Novel ethanol-sensitive mutants identified in an F3 forward genetic screen.
CONCLUSIONS: The phenotypes of these ethanol-sensitive mutants differ from those in previous characterizations of gene-ethanol interactions. Thus, each mutant is likely to provide novel insights into ethanol teratogenesis. Given that most of these mutants only have craniofacial defects in the presence of ethanol and our mapping of au29, it is also likely that many of the mutants will be previously uncharacterized. Collectively, our findings point to the importance of unbiased genetic screens in the identification, and eventual characterization, of risk alleles for FASD. PMID: 31742718 [PubMed - as supplied by publishe...
Source: Alcoholism, Clinical and Experimental Research - November 19, 2019 Category: Addiction Authors: Swartz ME, Lovely CB, McCarthy N, Kuka T, Eberhart JK Tags: Alcohol Clin Exp Res Source Type: research

Relational peer victimization interacts with depression severity to predict the timing of alcohol use initiation in adolescent girls.
CONCLUSIONS: Results demonstrate that relational (and not physical) victimization predicts earlier drinking among adolescent girls. Relational peer victimization conferred greater risk for alcohol use initiation when depression severity was lower, whereas girls with high depression severity engaged in early alcohol use regardless of peer victimization. Results suggest that interventions focused on relational peer victimization may have spillover effects for delaying girls' alcohol use initiation, particularly in early adolescence, when this association is most robust. PMID: 31742727 [PubMed - as supplied by publisher]...
Source: Alcoholism, Clinical and Experimental Research - November 19, 2019 Category: Addiction Authors: Woerner J, Ye F, Hipwell AE, Chung T, Sartor CE Tags: Alcohol Clin Exp Res Source Type: research

Alcohol intake in early pregnancy and risk of Attention-Deficit Hyperactivity Disorder (ADHD) in children up to 19 years of age: a cohort study.
CONCLUSION: We found no evidence that binge drinking or low alcohol intake in early pregnancy was associated with the risk of ADHD in the children. PMID: 31742728 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 19, 2019 Category: Addiction Authors: Kjaer Weile LK, Wu C, Hegaard HK, Kesmodel US, Henriksen TB, Nohr EA Tags: Alcohol Clin Exp Res Source Type: research

Prenatal alcohol exposure alters error detection during simple arithmetic processing: An EEG study.
CONCLUSIONS: Arithmetical error-related theta activity is altered by PAE and can be used to distinguish between exposed and nonexposed individuals and within diagnostic groups, supporting the use of numerical and quantitative processing patterns to derive a neurocognitive profile that could facilitate diagnosis and treatment of fetal alcohol spectrum disorders. PMID: 31742737 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 19, 2019 Category: Addiction Authors: Ben-Shachar MS, Shmueli M, Jacobson SW, Meintjes EM, Molteno CD, Jacobson JL, Berger A Tags: Alcohol Clin Exp Res Source Type: research

Cerebellar Morphometry and Cognition in the Context of Chronic Alcohol Consumption and Cigarette Smoking.
CONCLUSIONS: Our results show that both smoking and alcohol status are associated with smaller cerebellar structural measurements, with vermal areas more vulnerable to chronic alcohol consumption and less affected by chronic smoking. These morphometric cerebellar deficits were also associated with lower intelligence and related to duration of abstinence in sALC only. PMID: 31730240 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 15, 2019 Category: Addiction Authors: Cardenas VA, Hough CM, Durazzo TC, Meyerhoff DJ Tags: Alcohol Clin Exp Res Source Type: research

SNARE complex-associated proteins and alcohol.
This article is an endeavor in this direction, focusing on the effect of ethanol on the presynaptic proteins associated with the neurotransmitter release machinery. Studies on the effects of ethanol at the levels of gene, protein, and behavior are highlighted in this article. PMID: 31724225 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 14, 2019 Category: Addiction Authors: Das J Tags: Alcohol Clin Exp Res Source Type: research

