Disrupting Today's Healthcare System

This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other country on the planet. Prescription drugs cost around 50% more in the U.S. than in other industrialized countries. At current rates, by 2025, nearly ¼ of the US GDP will be spent on healthcare. It takes on average 12 years and $359 million to take a new drug from the lab to a patient. Only 5 in 5,000 of these new drugs make it to human testing. From there, only 1 of those 5 is actually approved for human use. And Now, the Good News: We are in the midst of a (medical) revolution driven by exponential technology: artificial intelligence, sensors, robotics, 3D printing, big data, genomics and stem cells. Today's $3 trillion healthcare industry is in the deceptive phase of its march towards dematerialization, demonetization and democratization. What does that mean? Imagine a time within the next 10 years when: AI-enabled autonomous health scans provide t...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Mesenchymal stem cell therapy for heart failure: a meta-analysis. Herz. 2018 Oct 19;: Authors: Fu H, Chen Q Abstract BACKGROUND: Mesenchymal stem cell (MSC) treatment has emerged as an important adjunct therapy for heart failure. However, the use of MSC to treat heart failure has not been well established. We conducted a systematic review and meta-analysis to evaluate the efficacy of MSC treatment for heart failure. METHODS: PubMed, Embase, and the Cochrane Central Register of Controlled Trials were searched. Randomized controlled trials (RCTs) assessing the influence of MSC treatment on ...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
CONCLUSIONS: The present study provides a working example of the applicability of functional PET imaging as a suitable tool to determine PK parameters in small animals. The comparative analysis in the current study demonstrates that it is feasible to use [18F]FDG PET and [18F]FAZA PET in the same model to analyze their blood PK parameters, and to estimate kinetic parameters for these tracers in tumor. This non-invasive imaging-based determination of tissue kinetic parameters facilitates translation from pre-clinical to clinical phases of drug development. This article is open to POST-PUBLICATION REVIEW. Registered rea...
Source: J Pharm Pharm Sci - Category: Drugs & Pharmacology Authors: Tags: J Pharm Pharm Sci Source Type: research
Publication date: February 2019Source: Carbon, Volume 142Author(s): Yanli Nan, Bo Li, Xiaolong Song, Noriaki SanoAbstractWe firstly reveal the unique tendency in the capacitance of an electric double layer capacitor (EDLC) made of single-walled carbon nanohorns (SWCNHs), where there is an optimized value of specific surface area (SSA) to achieve the high capacitance value at a high charge-discharge rate. As a result, in the experimental observation, SWCNHs treated by oxidation in air at 550 °C can exhibit 963.4 m2/g of SSA and 286.6 F/g of EDLC capacitance, whereas the ones treated at 500 °C can exhibit 797...
Source: Carbon - Category: Materials Science Source Type: research
In this study, we further explored the mechanism underlying CD133-mediated cisplatin resistance in glioblastoma stem cells. We sorted human glioblastoma T98G and U87MG cells into CD133+ and CD133− pools and measured apoptosis and CD133 expression levels in response to cisplatin treatment. We predicted candidate microRNAs that might target CD133 and assessed their levels in cisplatin-treated CD133+ cells. Finally, we overexpressed miR-29a in CD133+ cells and tested its effects in cisplatin-mediated apoptosis and survival of CD133+ tumor bearing mice receiving cisplatin treatment. We found that CD133+ glioblastoma stem...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
In conclusion, molecular alterations in ependymoma involve miRNAs. In our report, we review the level of evidence for the biomarker candidacy of identified miRNAs. Confirmatory studies are necessary to establish robust biomarkers for the clinical management of ependymoma. Proteins regulated by differentially expressed miRNAs are additional candidate biomarkers and may offer targets for novel therapeutic interventions.
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
AbstractAlzheimer ’s disease (AD) is a neurodegenerative disorder characterized by progressive neuronal loss, caused by misfolding and accumulation of tau and Amyloid β-42. Cellular mechanisms involving phosphatases, chaperones, ubiquitin proteasome system (UPS) and aggresomes solubilize or remove these toxic aggr egates. Chaperones such as Hsp70 and Hsp90 functions in folding tau to its native form or in the downstream degrade and eliminated tau from the cell. Chaperones are involved in lysosomal degradation of tau by a process called chaperone mediated autophagy (CMA). In pathological conditions, chaperones fa...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
AbstractIschemic stroke is one of the leading health issues and the major cause of permanent disability in adults worldwide. Energy depletion and hypoxia occurring after ischemic stroke result in cell death, which activates resident glia cells and promotes the peripheral immune cells breaching into brain performing various functions even contradictory effects. The infiltration of immune cells may mediate neuron apoptosis and escalate ischemic damage, while it enhances neuron repair, differentiation, and neuroregeneration. The central nervous system (CNS) is immune-privileged site as it is separated from the peripheral immu...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: In conclusion, our study demonstrated that SCH-527123, a small-molecule antagonist for CXCR1 and CXCR2 inhibited cell proliferation, migration and invasion in melanoma via PI3K/AKT pathway. PMID: 30340844 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
This article attempts to explore data on role of rosuvastatin for secondary prevention. PMID: 30341873 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Snehalatha C, Priscilla S, Nanditha A, Arun R, Satheesh K, Ramachandran A Abstract Identification and treatment of individuals with prediabetes is crucial. Effective interventional strategies are key to reducing the diabetes risk at the population level. Lifestyle intervention is found to be more effective but more expensive. Evidence of potential benefits from pharmacotherapy is accumulating. The choice of a pharmacologic intervention to reduce the progression of type 2 diabetes (T2DM) in high risk individuals must consider the balance between the benefit to risk ratio. A meta-analysis of the results of t...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
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