Disrupting Today's Healthcare System

This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other country on the planet. Prescription drugs cost around 50% more in the U.S. than in other industrialized countries. At current rates, by 2025, nearly ¼ of the US GDP will be spent on healthcare. It takes on average 12 years and $359 million to take a new drug from the lab to a patient. Only 5 in 5,000 of these new drugs make it to human testing. From there, only 1 of those 5 is actually approved for human use. And Now, the Good News: We are in the midst of a (medical) revolution driven by exponential technology: artificial intelligence, sensors, robotics, 3D printing, big data, genomics and stem cells. Today's $3 trillion healthcare industry is in the deceptive phase of its march towards dematerialization, demonetization and democratization. What does that mean? Imagine a time within the next 10 years when: AI-enabled autonomous health scans provide t...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Publication date: Available online 18 April 2019Source: Stem Cell ReportsAuthor(s): Friederike Matheus, Ejona Rusha, Rizwan Rehimi, Lena Molitor, Anna Pertek, Miha Modic, Regina Feederle, Andrew Flatley, Elisabeth Kremmer, Arie Geerlof, Valentyna Rishko, Alvaro Rada-Iglesias, Micha DrukkerSummaryThe neural crest (NC) gives rise to a multitude of fetal tissues, and its misregulation is implicated in congenital malformations. Here, we investigated molecular mechanisms pertaining to NC-related symptoms in Bohring-Opitz syndrome (BOS), a developmental disorder linked to mutations in the Polycomb group factor Additional sex com...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 18 April 2019Source: Stem Cell ReportsAuthor(s): Fani Papagiannouli, Cameron Wynn Berry, Margaret T. FullerSummaryTissue homeostasis and repair relies on proper communication of stem cells and their differentiating daughters with the local tissue microenvironment. In the Drosophila male germline adult stem cell lineage, germ cells proliferate and progressively differentiate enclosed in supportive somatic cyst cells, forming a small organoid, the functional unit of differentiation. Here we show that cell polarity and vesicle trafficking influence signal transduction in cyst cells, with pro...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 18 April 2019Source: Stem Cell ReportsAuthor(s): Yefim Zaltsman, Sayaka Masuko, Joshua J. Bensen, Laura L. KiesslingSummaryLeveraging the extraordinary potential of human pluripotent stem cells (hPSCs) requires an understanding of the mechanisms underlying cell-fate decisions. Substrate elasticity can induce differentiation by signaling through the transcriptional coactivator Yes-associated protein (YAP). Cells cultured on surfaces mimicking brain elasticity exclude YAP from their nuclei and differentiate to neurons. How YAP localization is controlled during neural differentiation has bee...
Source: Stem Cell Reports - Category: Stem Cells Source Type: research
Publication date: Available online 19 April 2019Source: Journal of Materials Research and TechnologyAuthor(s): Elieser de Araújo, Rafael Marinho Bandeira, Marcos Dorigão Manfrinato, Jéferson Aparecido Moreto, Roger Borges, Sandra dos Santos Vales, Paulo Atsushi Suzuki, Luciana Sgarbi RossinoAbstractThe aim of this work was to study the influence of thermochemical treatment of ionic plasma nitriding on the resistance to micro-abrasive wear and to the corrosion process of AISI 316L and AISI 470 stainless steels. The thermochemical treatment was performed at different times and temperatures with a gas mix...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 19 April 2019Source: Journal of Materials Research and TechnologyAuthor(s): Raphael Fialho Tomaz, Dagoberto Brandão Santos, Kenji Camey, Ronaldo Barbosa, Margareth Spangler Andrade, Diana Pérez EscobarAbstractMicroalloyed steels are required to have good strength and toughness, properties that are mostly influenced by microstructure and phase distribution in the steel, obtained by controlling the thermomechanical processing. High temperature processing (HTP) Steels, with lower manganese content, has been recently developed in order to reduce segregation, but reduction of Mn ...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Publication date: Available online 19 April 2019Source: Journal of Materials Research and TechnologyAuthor(s): Naseri Azari Golnaz, Taghizadeh Tabrizi Arvin, Hossein AghajaniAbstractEnhancing the copper-based composites with oxide nanoparticles attracts more attention and many routes are proposed. In this investigation, stoichiometric Cu–TiO2 nanocomposite is synthesized through the self-propagating high-temperature synthesis, and the effect of additional Cu contents of 10, 20, 30 wt% on mechanical and physical features of this composite was evaluated. To investigate the obtained properties of specimens, scannin...
Source: Journal of Materials Research and Technology - Category: Materials Science Source Type: research
Obsessive-compulsive disorder (OCD) is common and can be profoundly debilitating. Deep brain stimulation (DBS) —the delivery of high-frequency stimulation via electrodes to neural targets—is safe and effective for the treatment of refractory OCD (1,2). DBS has been approved by the United States Food and Drug Administration for treatment of Parkinson's disease since 2002 and OCD since 2009. Although this treatment is effective on a group level, why specific patients respond but others less so remains an open question.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research
Authors: Conte SC, Spagnol G, Biolo M, Confalonieri M Abstract The conventional-trans bronchial needle aspiration (c-TBNA) has been the first procedure for sampling hilar/mediastinal lymph node for the diagnosis/staging of lung cancer. In the last decade the endobronchial ultrasound trans bronchial needle aspiration (EBUS-TBNA) was introduced in clinical practice and became the first-choice exam in diagnosis and staging of lung cancer. The aim of this study was to compare the diagnostic accuracy (DA), sensitivity and adequacy of c-TBNA and EBUS-TBNA. It was a retrospective and observational multicenter study. The f...
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Luca A. Lotta, Jacek MokrosiƄski, Edson Mendes de Oliveira, Chen Li, Stephen J. Sharp, Jian’an Luan, Bas Brouwers, Vikram Ayinampudi, Nicholas Bowker, Nicola Kerrison, Vasileios Kaimakis, Diana Hoult, Isobel D. Stewart, Eleanor Wheeler, Felix R. Day, John R.B. Perry, Claudia Langenberg, Nicholas J. Wareham, I. Sadaf FarooqiSummaryThe melanocortin 4 receptor (MC4R) is a G protein-coupled receptor whose disruption causes obesity. We functionally characterized 61 MC4R variants identified in 0.5 million people from UK Biobank and examined their a...
Source: Cell - Category: Cytology Source Type: research
Publication date: 18 April 2019Source: Cell, Volume 177, Issue 3Author(s): Wantong Yao, Anirban MaitraIn this issue of Cell, Lytle et al. (2019) integrate functional genomic approaches to identify molecular dependencies of pancreatic cancer stem cells that may be exploited therapeutically. The comprehensive analysis reveals an unexpected role for retinoic acid receptor-related orphan receptor gamma (RORγ), a T-cell-associated transcription factor, in defining the stemness and the aggressive behavior of pancreatic cancer.
Source: Cell - Category: Cytology Source Type: research
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