced myocardial inflammatory injury through the miR‑26a/HMGB1/NF‑κB axis.
In conclusion, the present study demonstrated that PA can induce GAS5 expression and that the downregulation of GAS5 alleviated PA‑induced myocardial inflammatory injury through the miR‑26a/HMGB1/NF‑κB axis. These data may provide a novel insight into the mechanism of myocardial lipotoxic injury. PMID: 30365114 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 27, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Physical activity participation and the risk of chronic diseases among South Asian adults: protocol for a systematic review and meta-analysis
DiscussionThis review will summarise the strength of the association between physical activity and selected chronic diseases and their markers among South Asian adults 40  years or older. The findings will provide an evidence base to guide public health policy and interventions in the South Asian region and to inform future research to address the rising burden of chronic diseases.Systematic review registrationPROSPEROCRD42018096505
Source: Systematic Reviews - October 30, 2018 Category: International Medicine & Public Health Source Type: research

Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose ‐Derived Stromal/Stem Cell Therapies
The objective of this Review is to describe the safety and efficacy of adipose stem/stromal cells (ASC) and stromal vascular fraction (SVF) in treating common diseases and the next steps in research that must occur prior to clinical use. Pubmed, Ovid Medline, Embase, Web of Science, and the Cochrane Library were searched for articles about use of SVF or ASC for disease therapy published between 2012 and 2017. One meta ‐analysis, 2 randomized controlled trials, and 16 case series were included, representing 844 human patients. Sixty‐nine studies were performed in preclinical models of disease. ASCs improved symptoms, fi...
Source: Stem Cells - September 5, 2018 Category: Stem Cells Authors: Marjorie E. Bateman, Amy L. Strong, Jeffrey M. Gimble, Bruce A. Bunnell Tags: Regenerative Medicine Source Type: research

Differences in cardiovascular safety with non ‐steroidal anti‐inflammatory drug therapy ‐ a nationwide study in patients with osteoarthritis
This article is protected by copyright. All rights reserved.
Source: Basic and Clinical Pharmacology and Toxicology - November 28, 2018 Category: Drugs & Pharmacology Authors: Carlo Alberto Barcella, Morten Lamberts, Patricia McGettigan, Emil Loldrup Fosb øl, Jesper Lindhardsen, Christian Torp‐Pedersen, Gunnar Hilmar Gislason, Anne‐Marie Schjerning Olsen Tags: Original Article Source Type: research

A prospective study of health conditions related to alcohol consumption cessation among 97,852 drinkers aged 45 and over in Australia.
CONCLUSIONS: Diagnosis with a variety of health conditions appears to prompt drinking cessation in older adults. This article is protected by copyright. All rights reserved. PMID: 30758044 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - February 13, 2019 Category: Addiction Authors: Sarich P, Canfell K, Banks E, Paige E, Egger S, Joshy G, Korda R, Weber M Tags: Alcohol Clin Exp Res Source Type: research

Exercise as a Prescription for Patients with Various Diseases
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - April 20, 2019 Category: Sports Medicine Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 23, 2019 Category: Endocrinology Source Type: research

Genomic Observations of a Rare/Pathogenic SMAD3 Variant in Loeys ⁻Dietz Syndrome 3 Confirmed by Protein Informatics and Structural Investigations.
Conclusion: This case emphasizes the importance of comprehensive genetic testing to evaluate patients for connective tissue disorders, as well as the potential benefit of utilizing a protein informatics platform for the assessment of variant pathogenicity. PMID: 31096651 [PubMed - in process]
Source: Medicina (Kaunas) - May 14, 2019 Category: Universities & Medical Training Authors: Richter JE, Samreen A, Vadlamudi C, Helmi H, Mohammad AN, Wierenga K, Hines S, Atwal PS, Caulfield TR Tags: Medicina (Kaunas) Source Type: research

Mesenchymal Stromal Cells (Cyto-MSC) are Well-tolerated and Associated with Renal Function Improvement in Patients with Chronic Kidney Disease: An Observational Retrospective Study
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1c (ma...
Source: Cytotherapy - May 24, 2019 Category: Cytology Source Type: research

Bach impeller for suspension microcarrier cultures of mesenchymal stromal cells
ConclusionCulture of Wharton Jelly MSC at 1 litre with Solohill microcarriers showed 25% improved cell densities of the Bach impeller over the axial flow and paddle impellers: 4 × 10e5 cells/ml vs. 3 × 10e5 cells/ml. This was primarily due to extensive clumping of cell-microcarrier aggregates seen in the conventional impellers from day 3 onwards; whereas the laminar flow prevented aggregation up to the final day of harvesting.Significantly, when MSC were cultured on Cytodex microcarriers at 1 litre, cell yields increased dramatically to 15 × 10e5 cells/ml; viability and identity were equivalent to axial flow...
Source: Cytotherapy - May 24, 2019 Category: Cytology Source Type: research