Alcohol-Specific Communication and Emerging Adult Offspring's Perceived Parental Approval and Drinking in the Context of Parent Alcohol Expectancies.
CONCLUSIONS: Findings suggest consideration of mediators (e.g., perceived approval of drinking) helps clarify the mixed literature on parental communication about alcohol, and that parental attitudes about alcohol can impact the effectiveness with which parents convey the risk of alcohol to offspring. PMID: 33232523 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 24, 2020 Category: Addiction Authors: Ramer NE, Paige KJ, Colder CR Tags: Alcohol Clin Exp Res Source Type: research

Genes Associated with Calcium Signaling are Involved in Alcohol Induced Breast Cancer Growth.
CONCLUSION: Alcohol alters expression of genes that regulate intracellular calcium levels and downstream signaling pathways which drive breast cancer cell proliferation and disease progression. PMID: 33222221 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 22, 2020 Category: Addiction Authors: Ho C, Lin CY Tags: Alcohol Clin Exp Res Source Type: research

Fetal Alcohol Exposure Alters BOLD Activation Patterns in Brain Regions Mediating the Interpretation of Facial Affect.
CONCLUSIONS: These findings of greater BOLD signal in the FAS/PFAS group in response to neutral faces suggest less efficient neural processing of more difficult to interpret emotions, and the weaker BOLD response to angry faces suggests altered processing of angry stimuli. Although behavioral performance did not differ in this relatively simple affective appraisal task, these data suggest that in children with FAS and PFAS the appraisal of neutral affect and anger is likely to be more effortful in more challenging and dynamic social contexts. PMID: 33220071 [PubMed - as supplied by publisher] (Source: Alcoholism, Clin...
Source: Alcoholism, Clinical and Experimental Research - November 21, 2020 Category: Addiction Authors: Lindinger NM, Jacobson JL, Warton CMR, Malcolm-Smith S, Molteno CD, Dodge NC, Robertson F, Meintjes EM, Jacobson SW Tags: Alcohol Clin Exp Res Source Type: research

The "Why" of Drinking Matters: A Meta-analysis of the Association Between Drinking Motives and Drinking Outcomes.
The "Why" of Drinking Matters: A Meta-analysis of the Association Between Drinking Motives and Drinking Outcomes. Alcohol Clin Exp Res. 2020 Nov 18;: Authors: Bresin K, Mekawi Y Abstract Knowledge of how drinking motives are differentially associated with alcohol use (e.g., frequency, quantity) and drinking problems is critical in understanding risky drinking and the development of alcohol use disorder. The purpose of this paper was to use meta-analytic techniques to answer two overarching questions (a) Which types of drinking motives (i.e., enhancement, coping, social, conformity) are most ...
Source: Alcoholism, Clinical and Experimental Research - November 18, 2020 Category: Addiction Authors: Bresin K, Mekawi Y Tags: Alcohol Clin Exp Res Source Type: research

Glutathione Protects the Developing Heart from Defects and Global DNA Hypomethylation Induced by Prenatal Alcohol Exposure.
CONCLUSIONS: GSH supplementation shows promise to inhibit effects of PAE by improving survival, reducing the incidence of morphological defects including CHDs, and preventing global hypomethylation of DNA in heart tissues. PMID: 33206417 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 18, 2020 Category: Addiction Authors: Jawaid S, Strainic JP, Kim J, Ford MR, Thrane L, Karunamuni GH, Sheehan MM, Chowdhury A, Gillespie CA, Rollins AM, Jenkins MW, Watanabe M, Ford SM Tags: Alcohol Clin Exp Res Source Type: research

Daily Patterns of Emotional Functioning on Drinking and Nondrinking Days.
CONCLUSIONS: This study highlights the potentially reinforcing impact of alcohol via emotional stability. Overall, these findings highlight the importance of mood dynamics when examining the reinforcing effects of alcohol consumption. PMID: 33206419 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 18, 2020 Category: Addiction Authors: De Leon AN, Dvorak RD, Kramer MP, Peterson R, Pinto DA, Leary AV, Magri TD Tags: Alcohol Clin Exp Res Source Type: research

Subjective Effects of Alcohol Predict Alcohol Choice in Social Drinkers.
CONCLUSION: Both greater positive mood effects and lesser sedative effects after alcohol predicted preference under controlled conditions, suggesting that both factors can predict future consumption of alcohol. PMID: 33201577 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 17, 2020 Category: Addiction Authors: Li J, Murray CH, Weafer J, de Wit H Tags: Alcohol Clin Exp Res Source Type: research