Alcohol Binge Drinking and Anxiety-Like Behavior in Socialized Versus Isolated C57BL/6J Mice.
CONCLUSIONS: Together with previous literature, the present study suggests that social isolation can promote anxiety-associated behavior and produce sex-dependent changes in binge-like EtOH consumption. PMID: 31713874 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 12, 2019 Category: Addiction Authors: Evans O, Rodríguez-Borillo O, Font L, Currie PJ, Pastor R Tags: Alcohol Clin Exp Res Source Type: research

Growth Mindsets of Alcoholism Buffer Against Deleterious Effects of Drinking Identity on Problem Drinking Over Time.
CONCLUSIONS: Growth mindsets of alcoholism appear adaptive for college graduate heavy drinkers with a stronger drinking identity. Mindsets are amenable to interventions; targeting them may be useful in heavy drinking college graduates. PMID: 31709565 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 10, 2019 Category: Addiction Authors: Lindgren KP, Burnette JL, Hoyt CL, Peterson KP, Neighbors C Tags: Alcohol Clin Exp Res Source Type: research

Abstinence Not Required: Expanding the Definition of Recovery from Alcohol Use Disorder.
Abstract Nearly one-third of individuals in the United States meet lifetime criteria for an alcohol use disorder (AUD)(Grant et al., 2015). Fortunately, most individuals who develop an AUD will eventually resolve their problem, with "recovery" defined in various ways across studies (Dawson et al., 2005; Tucker et al., 2006, 2009; Witkiewitz et al., 2019). Having scientifically sound definitions of recovery from AUD that can be shared across population and individual levels of analysis is fundamental to recovery research. PMID: 31709568 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinica...
Source: Alcoholism, Clinical and Experimental Research - November 10, 2019 Category: Addiction Authors: Witkiewitz K, Tucker JA Tags: Alcohol Clin Exp Res Source Type: research

A novel mouse model of acute-on-chronic cholestatic alcoholic liver disease: A systems biology comparison with human alcoholic hepatitis.
CONCLUSIONS: We developed a novel mouse model of acute-on chronic cholestatic alcoholic liver injury that has considerable translational potential and can be used to test novel therapeutic modalities for AH. PMID: 31710124 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 10, 2019 Category: Addiction Authors: Furuya S, Argemi J, Uehara T, Katou Y, Fouts DE, Schnabl B, Dubuquoy L, Belorkar A, Vadigepalli R, Kono H, Bataller R, Rusyn I Tags: Alcohol Clin Exp Res Source Type: research

Drinking, Social Abstaining, and Refusing Invitations: Demographic Differences Persist across College.
CONCLUSION: First generation college students, first generation immigrant students, and Black and Asian students participated less in pro-drinking environments during college. These findings indicate that on drinking and non-drinking days students' participation in alcohol-present situations differed by background. Furthermore, our results indicate that the students who are most likely to refuse invitations to drinking events are the same students who drink most frequently. PMID: 31691982 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 6, 2019 Category: Addiction Authors: Greene KM, Maggs JL Tags: Alcohol Clin Exp Res Source Type: research

The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences.
DISCUSSION: These findings suggest that having both a family history of AUD and high BIS poor self-regulation is more strongly associated with alcohol-related consequences in the interpersonal and impulse control domains. Given the heterogeneity of impulsivity, these findings highlight the need for additional research to examine which facets of impulsivity are associated with which alcohol outcomes to narrow phenotypic risk for alcohol misuse. PMID: 31693193 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 6, 2019 Category: Addiction Authors: Haeny AM, Gueorguieva R, Morean ME, Krishnan-Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O'Malley SS Tags: Alcohol Clin Exp Res Source Type: research

Aldehyde Dehydrogenase Inhibition Ameliorates Cardiac Dysfunction and Exacerbates Hypotension Caused by Alcohol in Female Rats.
CONCLUSIONS: Contrary to our hypothesis, cyanamide attenuated the E2 -dependent cardiac dysfunction caused by alcohol, likely by preconditioning the heart to oxidative stress, while exacerbating the vasodilating effect of alcohol. The latter might predispose to syncope when cyanamide and alcohol are combined in females. PMID: 31693194 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 6, 2019 Category: Addiction Authors: Yao F, Abdel-Rahman AA Tags: Alcohol Clin Exp Res Source Type: research

