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Condition: Osteoarthritis
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Total 270 results found since Jan 2013.
Bergapten attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting Kv1.3 and Carbonyl reductase 1
Eur J Pharmacol. 2022 Sep 1:175242. doi: 10.1016/j.ejphar.2022.175242. Online ahead of print.ABSTRACTMicroglia-mediated neuroinflammation plays a vital role in the pathogenesis of ischemic stroke, which serves as a prime target for developing novel therapeutic agent. However, feasible and effective agents for controlling neuroinflammation are scarce. Bergapten were acknowledged to hold therapeutic potential in restricting inflammation in multiple diseases, including peripheral neuropathy, migraine headaches and osteoarthritis. Here, we aimed to investigate the impact of bergapten on microglia-mediated neuroinflammation and...
Source: European Journal of Pharmacology - September 4, 2022 Category: Drugs & Pharmacology Authors: Shenghan Gao Xinxin Zou Zibu Wang Xin Shu Xiang Cao Shengnan Xia Pengfei Shao Xinyu Bao Haiyan Yang Yun Xu Pinyi Liu Source Type: research
Perlecan: A Review of its Role in Neurologic and Musculoskeletal Disease
Perlecan is a 500 kDa proteoglycan residing in the extracellular matrix of endothelial basement membranes with five distinct protein domains and three heparan sulfate chains. The complex structure of perlecan and the interaction it has with its local environment accounts for its various cellular and tissue-related effects, to include cartilage, bone, neural and cardiac development, angiogenesis, and blood brain barrier stability. As perlecan is a key contributor to extracellular matrix health involved in many tissues and processes throughout the body, dysregulation of perlecan has the potential to contribute to various neu...
Source: Frontiers in Physiology - May 30, 2023 Category: Physiology Source Type: research
How To Avoid China ’ s Medicine Monopoly
I want to share a shocking statistic with you…
Around 80% of all the pharmaceuticals sold in America — both prescription and over-the-counter — are manufactured in China.
I’m talking about drugs for Parkinson’s and Alzheimer’s, blood pressure and blood thinners, diuretics, aspirin, antibiotics, and a big chunk of the world’s insulin and diabetes drugs — just to name a few.1
We don’t even make penicillin anymore. The last penicillin plant in the U.S. closed its doors in 2004.
Americans who rely on medicine are now almost entirely at the mercy of a country whose relations with the U.S. have become more ...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Health Source Type: news
Non-steroidal anti-inflammatory drugs and risk of cerebrovascular events in patients with osteoarthritis: a nested case–control study
This study aims to determine whether the use of NSAIDs is associated with an increased risk of cerebrovascular events in Italy. We performed a case–control analysis nested in a cohort of patients with osteoarthritis between 2002 and 2011 who were newly treated with NSAIDs. The patients were followed until December 31, 2012. Conditional logistic regression was used to estimate odds ratios (ORs) with 95 % confidence intervals (95 % CI) of cerebrovascular events (index date) associated with current (until 30 days before the index date), recent (31–365 days) and past (>365 days) use of NSAIDs. Within a cohort of 29...
Source: Internal and Emergency Medicine - August 14, 2015 Category: Emergency Medicine Source Type: research
Godly gift for arthritis pain
Big Pharma is at it again… Creating and selling a drug that causes thousands of heart attacks and strokes each year.
In 2015, the FDA asked drug makers to strengthen their warning labels.
Since then, most have listed their dangerous side effects on the bottle.
But one manufacturer thought they didn’t have to warn people about their dangerous drug.
They marketed their product as a “unique” breakthrough. They even published studies promising it was “safe for long-term use.” 1
The drug is a 7-year-old arthritis drug called Actemra. It’s made by the Swiss pharmaceutical company Roche.
...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news
Cardiovascular profile in osteoarthritis: A meta-analysis of cardiovascular events and risk factors
Conclusion: Our meta-analysis results revealed higher cardiovascular risk in OA patients. This highlights the importance of cardiovascular risk factor management in OA.
Source: Joint Bone Spine - July 17, 2019 Category: Orthopaedics Source Type: research
Role of Non ‐Steroidal Anti‐Inflammatory Drugs (NSAIDs) in the Association between Osteoarthritis and Cardiovascular Diseases: A Longitudinal Study
ConclusionFindings of this first study to evaluate NSAID's mediating role in OA ‐CVD relationship suggest that NSAID use substantially contributes to the OA‐CVD association.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - August 5, 2019 Category: Rheumatology Authors: Mohammad Atiquzzaman,
Mohammad E. Karim,
Jacek Kopec,
Hubert Wong,
Aslam H. Anis Tags: Full Length Source Type: research
Role of Nonsteroidal Antiinflammatory Drugs in the Association Between Osteoarthritis and Cardiovascular Diseases: A Longitudinal Study
ConclusionThe findings of this first study to evaluate the mediating role of NSAIDs in the relationship between OA and CVD suggest that NSAID use contributes substantially to the OA –CVD association.