Unravelling Apathy in Korsakoff Syndrome Patients Receiving Long-Term Care with and without Cerebrovascular Comorbidity.
CONCLUSIONS: Our results suggest that KS patients show increased levels of general apathy compared to healthy controls. Patients show a diminished competency to consent and increased emotional blunting, while motivation is not compromised. Cerebrovascular comorbidity in KS forms a high risk for emotional blunting. The results of this study suggest that apathy is a severe problem in KS. More attention in both the literature and clinical practice would benefit this complex patient population. PMID: 33196105 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 16, 2020 Category: Addiction Authors: Oey MJ, Brouwer VHEW, Buijs MJ, Wijnia JW, Postma A, Oudman E Tags: Alcohol Clin Exp Res Source Type: research

Patch-Clamp Recording of LFS-induced Long-Term Synaptic Depression in Rat Hippocampus Slices During Early and Late Periods of Neurodevelopment.
CONCLUSION: We concluded that whole-cell patch-clamp recordings are not suitable for studying synaptic LFS-induced LTD in rats older than 4 weeks of age and therefore, cannot be used to explore electrophysiological disturbances, such as those induced by alcohol binge-drinking during adolescence, which constitutes a late period of brain maturation. PMID: 33196109 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 16, 2020 Category: Addiction Authors: Bertrand C, Deschamps C, Rabiant K, Peineau S, Antol J, Martinetti M, Naassila M, Vilpoux C, Pierrefiche O Tags: Alcohol Clin Exp Res Source Type: research

Systematic Review: Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients with Liver Disease.
CONCLUSIONS: Urinary and scalp hair ethyl glucuronide are currently the most validated alcohol use biomarkers in patients with liver disease with good diagnostic accuracies. Phosphatidylethanol is a highly promising alcohol use biomarker, but so far less validated in liver patients. Alcohol use biomarkers can complement each other regarding diagnostic time window. More validation studies on alcohol use biomarkers in patients with liver disease are needed. PMID: 33190239 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 15, 2020 Category: Addiction Authors: Arnts J, Vanlerberghe BT, Roozen S, Crunelle CL, Masclee AA, Olde-Damink SW, Heeren RM, van Nuijs A, Neels H, Nevens F, Verbeek J Tags: Alcohol Clin Exp Res Source Type: research

Secondary Aanalysis of a Randomized Clinical Trial of Naltrexone among Women Living with HIV: Correlations between Reductions in Self-Reported Alcohol Use and Changes in Phosphatidylethanol (PEth).
Abstract BACKGROUND: Direct biomarkers such as phosphatidylethanol (PEth) have the capability to detect heavy alcohol use, but it is unclear how strongly self-reported reduction in alcohol use correlates with reduction in PEth. We sought to explore the strength of correlation between reductions in self-reported alcohol use and change in PEth among a sample of women living with HIV (WLWH) who participated in a clinical trial to reduce heavy alcohol use. We also sought to determine whether this correlation was stronger in women with lower body mass index (BMI) and women without an alcohol use disorder (AUD). ME...
Source: Alcoholism, Clinical and Experimental Research - November 15, 2020 Category: Addiction Authors: Richards VL, Sajdeya R, Villalba K, Wang Y, Bryant V, Brumback B, Bryant K, Hahn JA, Cook RL Tags: Alcohol Clin Exp Res Source Type: research

Cross-Sectional Analysis of Spatial Working Memory Development in Children with Histories of Heavy Prenatal Alcohol Exposure.
CONCLUSIONS: The atypical brain development that has previously been reported in children with heavy prenatal alcohol exposure may have clinically relevant implications for cognitive development; however, longitudinal cognitive analyses are needed. PMID: 33190244 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 15, 2020 Category: Addiction Authors: Moore EM, Glass L, Infante MA, Coles CD, Kable JA, Jones KL, Riley EP, Mattson SN Tags: Alcohol Clin Exp Res Source Type: research

Heterogeneity of Executive Function Abilities in Recently Detoxified Patients with Alcohol Use Disorder: Evidence from a Cluster Analysis.
CONCLUSIONS: This study highlights the importance of the cognitive heterogeneity in AUD by showing that AUD patients display substantially different EF patterns. Future studies should try to go beyond mere group comparisons to further deepen our understanding about cognitive differences between AUD patients. In the long run, this could lead to more personalized prevention and treatment programs specifically tailored to the patient's impairments. PMID: 33190273 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 15, 2020 Category: Addiction Authors: Schmid F, Benzerouk F, Barrière S, Henry A, Limosin F, Kaladjian A, Gierski F Tags: Alcohol Clin Exp Res Source Type: research