Acceptability of an eHealth intervention to prevent alcohol exposed pregnancy among American Indian/Alaska Native teens.
CONCLUSIONS: This study outlines the development of a web-based intervention for an AEP intervention for AI/AN teens and will inform future prevention efforts. Implications include an expansion of the evidence-based CHOICES intervention for AI/AN teens and also development of a web-based intervention for rural, reservation-based AI/AN communities. PMID: 31693195 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 6, 2019 Category: Addiction Authors: Hanson JD, Weber TL, Shrestha U, Bares VJ, Seiber M, Ingersoll K Tags: Alcohol Clin Exp Res Source Type: research

The Identification of Pretreatment Trajectories of Alcohol Use and Their Relationship to Treatment Outcome in Men and Women With Alcohol Use Disorder.
CONCLUSIONS: Study results have clinical and research implications including recommended changes to treatment protocols and research designs. Understanding the impact of pretreatment trajectories of alcohol use on within-treatment and posttreatment outcomes may provide important information about adapting treatment to increase efficiency and effectiveness. PMID: 31688963 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 5, 2019 Category: Addiction Authors: Stasiewicz PR, Bradizza CM, Ruszczyk MU, Lucke JF, Zhao J, Linn B, Slosman KS, Dermen KH Tags: Alcohol Clin Exp Res Source Type: research

Fetal Alcohol Spectrum Disorders in a Pacific Southwest City: Maternal and Child Characteristics.
CONCLUSIONS: Data from this general population sample in a large urban region in the United States demonstrate the variability of expression of FASD and point to risk and protective factors for mothers in this setting. PMID: 31688971 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 5, 2019 Category: Addiction Authors: Chambers CD, Coles C, Kable J, Akshoomoff N, Xu R, Zellner JA, Honerkamp-Smith G, Manning MA, Adam MP, Jones KL Tags: Alcohol Clin Exp Res Source Type: research

Volumetric Prefrontal Cortex Alterations in Patients With Alcohol Dependence and the Involvement of Self-Control.
CONCLUSION: Thus, our findings (i) indicate deficient GM volume in prefrontal areas related to self-control and (ii) might accentuate the phenotypic divergence of ALC patients and emphasize the importance of the development of individual treatment options. PMID: 31688973 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 5, 2019 Category: Addiction Authors: Rosenthal A, Beck A, Zois E, Vollstädt-Klein S, Walter H, Kiefer F, Lohoff FW, Charlet K Tags: Alcohol Clin Exp Res Source Type: research

Articles of Public Interest.
Authors: PMID: 31674685 [PubMed - in process] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - November 1, 2019 Category: Addiction Tags: Alcohol Clin Exp Res Source Type: research

High Opportunity Cost Demand as an Indicator of Weekday Drinking and Distinctly Severe Alcohol Problems: A Behavioral Economic Analysis.
This study used a modified demand-curve paradigm to examine alcohol demand in the context of a next-day contingency (high opportunity cost demand) as a specific indicator of a severe pattern of alcohol problems. METHODS: Participants were 370 undergraduates (61.1% female, 86.5% white, Mage  = 18.8) reporting multiple past-month heavy drinking episodes (5/4 drinks per occasion for men/women) who completed 2 versions of an alcohol purchase task (APT), along with measures of past-month alcohol use and problems. In 1 APT (low opportunity cost), students imagined they had no next-day responsibilities, and in the ...
Source: Alcoholism, Clinical and Experimental Research - October 29, 2019 Category: Addiction Authors: Joyner KJ, Meshesha LZ, Dennhardt AA, Borsari B, Martens MP, Murphy JG Tags: Alcohol Clin Exp Res Source Type: research

