Course of Grip Force Impairment in Patients With Early Rheumatoid Arthritis Over the First Five Years After Diagnosis
The objective of this study was to investigate grip strength in patients with early RA. MethodsAn inception cohort of 225 patients with early RA was followed in accordance with a structured protocol. Average and peak grip force values of the dominant hand (measured using a Grippit device [AB Detektor]) were evaluated and compared to expected age‐ and sex‐specific reference values from the literature. Separate analyses were performed for those with limited self‐reported disability (Health Assessment Questionnaire disability index [HAQ DI] score ≤0.5) and clinical remission (Disease Activity Score in 28 joints
Source: Arthritis Care and Research - March 11, 2018 Category: Rheumatology Authors: Maria Rydholm, Christina Book, Ingegerd Wikstr öm, Lennart Jacobsson, Carl Turesson Tags: Original Article Source Type: research

Rheumatoid Arthritis Patients ’ Motivations for Accepting or Resisting Disease‐Modifying Antirheumatic Drug Treatment Regimens
ConclusionFeelings in response to experiences and information played a major role in how patients weighed the benefits and costs of treatment options, suggesting that addressing patients’ feelings may be important when rheumatologists counsel about therapeutic options. Further research is needed to learn how best to address patients’ feelings throughout the treatment decision‐making process. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 11, 2018 Category: Rheumatology Authors: Yomei Shaw, Ilinca D. Metes, Kaleb Michaud, Julie M. Donohue, Mark S. Roberts, Marc C. Levesque, Judy C. Chang Tags: Original Article Source Type: research

Relationship Between Knee Pain and Infrapatellar Fat Pad Morphology: A Within ‐ and Between‐Person Analysis From the Osteoarthritis Initiative
ConclusionIndependent of the ambiguous role of the infrapatellar fat pad in knee osteoarthritis (a potential source of proinflammatory cytokines or a mechanical shock absorber), the size of the infrapatellar fat pad does not appear to be related to knee pain. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 11, 2018 Category: Rheumatology Authors: Eva Steidle ‐Kloc, Adam G. Culvenor, Jan Dörrenberg, Wolfgang Wirth, Anja Ruhdorfer, Felix Eckstein Tags: Original Article Source Type: research

Determinants of Perceived Health Nonimprovement in Early Rheumatoid Arthritis Patients With Favorable Treatment Outcomes
ObjectiveTo explore the association between achieving favorable clinical outcomes and patients’ perceived change in overall health status after 12 months of treat‐to‐target in patients with early rheumatoid arthritis (RA) and to identify determinants of subjective nonimprovement. MethodsBaseline and 12‐month data of patients included in the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study with at least a moderate response (by European League Against Rheumatism criteria) after 1 year were selected for analysis. Logistic regression analysis was used to identify factors associated with nonimp...
Source: Arthritis Care and Research - March 7, 2018 Category: Rheumatology Authors: L. M. M. Steunebrink, M. A. H. Oude Voshaar, E. Taal, H. E. Vonkeman, T. R. Zijlstra, M. A. F. J. Laar Tags: Original Article Source Type: research

Restrictive Use of Oral Glucocorticoids in Systemic Lupus Erythematosus and Prevention of Damage Without Worsening Long ‐Term Disease Control: An Observational Study
ObjectiveTo analyze the influence of 2 different treatment strategies on general and specific damage accrual in patients with systemic lupus erythematosus (SLE). MethodsTwo cohorts were identified according to the responsible physicians: patients treated at the autoimmune diseases unit (ADU), and patients treated by other members of the internal medicine (IM) department. Members of the ADU worked with a protocol including the universal prescription of hydroxychloroquine (HCQ), the use of maximum oral prednisone dosages ≤30 mg/day and maintenance therapy with ≤5 mg/day, by using methylprednisolone pulses and/or early ...
Source: Arthritis Care and Research - March 7, 2018 Category: Rheumatology Authors: Ioana Ruiz ‐Arruza, Jesús Lozano, Ivan Cabezas‐Rodriguez, Jose‐Alejandro Medina, Amaia Ugarte, José‐Gabriel Erdozain, Guillermo Ruiz‐Irastorza Tags: Original Article Source Type: research