Alcohol Use Disorder is Associated with Upregulation of MicroRNAs-34a and -34c in Hippocampal Postmortem Tissue.
CONCLUSIONS: Hippocampal upregulation of miRs-34a and miRs-34c may be involved in the cognitive decline associated with chronic alcohol consumption. PMID: 33190281 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 15, 2020 Category: Addiction Authors: Santos-Bezerra DP, Cavaleiro AM, Santos AS, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Leite REP, Passarelli M, Marie SKN, Machado UF, Correa-Giannella ML Tags: Alcohol Clin Exp Res Source Type: research

A Critical Review of Alcohol Administration Guidelines in Laboratory Medication Screening Research: Is It Time to Include Treatment Seekers?
This article considers the practice of recruiting nontreatment-seeking heavy drinkers to participate in laboratory screening studies. By convention, volunteers are excluded from laboratory screening studies that involve alcohol administration if they are deemed "treatment seeking," meaning that they recently stopped drinking or are motivated to do so. Although this common practice may reduce risk to participants, findings may not accurately predict medication effects on treatment seekers. Indeed, there is empirical evidence that treatment seekers differ from non-treatment seekers in their responses to medications...
Source: Alcoholism, Clinical and Experimental Research - November 15, 2020 Category: Addiction Authors: Roberts W, Verplaetse TL, Ramchandani VA, McKee SA Tags: Alcohol Clin Exp Res Source Type: research

Binges, Brains, Birthdays and BACs.
Abstract All of us have encountered attention-grabbing headlines such as "You may be boozing your brain cells away," but many of us don't accept that claim in stark, literal terms. Similarly, evidence in rodents that single, high oral doses of ethanol can be significantly neurotoxic, are often dismissed as "well rats are not people." It may be time to change our minds. Hua et al. (2020) now show us for the first time, in a highly original and well-conceived experiment, persuasive evidence for persisting structural brain alterations consequent on a single extreme drinking episode. PMID...
Source: Alcoholism, Clinical and Experimental Research - November 11, 2020 Category: Addiction Authors: Pearlson G Tags: Alcohol Clin Exp Res Source Type: research

Association between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta-Analysis.
Abstract BACKGROUND: Alcohol may increase gastric cancer risk. Alcohol can be more carcinogenic in persons who possess inactive ALDH2. The aim of this meta-analysis was to evaluate whether ALDH2 polymorphism can affect alcohol-induced gastric carcinogenesis. METHODS: We searched the PubMed, EMBASE, and Cochrane databases to identify relevant articles published between January 2000 and September 2019. Eligible articles were selected according to inclusion and exclusion criteria. The data were analyzed using Review Manager 5.3. RESULTS: A total of 7 case-control studies on ALDH2 rs671 polymorphism consisti...
Source: Alcoholism, Clinical and Experimental Research - November 10, 2020 Category: Addiction Authors: Kang SJ, Shin CM, Sung J, Kim N Tags: Alcohol Clin Exp Res Source Type: research

Attacking Alcohol-Related Liver Disease by Taxing Alcohol Sales.
Abstract The public health impact of ALD is large and growing (Liangpunsakul et al., 2016). The incidence of cirrhosis due to ALD is rising, driven in part by recent and historically unparalleled increases among young people (Mellinger et al., 2018, Flemming et al., 2018). In parallel, mortality and liver transplantation rates for persons with ALD have risen substantially (Tapper and Parikh, 2018, Mellinger et al., 2018, Lee et al., 2019). PMID: 33164216 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 9, 2020 Category: Addiction Authors: Tapper EB, Parikh ND, Liangpunsakul S Tags: Alcohol Clin Exp Res Source Type: research

Altered Resting-State Neural Oscillations and Spectral Power in Children with Fetal Alcohol Spectrum Disorder.
CONCLUSIONS: Our results were consistent with previous studies and provide new insight into resting-state oscillatory differences both between children with FAS and TDC, and within FASD subgroups. Further understanding of these resting-state variations and their impact on cognitive function may help provide early targets for intervention and enhance outcomes for individuals with a FASD. PMID: 33164218 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 9, 2020 Category: Addiction Authors: Candelaria-Cook FT, Schendel ME, Flynn L, Hill D, Stephen JM Tags: Alcohol Clin Exp Res Source Type: research