Chronic alcohol consumption enhances skeletal muscle wasting in mice bearing cachectic cancers: the role of TNF α/myostatin axis.
CONCLUSIONS: Chronic alcohol consumption enhances cancer-associated skeletal muscle loss through suppressing Akt/mTOR-mediated protein synthesis pathway and enhancing protein degradation pathways. This process is initiated by TNFα and mediated by myostatin. PMID: 31657476 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 28, 2019 Category: Addiction Authors: Li Y, Zhang F, Modrak S, Little A, Zhang H Tags: Alcohol Clin Exp Res Source Type: research

Macrophage migration inhibitory factor: New insights into the pathogenesis of alcoholic liver disease.
Abstract Alcoholic liver disease (ALD) is characterized by pathological changes that occur along a continuum that extends from liver injury to fibrosis and, finally, to hepatocellular carcinoma. Inflammatory cytokines and chemokines have long been implicated in this process (Gao et al., 2019), with many cell types involved, including macrophages, monocytes and other cell types in the innate and adaptive immune systems. Specifically, macrophages and neutrophils in the liver are important for clearing pathogens, including bacteria, viruses, immune complexes, bacterial products and tumor cells (Ju and Mandrekar, 2015...
Source: Alcoholism, Clinical and Experimental Research - October 21, 2019 Category: Addiction Authors: Wang H, Liu R Tags: Alcohol Clin Exp Res Source Type: research

Social desirability bias impacts self-reported alcohol use among persons with HIV in Uganda.
CONCLUSIONS: While use of objective measures (e.g. alcohol biomarkers) is desirable for measuring alcohol use, SDS scores may be used to adjust self-reported drinking levels by participants' level of social desirability in HIV research studies. PMID: 31610017 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 14, 2019 Category: Addiction Authors: Adong J, Fatch R, Emenyonu NI, Cheng DM, Muyindike WR, Ngabirano C, Kekibiina A, Woolf-King SE, Samet JH, Hahn JA Tags: Alcohol Clin Exp Res Source Type: research

Effects of oxytocin administration on cue-induced craving in co-occurring alcohol use disorder and PTSD: a within-participant randomized clinical trial.
CONCLUSIONS: These preliminary findings suggest that oxytocin does not affect cue-induced craving. Our results contribute to an ever-growing field of research investigating the effects of intranasal oxytocin on the symptoms of substance use disorders and will help further refine methodology and streamline future inquiries in this area. PMID: 31610033 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 14, 2019 Category: Addiction Authors: Stauffer CS, Meinzer NK, Morrison T, Wen JH, Radanovich L, Leung D, Niles A, O'Donovan A, Batki SL, Woolley JD Tags: Alcohol Clin Exp Res Source Type: research

Wake Forest Alcohol Imagery Set (WFAIS): Development and validation of a large standardized alcohol imagery dataset.
CONCLUSION: The established imagery set includes 1,650 alcohol-related images, rated on scales of valence, arousal, and relation to alcohol, and categorized by type of alcohol depicted. The imagery database will be available for open-access download and use on Creative Commons. PMID: 31595975 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 9, 2019 Category: Addiction Authors: Peterson H, Simpson SL, Laurienti PJ Tags: Alcohol Clin Exp Res Source Type: research

The Role of Drugs in Alcohol Poisoning and Blackout Events: A Latent Class Analysis of a Residential Treatment Sample.
CONCLUSIONS: Combining drug classes with alcohol prior to OD was common and associated with a higher likelihood of hospitalization. Overdose prevention efforts should address acute risks of alcohol ingestion with other drugs. PMID: 31596516 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 9, 2019 Category: Addiction Authors: Fernandez AC, Gicquelais RE, Jannausch M, Bohnert ASB Tags: Alcohol Clin Exp Res Source Type: research

