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MassDevice.com +5 | The top 5 medtech stories for November 30, 2016
Say hello to MassDevice +5, a bite-sized view of the top five medtech stories of the day. This feature of MassDevice.com’s coverage highlights our 5 biggest and most influential stories from the day’s news to make sure you’re up to date on the headlines that continue to shape the medical device industry. Get this in your inbox everyday by subscribing to our newsletters.   5. Smart patch monitors blood, releases blood thinners to prevent clots Researchers from the North Carolina State University and the University of North Carolina at Chapel Hill have developed a patch designed to monitor a patient...
Source: Mass Device - November 30, 2016 Category: Medical Equipment Authors: MassDevice Tags: News Well Plus 5 Source Type: news

A machine learning approach to measure and monitor physical activity in children
Publication date: 8 March 2017 Source:Neurocomputing, Volume 228 Author(s): Paul Fergus, Abir J. Hussain, John Hearty, Stuart Fairclough, Lynne Boddy, Kelly Mackintosh, Gareth Stratton, Nicky Ridgers, Dhiya Al-Jumeily, Ahmed J. Aljaaf, Jenet Lunn The growing trend of obesity and overweight worldwide has reached epidemic proportions with one third of the global population now considered obese. This is having a significant medical impact on children and adults who are at risk of developing osteoarthritis, coronary heart disease and stroke, type 2 diabetes, cancers, respiratory problems, and non-alcoholic fatty liver disease...
Source: Neurocomputing - January 16, 2017 Category: Neuroscience Source Type: research

Can we target CCR2 to treat osteoarthritis? The trick is in the timing!
C-C motif chemokines, including CCL2, CCL7, and CCL12, affect cells that express the C-C chemokine receptor type 2, CCR2, a seven-transmembrane domain G-protein coupled receptor (GPCR) [1]. Signaling through CCR2 has been implicated in many pathologies, including autoimmune disorders, tumor metastasis, atherosclerosis, stroke, neurodegenerative disorders, and neurological complications of HIV [2]. As a GPCR, CCR2 is eminently druggable and many small-molecule antagonists have been tested in clinical trials for different conditions [2, 3].
Source: Osteoarthritis and Cartilage - February 7, 2017 Category: Rheumatology Authors: Rachel E. Miller, Anne-Marie Malfait Source Type: research

Three ‐Year Changes in Physical Activity and Decline in Physical Performance Over 9 Years of Follow‐Up in Older Adults: The Invecchiare in Chianti Study
ConclusionMaintaining or increasing PA levels may attenuate age‐associated physical performance decline.
Source: Journal of the American Geriatrics Society - February 28, 2017 Category: Geriatrics Authors: David Martinez ‐Gomez, Stefania Bandinelli, Vieri Del‐Panta, Kushang V. Patel, Jack M. Guralnik, Luigi Ferrucci Tags: Clinical Investigation Source Type: research

Task-based weight management programme delivered in primary care promotes better long-term weight loss among women from lower socioeconomic groups than usual practice
Commentary on: McRobbie H, Hajek P, Peerbux S, et al.. Tackling obesity in areas of high social deprivation: clinical effectiveness and cost-effectiveness of a task-based weight management group programme—a randomised controlled trial and economic evaluation. Health Technol Assess 2016;20:1–150. Implications for practice and research The study is important in demonstrating that a task-based weight management programme can potentially be effective in reducing obesity among lower socioeconomic groups. The role of nurses in delivering such weight loss interventions should be evaluated. Context Obesity is recognise...
Source: Evidence-Based Nursing - March 22, 2017 Category: Nursing Authors: Bambra, C. Tags: Health promotion and public health Source Type: research

Imidazoline I2 receptors: An update
Publication date: Available online 16 March 2017 Source:Pharmacology & Therapeutics Author(s): Jun-Xu Li Since first introduced more than two decades ago, the research in imidazoline I2 receptors has been steadily increasing. This review provides an update on the current status of I2 receptor pharmacology. Imidazoline I2 receptors or I2 binding sites refer to several (at least four) different proteins that bind to [3H]-idazoxan and [3H]-2-BFI with high affinity. The molecular identities of the proteins remain elusive. One of the proteins (45kD) seems to be consistent with the identity of brain creatine kinase. The...
Source: Pharmacology and Therapeutics - March 23, 2017 Category: Drugs & Pharmacology Source Type: research

Impact of Physical Activity in Cardiovascular and Musculoskeletal Health: Can Motion Be Medicine?
Abstract Physical activity is a well-known therapeutic tool for various types of medical conditions, including vasculopathic diseases such as coronary artery disease, stroke, type 2 diabetes, and obesity. Additionally, increased physical activity has been proposed as a therapy to improve musculoskeletal health; however, there are conflicting reports about physical activity potentially leading to degenerative musculoskeletal disease, especially osteoarthritis (OA). Additionally, although physical activity is known to have its benefits, it is unclear as to what amount of physical activity is the most advantageous. T...
Source: Clin Med Res - April 12, 2017 Category: Research Authors: Curtis GL, Chughtai M, Khlopas A, Newman JM, Khan R, Shaffiy S, Nadhim A, Bhave A, Mont MA Tags: J Clin Med Res Source Type: research