Comparison of the Diagnostic Value of Phosphatidylethanol and Carbohydrate-Deficient Transferrin as Biomarkers of Alcohol Consumption.
gstrand ST Abstract BACKGROUND: The aim of this study was to compare the results of Phosphatidylethanol (PEth) and Carbohydrate-Deficient Transferrin (CDT) in blood as biomarkers of alcohol consumption in a large clinical cohort and to evaluate concentrations in relation to age and sex. METHODS: Results of PEth 16:0/18:1 in blood and CDT in serum were included, together with information of age and sex, which were extracted from a clinical chemistry database containing samples mostly from patients of primary care physicians and social care institutions. PEth concentrations were determined using Ultra Performan...
Source: Alcoholism, Clinical and Experimental Research - November 9, 2020 Category: Addiction Authors: Årving A, Høiseth G, Hilberg T, Trydal T, Husa A, Djordjevic A, Kabashi S, Vindenes V, Bogstrand ST Tags: Alcohol Clin Exp Res Source Type: research

Microglia Phenotype is Not as Simple as M1- or M2-like after Alcohol Dependence in Adolescent Rats.
CONCLUSIONS: Altogether, these data support that microglia phenotype after alcohol dependence is not a simple M1 or M2 phenotype, though more indicators of an anti-inflammatory phenotype were observed. Determining microglia phenotype is critical for understanding their role in the development of AUDs. PMID: 33164228 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 9, 2020 Category: Addiction Authors: Peng H, Nixon K Tags: Alcohol Clin Exp Res Source Type: research

Binge-Like Exposure During Adolescence Induces Alveolar Bone Detrimental Effects With Repercussion Until Adulthood.
CONCLUSIONS: Ethanol binge-drinking during adolescence results in alveolar bone damage that may last until adulthood, even after abstinence. PMID: 33165940 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 9, 2020 Category: Addiction Authors: do Socorro Ferraz Maia C, Queiroz LY, de Oliveira IG, da Silva CCS, Cunha RA, Souza-Monteiro D, Ferreira MKM, Silveira FM, da Silva JC, de Souza Balbinot G, Collares FM, Martins MAT, Martins MD, Lima RR Tags: Alcohol Clin Exp Res Source Type: research

Associations Between Psychiatric Disorders and Alcohol Consumption Levels in an Adult Primary Care Population.
CONCLUSIONS: Findings suggest that patients with anxiety disorder, depression, and bulimia nervosa who drink alcohol are more likely to exceed recommended limits, increasing risk of developing more serious problems. Health systems and clinicians may wish to consider implementing more robust screening, assessment, and intervention approaches to support these vulnerable subgroups in limiting their drinking. PMID: 33151592 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 5, 2020 Category: Addiction Authors: Palzes VA, Parthasarathy S, Chi FW, Kline-Simon AH, Lu Y, Weisner C, Ross TB, Elson J, Sterling SA Tags: Alcohol Clin Exp Res Source Type: research

Acceptability and Co-Development of an Online Cognitive Bias Modification Intervention for Emerging Adults With Hazardous Alcohol Use and Social Anxiety: A Mixed Methods Study.
CONCLUSIONS: The current findings reflect positively on the acceptability of a hybrid ApBM + IBM for emerging adults with co-occurring hazardous alcohol use and social anxiety. Service providers and emerging adults identified a number of ways to improve the design and implementation of the program, which will likely improve adherence to, and outcomes of, the intervention when added as an adjunct to treatment as usual. PMID: 33146919 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 4, 2020 Category: Addiction Authors: Prior K, Salemink E, Wiers RW, Teachman BA, Piggott M, Newton NC, Teesson M, Baillie AJ, Campbell S, Stapinski LA Tags: Alcohol Clin Exp Res Source Type: research

Prevention of Alcohol-Exposed Pregnancies and Fetal Alcohol Spectrum Disorder among Pregnant and Postpartum Women: A Systematic Review.
CONCLUSIONS: The current review identified variable results from available interventions to prevent alcohol use among pregnant and postpartum women. Preliminary evidence demonstrated that brief interventions may be effective among subgroups of pregnant women with higher initial alcohol consumption, those with partner involvement, and those who used alcohol and other substances concurrently. Some preliminary evidence relating to long-term interventions with pregnant women with poly-substance use emerged, specifically case management that not only focused on reduction of substance use, but also on addressing the complex inte...
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Erng MN, Smirnov A, Reid N Tags: Alcohol Clin Exp Res Source Type: research

