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Condition: Osteoarthritis

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Total 270 results found since Jan 2013.

Sleep disordered breathing in hospitalized patients
Abstract Sleep is a ubiquitous phenomenon that is both adaptive and restorative. Obstructive sleep apnea, obesity–hypoventilation syndrome, primary central sleep apnea, and Cheyne–Stokes breathing/complex sleep apnea are the most common sleep-related breathing disorders encountered in the hospitalized population. Sleep disordered breathing (SDB) is commoner in hospitalized patients with obesity, congestive cardiac failure, COPD, and osteoarthritis. Various hospital and ICU-related factors contribute to disruption of sleep architecture and circadian rhythm. Sleep deprivation has been linked to higher incidence ...
Source: Current Respiratory Care Reports - March 16, 2016 Category: Respiratory Medicine Source Type: research

Edaravone suppresses degradation of type II collagen.
In this study, we investigated the chondrocyte protective effects of Edaravone on TNF-α induced degradation of type Ⅱ collagen. And our results indicated that TNF-α treatment resulted in degradation of type Ⅱ collagen, which can be ameliorated by treatment with Edaravone in a dose dependent manner. Notably, it was found that the inhibitory effects of Edaravone on TNF-α-induced reduction of type Ⅱ collagen were mediated by MMP-3 and MMP-13. Mechanistically, we found that Edaravone alleviated TNF-α induced activation of STAT1 and expression of IRF-1. These findings suggest a potential protective effect of Edaravone...
Source: Biochemical and Biophysical Research communications - March 28, 2016 Category: Biochemistry Authors: Huang C, Liao G, Han J, Zhang G, Zou B Tags: Biochem Biophys Res Commun Source Type: research

Association of Osteoarthritis With Increased Risk of Cardiovascular Diseases in the Elderly: Findings From the Progetto Veneto Anziano Study Cohort
ConclusionOA may be a significant predictor of the onset of CVD in elderly individuals, particularly in women with OA and when OA affects the lower limbs or ≥2 joints are involved.
Source: Arthritis and Rheumatism - April 26, 2016 Category: Rheumatology Authors: Nicola Veronese, Caterina Trevisan, Marina De Rui, Francesco Bolzetta, Stefania Maggi, Sabina Zambon, Estella Musacchio, Leonardo Sartori, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi Tags: Osteoarthritis Source Type: research

Medial unicompartmental knee arthroplasty in the ACL-deficient knee
Abstract Symptomatic osteoarthritis (OA) of the knee develops often in association with anterior cruciate ligament (ACL) deficiency. Two distinct pathologies should be recognised while considering treatment options in patients with end-stage medial compartment OA and ACL deficiency. Patients with primary ACL deficiency (usually traumatic ACL rupture) can develop secondary OA (typically presenting with symptoms of instability and pain) and these patients are typically young and active. Patients with primary end stage medial compartment OA can develop secondary ACL deficiency (usually degenerate ACL rupture) and the...
Source: Journal of Orthopaedics and Traumatology - May 8, 2016 Category: Orthopaedics Source Type: research

Association between osteoarthritis and cardiovascular disease: Systematic review and meta-analysis
Conclusions Prevalence of cardiovascular disease in patients with osteoarthritis is significant. There was an observed increased risk of incident heart failure and ischaemic heart disease in people with osteoarthritis compared with matched controls. However, the relationship between osteoarthritis and cardiovascular disease is not straightforward and there is a need to better understand the potential common pathways linking pathophysiological mechanisms.
Source: European Journal of Preventive Cardiology - May 10, 2016 Category: Cardiology Authors: Hall, A. J., Stubbs, B., Mamas, M. A., Myint, P. K., Smith, T. O. Tags: Review Source Type: research

How hand osteoarthritis, comorbidity and pain interact to determine functional limitation in older people: Observations from the eposa study
Conclusions. Study results have demonstrated that although comorbidity was decidedly and independently associated with hand functional limitation, it has no effect on the hand OA‐physical function relationship. Hand OA was found to be associated with self‐reported as well as with performance‐based physical function impairment; the association was found to be partially mediated by pain, which reduces its impact. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - May 22, 2016 Category: Rheumatology Authors: Paola Siviero, Sabina Zambon, Federica Limongi, Maria Victoria Castell, Cyrus Cooper, Dorly J.H. Deeg, Michael D. Denkinger, Elaine M. Dennison, Mark H. Edwards, Antonella Gesmundo, Ángel Otero, Nancy L. Pedersen, Richard Peter, Rocio Queipo, Erik J. Tim Tags: Full Length Source Type: research