Physical Functioning, Pain, and Health ‐Related Quality of Life in Adults With Juvenile Idiopathic Arthritis: A Longitudinal 30‐Year Followup Study
ObjectiveTo describe physical functioning, pain, and health‐related quality of life (HRQoL) in adults with juvenile idiopathic arthritis (JIA), investigate changes over time, and identify predictors of poorer HRQoL after 30 years of disease. MethodsPatients (n = 176) clinically examined after 15 years were reassessed using the Health Assessment Questionnaire disability index (HAQ DI), the visual analog scale pain subscale (VAS pain), and the Medical Outcomes Study Short Form 36 (SF‐36) after 23 years and 30 years. Patients with signs of active disease after a minimum of 15 years were clinically examined again at 30 yea...
Source: Arthritis Care and Research - March 7, 2018 Category: Rheumatology Authors: Anita Tollisen, Anne M. Selvaag, Hanne A. Aulie, Vibke Lilleby, Astrid Aasland, Anners Lerdal, Berit Flat ø Tags: Original Article Source Type: research

Occupation and Risk of Developing Rheumatoid Arthritis: Results From a Population ‐Based Case–Control Study
ConclusionMainly occupations related to potential noxious airborne agents were associated with an increased risk of ACPA+ or ACPA− RA, after adjustments for previously known confounders. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 7, 2018 Category: Rheumatology Authors: Anna Ilar, Lars Alfredsson, Pernilla Wiebert, Lars Klareskog, Camilla Bengtsson Tags: Original Article Source Type: research

Impact of Comorbidities on Tumor Necrosis Factor Inhibitor Therapy in Psoriatic Arthritis: A Population ‐Based Cohort Study
The objective of this population‐based cohort study was to investigate the impact of comorbidities on disease activity, treatment response, and persistence with the first‐tried tumor necrosis factor inhibitor (TNFi) in patients with psoriatic arthritis (PsA). MethodsData on patient characteristics, disease activity, and treatment response and persistence were obtained from the DANBIO registry. Information on comorbidities according to the Charlson Comorbidity Index (CCI) was obtained through linkage with the Danish National Patient Register. Kaplan‐Meier plots and Cox proportional hazard regression analyses were perf...
Source: Arthritis Care and Research - March 7, 2018 Category: Rheumatology Authors: Christine Ballegaard, Pil H øjgaard, Lene Dreyer, René Cordtz, Tanja Schjødt Jørgensen, Marie Skougaard, Simon Tarp, Lars Erik Kristensen Tags: Original Article Source Type: research

What imaging detected pathologies are associated with shoulder symptoms and their persistence? A systematic literature review
ConclusionThere were conflicting results on the association of imaging features with shoulder symptoms and its persistence. The existing evidence was very low in quality based on the GRADE. Further high quality studies are required to understand the relationship between imaging and shoulder symptoms and determine the appropriate role of imaging in care pathways.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 1, 2018 Category: Rheumatology Authors: Gui Tran, Paul Cowling, Toby Smith, Julie Bury, Adam Lucas, Andrew Barr, Sarah R Kingsbury, Philip G Conaghan Tags: Original Article Source Type: research

Causes of death in rheumatoid arthritis: How do they compare to the general population?
ConclusionMortality rates were increased in RA patients relative to the general population across most causes of death. The potential life years lost (before the age of 75) among RA patients was roughly double that among those without RA, reflecting higher rate ratios for most causes of death and RA patients dying at earlier ages.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - March 1, 2018 Category: Rheumatology Authors: Jessica Widdifield, J. Michael Paterson, Anjie Huang, Sasha Bernatsky Tags: Original Article Source Type: research

Phenome ‐wide association studies uncover a novel association of increased atrial fibrillation in males with systemic lupus erythematosus
ConclusionUsing PheWAS to compare males vs. females with SLE, we uncovered a novel association of increased AF in SLE males. SLE disease status was independently associated with AF even after adjusting for age, sex, race, and CAD. These results demonstrate the utility of PheWAS as an EHR discovery tool for SLE.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 27, 2018 Category: Rheumatology Authors: April Barnado, Robert J. Carroll, Carolyn Casey, Lee Wheless, Joshua C. Denny, Leslie J. Crofford Tags: Original Article Source Type: research

