Size does matter: An exploration of the relationship between licensed venue capacity and on-premise assaults
CONCLUSIONS: Greater venue capacity was strongly associated with an increased risk of violent incidents for any given venue. This was exacerbated by late-night trading, which substantially adds to the risk of assaults inside the venue.PMID:34156710 | DOI:10.1111/acer.14621 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 22, 2021 Category: Addiction Authors: Peter Miller Ashlee Curtis Melanie Millsteed Travis Harries Smriti Nepal Samantha Walker Tanya Chikritzhs Kerri Coomber Source Type: research

Size does matter: An exploration of the relationship between licensed venue capacity and on-premise assaults
CONCLUSIONS: Greater venue capacity was strongly associated with an increased risk of violent incidents for any given venue. This was exacerbated by late-night trading, which substantially adds to the risk of assaults inside the venue.PMID:34156710 | DOI:10.1111/acer.14621 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 22, 2021 Category: Addiction Authors: Peter Miller Ashlee Curtis Melanie Millsteed Travis Harries Smriti Nepal Samantha Walker Tanya Chikritzhs Kerri Coomber Source Type: research

44th Annual Speaker & amp; Poster Abstracts of the Research Society on Alcoholism jointly with the International Society for Biomedical Research on Alcoholism, June 2021
Alcohol Clin Exp Res. 2021 Jun;45 Suppl 1:5-283. doi: 10.1111/acer.14646.NO ABSTRACTPMID:34128239 | DOI:10.1111/acer.14646 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 15, 2021 Category: Addiction Source Type: research

44th Annual Speaker & amp; Poster Abstracts of the Research Society on Alcoholism jointly with the International Society for Biomedical Research on Alcoholism, June 2021
Alcohol Clin Exp Res. 2021 Jun;45 Suppl 1:5-283. doi: 10.1111/acer.14646.NO ABSTRACTPMID:34128239 | DOI:10.1111/acer.14646 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 15, 2021 Category: Addiction Source Type: research

44th Annual Speaker & amp; Poster Abstracts of the Research Society on Alcoholism jointly with the International Society for Biomedical Research on Alcoholism, June 2021
Alcohol Clin Exp Res. 2021 Jun;45 Suppl 1:5-283. doi: 10.1111/acer.14646.NO ABSTRACTPMID:34128239 | DOI:10.1111/acer.14646 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 15, 2021 Category: Addiction Source Type: research

44th Annual Speaker & amp; Poster Abstracts of the Research Society on Alcoholism jointly with the International Society for Biomedical Research on Alcoholism, June 2021
Alcohol Clin Exp Res. 2021 Jun;45 Suppl 1:5-283. doi: 10.1111/acer.14646.NO ABSTRACTPMID:34128239 | DOI:10.1111/acer.14646 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 15, 2021 Category: Addiction Source Type: research

44th Annual Speaker & amp; Poster Abstracts of the Research Society on Alcoholism jointly with the International Society for Biomedical Research on Alcoholism, June 2021
Alcohol Clin Exp Res. 2021 Jun;45 Suppl 1:5-283. doi: 10.1111/acer.14646.NO ABSTRACTPMID:34128239 | DOI:10.1111/acer.14646 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 15, 2021 Category: Addiction Source Type: research

44th Annual Speaker & amp; Poster Abstracts of the Research Society on Alcoholism jointly with the International Society for Biomedical Research on Alcoholism, June 2021
Alcohol Clin Exp Res. 2021 Jun;45 Suppl 1:5-283. doi: 10.1111/acer.14646.NO ABSTRACTPMID:34128239 | DOI:10.1111/acer.14646 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 15, 2021 Category: Addiction Source Type: research