Spatial navigation in children and young adults with fetal alcohol spectrum disorders.
CONCLUSIONS: These data demonstrate deficits in spatial navigation among heavily exposed syndromal boys and girls and in non-syndromal exposed boys. PMID: 31593324 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 8, 2019 Category: Addiction Authors: Dodge NC, Thomas KGF, Meintjes EM, Molteno CD, Jacobson JL, Jacobson SW Tags: Alcohol Clin Exp Res Source Type: research

F654A and K558Q Mutations in NMDA Receptor 1 affect ethanol-induced behaviors in Drosophila.
CONCLUSIONS: Mutations in transmembrane domain 3 and in the extracellular vestibule calcium binding site of the NR1 NMDA subunit affect ethanol sensitivity in Drosophila. PMID: 31593608 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 8, 2019 Category: Addiction Authors: Troutwine B, Park A, Velez-Hernandez ME, Lew L, Mihic SJ, Atkinson NS Tags: Alcohol Clin Exp Res Source Type: research

Time course of blood and brain cytokine/chemokine levels following adolescent alcohol exposure and withdrawal in rats.
CONCLUSION: These data demonstrate that ethanol exposure during adolescence produces significant microglial activation, however, inflammatory markers seen in the blood appear to differ from those observed in the brain. PMID: 31589333 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 7, 2019 Category: Addiction Authors: Sanchez-Alavez M, Nguyen W, Mori S, Wills DN, Otero D, Aguirre CA, Singh M, Ehlers CL, Conti B Tags: Alcohol Clin Exp Res Source Type: research

Long chain ω-3 levels are associated with increased alcohol sensitivity in a population-based sample of adolescents.
CONCLUSIONS: Plasma ω-3 LC-PUFA levels may be related to initial sensitivity to alcohol during adolescence. These data indicate that diet-related factors have the potential to impact humans' earliest responses to alcohol exposure. PMID: 31589770 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 7, 2019 Category: Addiction Authors: Edwards AC, Heron J, Hibbeln J, Schuckit MA, Webb BT, Hickman M, Davies AG, Bettinger JC Tags: Alcohol Clin Exp Res Source Type: research

Social interaction with an alcohol-intoxicated or cocaine-injected peer selectively alters social behaviors and drinking in adolescent male and female rats.
CONCLUSIONS: The present results are consistent and extend our previous work showing that social interaction with an alcohol-intoxicated peer selectively alters social behaviors and alcohol-drinking in adolescent rats. Females appear to be more sensitive to the elevating effects of social interaction on voluntary ethanol consumption. PMID: 31585020 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 4, 2019 Category: Addiction Authors: Gamble DN, Josefson CC, Hennessey MK, Davis AM, Waters RC, Jones BN, Belton DM, Hall NI, Costen TJ, Kirstein CL, Maldonado-Devincci AM Tags: Alcohol Clin Exp Res Source Type: research

Prevalence and Correlates of Past-Year Recovery From DSM-5 Alcohol Use Disorder: Results From National Epidemiologic Survey on Alcohol and Related Conditions-III.
CONCLUSIONS: There appears to be substantial level of recovery from AUD. Information on specific factors associated with AUD outcomes can be useful in targeting appropriate treatment efforts. PMID: 31580502 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 3, 2019 Category: Addiction Authors: Fan AZ, Chou SP, Zhang H, Jung J, Grant BF Tags: Alcohol Clin Exp Res Source Type: research

Resistance of postnatal hippocampal neurogenesis to alcohol toxicity in a third trimester-equivalent mouse model of gestational alcohol exposure.
CONCLUSIONS: Both early postnatal dentate neurogenesis and adult dentate neurogenesis, as well as the adult neurogenic response to EE, are surprisingly resistant to early postnatal EtOH vapor exposure in mice. PMID: 31573091 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - October 1, 2019 Category: Addiction Authors: Gustus K, Lozano E, Newville J, Li L, Valenzuela CF, Cunningham LA Tags: Alcohol Clin Exp Res Source Type: research