Training Physical Therapists in Person ‐Centered Practice for People With Osteoarthritis: A Qualitative Case Study
ConclusionAlthough physical therapists found training overwhelming initially as they realized the limitations of their current knowledge and clinical practice, they felt more confident and able to provide person‐centered care to people with knee osteoarthritis by the end of training. Training in structured person‐centered methodology that provides opportunity for skills practice with patients using a restructured consultation framework can change physical therapists’ beliefs about their roles when managing patients with osteoarthritis and positively impact their clinical practice. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Authors: Belinda J. Lawford, Clare Delany, Kim L. Bennell, Caroline Bills, Janette Gale, Rana S. Hinman Tags: Original Article Source Type: research

Intramuscular Fat Accumulation and Associations with Body Composition, Strength and Physical Functioning in Rheumatoid Arthritis
ConclusionsLow muscle density observed among patients with RA is observed in association with low muscle mass, excess adiposity, poor strength, and greater disability. Interventions to address poor muscle quality could potentially affect important functional outcomes.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Authors: Joshua F. Baker, Sogol Mostoufi ‐Moab, Jin Long, Babette Zemel, Said Ibrahim, Elena Taratuta, Mary B. Leonard Tags: Original Article Source Type: research

Prescribing for Children with Rheumatic Disease: Perceived Treatment Approaches between Pediatric and Adult Rheumatologists
This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Authors: Daniel Albert Tags: Letter to the editor Source Type: research

Ultrasonographic efficacy of biologic and targeted synthetic DMARDs therapy in RA from multicenter RA ultrasound prospective cohort in Japan
ConclusionThe present prospective US cohort has for the first time shown the variables that are associated with initial PD response to b/tsDMARDs.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Authors: Ayako Nishino, Shin ‐ya Kawashiri, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yukitaka Ueki, Tamami Yoshitama, Nobutaka Eiraku, Naoki Matsuoka, Akitomo Okada, Keita Fujikawa, Hiroaki Hamada, Tomomi Tsu Tags: Original Article Source Type: research

ARHP Announcements
(Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Tags: ARHP Announcements Source Type: research

Quantifying Digital Ulcers in Systemic Sclerosis: Reliability of Computer ‐Assisted Planimetry in Measuring Lesion Size
ConclusionOur findings indicate that computer‐assisted planimetry methods applied to SSc‐related digital ulcers can be extremely reliable. Further work is needed to move toward applying these methods as outcome measures for clinical trials and in clinical settings. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Authors: V. Simpson, M. Hughes, J. Wilkinson, A. L. Herrick, G. Dinsdale Tags: Brief Report Source Type: research

Depression Risk in Young Adults With Juvenile ‐ and Adult‐Onset Lupus: Twelve Years of Followup
ObjectiveTo compare major depression risk among young adults with juvenile‐onset and adult‐onset systemic lupus erythematosus (SLE), and to determine demographic and health‐related predictors of depression. MethodsYoung adults with SLE ages 18–45 years (n = 546) in the Lupus Outcomes Study completed annual telephone surveys from 2002–2015, including assessment of depression using the Center for Epidemiologic Studies Depression Scale (CES‐D), and self‐report measures of sociodemographics and health characteristics. Juvenile‐onset SLE was defined as age
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Authors: Andrea M. Knight, Laura Trupin, Patricia Katz, Edward Yelin, Erica F. Lawson Tags: Brief Report Source Type: research

Differentiating Psoriatic Arthritis From Psoriasis Without Psoriatic Arthritis Using Novel Serum Biomarkers
ConclusionCD5L, ITGβ5, M2BP, MPO, MMP‐3, and CRP level are markers for PsA. The combination of ITGβ5, M2BP, and CRP level differentiates PsA from PsC, and performs better than CRP level alone. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Authors: Daniela Cretu, Lisa Gao, Kun Liang, Antoninus Soosaipillai, Eleftherios P. Diamandis, Vinod Chandran Tags: Original Article Source Type: research

Issue Information
(Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 26, 2018 Category: Rheumatology Tags: Issue Information Source Type: research