Pilot randomized placebo-controlled clinical trial of high-dose gabapentin for alcohol use disorder
CONCLUSIONS: Gabapentin treatment rapidly titrated to a dose of 3600 mg per day is associated with a reduction in the proportion of HDD per week and an increase in PDA per week in actively drinking outpatients with AUD. High-dose gabapentin is potentially a feasible approach to treating AUD and deserving of further study.PMID:34120336 | DOI:10.1111/acer.14648 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: John J Mariani Martina Pavlicova Cale Basaraba Agnieszka Mamczur-Fuller Daniel J Brooks Adam Bisaga Kenneth M Carpenter Edward Nunes Frances R Levin Source Type: research

Rosiglitazone restores nitric oxide synthase-dependent reactivity of cerebral arterioles in rats exposed to prenatal alcohol
CONCLUSIONS: PPARγ activation may be an effective and relevant treatment to reverse or prevent cerebral vascular abnormalities associated with prenatal exposure to alcohol.PMID:34120346 | DOI:10.1111/acer.14634 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Partha S Saha Kirsten R Kim Sawtelle Brittany N Bamberg Denise M Arrick Michael J Watt Jamie L Scholl Hong Zheng William G Mayhan Source Type: research

Regionally specific gray matter volume decreases in Alcohol Use Disorder: Implications for non-invasive brain stimulation treatment: Implications for non-invasive brain stimulation treatment
This study tested the hypotheses that these aspects of neural architecture are compromised in AUD patients, and that, accordingly AUD patients may need a higher TMS dose in order to depolarize the cortex.METHODS: High-resolution magnetic resonance images were acquired from 44 individuals with AUD and 44 age-matched healthy controls (n=88). Whole brain voxel-based morphometry was conducted. Subsequent region-of-interest analysis was performed at three EEG 10-20 sites commonly used in TMS for AUD: FP1 (left frontal pole), F3 (left DLPFC) and C3 (left motor cortex). Scalp-to-cortex distance and TMS electric fields were assess...
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Daniel M McCalley Colleen A Hanlon Source Type: research

The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis
Alcohol Clin Exp Res. 2021 Jun 12. doi: 10.1111/acer.14655. Online ahead of print.ABSTRACTIn this narrative review, we present the hypothesis that key mutations in two genes, occurring 15 and 10 million years ago, were individually and then collectively adaptive for ancestral humans during periods of starvation, but are maladaptive in modern civilization (i.e., "thrifty genes"), with the consequence that these genes not only increase our risk today for obesity, but also for alcoholism. Both mutations occurred when ancestral apes were experiencing loss of fruit availability during periods of profound climate chang...
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: David Carn Miguel A Lanaspa Steven A Benner Peter Andrews Robert Dudley Ana Andres-Hernando Dean R Tolan Richard J Johnson Source Type: research

A meta-regression of methodological features predicting the effects of pharmacotherapies on subjective response to alcohol
This study consists of a meta-regression testing whether the drinking level of the study sample and the peak breath alcohol concentration (BrAC) in the alcohol administration study predicts the efficacy of AUD pharmacotherapies on subjective responses to alcohol.METHODS: Medication effects on alcohol-induced stimulation, sedation, negative mood, and craving during the alcohol administration were computed (k=49 studies, 24 medications).RESULTS: Meta-regression analyses indicated a significant and positive effect of drinks per month on alcohol-induced stimulation (β=.142, p
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: ReJoyce Green Han Du Erica N Grodin Steven J Nieto Spencer Bujarski Daniel J O Roche Lara A Ray Source Type: research

Potential causal effect of posttraumatic stress disorder (PTSD) on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study
CONCLUSIONS: These findings are consistent with the self-medication model, in which individuals misuse alcohol as a way of coping with aversive trauma-related symptoms. These findings extend latent and molecular findings of shared and correlated risk between PTSD and alcohol phenotypes. Given the health behaviors associated with these phenotypes, these findings are important in that they suggest groups on which to prioritize prevention efforts. Further, they provide a rationale for future pre-clinical and clinical studies examining the biological mechanisms by which PTSD may impact AUD.PMID:34120358 | DOI:10.1111/acer.1464...
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Kaitlin E Bountress Frank Wendt Daniel Bustamante Arpana Agrawal Bradley Webb Nathan Gillespie Howard Edenberg Christina Sheerin Emma Johnson Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group Renato Polimanti Ananda Amstadter Source Type: research