Lifetime Drinking Trajectories and Nonfatal Acute Myocardial Infarction.
CONCLUSIONS: Epidemiological studies of alcohol and health in populations over age 35 may have underestimated the impact of heavy episodic drinking during adolescence and emerging adulthood on the cardiovascular system. PMID: 31566766 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 30, 2019 Category: Addiction Authors: Russell M, Fan AZ, Freudenheim JL, Dorn J, Trevisan M Tags: Alcohol Clin Exp Res Source Type: research

Technology-Delivered Cognitive-Behavioral Interventions for Alcohol Use: A Meta-Analysis.
CONCLUSIONS: These results show a benefit for technology-delivered, CBT-based interventions as a stand-alone therapy for heavy drinking or as an addition to usual care in specialty substance use settings. PMID: 31566787 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 30, 2019 Category: Addiction Authors: Kiluk BD, Ray LA, Walthers J, Bernstein M, Tonigan JS, Magill M Tags: Alcohol Clin Exp Res Source Type: research

Longitudinal Associations between Sleep, Intrusive Thoughts, and Alcohol Problems Among Veterans.
CONCLUSIONS: PTSD intrusions are associated with more alcohol problems and help explain the long-term association between sleep and alcohol problems among veterans. Because sleep disturbances are associated with more intrusive thoughts about trauma, we recommend that treatments targeting sleep in the context of PTSD and alcohol use include a cognitive component. PMID: 31560410 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 27, 2019 Category: Addiction Authors: Miller MB, Metrik J, Borsari B, Jackson KM Tags: Alcohol Clin Exp Res Source Type: research

Voluntary Chronic Heavy Alcohol Consumption in Male Rhesus Macaques Suppresses Cancellous Bone Formation and Increases Bone Marrow Adiposity.
CONCLUSIONS: Voluntary chronic heavy ethanol consumption reduces cancellous bone formation in lumbar vertebra by decreasing osteoblast-lined bone perimeter, a response associated with an increase in bone marrow adiposity. PMID: 31557335 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 26, 2019 Category: Addiction Authors: Kahler-Quesada AM, Grant KA, Walter NAR, Newman N, Allen MR, Burr DB, Branscum AJ, Maddalozzo GF, Turner RT, Iwaniec UT Tags: Alcohol Clin Exp Res Source Type: research

The efficacy of technology-based interventions for alcohol and illicit drug use among women of childbearing age: A systematic review and meta-analysis.
CONCLUSIONS: This systematic review and meta-analysis found evidence of technology-based interventions' efficacy in reducing alcohol and illicit drug use among women of childbearing age. Implications for future research and practice are discussed. PMID: 31557336 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 26, 2019 Category: Addiction Authors: Hai AH, Hammock K, Velasquez MM Tags: Alcohol Clin Exp Res Source Type: research

Concordance of self- and partner-reported alcohol consumption among couples experiencing intimate partner violence in Zambia.
Abstract BACKGROUND: Hazardous alcohol use is a predictor of intimate partner violence (IPV) and both are increasingly prevalent in sub-Saharan Africa. The accurate measurement of alcohol consumption is therefore critical in IPV intervention studies that target hazardous drinking. Collecting a collateral report in addition to self-report is one convergent validity approach to improve alcohol measurement. We investigated concordance between self- and partner-reported alcohol use among women who reported recent IPV and their male partners in Zambia. METHODS: Data were from the baseline of a randomized IPV inter...
Source: Alcoholism, Clinical and Experimental Research - September 26, 2019 Category: Addiction Authors: Kane JC, Murray SM, Vinikoor MJ, Greene MC, Fine SL, Paul R, Murray LK Tags: Alcohol Clin Exp Res Source Type: research

Event-level correlates of drinking events characterized by alcohol-induced blackouts.
CONCLUSIONS: Event-level findings of this study document that events leading to alcohol-induced memory loss are associated with other adverse experiences relative to drinking events that do not result in blackout, and offer potentially motivational levers for preventive interventions. PMID: 31557348 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 26, 2019 Category: Addiction Authors: Merrill JE, Boyle HK, Jackson KM, Carey KB Tags: Alcohol Clin Exp Res Source Type: research