Developing and Refining New Candidate Criteria for Systemic Lupus Erythematosus Classification: An International Collaboration
ConclusionUsing a data‐driven process, consensus was reached on new, refined criteria definitions and organization based on operating characteristics. This work will be followed by a multicriteria decision analysis exercise to weight criteria and to identify a threshold score for classification on a continuous probability scale. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 22, 2018 Category: Rheumatology Authors: Sara K. Tedeschi, Sindhu R. Johnson, Dimitrios Boumpas, David Daikh, Thomas D örner, David Jayne, Diane Kamen, Kirsten Lerstrøm, Marta Mosca, Rosalind Ramsey‐Goldman, Corine Sinnette, David Wofsy, Josef S. Smolen, Raymond P. Naden, Martin Aringer, Kar Tags: Original Article Source Type: research

Comparable Rates of Glucocorticoid ‐Associated Adverse Events in Patients With Polymyalgia Rheumatica and Comorbidities in the General Population
ConclusionRelapse rates in PMR are highest in the early stages of therapy. Despite often protracted therapy, with the exception of cataracts, the rates of studied morbidities linked to GC are not more common in PMR than comparators. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 22, 2018 Category: Rheumatology Authors: Izzat Shbeeb, Divya Challah, Shafay Raheel, Cynthia S. Crowson, Eric L. Matteson Tags: Brief Report Source Type: research

Trends in Hospitalizations for Serious Infections in Patients With Rheumatoid Arthritis in the US Between 1993 and 2013
ConclusionBetween 1993 and 2013, the proportion of hospitalizations for infections among RA patients appeared to decline for pneumonia and OIs, with a slight decrease in UTI, a slight increase in SSTIs, and a substantial increase in hospitalizations with sepsis. Our results are consistent with previous reports that the sensitivity of sepsis coding has increased over time. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 18, 2018 Category: Rheumatology Authors: Sadao Jinno, Na Lu, S. Reza Jafarzadeh, Maureen Dubreuil Tags: Brief Report Source Type: research

Affect and Incident Participation Restriction in Adults With Knee Osteoarthritis
ConclusionLow positive and high negative affect, both alone and in combination, increase the risk of participation restriction among adults with knee OA. Efforts aimed at preventing participation restriction in this population should consider these mood states. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 18, 2018 Category: Rheumatology Authors: Molly W. Vaughan, Michael P. LaValley, David T. Felson, Gael I. Orsmond, Jingbo Niu, Cora E. Lewis, Neil A. Segal, Michael C. Nevitt, Julie J. Keysor Tags: Original Article Source Type: research

A Young Woman With Sudden Urinary Retention and Sensory Deficits
(Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 18, 2018 Category: Rheumatology Authors: Sarah L. Patterson, Kashif Jafri, Jared A. Narvid, Mary Margaretten Tags: Clinicopathologic Conference Source Type: research

Levels of cytokines and microRNAs in individuals with asymptomatic hyperuricemia and ultrasonographic findings of gout: a bench ‐to‐bedside approach
ConclusionIn asymptomatic individuals with chronic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystals nucleation, capable of triggering inflammatory pathways (IL‐6 and IL‐8) and mechanisms of intercellular communication (miR‐155) similar to what is observed in gout.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 18, 2018 Category: Rheumatology Authors: Irving O. Estevez ‐Garcia, Selma Gallegos‐Nava, Erika Vera‐Pérez, Luis H. Silveira, Lucio Ventura‐Ríos, Gonzalo Vancini, Cristina Hernández‐Díaz, Fausto Sánchez‐Muñoz, Martha A. Ballinas‐Verdugo, Marwin Gutierrez, Carlos Pineda, Pedro Tags: Original Article Source Type: research