Altered effective connectivity of the reward network during an incentive processing task in adults with alcohol use disorder
CONCLUSIONS: Individuals with AUD have disrupted EC in both instrumentally-driven and automatized cortico-striatal reward circuits during non-alcohol reward feedback. These results point to disrupted corticostriatal EC in both "top-down" and "bottom-up" pathways among individuals with AUD.PMID:34120362 | DOI:10.1111/acer.14650 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Albert J Arias Liangsuo Ma James M Bjork Christopher J Hammond Yi Zhou Andrew Snyder F Gerard Moeller Source Type: research

Repeated ethanol intoxications of Drosophila melanogaster adults increase the resistance to ethanol of their progeny
CONCLUSION: To our knowledge, this is the first demonstration that repeated daily intoxications can affect the progeny's response to ethanol in fruit flies. Our findings will hopefully unleash the power of D. melanogaster to explore conserved pathways underlying the transmission of ethanol tolerance and thus contribute to novel strategies for the management of alcohol use disorders.PMID:34120365 | DOI:10.1111/acer.14647 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Michelle Bonilla Michael McPherson Jocelyn Coreas Michael Boulos Paniz Chavol Ranna I Alrabadi Mariano Loza-Coll Source Type: research

World Health Organization Risk Drinking Levels as a Treatment Outcome Measure in Topiramate Trials
CONCLUSIONS: Topiramate is an efficacious pharmacotherapy for AUD. Although continuous measures of drinking and alcohol-related problems yielded larger effect sizes than the WHO RDLs, the latter capture changes in drinking behavior in response to treatment with topiramate and provide a categorical alternative for use in both clinical care and pharmacotherapy trials.PMID:34120366 | DOI:10.1111/acer.14652 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Emily E Hartwell Richard Feinn Katie Witkiewitz Timothy Pond Henry R Kranzler Source Type: research

Pilot randomized placebo-controlled clinical trial of high-dose gabapentin for alcohol use disorder
CONCLUSIONS: Gabapentin treatment rapidly titrated to a dose of 3600 mg per day is associated with a reduction in the proportion of HDD per week and an increase in PDA per week in actively drinking outpatients with AUD. High-dose gabapentin is potentially a feasible approach to treating AUD and deserving of further study.PMID:34120336 | DOI:10.1111/acer.14648 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: John J Mariani Martina Pavlicova Cale Basaraba Agnieszka Mamczur-Fuller Daniel J Brooks Adam Bisaga Kenneth M Carpenter Edward Nunes Frances R Levin Source Type: research

Rosiglitazone restores nitric oxide synthase-dependent reactivity of cerebral arterioles in rats exposed to prenatal alcohol
CONCLUSIONS: PPARγ activation may be an effective and relevant treatment to reverse or prevent cerebral vascular abnormalities associated with prenatal exposure to alcohol.PMID:34120346 | DOI:10.1111/acer.14634 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Partha S Saha Kirsten R Kim Sawtelle Brittany N Bamberg Denise M Arrick Michael J Watt Jamie L Scholl Hong Zheng William G Mayhan Source Type: research

Regionally specific gray matter volume decreases in Alcohol Use Disorder: Implications for non-invasive brain stimulation treatment: Implications for non-invasive brain stimulation treatment
This study tested the hypotheses that these aspects of neural architecture are compromised in AUD patients, and that, accordingly AUD patients may need a higher TMS dose in order to depolarize the cortex.METHODS: High-resolution magnetic resonance images were acquired from 44 individuals with AUD and 44 age-matched healthy controls (n=88). Whole brain voxel-based morphometry was conducted. Subsequent region-of-interest analysis was performed at three EEG 10-20 sites commonly used in TMS for AUD: FP1 (left frontal pole), F3 (left DLPFC) and C3 (left motor cortex). Scalp-to-cortex distance and TMS electric fields were assess...
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Daniel M McCalley Colleen A Hanlon Source Type: research