A Systematic Review of Interventions to Improve Mental Health and Substance Use Outcomes for Individuals with Prenatal Alcohol Exposure and Fetal Alcohol Spectrum Disorder.
Abstract Individuals with Fetal Alcohol Spectrum Disorder (FASD) experience remarkably high rates of mental health and substance use challenges, beginning early in life and extending throughout adulthood. Proactive intervention can help to mitigate some of these negative experiences. Although the literature on FASD intervention is growing, there is currently a lack of consolidated evidence on interventions that may improve mental health and substance use outcomes in this population. Informed by a life course perspective, we undertook a systematic review of the literature to identify interventions that improve ment...
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Flannigan K, Coons-Harding KD, Anderson T, Wolfson L, Campbell A, Mela M, Pei J Tags: Alcohol Clin Exp Res Source Type: research

Jacobian Mapping Reveals Converging Substrates of Disruption and Repair in Response to Ethanol Exposure and Abstinence in Two Strains of Rats.
CONCLUSIONS: Given the high metabolic rate of these enduringly affected regions, the current findings suggest that EtOH per se may affect cellular respiration leading to brain volume deficits. Further, responsivity greatly diminished likely reflecting neuroadaptation to repeated alcohol exposure. In summary, this unbiased, in vivo based approach demonstrating convergent brain systems responsive to two EtOH exposure protocols in two rat strains highlights regions that warrant further investigation in both animal models of alcoholism and in humans with Alcohol Use Disorder. PMID: 33119896 [PubMed - as supplied by publis...
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Zhao Q, Pohl KM, Sullivan EV, Pfefferbaum A, Zahr NM Tags: Alcohol Clin Exp Res Source Type: research

Systematic Review of Clinician-Reported Barriers to Provision of Brief Advice for Alcohol Intake in Hospital Inpatient and Emergency Settings.
Abstract Hospital inpatient and emergency care settings provide frequent opportunities for clinicians to screen and provide brief interventions to patients who engage in harmful use of alcohol. However, these services are not always provided, with several reasons given in different studies. We aimed to systematically review clinician-reported barriers in the provision of brief alcohol screening, brief advice and intervention specific to hospital inpatient and emergency department settings. A systematic literature review was conducted of Medline, PsycINFO and CINAHL to identify the barriers perceived by healthcare ...
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Gargaritano KL, Murphy C, Auyeung AB, Doyle F Tags: Alcohol Clin Exp Res Source Type: research

Identification of Functional Genetic Variants Associated with Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay.
Abstract BACKGROUND: Genome Wide Association Studies (GWAS) of Alcohol Dependence (AD) and related phenotypes have identified multiple loci, but the functional variants underlying the loci have in most cases not been identified. Non-coding variants can influence phenotype by affecting gene expression; for example, variants in the 3' untranslated regions (3'UTR) can affect gene expression post-transcriptionally. METHODS: We adapted a high-throughput assay known as PASSPORT-seq (parallel assessment of polymorphisms in miRNA target-sites by sequencing) to identify among variants associated with AD and related ph...
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Thapa KS, Chen AB, Lai D, Xuei X, Wetherill L, Tischfield JA, Liu Y, Edenberg HJ Tags: Alcohol Clin Exp Res Source Type: research

In Memoriam: Linda Patia Spear, PhD.
Abstract Linda Patia Spear, PhD, died on October 13, 2020. She was a Distinguished Professor Emerita in the Department of Psychology, at the State University of New York at Binghamton. Linda served as director of the Developmental Exposure Alcohol Research Center (DEARC) and was a major force in the Neurobiology of Adolescent Drinking in Adulthood (NADIA) consortium. Linda's exceptional service to the National Institutes of Health (NIH) included serving on the Steering Committee for Underage Drinking Prevention, Extramural Advisory Board and National Advisory Council of the National Institute on Alcohol Abuse and ...
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Silveri MM Tags: Alcohol Clin Exp Res Source Type: research

Intoxication Effects on Impulsive Alcohol Choice in Heavy Drinkers; Correlation with Sensation Seeking and Differential Effects by Commodity.
CONCLUSIONS: Alcohol increased impulsive alcohol choice in high sensation seekers, suggesting an interaction that may underlie impaired control of drinking, at least in a subset of heavy drinkers-consistent with models highlighting high novelty/sensation seeking AUD subtypes. Discounting behavior overall appears to be a generalized process, and relatively stable across methods, repeated testing, and intoxication. These findings further support the utility of behavioral tasks in uncovering key behavioral phenotypes in AUD. PMID: 33119917 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Oberlin BG, Carron CR, Ramer NE, Plawecki MH, O'Connor SJ, Kareken DA Tags: Alcohol Clin Exp Res Source Type: research