An International, Multi ‐Specialty Validation Study of the IgG4‐Related Disease Responder Index
Abstract ObjectiveIgG4‐related disease (IgG4‐RD) can cause fibro‐inflammatory lesions in nearly any organ, leading to organ dysfunction and failure. The IgG4‐RD Responder Index (RI) was developed to help investigators assess the efficacy of treatment in a structured manner. We sought to validate the RI in a multi‐national investigation. MethodsThe RI guides investigators through assessments of disease activity and damage in 25 domains, incorporating higher weights for disease manifestations that require treatment urgently or that worsen despite treatment. After a training exercise, investigators reviewed 12 writt...
Source: Arthritis Care and Research - February 18, 2018 Category: Rheumatology Authors: Zachary S Wallace, Arezou Khosroshahi, Mollie D Carruthers, Cory A Perugino, Hyon Choi, Corrado Campochiaro, Emma L Culver, Frank Cortazar, Emanuel Dellatorre, Mikael Ebbo, Ana Fernandes, Luca Frulloni, Philip Hart, Omer Karadag, Shigeyuki Kawa, Mitsuhiro Tags: Original Article Source Type: research

Experience and context shape patient and clinician goals for treatment of rheumatoid arthritis: a qualitative study
ConclusionKnowledge is a shared goal, but RA patients and clinicians hold divergent attitudes towards this goal. While knowledge is integral to self‐management and effective shared decision making, mismatch in attitudes may lead to suboptimal communication. Tools to support patient goal‐directed RA care may promote high quality patient‐centered care and result in reduced disparities.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 13, 2018 Category: Rheumatology Authors: Jennifer L. Barton, Elizabeth Hulen, Allison Schue, Edward H. Yelin, Sarah S. Ono, Anais Tuepker, Christopher J. Koenig Tags: Original Article Source Type: research

From early radiographic knee osteoarthritis to joint arthroplasty: Determinants of structural progression and symptoms
ConclusionOver half of the knees with no/mild ROA before KR progressed to severe ROA over 4 years of follow‐up. BMLs in the PFJ were more often seen among knees that had no/mild ROA. Worsening pain status may contribute to KR in knees with no/mild ROA.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 13, 2018 Category: Rheumatology Authors: Frank W. Roemer, C. Kent Kwoh, Tomoko Fujii, Michael J. Hannon, Robert M. Boudreau, David J. Hunter, Felix Eckstein, Markus R. John, Ali Guermazi Tags: Original Article Source Type: research

Understanding the factors that influence risk tolerance among minority women: A qualitative study
ConclusionWhile our results point out several concerns that may be addressed through medical providers implementing more effective communication strategies, they also highlight that disparities are strongly influenced by the complex ways financial and social constraints influence minority women's healthcare decisions.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 13, 2018 Category: Rheumatology Authors: Betty Hsiao, Sonal Balla, Kristin Mattocks, Liana Fraenkel Tags: Original Article Source Type: research

Clinician and patients ’ views about self‐management support in arthritis: a cross‐sectional UK survey
ConclusionsOnly a small proportion of patients with arthritis have attended a structured support programme. Although healthcare professionals report engaging in self‐management support embedded in routine care, patients do not necessarily agree and these differences could impact on the experience of patients with arthritis. When embedded self‐management support does occur this is a significant predictor of patients’ knowledge, skills and confidence to self‐manage, as opposed to attendance at a structured programme.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 13, 2018 Category: Rheumatology Authors: Hayley McBain, Michael Shipley, Stanton Newman Tags: Original Article Source Type: research

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis
ConclusionThe incidence and prevalence of depression, anxiety disorder and bipolar disorder are elevated in the RA population as compared to a matched population.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 13, 2018 Category: Rheumatology Authors: Ruth Ann Marrie, Carol A Hitchon, Randy Walld, Scott B Patten, James M Bolton, Jitender Sareen, John R Walker, Alexander Singer, Lisa M. Lix, Ren ée El‐Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein, Tags: Original Article Source Type: research

Efficacy of Mycophenolate Mofetil and Oral Cyclophosphamide on Skin Thickness: Post Hoc Analyses From Two Randomized Placebo ‐Controlled Trials
ObjectiveTo assess the efficacy of mycophenolate mofetil (MMF) and cyclophosphamide (CYC) on modified Rodnan skin score (MRSS) in participants enrolled in the Scleroderma Lung Study (SLS) I and II. MethodsSLS I participants received daily oral CYC or matching placebo for 1 year, whereas SLS II participants received daily MMF for 2 years or daily oral CYC for 1 year followed by placebo for second year. We assessed the impact of MMF and CYC on the MRSS in SLS II over a 24‐month period. We also compared the change in MRSS in patients with diffuse cutaneous systemic sclerosis (dcSSc) assigned to CYC and MMF in SLS II and SLS...
Source: Arthritis Care and Research - February 9, 2018 Category: Rheumatology Authors: Rajaie Namas, Donald P. Tashkin, Daniel E. Furst, Holly Wilhalme, Chi ‐Hong Tseng, Michael D. Roth, Suzanne Kafaja, Elizabeth Volkmann, Philip J. Clements, Dinesh Khanna, Tags: Original Article Source Type: research

