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Condition: Osteoarthritis

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Total 270 results found since Jan 2013.

The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient
Conclusion Our current results using simultaneously collected blood and bone marrow samples suggest that the detrimental effects of S1P on bone metabolism in humans may depend on the S1P gradient between the peripheral blood and bone marrow cavity.
Source: Journal of Endocrinological Investigation - July 28, 2015 Category: Endocrinology Source Type: research

Use of Nonsteroidal Anti-Inflammatory Drugs and Risk of Chronic Kidney Disease in Subjects With Hypertension: Nationwide Longitudinal Cohort Study Kidney
Limited studies have examined the effects of nonsteroidal anti-inflammatory drug (NSAID) use on the risk of chronic kidney disease (CKD), especially in subjects with hypertension. Using National Health Insurance claims data in Taiwan, we conducted a propensity score–matched cohort study to investigate the relationship between NSAID use and CKD in subjects with hypertension. A total of 31976 subjects were included in this study: subjects not taking any NSAIDs in 2007 (n=10782); subjects taking NSAIDs for 1 to 89 days in 2007 (n=10605); and subjects taking NSAIDs for ≥90 days in 2007 (n=10589). We performed multivar...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Hsu, C.-C., Wang, H., Hsu, Y.-H., Chuang, S.-Y., Huang, Y.-W., Chang, Y.-K., Liu, J.-S., Hsiung, C. A., Tsai, H.-J. Tags: Clinical Studies Kidney Source Type: research

The Mobilize Center: an NIH big data to knowledge center to advance human movement research and improve mobility
Regular physical activity helps prevent heart disease, stroke, diabetes, and other chronic diseases, yet a broad range of conditions impair mobility at great personal and societal cost. Vast amounts of data characterizing human movement are available from research labs, clinics, and millions of smartphones and wearable sensors, but integration and analysis of this large quantity of mobility data are extremely challenging. The authors have established the Mobilize Center (http://mobilize.stanford.edu) to harness these data to improve human mobility and help lay the foundation for using data science methods in biomedicine. T...
Source: Journal of the American Medical Informatics Association - August 13, 2015 Category: Information Technology Authors: Ku, J. P., Hicks, J. L., Hastie, T., Leskovec, J., Re, C., Delp, S. L. Tags: Brief Communication Source Type: research

Systemic connective tissue features in women with fibromuscular dysplasia
In conclusion, in a cohort of women with FMD, there was a prevalence of moderately severe myopia, high palate, dental crowding, and early-onset osteoarthritis. However, a characteristic phenotype was not discovered. Several connective tissue features such as high palate and pneumothorax were more prominent among FMD patients with a high vascular risk profile.
Source: Vascular Medicine - October 2, 2015 Category: Internal Medicine Authors: O'Connor, S., Kim, E. S., Brinza, E., Moran, R., Fendrikova-Mahlay, N., Wolski, K., Gornik, H. L. Tags: Original Articles Source Type: research

Medical morbidities in people following hip and knee arthroplasty: data from the Osteoarthritis Initiative
Conclusions People who undergo THA or TKA may present with a variety of medical morbidities. Accordingly consideration should be made on how to encourage the adoption and maintenance of physical activity and healthy lifestyle choices for this population.
Source: European Journal of Orthopaedic Surgery and Traumatology - October 16, 2015 Category: Orthopaedics Source Type: research

Osteoarthritis, comorbidity and pain: Their role in determining functional limitations in older populations (European project on Osteoarthritis)
Conclusions: These findings demonstrate that while comorbidity is strongly and independently associated to functional limitations, it does not affect the OA‐physical function association. Hip/knee OA is associated to self‐reported impairment in physical function, which was only partially mediated by pain. Its association to physical function, as evaluated by the walking test, was, instead, completely mediated by pain. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - October 16, 2015 Category: Rheumatology Authors: Sabina Zambon, Paola Siviero, Michael Denkinger, Federica Limongi, Maria Victoria Castell, Suzan van der Pas, Ángel Otero, Mark H Edwards, Richard Peter, Nancy L Pedersen, Mercedes Sánchez‐Martinez, Elaine M Dennison, Antonella Gesmundo, Laura A Schaa Tags: Original Article Source Type: research

An Update on the Cardiovascular Risks Associated With NSAIDs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used medications for osteoarthritis, rheumatoid arthritis, and myalgias (Table 1). In 2005, the United States Food and Drug Administration (FDA) placed a black box warning in the prescribing information of NSAIDs for the risk of myocardial infarction (MI) and stroke associated with their use.1 Last year, the FDA met to discuss new literature on NSAID cardiovascular (CV) risk to determine how it would affect prescription labeling.2 There were several observational studies and meta-analyses reviewed.
Source: The Journal for Nurse Practitioners - October 31, 2015 Category: Nursing Authors: Jason Babby, Archna Lall Tags: Prescription Pad Source Type: research