Clinical and neural correlates of reward and relief drinking.
CONCLUSIONS: Our findings support and extend the differentiation of reward from relief/habit-motivated drinking and suggest that differences in dorsal striatal response to conditioned alcohol cues may underlie this distinction. Elucidating neurobiological and clinical differences between these subtypes may facilitate treatment matching and precision medicine for AUD. PMID: 33119924 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Burnette EM, Grodin EN, Schacht JP, Ray LA Tags: Alcohol Clin Exp Res Source Type: research

Depression, Alcoholics Anonymous Involvement, and Daily Drinking Among Patients with Cooccurring Conditions: A Longitudinal Parallel Growth Mixture Model.
CONCLUSIONS: These findings can inform future clinical interventions among patients with cooccurring mental health and substance use disorders. Specifically, patients with more severe symptoms of depression may benefit from increased AA involvement, whereas patients with less severe symptoms of depression may not. PMID: 33104268 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 26, 2020 Category: Addiction Authors: Vest N, Sox-Harris A, Ilgen M, Humphreys K, Timko C Tags: Alcohol Clin Exp Res Source Type: research

Drinking Motives as Moderators of In-the-Moment Drinking Risks in Response to Trauma-Related Distress.
CONCLUSIONS: Coping motives may increase drinking urge immediately following exposure to trauma cues and may differentiate individuals most at risk for problematic drinking during trauma-associated distress. Findings support momentary negative affect processes driving dynamic, immediate trauma-related drinking risks. PMID: 33084082 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 20, 2020 Category: Addiction Authors: Zaso MJ, Read JP Tags: Alcohol Clin Exp Res Source Type: research

Health System-Based Unhealthy Alcohol Use Screening and Treatment Comparing Demographically-Matched Participants With and Without HIV.
CONCLUSIONS: Unhealthy alcohol use was lower in PLWH, but the treatment approach by HIV status differed. PLWH reporting unhealthy alcohol use received less brief interventions and more addiction specialty care than HIV-uninfected participants. PMID: 33067802 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Silverberg MJ, Levine-Hall T, Hood N, Anderson AN, Alexeeff SE, Lam JO, Slome SB, Flamm JA, Hare CB, Ross T, Justice A, Sterne JAC, Williams A, Bryant KJ, Weisner CM, Horberg MA, Sterling SA, Satre DD Tags: Alcohol Clin Exp Res Source Type: research

Involvement of Cxcl12a/Cxcr4b Chemokine System in Mediating the Stimulatory Effect of Embryonic Ethanol Exposure on Neuronal Density in Zebrafish Hypothalamus.
CONCLUSIONS: These results provide clear evidence that EtOH's stimulatory effects at low-moderate doses on the number of hypothalamic neurons early in development are mediated, in part, by increased transcription and intracellular activation of this chemokine system, likely due to autocrine signaling of Cxcl12a at its Cxcr4b receptor within the neurons. PMID: 33067812 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Collier AD, Khalizova N, Chang GQ, Min S, Campbell S, Gulati G, Leibowitz SF Tags: Alcohol Clin Exp Res Source Type: research

Assessing the Role of Long-Noncoding RNA in Nucleus Accumbens in Subjects with Alcohol Dependence.
CONCLUSIONS: Our study identified lncRNA and gene networks significantly associated with AD in the NAc, coordinated lncRNA and mRNA co-expression changes, highlighting potentially regulatory functions for the lncRNA, and our genetic (cis-eQTL) analysis provides novel insights into the etiological mechanisms of AD. PMID: 33067813 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Drake J, McMichael GO, Vornholt ES, Cresswell K, Williamson V, Chatzinakos C, Mamdani M, Hariharan S, Kendler KS, Kalsi G, Riley BP, Dozmorov M, Miles MF, Bacanu SA, Vladimirov VI Tags: Alcohol Clin Exp Res Source Type: research

Changes in circulating metabolome precede alcohol-related diseases in middle-aged men: a prospective population-based study with a 30-year follow-up.
CONCLUSIONS: Changes in the circulating metabolome, especially lower serum levels of asparagine and serotonin, are associated with later diagnoses of alcohol-related diseases, even after adjustment for the baseline level of alcohol use. PMID: 33067815 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Kärkkäinen O, Klåvus A, Voutilainen A, Virtanen J, Lehtonen M, Auriola S, Kauhanen J, Rysä J Tags: Alcohol Clin Exp Res Source Type: research