Unravelling the mechanisms of behaviors associated with AUDs using flies and worms.
Abstract Alcohol use disorders (AUDs) are very common worldwide and negatively affect both individuals and societies. To understand how normal behavior turns into uncontrollable use of alcohol, several approaches have been utilized in the last decades. However, we still do not completely understand how AUDs evolve or how they are maintained in the brains of affected individuals. In addition, efficient and effective treatment is still in need of development. This review focuses on alternative approaches developed over the last 20 years using Drosophila melanogaster (Drosophila) and Caenorhabditis elegans (C. elegan...
Source: Alcoholism, Clinical and Experimental Research - September 17, 2019 Category: Addiction Authors: Scholz H Tags: Alcohol Clin Exp Res Source Type: research

Morphometric Biomarkers of Adolescents with Familial Risk for Alcohol Use Disorder.
Abstract BACKGROUND: While many adolescents exhibit risky behavior, teenagers with a family history (FH+) of an alcohol use disorder (AUD) are at a heightened risk for earlier initiation of alcohol use, a more rapid escalation in frequency and quantity of alcohol consumption and developing a subsequent AUD in comparison to youth without such family history (FH-). Neuroanatomically, developmentally normative risk-taking behavior parallels an imbalance between more protracted development of the pre-frontal cortex (PFC) and earlier development of limbic regions. Magnetic resonance imaging (MRI) derived volumetric pro...
Source: Alcoholism, Clinical and Experimental Research - September 17, 2019 Category: Addiction Authors: Maksimovskiy AL, Oot EN, Seraikas AM, Rieselbach M, Caine C, Sneider JT, Cohen-Gilbert JE, Harris SK, Nickerson LD, Rohan ML, Silveri MM Tags: Alcohol Clin Exp Res Source Type: research

Assessment of Acute Motor Effects and Tolerance Following Self-Administration of Alcohol and Edible THC in Adolescent Male Mice.
CONCLUSIONS: Adolescent mice self-administered both alcohol and edible THC to a degree sufficient to acutely impact locomotor activity. However, only edible THC consumption had lasting effects during short-term abstinence. Thus, this adolescent co-use model could be used to explore sex differences in self-administration as well as the impact substance co-use might have on other domains such as mood and cognition. PMID: 31524960 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 16, 2019 Category: Addiction Authors: Smoker MP, Hernandez M, Zhang Y, Boehm SL Tags: Alcohol Clin Exp Res Source Type: research

Alcohol's dysregulation of maternal-fetal IL-6 and p-STAT3 is a function of maternal iron status.
Abstract BACKGROUND: Prenatal alcohol exposure (PAE) causes long-term growth and neurodevelopmental deficits that are worsened by maternal iron deficiency (ID). In our preclinical rat model, PAE causes fetal anemia, brain ID, and elevated hepatic iron via increased maternal and fetal hepcidin synthesis. These changes are normalized by a prenatal iron-fortified (IF) diet. Here, we hypothesize that iron status and PAE dysregulate the major upstream pathways that govern hepcidin production - EPO/BMP6/SMAD and IL-6/JAK2/STAT3. METHODS: Pregnant, Long-Evans rat dams consumed ID (2-6ppm iron), iron-sufficient (IS, ...
Source: Alcoholism, Clinical and Experimental Research - September 16, 2019 Category: Addiction Authors: Saini N, Helfrich KK, Kwan STC, Huebner SM, Abazi J, Flentke GR, Blohowiak SE, Kling PJ, Smith SM Tags: Alcohol Clin Exp Res Source Type: research

Inter-Individual Variation and Factors regulating the Formation of Phosphatidylethanol (PEth).
CONCLUSION: Inter-individual variation in the formation rate of PEth appears to be a significant but relatively modest source of variation in the relation between B-PEth and reported consumption. Correction for inter-individual variation in PC concentrations might substantially reduce the inter-individual variability in PEth formation and consequently in B-PEth. This article is protected by copyright. All rights reserved. PMID: 31509266 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 11, 2019 Category: Addiction Authors: Stenton J, Walther L, Hansson T, Andersson A, Isaksson A Tags: Alcohol Clin Exp Res Source Type: research