The Prevalence of Obesity Among Saudi Males in the Riyadh Region
Attendees of 15 health centers in Urban and rural areas in the Riyadh region were screened for obesity during May and June 1994. Systemic selection yielded 1580 Saudi males for analysis. The mean age was 33.6± 13.5 years and body mass index (BMI) was 26.9± 5.7 kg/m2. Only 36.6% of subjects were their ideal weight (BMI< 25 kg/m2), while 34.8% were overweight (BMI 25-29.9 kg/m2), 26.9% were moderately obese (BMI 3.0-40 kg/m2) and 1.7% were morbidly obese (BMI> 40 kg/m2). Middle age, lower education and joblessness predicted a higher risk for obesity. Patients living in rural areas had greater BMIs than th...
Source: Annals of Saudi Medicine - May 10, 2017 Category: General Medicine Tags: ISSUE 3 Source Type: research

Randomized trial of switching from prescribed non-selective non-steroidal anti-inflammatory drugs to prescribed celecoxib: the Standard care vs. Celecoxib Outcome Trial (SCOT)
This study excluded an increased risk of the primary endpoint of more than two events per 1000 patient-years associated with switching to prescribed celecoxib.Clinical Trial Registrationhttps://clinicaltrials.gov/show/NCT00447759; Unique identifier: NCT00447759.
Source: European Heart Journal - October 4, 2016 Category: Cardiology Source Type: research

Osteoarthritis increases the risk of cardiovascular disease: Data from the osteoarthritis initiative
ConclusionsOA, in particular, when it affects the hand and in women, was associated with a higher risk of developing CVD.
Source: The Journal of Nutrition, Health and Aging - June 15, 2017 Category: Nutrition Source Type: research

Cerebral Blood Flow Responses to Aquatic Treadmill Exercise
Introduction: Aquatic treadmills are used as a rehabilitation method for conditions such as spinal cord injury, osteoarthritis, and stroke, and can facilitate an earlier return to exercise training for athletes. However, their effect on cerebral blood flow (CBF) responses has not been examined. We tested the hypothesis that aquatic treadmill exercise would augment CBF and lower HR compared with land-based treadmill exercise. Methods: Eleven participants completed incremental exercise (crossover design) starting from walking pace (4 km·h−1, immersed to iliac crest [aquatic], 6 km·h−1 [land]) and increasing 1 km·h−...
Source: Medicine and Science in Sports and Exercise - June 17, 2017 Category: Sports Medicine Tags: Clinical Sciences Source Type: research

Association of cancer and Alzheimer's disease risk in a national cohort of veterans
Discussion Survivors of some cancers have a lower risk of AD but not other age-related conditions, arguing that lower AD diagnosis is not simply due to bias. Cancer treatment may be associated with decreased risk of AD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - July 13, 2017 Category: Geriatrics Source Type: research

Association of cancer and Alzheimer's disease risk in a national cohort of veterans.
DISCUSSION: Survivors of some cancers have a lower risk of AD but not other age-related conditions, arguing that lower AD diagnosis is not simply due to bias. Cancer treatment may be associated with decreased risk of AD. PMID: 28711346 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - July 19, 2017 Category: Psychiatry Tags: Alzheimers Dement Source Type: research

The validity and reliability of the four square step test in different adult populations: a systematic review
ConclusionsThe FSST may be an effective and valid tool for measuring dynamic balance and a participants ’ falls risk. It has been shown to have strong correlations with other measures of balance and mobility with good reliability shown in a number of populations. However, the quality of the papers reviewed was variable with key factors, such as sample size and test set up, needing to be addressed be fore the tool can be confidently used in these specified populations.
Source: Systematic Reviews - September 11, 2017 Category: International Medicine & Public Health Source Type: research

Association between Exposure to p,p ′-DDT and Its Metabolite p,p′-DDE with Obesity: Integrated Systematic Review and Meta-Analysis
Conclusions: We classified p,p′-DDT and p,p′-DDE as “presumed” to be obesogenic for humans, based on a moderate level of primary human evidence, a moderate level of primary in vivo evidence, and a moderate level of supporting evidence from in vivo and in vitro studies. https://doi.org/10.1289/EHP527 Received: 17 May 2016 Revised: 04 May 2017 Accepted: 09 May 2017 Published: 18 September 2017 Please address correspondence to M.A. La Merrill, Dept. of Environmental Toxicology, University of California, Davis, 1 Shields Ave., 4245 Meyer Hall, Davis, CA 95616-5270 USA. Telephone: (530) 754-7254. Email: mlamerrill...
Source: EHP Research - September 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Review Source Type: research