Changes in Drinking Contexts over the Night Course: Concurrent and Lagged Associations with Adolescents' Nightly Alcohol Use.
CONCLUSIONS: Findings indicated substantive concurrent and lagged social, situational, and location-based contextual effects on adolescent alcohol use over the course of an evening. Importantly, context characteristics were differentially associated with alcohol use over the course of the evening. The fact that these contextual factors are modifiable suggests that the use of prevention strategies delivered to adolescents throughout the evening may reduce adolescents' drinking and related problems over the evening hours. PMID: 33067817 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Finan LJ, Lipperman-Kreda S Tags: Alcohol Clin Exp Res Source Type: research

Red Blood Cell Distribution Width as a Predictor of 28-day Mortality in Critically Ill Patients with Alcohol Use Disorder.
CONCLUSIONS: High RDW was associated with increased short-term mortality risks in critically ill patients with AUD. PMID: 33067833 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Liao L, Liao P Tags: Alcohol Clin Exp Res Source Type: research

The Effect of Chronic Ethanol Exposure and Thiamine Deficiency on Myelin-related Genes in the Cortex and the Cerebellum.
CONCLUSION: Moderate chronic EtOH alone had a minor effect on the suppression of myelin-related genes in the cortex; however, when combined with thiamine deficiency, the reduction was amplified. There was a suppression of myelin-related genes following long-term EtOH and thiamine deficiency in the cerebellum. However, the suppression in the myelin-related genes mostly occurred 24-h after EtOH removal or following thiamine restoration; within three weeks of abstinence or thiamine recovery, gene expression rebounded. PMID: 33067870 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 17, 2020 Category: Addiction Authors: Chatterton BJ, Nunes PT, Savage LM Tags: Alcohol Clin Exp Res Source Type: research

Individual and Contextual Factors Associated With Hazardous Drinking in Spain: Evidence From a National Population-Based Study.
CONCLUSIONS: Except for age, both drinking patterns have similar associations with individual-level variables but disparate links to contextual-level indicators. In both cases, accounting for area of residence substantially increased the ability to discriminate between high-risk drinkers from nonhazardous alcohol consumers. PMID: 33058209 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 15, 2020 Category: Addiction Authors: Galán I, Simón L, Rodríguez-Blázquez C, Ortiz C, López-Cuadrado T, Merlo J Tags: Alcohol Clin Exp Res Source Type: research

Relationship of Phosphatidylethanol (PEth) Biomarker to Self-Reported Alcohol Drinking Patterns in Older and Middle Age Adults.
CONCLUSIONS: Overall, findings suggest a strong relationship between alcohol consumption and PEth levels with age a small but contributing factor to predicting PEth levels. PMID: 33038267 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 10, 2020 Category: Addiction Authors: Cherrier MM, Shireman LM, Wicklander K, Yeung W, Kooner P, Saxon AJ, Simpson T, Terman G, Shen D Tags: Alcohol Clin Exp Res Source Type: research

The Feasibility, Tolerability, and Safety of Administering a Very High Alcohol Dose to Drinkers with Alcohol Use Disorder.
Abstract INTRODUCTION: There remains a paucity of research quantifying alcohol's effects in drinkers with alcohol use disorder (AUD), particularly responses to very high alcohol doses (≥0.8 g/kg). As drinkers with AUD frequently engage in very heavy drinking (8-10 drinks/occasion), doses of ≤ 0.8 g/kg may lack ecological validity. The present study examined the feasibility, tolerability, and safety of administering a very high alcohol dose (1.2 g/kg) to non-treatment seeking AUD participants. METHODS: Sixty-one young-adult AUD drinkers enrolled in the Chicago Social Drinking Pro...
Source: Alcoholism, Clinical and Experimental Research - October 10, 2020 Category: Addiction Authors: Vena A, Howe M, Fridberg D, Cao D, King AC Tags: Alcohol Clin Exp Res Source Type: research

Does Reducing Drinking in Patients with Unhealthy Alcohol Use Improve Pain Interference, Use of Other Substances, and Psychiatric Symptoms?
Abstract BACKGROUND: We aimed to investigate the impact of reducing drinking in patients with unhealthy alcohol use on improvement of chronic pain interference, substance use, and psychiatric symptoms. METHODS: We analyzed longitudinal data from 2003 to 2015 in the Veterans Aging Cohort Study, a prospective, multisite observational study of US veterans, by emulating a hypothetical randomized trial (a target trial). Alcohol use was assessed using the AUDIT questionnaire, and outcome conditions were assessed via validated survey items. Individuals were followed from the first time their AUDIT score was &ge...
Source: Alcoholism, Clinical and Experimental Research - October 8, 2020 Category: Addiction Authors: Caniglia EC, Stevens ER, Khan M, Young KE, Ban K, Marshall BDL, Chichetto NE, Gaither JR, Crystal S, Edelman EJ, Fiellin DA, Gordon AJ, Bryant KJ, Tate J, Justice AC, Braithwaite RS Tags: Alcohol Clin Exp Res Source Type: research