The role of thrifty genes in the origin of alcoholism: A narrative review and hypothesis
Alcohol Clin Exp Res. 2021 Jun 12. doi: 10.1111/acer.14655. Online ahead of print.ABSTRACTIn this narrative review, we present the hypothesis that key mutations in two genes, occurring 15 and 10 million years ago, were individually and then collectively adaptive for ancestral humans during periods of starvation, but are maladaptive in modern civilization (i.e., "thrifty genes"), with the consequence that these genes not only increase our risk today for obesity, but also for alcoholism. Both mutations occurred when ancestral apes were experiencing loss of fruit availability during periods of profound climate chang...
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: David Carn Miguel A Lanaspa Steven A Benner Peter Andrews Robert Dudley Ana Andres-Hernando Dean R Tolan Richard J Johnson Source Type: research

A meta-regression of methodological features predicting the effects of pharmacotherapies on subjective response to alcohol
This study consists of a meta-regression testing whether the drinking level of the study sample and the peak breath alcohol concentration (BrAC) in the alcohol administration study predicts the efficacy of AUD pharmacotherapies on subjective responses to alcohol.METHODS: Medication effects on alcohol-induced stimulation, sedation, negative mood, and craving during the alcohol administration were computed (k=49 studies, 24 medications).RESULTS: Meta-regression analyses indicated a significant and positive effect of drinks per month on alcohol-induced stimulation (β=.142, p
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: ReJoyce Green Han Du Erica N Grodin Steven J Nieto Spencer Bujarski Daniel J O Roche Lara A Ray Source Type: research

Potential causal effect of posttraumatic stress disorder (PTSD) on alcohol use disorder and alcohol consumption in individuals of European descent: A Mendelian Randomization Study
CONCLUSIONS: These findings are consistent with the self-medication model, in which individuals misuse alcohol as a way of coping with aversive trauma-related symptoms. These findings extend latent and molecular findings of shared and correlated risk between PTSD and alcohol phenotypes. Given the health behaviors associated with these phenotypes, these findings are important in that they suggest groups on which to prioritize prevention efforts. Further, they provide a rationale for future pre-clinical and clinical studies examining the biological mechanisms by which PTSD may impact AUD.PMID:34120358 | DOI:10.1111/acer.1464...
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Kaitlin E Bountress Frank Wendt Daniel Bustamante Arpana Agrawal Bradley Webb Nathan Gillespie Howard Edenberg Christina Sheerin Emma Johnson Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group Renato Polimanti Ananda Amstadter Source Type: research

Altered effective connectivity of the reward network during an incentive processing task in adults with alcohol use disorder
CONCLUSIONS: Individuals with AUD have disrupted EC in both instrumentally-driven and automatized cortico-striatal reward circuits during non-alcohol reward feedback. These results point to disrupted corticostriatal EC in both "top-down" and "bottom-up" pathways among individuals with AUD.PMID:34120362 | DOI:10.1111/acer.14650 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Albert J Arias Liangsuo Ma James M Bjork Christopher J Hammond Yi Zhou Andrew Snyder F Gerard Moeller Source Type: research

Repeated ethanol intoxications of Drosophila melanogaster adults increase the resistance to ethanol of their progeny
CONCLUSION: To our knowledge, this is the first demonstration that repeated daily intoxications can affect the progeny's response to ethanol in fruit flies. Our findings will hopefully unleash the power of D. melanogaster to explore conserved pathways underlying the transmission of ethanol tolerance and thus contribute to novel strategies for the management of alcohol use disorders.PMID:34120365 | DOI:10.1111/acer.14647 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Michelle Bonilla Michael McPherson Jocelyn Coreas Michael Boulos Paniz Chavol Ranna I Alrabadi Mariano Loza-Coll Source Type: research