Effect of Fatigue, Older Age, Higher Body Mass Index, and Female Sex on Disability in Early Rheumatoid Arthritis in the Treatment ‐to‐Target Era
ConclusionTreat‐to‐target therapy gave more favorable trajectories of change in DAS28 and HAQ, but adverse HAQ trajectory was more likely in women with greater fatigue, suggesting such patients would benefit from interventions to improve function as well as reduce inflammation. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 9, 2018 Category: Rheumatology Authors: Sarah Twigg, Elizabeth M. A. Hensor, Jane Freeston, Ai Lyn Tan, Paul Emery, Alan Tennant, Ann W. Morgan, Tags: Original Article Source Type: research

Examination of Hydroxychloroquine Use and Hemolytic Anemia in G6PDH ‐Deficient Patients
ConclusionThis is the largest study to date evaluating G6PDH deficiency with concurrent use of HCQ. Of 11 patients with G6PDH deficiency, 2 had episodes of hemolysis, but these did not occur during HCQ therapy. These data do not support routine measurement of G6PDH levels or withholding HCQ therapy among African American patients with G6PDH deficiency. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 9, 2018 Category: Rheumatology Authors: Samya Mohammad, Megan E. B. Clowse, Amanda M. Eudy, Lisa G. Criscione ‐Schreiber Tags: Brief Report Source Type: research

Delays to Care in Pediatric Lupus Patients: Data From the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry
ObjectivePrompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographic and clinical characteristics of lupus patients within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry with regard to time between symptom onset and presentation to a pediatric rheumatologist. MethodsWe analyzed data from 598 CARRA Legacy Registry participants for difference...
Source: Arthritis Care and Research - February 7, 2018 Category: Rheumatology Authors: Tamar B. Rubinstein, Wenzhu B. Mowrey, Norman T. Ilowite, Dawn M. Wahezi, Tags: Original Article Source Type: research

Effects of a Web ‐Based Patient Decision Aid on Biologic and Small‐Molecule Agents for Rheumatoid Arthritis: Results From a Proof‐of‐Concept Study
ObjectiveTo assess the extent to which ANSWER‐2, an interactive online patient decision aid, reduces patients’ decisional conflict and improves their medication‐related knowledge and self‐management capacity. MethodsWe used a pre–post study design. Eligible participants had a diagnosis of rheumatoid arthritis (RA), had been recommended to start using a biologic agent or small‐molecule agent or to switch to a new one, and had internet access. Access to ANSWER‐2 was provided immediately after enrollment. Outcome measures included 1) the Decisional Conflict Scale (DCS), 2) the Medication Education Impact...
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Linda C. Li, Chris D. Shaw, Diane Lacaille, Elaine Yacyshyn, C. Allyson Jones, Cheryl Koehn, Alison M. Hoens, Jasmina Geldman, Eric C. Sayre, Graham G. Macdonald, Jenny Leese, Nick Bansback Tags: Original Article Source Type: research

Cluster ‐Randomized Trial of a Behavioral Intervention to Incorporate a Treat‐to‐Target Approach to Care of US Patients With Rheumatoid Arthritis
ConclusionThis study is the first to examine the feasibility and efficacy of a treat‐to‐target approach in typical US rheumatology practice. Treat‐to‐target care was not associated with increased likelihood of treatment acceleration or achievement of LDA, and barriers to treatment acceleration were identified. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Leslie R. Harrold, George W. Reed, Ani John, Christine J. Barr, Kevin Soe, Robert Magner, Katherine C. Saunders, Eric M. Ruderman, Tmirah Haselkorn, Jeffrey D. Greenberg, Allan Gibofsky, J. Timothy Harrington, Joel M. Kremer Tags: Original Article Source Type: research

