Disrupting Today's Healthcare System

This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other country on the planet. Prescription drugs cost around 50% more in the U.S. than in other industrialized countries. At current rates, by 2025, nearly ¼ of the US GDP will be spent on healthcare. It takes on average 12 years and $359 million to take a new drug from the lab to a patient. Only 5 in 5,000 of these new drugs make it to human testing. From there, only 1 of those 5 is actually approved for human use. And Now, the Good News: We are in the midst of a (medical) revolution driven by exponential technology: artificial intelligence, sensors, robotics, 3D printing, big data, genomics and stem cells. Today's $3 trillion healthcare industry is in the deceptive phase of its march towards dematerialization, demonetization and democratization. What does that mean? Imagine a time within the next 10 years when: AI-enabled autonomous health scans provide t...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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ConclusionsA single institution KBP model can be applied as a QC tool for multi-institutional clinical trials to improve overall plan quality and provide decision-support to determine the need for anatomy-based dosimetric trade-offs.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 November 2018Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Shahram Mori, Rushang D. Patel, Sarfraz Ahmad, Juan Varela, Tori Smith, Rola Altoos, Qi Shen, Steven C. Goldstein, Daniel O. PerskyAbstractClassical Mantle cell lymphoma (cMCL) is a B-cell neoplasm characterized immunohistochemically by their CD5+, CD19+, CD20+, CD23- and cyclinD1+ nature and confirmed genetically by the presence of t(11;14), resulting in the over-expression of Cyclin D1. Classical MCL generally presents with adenopathy, spleen, bone marrow involvement and extra-nodal sites most commonly the GI tract...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Our data show that TBX1 is frequently inactivated by promoter methylation, and functions as a potential tumor suppressor in thyroid cancer through inhibiting the activities of PI3K/AKT and MAPK/ERK signaling pathways. PMID: 30543152 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
In conclusion, the evidence from current research supports the use of medical cannabis in the treatment of chronic pain in adults. Careful follow-up and monitoring of patients using cannabis/cannabinoids are mandatory. PMID: 30542280 [PubMed]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Front Pharmacol Source Type: research
Publication date: Available online 14 December 2018Source: Stem Cell ResearchAuthor(s): Xinyue Bai, Xianjie Yang, Yun Cheng, Ling ChenAbstractPathological myopia (PM) is a retinal degenerative disease with an increasing prevalence in Asia. The peripheral blood mononuclear cells (PBMCs) from a patient with PM were successfully reprogrammed to induced pluripotent stem cells (iPSCs) using integration-free method, Sendai viral (SeV) vectors expressing OCT4, SOX2, KLF4 and C-MYC. This line may provide a useful resource for exploring the pathogenesis of PM.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 14 December 2018Source: Stem Cell ResearchAuthor(s): Elena Daoutsali, Ronald A.M. Buijsen, Simone van de Pas, Anke't Jong, Harald Mikkers, Tom Brands, Bert Eussen, Annelies de Klein, Linda M. van der Graaf, Barry A. Pepers, Christian Freund, Gisela M. Terwindt, Valeria Orlova, Willeke M.C. van Roon-MomAbstractHereditary Cerebral Hemorrhage with Amyloidosis-Dutch type (HCHWA-D) is an autosomal dominant hereditary disease caused by a point mutation in exon 17 of the APP gene. We generated human induced pluripotent stem cells (hiPSCs) from a symptomatic HCHWA-D patient by using non-integrati...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 14 December 2018Source: Stem Cell ResearchAuthor(s): Ponthip Potirat, Methichit Wattanapanitch, Vip Viprakasit, Pakpoom Kheolamai, Surapol IssaragrisilAbstractWe generated an induced pluripotent stem cell (iPSC) line from peripheral blood mononuclear cells (PBMNCs) isolated from a 1-year old female carrying compound heterozygote for KLF1 mutations (G176RfsX179 and A298P mutations). Non-integrating Sendai viral (SeV) vectors containing KOS, hc-MYC and hKLF4 were used for reprogramming. The established MUSIi008-A cell line contained the same mutations found in the patient, expressed pluripo...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 14 December 2018Source: Neurochemistry InternationalAuthor(s): Bruk Getachew, Antonei B. Csoka, Michael Aschner, Yousef TizabiAbstractManganese (Mn) and iron (Fe) are trace elements that are essential for proper growth and physiological functions as both play critical role in a variety of enzymatic reactions. At high concentrations, however, they can be toxic and cause neurodegenerative disorders, particularly Parkinson-like syndromes. Nicotine, on the other hand, has been shown to have neuroprotective effects against various endogenous or exogenous toxins that selectively damage the dopa...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Conclusion: Various surgical approaches utilized in managing macular holes may effectively close macular holes and reattach retinas. This trial is registered with NCT 03618498. PMID: 30524755 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
Authors: Bondeelle L, Bergeron A Abstract INTRODUCTION: Progress in allogeneic hematopoietic stem cell transplantation (HSCT) procedures have been associated with improved survival in HSCT recipients. However, they have also brought to light organ-specific complications, especially pulmonary complications. In this setting, pulmonary complications are consistently associated with poor outcomes, and improved management of these complications is required. Areas covered: We review the multiple infectious and noninfectious lung complications that occur both early and late after allogeneic HSCT. This includes the descrip...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
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