World Health Organization Risk Drinking Levels as a Treatment Outcome Measure in Topiramate Trials
CONCLUSIONS: Topiramate is an efficacious pharmacotherapy for AUD. Although continuous measures of drinking and alcohol-related problems yielded larger effect sizes than the WHO RDLs, the latter capture changes in drinking behavior in response to treatment with topiramate and provide a categorical alternative for use in both clinical care and pharmacotherapy trials.PMID:34120366 | DOI:10.1111/acer.14652 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 13, 2021 Category: Addiction Authors: Emily E Hartwell Richard Feinn Katie Witkiewitz Timothy Pond Henry R Kranzler Source Type: research

Dual trajectories of cannabis and alcohol use among young adults in a state with legal nonmedical cannabis
CONCLUSIONS: Overall, we found no evidence of substitution. Rather, the results suggest a complementary relationship between cannabis and alcohol use, such that the use of cannabis and alcohol rises and falls together.PMID:34089527 | DOI:10.1111/acer.14629 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 5, 2021 Category: Addiction Authors: Katarina Guttmannova Charles B Fleming Isaac C Rhew Devon Alisa Abdallah Megan E Patrick Jennifer C Duckworth Christine M Lee Source Type: research

Dual trajectories of cannabis and alcohol use among young adults in a state with legal nonmedical cannabis
CONCLUSIONS: Overall, we found no evidence of substitution. Rather, the results suggest a complementary relationship between cannabis and alcohol use, such that the use of cannabis and alcohol rises and falls together.PMID:34089527 | DOI:10.1111/acer.14629 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 5, 2021 Category: Addiction Authors: Katarina Guttmannova Charles B Fleming Isaac C Rhew Devon Alisa Abdallah Megan E Patrick Jennifer C Duckworth Christine M Lee Source Type: research

Dual trajectories of cannabis and alcohol use among young adults in a state with legal nonmedical cannabis
CONCLUSIONS: Overall, we found no evidence of substitution. Rather, the results suggest a complementary relationship between cannabis and alcohol use, such that the use of cannabis and alcohol rises and falls together.PMID:34089527 | DOI:10.1111/acer.14629 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 5, 2021 Category: Addiction Authors: Katarina Guttmannova Charles B Fleming Isaac C Rhew Devon Alisa Abdallah Megan E Patrick Jennifer C Duckworth Christine M Lee Source Type: research

Dual trajectories of cannabis and alcohol use among young adults in a state with legal nonmedical cannabis
CONCLUSIONS: Overall, we found no evidence of substitution. Rather, the results suggest a complementary relationship between cannabis and alcohol use, such that the use of cannabis and alcohol rises and falls together.PMID:34089527 | DOI:10.1111/acer.14629 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 5, 2021 Category: Addiction Authors: Katarina Guttmannova Charles B Fleming Isaac C Rhew Devon Alisa Abdallah Megan E Patrick Jennifer C Duckworth Christine M Lee Source Type: research

Dual trajectories of cannabis and alcohol use among young adults in a state with legal nonmedical cannabis
CONCLUSIONS: Overall, we found no evidence of substitution. Rather, the results suggest a complementary relationship between cannabis and alcohol use, such that the use of cannabis and alcohol rises and falls together.PMID:34089527 | DOI:10.1111/acer.14629 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 5, 2021 Category: Addiction Authors: Katarina Guttmannova Charles B Fleming Isaac C Rhew Devon Alisa Abdallah Megan E Patrick Jennifer C Duckworth Christine M Lee Source Type: research