Source: Arthritis and Rheumatology - September 4, 2019 Category: Rheumatology Authors: Mohammad Atiquzzaman,
Mohammad E. Karim,
Jacek Kopec,
Hubert Wong,
Aslam H. Anis Tags: Original Article Source Type: research
O27 Frailty and co-morbidity in people with osteoarthritis and rheumatoid arthritis
Conclusion Co-morbidity is associated with an increased occurrence of pre-frailty and frailty among people with OA and RA and interacts synergistically with OA and RA to increase the likelihood of pre-frailty and frailty.Disclosure M.J. Cook: None.M. Lunt: None.S.M.M. Verstappen: None.T.W. O'Neill: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research
A discrete-choice experiment of United Kingdom patients' willingness to risk adverse events for improved function and pain control in osteoarthritis
Conclusion: Patients ranked ambulatory pain as a more important benefit than resting pain; likely due to its impact on ability to do daily activities. For a 25-mm reduction, patients were willing to accept four times the risk of MI in ambulatory pain vs resting pain.
Source: Osteoarthritis and Cartilage - January 23, 2013 Category: Rheumatology Authors: A.B. Hauber, N.K. Arden, A.F. Mohamed, F.R. Johnson, P.M. Peloso, D.J. Watson, P. Mavros, A. Gammaitoni, S.S. Sen, S.D. Taylor Tags: Original Articles Source Type: research
Partial and complete retirement due to ill-health among mature age Australians
Conclusions: To reduce early retirement due to ill-health, health practitioners, governments and employers should address targeted health problems, particularly in areas outside capital cities.
Source: Public Health - February 20, 2013 Category: Global & Universal Authors: S.W. Pit, R. Shrestha, D. Schofield, M. Passey Tags: Original Research Source Type: research
Comparative evaluation of cardiovascular outcomes in patients with osteoarthritis and rheumatoid arthritis on recommended doses of nonsteroidal anti-inflammatory drugs
Conclusion:
From the analysis conducted, it appears that the risk for cardiovascular events in arthritis patients on licensed doses of NSAIDs varies considerably and is likely to depend on the individual compound.
Source: Therapeutic Advances in Musculoskeletal Disease - August 4, 2014 Category: Orthopaedics Authors: Fabule, J., Adebajo, A. Tags: Original Research Source Type: research
Rethinking Retirement in the 21st Century
Conclusion
In the 21st century, many seniors are not retiring from something. Instead, retirement is an opportunity for reinventing, reimagining and reconnecting to one's self, family, friends and community. Robert Browning once wrote, "Grow old along with me! The best is yet to be." By investing in your physical, mental and financial health today, you can help ensure that your best years are just ahead.
Rear Admiral Susan Blumenthal, M.D., M.P.A. (ret.) is the Public Health Editor of The Huffington Post. She is a Senior Fellow in Health Policy at New America and a Clinical Professor at Tufts and Georgetown University Sc...
Source: Healthy Living - The Huffington Post - May 1, 2015 Category: Consumer Health News Source Type: news
Medtech approvals: FDA releases August 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in August 2015:
Summary of PMA Originals & Supplements Approved
Originals: 2
Supplements: 70
Summary of PMA Originals Under Review
Total Under Review: 57
Total Active: 28
Total On Hold: 29
Summary of PMA Supplements Under Review
Total Under Review: 569
Total Active: 422
Total On Hold: 147
Summary of All PMA Submissions
Originals: 5
Supplements: 90
Summary of PMA Supplement PMA Approval/Denial Decision Times
Number of Approvals: 70
Number of Denials: 0
Average Days Fr Receipt to Decision (Total Time): 229.0
FDA Time: 130...
Source: Mass Device - October 23, 2015 Category: Medical Equipment Authors: Brad Perriello Tags: Food & Drug Administration (FDA) Pre-Market Approval (PMA) Regulatory/Compliance Source Type: news
The relative impact of chronic conditions and multimorbidity on health-related quality of life in Ontario long-stay home care clients
Conclusion
Clinically important negative effects on HRQL were observed for clients with a previous diagnosis of stroke, osteo- and rheumatoid arthritis, or CHF, as well as with increasing levels of multimorbidity. Findings provide baseline preference-based HRQL scores for home care clients with different diagnoses and may be useful for identifying, targeting and evaluating care strategies toward populations with significant HRQL impairments.
Source: Quality of Life Research - April 5, 2016 Category: Health Management Source Type: research