A Call to Action: A Systematic Review Examining the Failure to Include Females and Members of Minoritized Racial/Ethnic Groups in Clinical Trials of Pharmacological Treatments for Alcohol Use Disorder.
Abstract Alcohol use disorder (AUD) presents a significant public health concern given the high prevalence estimates and numerous deleterious-associated consequences. The FDA currently has approved 3 pharmacological treatments for alcohol use disorder: acamprosate, naltrexone, and disulfiram. Previous research suggests that there may exist differences in the prevalence of and outcomes related to AUD across sex and racial/ethnic groups. Other work indicates that there may be differences in the efficacy of existing pharmacological treatments for AUD across demographic groups. The purpose of the present study was to ...
Source: Alcoholism, Clinical and Experimental Research - September 29, 2020 Category: Addiction Authors: Schick MR, Spillane NS, Hostetler KL Tags: Alcohol Clin Exp Res Source Type: research

Differences in Sociodemographic and Alcohol-Related Clinical Characteristics Between Treatment Seekers and Nontreatment Seekers and Their Role in Predicting Outcomes in the COMBINE Study of Alcohol Use Disorder.
Abstract BACKGROUND: One of the challenges in early-stage clinical research aimed at developing novel treatments for alcohol use disorder (AUD) is that the enrolled participants are heavy drinkers, but do not seek treatment for AUD. AIMS: To compare nontreatment seekers with alcohol dependence (AD) from 4 human laboratory studies conducted at Brown University (N = 240; 65.4% male) to treatment seekers with AD from the multisite COMBINE study (N = 1,383; 69.1% male) across sociodemographic and alcohol-related clinical variables and to evaluate whether the variables that significantly differ...
Source: Alcoholism, Clinical and Experimental Research - September 29, 2020 Category: Addiction Authors: Haass-Koffler CL, Piacentino D, Li X, Long VM, Lee MR, Swift RM, Kenna GA, Leggio L Tags: Alcohol Clin Exp Res Source Type: research

A Commentary on Drinking to Cope During the COVID-19 Pandemic: The Role of External and Internal Factors in Coping Motive Pathways to Alcohol Use, Solitary Drinking, and Alcohol Problems.
Abstract The coronavirus disease (COVID-19) pandemic began in March 2020 (World Health Organization, 2019) and has caused unprecedented disruptions to society as we know it. Widespread stay-at-home directives and the closures of non-essential businesses, while necessary to contain the spread of the virus, have wreaked havoc on the economy (Nicola et al., 2020) and contributed to marked increases in negative affect and stress for large portions of the population (Brooks et al., 2020). PMID: 32981074 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 26, 2020 Category: Addiction Authors: Creswell KG, Bachrach RL Tags: Alcohol Clin Exp Res Source Type: research

A Distinct Neurophenotype of Fearful Face Processing in Alcohol Use Disorder With and Without Comorbid Anxiety.
CONCLUSIONS: This suggests AUD with anxiety symptomology may have a unique neurobiological underpinning, and treatment and intervention should be tailored to individual constellations of symptoms. PMID: 32981080 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 26, 2020 Category: Addiction Authors: MacIlvane N, Fede SJ, Pearson EE, Diazgranados N, Momenan R Tags: Alcohol Clin Exp Res Source Type: research

Proteomic Profiling Reveals Roles of Stress Response, Ca2+ Transient Dysregulation and Novel Signaling Pathways in Alcohol-Induced Cardiotoxicity.
CONCLUSIONS: The observed changes in protein expression highlight the involvement of oxidative stress and dysregulation of Ca2+ handling and contraction while also implicating potential novel targets in alcohol-induced cardiotoxicity. These findings facilitate further exploration of potential mechanisms, discovery of novel biomarkers, and development of targeted therapeutics against ethanol-induced cardiotoxicity. PMID: 32981093 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 26, 2020 Category: Addiction Authors: Liu R, Sun F, Forghani P, Armand LC, Rampoldi A, Li D, Wu R, Xu C Tags: Alcohol Clin Exp Res Source Type: research