Dual trajectories of cannabis and alcohol use among young adults in a state with legal nonmedical cannabis
CONCLUSIONS: Overall, we found no evidence of substitution. Rather, the results suggest a complementary relationship between cannabis and alcohol use, such that the use of cannabis and alcohol rises and falls together.PMID:34089527 | DOI:10.1111/acer.14629 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 5, 2021 Category: Addiction Authors: Katarina Guttmannova Charles B Fleming Isaac C Rhew Devon Alisa Abdallah Megan E Patrick Jennifer C Duckworth Christine M Lee Source Type: research

Dual trajectories of cannabis and alcohol use among young adults in a state with legal nonmedical cannabis
CONCLUSIONS: Overall, we found no evidence of substitution. Rather, the results suggest a complementary relationship between cannabis and alcohol use, such that the use of cannabis and alcohol rises and falls together.PMID:34089527 | DOI:10.1111/acer.14629 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 5, 2021 Category: Addiction Authors: Katarina Guttmannova Charles B Fleming Isaac C Rhew Devon Alisa Abdallah Megan E Patrick Jennifer C Duckworth Christine M Lee Source Type: research

Inhibition of AMPA receptors containing TARP γ-8 with JNJ-55511118 shows preclinical efficacy for pharmacotherapeutic treatment of chronic repetitive alcohol self-administration
CONCLUSIONS: This study shows for the first time that TARP γ-8 bound AMPARs regulate a behavioral pathology associated with addiction. Preclinical efficacy of JNJ-55511118 to reduce alcohol self-administration in male mice suggests that inhibition of TARP γ-8 bound AMPARs is a novel and highly significant neural target for the development of medications to treat AUD and other forms of addiction.PMID:34086361 | DOI:10.1111/acer.14639 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 4, 2021 Category: Addiction Authors: Jessica L Hoffman Sara Faccidomo Briana L Saunders Seth M Taylor Michelle Kim Clyde W Hodge Source Type: research

Relationship between level of response to alcohol and acute tolerance
CONCLUSION: These data do not support a role of acute tolerance in the low LR to alcohol as measured by subjective feelings of intoxication or body sway in these subjects, findings that were similar across males and females. In addition, consistent with the literature, the analyses demonstrated differences in acute tolerance across measures such that this phenomenon was observed for most measures of subjective effects but not for body sway. Among the subjective effects, acute tolerance was observed for alcohol's intoxicating effect but not for feeling sleepy.PMID:34086362 | DOI:10.1111/acer.14642 (Source: Alcoholism, Clini...
Source: Alcoholism, Clinical and Experimental Research - June 4, 2021 Category: Addiction Authors: Robert M Anthenelli Benjamin S McKenna Tom L Smith Marc A Schuckit Source Type: research

Opportunities for reducing college drinking: The roles of drinking attitudes and blackout experience
CONCLUSIONS: Findings support that the attitude on motivation and drinking over time association varies as a function of blackout. For young adults who do not positively endorse heavy drinking, blackouts may present a "moment of opportunity".PMID:34086367 | DOI:10.1111/acer.14638 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 4, 2021 Category: Addiction Authors: Angelo M DiBello Melissa R Hatch Mary Beth Miller Clayton Neighbors Kate B Carey Source Type: research

Inhibition of AMPA receptors containing TARP γ-8 with JNJ-55511118 shows preclinical efficacy for pharmacotherapeutic treatment of chronic repetitive alcohol self-administration
CONCLUSIONS: This study shows for the first time that TARP γ-8 bound AMPARs regulate a behavioral pathology associated with addiction. Preclinical efficacy of JNJ-55511118 to reduce alcohol self-administration in male mice suggests that inhibition of TARP γ-8 bound AMPARs is a novel and highly significant neural target for the development of medications to treat AUD and other forms of addiction.PMID:34086361 | DOI:10.1111/acer.14639 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 4, 2021 Category: Addiction Authors: Jessica L Hoffman Sara Faccidomo Briana L Saunders Seth M Taylor Michelle Kim Clyde W Hodge Source Type: research