Disrupting Today's Healthcare System
This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other count...
Source: Healthy Living - The Huffington Post - November 9, 2015 Category: Consumer Health News Source Type: news

Osteoarthritis increases the risk of cardiovascular diseases in the elderly: The progetto veneto anziano study
Conclusions: OA significantly predicted the onset of CVD in elderly people, particularly when it involved lower limbs, women, and more than two joints. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - December 29, 2015 Category: Rheumatology Authors: Nicola Veronese, Caterina Trevisan, Marina De Rui, Francesco Bolzetta, Stefania Maggi, Sabina Zambon, Estella Musacchio, Leonardo Sartori, Egle Perissinotto, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi Tags: Full Length Source Type: research

Obesity Statistics
Obesity is a chronic disease that is strongly associated with an increase in mortality and morbidity including, certain types of cancer, cardiovascular disease, disability, diabetes mellitus, hypertension, osteoarthritis, and stroke. In adults, overweight is defined as a body mass index (BMI) of 25 kg/m2 to 29 kg/m2 and obesity as a BMI of greater than 30 kg/m2. If current trends continue, it is estimated that, by the year 2030, 38% of the world’s adult population will be overweight and another 20% obese. Significant global health strategies must reduce the morbidity and mortality associated with the obesity epidemic.
Source: Primary Care: Clinics in Office Practice - January 12, 2016 Category: Primary Care Authors: Kristy Breuhl Smith, Michael Seth Smith Source Type: research

Functional MRI 2.0 : ²³Na and CEST imaging.
Abstract In recent years the purely morphological magnetic resonance imaging (MRI) has been increasingly flanked by so-called functional imaging methods, such as diffusion-weighted imaging (DWI), to obtain additional information about tissue or pathological processes. This review article presents two MR techniques that can detect physiological processes in the human body. In contrast to all other functional MR imaging techniques, which are based on hydrogen protons, the first technique presented (X-nuclei imaging) uses the spin of other nuclei for imaging and consequently allows a completely different insight into...
Source: Der Radiologe - January 21, 2016 Category: Radiology Authors: Haneder S, Konstandin S Tags: Radiologe Source Type: research

Pediatric obesity: Causes, symptoms, prevention and treatment.
Authors: Xu S, Xue Y Abstract Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults. Obe...
Source: Experimental and Therapeutic Medicine - February 4, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Obesity Statistics.
Abstract Obesity is a chronic disease that is strongly associated with an increase in mortality and morbidity including, certain types of cancer, cardiovascular disease, disability, diabetes mellitus, hypertension, osteoarthritis, and stroke. In adults, overweight is defined as a body mass index (BMI) of 25 kg/m(2) to 29 kg/m(2) and obesity as a BMI of greater than 30 kg/m(2). If current trends continue, it is estimated that, by the year 2030, 38% of the world's adult population will be overweight and another 20% obese. Significant global health strategies must reduce the morbidity and mortality associated with...
Source: Primary Care - February 21, 2016 Category: Primary Care Authors: Smith KB, Smith MS Tags: Prim Care Source Type: research

Optimizing Acute Pain Management in the Obese Patient: Treatment and Monitoring Considerations
THE CHALLENGES OF PROVIDING SAFE AND EFFECTIVE pain management for patients with obesity are present throughout the perioperative setting. Obesity is associated with chronic medical comorbidities, such as coronary artery disease, stroke, chronic kidney disease, nonalcoholic fatty liver disease, and type 2 diabetes.1 Other obesity-associated comorbidities include breast, endometrial, ovarian, colorectal, esophageal, kidney, pancreatic, and prostate cancers, chronic back pain, and osteoarthritis.1 The demand for bariatric surgery has risen markedly in recent years with the total number of surgeries performed in the United St...
Source: Journal of PeriAnesthesia Nursing - February 27, 2016 Category: Nursing Authors: Maureen F. Cooney Tags: Pain Care Source Type: research

Effects of gait retraining with real-time biofeedback in patients with knee osteoarthritis: systematic review and meta-analysis
Purpose: Use of real time biofeedback during gait retraining has been shown to be an effective form of therapy in stroke patients and other neurological conditions, such as Parkinson’s disease. In recent years, there has been increasing use of biofeedback for gait retraining in orthopedic conditions, with a particular focus on knee osteoarthritis. The aim of our systematic review was to investigate the effects of real-time biofeedback when used during gait retraining in knee osteoarthritis (KOA) patients.
Source: Osteoarthritis and Cartilage - March 20, 2016 Category: Rheumatology Authors: R. Richards, J. van den Noort, J. Dekker, J. Harlaar Source Type: research