Innate and Acquired Quinine-Resistant Alcohol, but not Saccharin, Drinking in Crossed High Alcohol Preferring Mice.
This article is protected by copyright. All rights reserved. PMID: 31509609 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 11, 2019 Category: Addiction Authors: Houck CA, Carron CR, Millie LA, Grahame NJ Tags: Alcohol Clin Exp Res Source Type: research

Changes in alcohol intake during pregnancy in Spain, 1980-2014.
CONCLUSIONS: Alcohol consumption among expectant mothers has declined substantially in the last 35 years. However, it is worth highlighting the significant and substantial associations between alcohol use and consumption of tobacco, which have become stronger in the most recent years. This article is protected by copyright. All rights reserved. PMID: 31509616 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 11, 2019 Category: Addiction Authors: Romero-Rodríguez E, Cuevas L, Simón L, ECEMC Peripheral Group, Bermejo-Sánchez E, Galán I Tags: Alcohol Clin Exp Res Source Type: research

(Pro)renin Receptor is Involved in Myocardial Damage in Alcoholic Cardiomyopathy.
CONCLUSIONS: Our results show that PRR-ERK1/2 signaling was involved in the development of ACM and that PRR could be a new target for the treatment of alcoholic cardiomyopathy. This article is protected by copyright. All rights reserved. PMID: 31498445 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 9, 2019 Category: Addiction Authors: Xiong J, Cao X, Qiao S, Yu S, Li L, Yu Y, Fu C, Jiang F, Dong B, Su Q Tags: Alcohol Clin Exp Res Source Type: research

Genetic Selection for Alcohol Preference in Mice Alters Dorsal Striatum Neurotransmission.
CONCLUSIONS: Collectively, these results suggest that genetic predisposition for high or low alcohol consumption produces significantly different basal functional states within both DLS and DMS which may be important factors in the behavioral phenotypes of HAP and LAP mice. This article is protected by copyright. All rights reserved. PMID: 31491046 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 6, 2019 Category: Addiction Authors: Fritz BM, Munoz B, Atwood BK Tags: Alcohol Clin Exp Res Source Type: research

Reduced serum osteocalcin in high-risk alcohol using people living with HIV (PLWH) does not correlate with systemic oxidative stress or inflammation: data from the New Orleans Alcohol Use in HIV (NOAH) study.
CONCLUSIONS: In this sub-cohort of PLWH, we detected significant associations between at-risk alcohol use and osteocalcin, and at-risk alcohol use and serum 4-HNE, suggesting suppression of bone formation independent of increased systemic oxidative stress with increasing alcohol consumption. This article is protected by copyright. All rights reserved. PMID: 31483873 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 4, 2019 Category: Addiction Authors: Watt J, Schuon J, Davis J, Ferguson TF, Welsh DA, Molina PE, Ronis MJJ Tags: Alcohol Clin Exp Res Source Type: research

Effects of Alcohol and Estrogen Receptor Blockade Using ICI 182,780 on Bone in Ovariectomized Rats.
CONCLUSION: Alcohol exaggerated bone loss in ovx rats in the presence or absence of estrogen receptor blockade with ICI. The negligible effect of alcohol on uterus and limited effects of ICI on bone in alcohol-fed ovx rats suggests that estrogen receptor signaling plays a limited role in the action of alcohol on bone in a rat model for chronic alcohol abuse. This article is protected by copyright. All rights reserved. PMID: 31479513 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 3, 2019 Category: Addiction Authors: Wagner L, Howe K, Philbrick KA, Maddalozzo GF, Kuah AF, Wong CP, Olson DA, Branscum AJ, Iwaniec UT, Turner RT Tags: Alcohol Clin Exp Res Source Type: research