Turmeric: Bali’s Anti-Cancer Tonic
I’m always happy to find things in my travels to bring back to you. Today I want to tell you about a miracle of nature called turmeric. Turmeric has been used to treat a wide variety of conditions. You can read about it in-depth in my latest book, Healing Herbs of Paradise. The roots of this exotic leafy plant contain curcumin, a very powerful antioxidant that also has remarkable anti-inflammatory properties.1,2,3 What Does Curcumin Do? Curcumin neutralizes free radicals… those nasty little chemicals that travel through your body and cause damage to healthy cells and cell membranes. Which means curcumin effectivel...
Source: Al Sears, MD Natural Remedies - May 25, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Cancer Source Type: news

Role of Osteoarthritis, Comorbidity, and Pain in Determining Functional Limitations in Older Populations: European Project on Osteoarthritis
ConclusionThese findings demonstrate that while comorbidity is strongly and independently associated with functional limitations, it does not affect the OA–physical function association. Hip/knee OA is associated with self‐reported impairment in physical function, which was only partially mediated by pain. Its association with physical function, as evaluated by the walking test, was instead completely mediated by pain.
Source: Arthritis Care and Research - May 25, 2016 Category: Rheumatology Authors: Sabina Zambon, Paola Siviero, Michael Denkinger, Federica Limongi, Maria Victoria Castell, Suzan van der Pas, Ángel Otero, Mark H. Edwards, Richard Peter, Nancy L. Pedersen, Mercedes Sánchez‐Martinez, Elaine M. Dennison, Antonella Gesmundo, Laura A. S Tags: Osteoarthritis Source Type: research

Exome sequencing in Thai patients with familial obesity.
Abstract Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of cancer. Previous genome-wide association studies have identified several genes associated with obesity, including LEP, LEPR, POMC, PCSK1, FTO, MC3R, MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B, SIM1, and TNKS/MSRA. However, most of these variants are found in t...
Source: Genetics and Molecular Research - July 16, 2016 Category: Genetics & Stem Cells Authors: Kaewsutthi S, Santiprabhob J, Phonrat B, Tungtrongchitr A, Lertrit P, Tungtrongchitr R Tags: Genet Mol Res Source Type: research

From Leptin, DEXA, and Beyond
Kahn and Bullard “recommend that waist circumference be added to BMI [body mass index] as a primary tool for assessing adiposity.”1 Suggesting “a need for alternative approaches to anthropometry”1 is necessary because BMI incorrectly classifies obesity by 39%.2 Many adults are obese by American Society of Ba riatric Physicians criteria of body fat: ≥25% for men and ≥30% for women.3 Normal-weight obese adults have increased mortality risk from diabetes, hypertension, heart disease, stroke, cancer, dyslipidemia, liver and gallbladder disease, sleep apnea and respiratory problems, and osteoarthritis.
Source: The American Journal of Medicine - July 22, 2016 Category: Journals (General) Authors: Eric R. Braverman Tags: AJM online Source Type: research

Patient Engagement in Randomized Controlled Clinical Trials with Tai Chi Intervention.
CONCLUSION: Considering that the purpose of Tai Chi practice is to integrate and balance all aspects of a patient's life, we hope to use Tai Chi intervention as an example to illustrate patient engagement process. However, we found that patient engagement, as a concept, was not well defined. It covers a wide range of related terms, such as patient involvement, participation, shared decision-making, patient activation, adherence, compliance, and self-management. Novel research design may explore ways to measure patient engagement in such complex interventions to help identify its specific role on health. PMID: 27527892...
Source: Reviews on Recent Clinical Trials - August 14, 2016 Category: Cancer & Oncology Authors: Jiang D, Kong W, Jiang JJ Tags: Rev Recent Clin Trials Source Type: research

TNP N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
Conclusion We demonstrate that pharmacologic inhibition of the inositol pyrophosphate pathway has strong therapeutic potential in obesity, T2D, and other metabolic diseases.
Source: Molecular Metabolism - August 20, 2016 Category: Endocrinology Source Type: research

Inter-session agreement and reliability of the Global Gait Asymmetry index in healthy adults
Gait symmetry is generally defined as the identical behaviour of the left and right limbs during gait [1]. Pronounced asymmetry levels have been associated with pathological conditions such as stroke [2], lower limb amputations [3], osteoarthritis [4] and arthroplasties [5], as well as anterior cruciate ligament injury [6]. Consequently, there has been a growing effort in restoring/increasing gait symmetry in several clinical conditions [7] back to those found in asymptomatic individuals.
Source: Gait and Posture - September 13, 2016 Category: Orthopaedics Authors: Silvia Cabral, Rita Fernandes, W.Scott Selbie, Vera Moniz-Pereira, Ant ónio P. Veloso Tags: Full length article Source Type: research

The Genetics of Pain
This article aims to review some human pain conditions, both common and rare, and their possible association with ion channels, receptors and the genes involved. Current and ongoing research evidence of the involvement of multiple cellular and molecular pathways in pain, advances in gene therapy and new medications are mentioned, as well as their limitations due to the complexity of pain.
Source: Current Anesthesiology Reports - November 16, 2016 Category: Anesthesiology Source Type: research