Relationship between level of response to alcohol and acute tolerance
CONCLUSION: These data do not support a role of acute tolerance in the low LR to alcohol as measured by subjective feelings of intoxication or body sway in these subjects, findings that were similar across males and females. In addition, consistent with the literature, the analyses demonstrated differences in acute tolerance across measures such that this phenomenon was observed for most measures of subjective effects but not for body sway. Among the subjective effects, acute tolerance was observed for alcohol's intoxicating effect but not for feeling sleepy.PMID:34086362 | DOI:10.1111/acer.14642 (Source: Alcoholism, Clini...
Source: Alcoholism, Clinical and Experimental Research - June 4, 2021 Category: Addiction Authors: Robert M Anthenelli Benjamin S McKenna Tom L Smith Marc A Schuckit Source Type: research

Opportunities for reducing college drinking: The roles of drinking attitudes and blackout experience
CONCLUSIONS: Findings support that the attitude on motivation and drinking over time association varies as a function of blackout. For young adults who do not positively endorse heavy drinking, blackouts may present a "moment of opportunity".PMID:34086367 | DOI:10.1111/acer.14638 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 4, 2021 Category: Addiction Authors: Angelo M DiBello Melissa R Hatch Mary Beth Miller Clayton Neighbors Kate B Carey Source Type: research

COVID-19 impacts on drinking and mental health in emerging adults: Longitudinal changes and moderation by economic disruption and sex
CONCLUSIONS: During the initial phase of the pandemic, reductions in heavy drinking and alcohol consequences were present in this sample of emerging adults, perhaps due to restrictions on socializing. In contrast, there was an increase in internalizing symptoms , especially in females, highlighting disparities in the mental health impacts of the pandemic.PMID:34081349 | DOI:10.1111/acer.14624 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 3, 2021 Category: Addiction Authors: Meenu Minhas Kyla Belisario Alba Gonz ález-Roz Jillian Halladay James G Murphy James MacKillop Source Type: research

Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice
CONCLUSIONS: These data show anti-alcohol effects of Sig-1R antagonism in heavy drinking mice as well as its efficacy in reducing alcohol-induced hyperalgesia, thereby laying the foundation for the development of novel treatments for AUD and associated pain states.PMID:34060104 | DOI:10.1111/acer.14635 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 1, 2021 Category: Addiction Authors: Sema G Quadir Sean M Tanino Yasmine N Sami Margaret A Minnig Malliga R Iyer Kenner C Rice Pietro Cottone Valentina Sabino Source Type: research

Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
CONCLUSIONS: These data indicate that ethanol, during the delayed neurogenic period, may stimulate cell cycle, but otherwise, results in widely divergent molecular effects in hippocampus and cerebellum. Moreover, these data also provide evidence for region and cell-type specific vulnerability which may contribute to the pathogenetic effects of developmental ethanol exposure.PMID:34060105 | DOI:10.1111/acer.14633 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 1, 2021 Category: Addiction Authors: Marisa R Pinson Kalee N Holloway James C Douglas Cynthia J M Kane Rajesh C Miranda Paul D Drew Source Type: research

Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice
CONCLUSIONS: These data show anti-alcohol effects of Sig-1R antagonism in heavy drinking mice as well as its efficacy in reducing alcohol-induced hyperalgesia, thereby laying the foundation for the development of novel treatments for AUD and associated pain states.PMID:34060104 | DOI:10.1111/acer.14635 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 1, 2021 Category: Addiction Authors: Sema G Quadir Sean M Tanino Yasmine N Sami Margaret A Minnig Malliga R Iyer Kenner C Rice Pietro Cottone Valentina Sabino Source Type: research

Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
CONCLUSIONS: These data indicate that ethanol, during the delayed neurogenic period, may stimulate cell cycle, but otherwise, results in widely divergent molecular effects in hippocampus and cerebellum. Moreover, these data also provide evidence for region and cell-type specific vulnerability which may contribute to the pathogenetic effects of developmental ethanol exposure.PMID:34060105 | DOI:10.1111/acer.14633 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 1, 2021 Category: Addiction Authors: Marisa R Pinson Kalee N Holloway James C Douglas Cynthia J M Kane Rajesh C Miranda Paul D Drew Source Type: research

Antagonism of Sigma-1 receptor blocks heavy alcohol drinking and associated hyperalgesia in male mice
CONCLUSIONS: These data show anti-alcohol effects of Sig-1R antagonism in heavy drinking mice as well as its efficacy in reducing alcohol-induced hyperalgesia, thereby laying the foundation for the development of novel treatments for AUD and associated pain states.PMID:34060104 | DOI:10.1111/acer.14635 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 1, 2021 Category: Addiction Authors: Sema G Quadir Sean M Tanino Yasmine N Sami Margaret A Minnig Malliga R Iyer Kenner C Rice Pietro Cottone Valentina Sabino Source Type: research

Divergent and overlapping hippocampal and cerebellar transcriptome responses following developmental ethanol exposure during the secondary neurogenic period
CONCLUSIONS: These data indicate that ethanol, during the delayed neurogenic period, may stimulate cell cycle, but otherwise, results in widely divergent molecular effects in hippocampus and cerebellum. Moreover, these data also provide evidence for region and cell-type specific vulnerability which may contribute to the pathogenetic effects of developmental ethanol exposure.PMID:34060105 | DOI:10.1111/acer.14633 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - June 1, 2021 Category: Addiction Authors: Marisa R Pinson Kalee N Holloway James C Douglas Cynthia J M Kane Rajesh C Miranda Paul D Drew Source Type: research

Policy changes for Alcoholism: Clinical and Experimental Research (ACER)
Alcohol Clin Exp Res. 2021 May;45(5):898. doi: 10.1111/acer.14622.NO ABSTRACTPMID:33998680 | DOI:10.1111/acer.14622 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - May 17, 2021 Category: Addiction Authors: Henry R Kranzler Source Type: research

Partner influence as a factor in maternal alcohol consumption and depressive symptoms, and maternal effects on infant neurodevelopmental outcomes
CONCLUSIONS: Partner influence is an important contributor to prenatal alcohol use and maternal depressive symptoms, over and above the effect of SES. The significant paths from prenatal alcohol exposure to infant neurodevelopmental outcomes underscore the importance of partner influence during pregnancy.PMID:33999430 | DOI:10.1111/acer.14612 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - May 17, 2021 Category: Addiction Authors: Carson Kautz-Turnbull Christie L M Petrenko Elizabeth D Handley Claire D Coles Julie A Kable Wladimir Wertelecki Lyubov Yevtushok Natalya Zymak-Zakutnya Christina D Chambers Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) Source Type: research

Policy changes for Alcoholism: Clinical and Experimental Research (ACER)
Alcohol Clin Exp Res. 2021 May;45(5):898. doi: 10.1111/acer.14622.NO ABSTRACTPMID:33998680 | DOI:10.1111/acer.14622 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - May 17, 2021 Category: Addiction Authors: Henry R Kranzler Source Type: research

Partner influence as a factor in maternal alcohol consumption and depressive symptoms, and maternal effects on infant neurodevelopmental outcomes
CONCLUSIONS: Partner influence is an important contributor to prenatal alcohol use and maternal depressive symptoms, over and above the effect of SES. The significant paths from prenatal alcohol exposure to infant neurodevelopmental outcomes underscore the importance of partner influence during pregnancy.PMID:33999430 | DOI:10.1111/acer.14612 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - May 17, 2021 Category: Addiction Authors: Carson Kautz-Turnbull Christie L M Petrenko Elizabeth D Handley Claire D Coles Julie A Kable Wladimir Wertelecki Lyubov Yevtushok Natalya Zymak-Zakutnya Christina D Chambers Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD) Source Type: research