Relationship Between Fish Consumption and Disease Activity in Rheumatoid Arthritis
ObjectiveTo assess whether more frequent fish consumption is associated with lower rheumatoid arthritis (RA) disease activity scores among participants in an RA cohort. MethodsWe conducted a cross‐sectional analysis using baseline data from participants in the Evaluation of Subclinical Cardiovascular Disease and Predictors of Events in Rheumatoid Arthritis cohort study. Frequency of fish consumption was assessed by a baseline food frequency questionnaire assessing usual diet in the past year. Multivariable, total energy–adjusted linear regression models provided effect estimates and 95% confidence intervals (95% CI...
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Sara K. Tedeschi, Joan M. Bathon, Jon T. Giles, Tzu ‐Chieh Lin, Kazuki Yoshida, Daniel H. Solomon Tags: Original Article Source Type: research

Characterization of Patients With Ankylosing Spondylitis and Non ‐Radiographic Axial Spondyloarthritis in the US‐Based Corrona Registry
ConclusionThis was the first nationwide study to characterize patients with AS and nr‐axSpA in the United States. Consistent with studies published outside the United States, this study showed that patients with nr‐axSpA and AS shared a comparable degree of disease burden, and had similar treatment patterns in clinical practice.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Philip J. Mease, D ésirée van der Heijde, Chitra Karki, Jacqueline B. Palmer, Mei Liu, Renganayaki Pandurengan, Yujin Park, Jeffrey D. Greenberg Tags: Original Article Source Type: research

A mixed ‐methods study identifying key intervention targets to improve participation in daily living activities in primary Sjögren's syndrome patients
ConclusionOur data highlighted that in addition to managing PSS symptoms; interventions aiming to improve patient empowerment, general wellbeing, access to healthcare, patient education and social support are important to facilitate improved participation in daily living activities.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Katie L Hackett, Katherine H.O. Deane, Julia L Newton, Vincent Deary, Simon Bowman, Tim Rapley, Wan ‐Fai Ng, Tags: Original Article Source Type: research

Is Rheumatoid Arthritis a Cardiovascular Risk Equivalent to Diabetes?
ConclusionFindings from the present study suggest that while CVD risk in RA is elevated, it is lower in magnitude compared to the CVD risk associated with diabetes. It therefore may not be appropriate to consider RA a diabetes risk‐equivalent with respect to hyperlipidemia management.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Jeffrey R Curtis, Shuo Yang, Jasvinder A. Singh, Fenglong Xie, Lang Chen, Huifeng Yun, Paul Muntner, Shia T Kent, Emily B. Levitan, Monika M. Safford, Kenneth G. Saag, Jie Zhang Tags: Brief Report Source Type: research

Evaluation of a Methodological Approach to Define An Inception Cohort of Rheumatoid Arthritis Patients Using Administrative Data
ConclusionClaims‐based algorithms can accurately identify incident RA.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Jeffrey R Curtis, Fenglong Xie, Lang Chen, Jeffrey D Greenberg, Jie Zhang Tags: Brief Report Source Type: research

Measuring Disease Damage and its Severity in Childhood ‐Onset Systemic Lupus Erythematosus
Abstract ObjectivesTo describe the frequency and types of disease damage occurring with childhood‐onset systemic lupus erythematosus (cSLE) as measured by the 41‐item Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI), and to assess the SDI's ability to reflect damage severity. MethodsInformation for the SDI was prospectively collected from 1,048 cSLE patients. For a subset of 559 patients physician‐rated damage severity measured by visual analog scale (MD‐VASdamage) was also available. Frequency of SDI‐items, and the association between SDI summary‐scores and...
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Michael J. Holland, Michael W. Beresford, Brian M. Feldman, Jennifer Huggins, Ximena Norambuena, Clovis A. Silva, Gordana Susic, Sztajnbok Flavio, Yosef Uziel, Simone Appenzeller, Stacy P. Ardoin, Tadej Avcin, Francisco Flores, Beatrice Goilav, Raju Khubc Tags: Original Article Source Type: research

Baseline Retinal Examinations among SLE Patients Newly Initiating Hydroxychloroquine in a U.S. Medicaid SLE Population, 2000 ‐2010
ConclusionOnly one third of Medicaid SLE patients newly initiating HCQ received recommended baseline retinal examinations and this proportion did not significantly increase during these years. The sociodemographic variation in this indicated care has been observed for other recommended medical care for SLE and requires both further investigation and interventions to address it.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Tzu ‐Chieh Lin, Michael F. Marmor, Medha Barbhaiya, Hongshu Guan, Sarah K. Chen, Candace H. Feldman, Karen H. Costenbader Tags: Brief Report Source Type: research

Validation of the Brief Fear of Negative Evaluation Scale ‐II in patients with systemic sclerosis: A Scleroderma Patient‐centered Intervention Network Cohort study
ConclusionPsychometric support was found for all three versions of the BFNE, though the longer 12‐item BFNE‐II did not improve measurement compared to the shorter eight‐item versions. Of these two, the BFNE‐S has been more widely studied with strong validity data in a greater number of populations. Therefore, the BFNE‐S is recommended to assess fear of negative evaluation among patients with SSc.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Rina S. Fox, Linda Kwakkenbos, Marie ‐Eve Carrier, Sarah D. Mills, Shadi Gholizadeh, Lisa R. Jewett, Scott C. Roesch, Erin L. Merz, Shervin Assassi, Daniel E Furst, Karen Gottesman, Maureen D. Mayes, Brett D. Thombs, Vanessa L. Malcarne, Tags: Original Article Source Type: research

Mortality in Patients with Giant Cell Arteritis: A Cohort Study in UK Primary Care
ConclusionGCA patients had an increased risk of mortality during the period shortly after the GCA diagnosis, in particular during the first year, but no increased risk after 5 years post‐diagnosis. The mortality risk differed by age with an even greater increased one‐year mortality in those aged
Source: Arthritis Care and Research - February 6, 2018 Category: Rheumatology Authors: Lin Li, Tuhina Neogi, Susan Jick Tags: Brief Report Source Type: research

Are older adults with symptomatic knee osteoarthritis less active than the general population?: Analysis from the Osteoarthritis Initiative and NHANES
ConclusionTime spent in MVPA was similarly low in those with SxOA as in older adults without knee pain or OA.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 1, 2018 Category: Rheumatology Authors: Louise M. Thoma, Dorothy Dunlop, Jing Song, Jungwha Lee, Catrine Tudor ‐Locke, Elroy J. Aguiar, Hiral Master, Meredith B. Christiansen, Daniel K. White Tags: Original Article Source Type: research

Clinical characteristics and factors associated with disability and impaired quality of life in children with juvenile systemic sclerosis
ConclusionIn the first multicenter prospective cohort of juvenile SSc patients in North America, disease burden was large: multi‐organ manifestations were common, and functional disability was greater than other childhood rheumatic diseases. Gastrointestinal involvement had the greatest impact on quality of life.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 1, 2018 Category: Rheumatology Authors: Brandi E. Stevens, Kathryn S. Torok, Suzanne C. Li, Nicole Hershey, Megan Curran, Gloria C. Higgins, Katharine F. Moore, C. Egla Rabinovich, Samuel Dodson, Anne M. Stevens, Tags: Original Article Source Type: research

High Adherence Observed to System ‐Level Performance Measures for Rheumatoid Arthritis in a National Early Arthritis Cohort Over 8 Years
ConclusionThere was evidence of high adherence to system‐level performance measures in this protocolized ERA cohort. Small declines in performance were noted with increasing length of patient follow‐up. Our findings are useful for performance measure benchmarking.This article is protected by copyright. All rights reserved. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - February 1, 2018 Category: Rheumatology Authors: Claire E H Barber, Orit Schieir, Diane Lacaille, Deborah A. Marshall, Cheryl Barnabe, Glen Hazlewood, Carter Thorne, Vandana Ahluwalia, Susan J. Bartlett, Gilles Boire, Boulos Haraoui, Carol A Hitchon, Edward Keystone, Diane Tin, Janet Pope, Lisa Denning, Tags: Original Article Source Type: research