A Shift in Perspective on Secondary Disabilities in Fetal Alcohol Spectrum Disorders
Alcohol Clin Exp Res. 2021 Mar 2. doi: 10.1111/acer.14586. Online ahead of print.ABSTRACTIndividuals with fetal alcohol spectrum disorders (FASD) often contend with daily life challenges. For many years, these have been called "secondary disabilities." Ranging widely, these are described as school disruption, legal problems, independent living needs, mental health difficulties, and more. Starting in the mid-1990's, in multiple countries, clinic-based and national register studies documented elevated rates of problems in adaptive behavior and secondary disabilities occurring for individuals with FASD (e.g., Streis...
Source: Alcoholism, Clinical and Experimental Research - March 2, 2021 Category: Addiction Authors: Heather Carmichael Olson Joanne Sparrow Source Type: research

Role of an Anti-Aging Molecule in a Toxic Lifestyle: Relevance for Alcohol Effects on Sepsis
Alcohol Clin Exp Res. 2021 Mar 2. doi: 10.1111/acer.14587. Online ahead of print.ABSTRACTSepsis is a clinical syndrome associated with life-threatening multiple organ dysfunction induced by an excessive host defense response to infectious agents (Hotchkiss et al., 2016). Sepsis is also a leading cause of critical illness and mortality worldwide (Lonsdale et al., 2020, Hotchkiss et al., 2016). The global incidence of sepsis in 2017 alone was estimated at 48.9 million cases with 11 million resulting in mortality (Rudd et al., 2020).PMID:33650706 | DOI:10.1111/acer.14587 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - March 2, 2021 Category: Addiction Authors: Duane Jeansonne Samithamby Jeyaseelan Source Type: research

A Shift in Perspective on Secondary Disabilities in Fetal Alcohol Spectrum Disorders
Alcohol Clin Exp Res. 2021 Mar 2. doi: 10.1111/acer.14586. Online ahead of print.ABSTRACTIndividuals with fetal alcohol spectrum disorders (FASD) often contend with daily life challenges. For many years, these have been called "secondary disabilities." Ranging widely, these are described as school disruption, legal problems, independent living needs, mental health difficulties, and more. Starting in the mid-1990's, in multiple countries, clinic-based and national register studies documented elevated rates of problems in adaptive behavior and secondary disabilities occurring for individuals with FASD (e.g., Streis...
Source: Alcoholism, Clinical and Experimental Research - March 2, 2021 Category: Addiction Authors: Heather Carmichael Olson Joanne Sparrow Source Type: research

Role of an Anti-Aging Molecule in a Toxic Lifestyle: Relevance for Alcohol Effects on Sepsis
Alcohol Clin Exp Res. 2021 Mar 2. doi: 10.1111/acer.14587. Online ahead of print.ABSTRACTSepsis is a clinical syndrome associated with life-threatening multiple organ dysfunction induced by an excessive host defense response to infectious agents (Hotchkiss et al., 2016). Sepsis is also a leading cause of critical illness and mortality worldwide (Lonsdale et al., 2020, Hotchkiss et al., 2016). The global incidence of sepsis in 2017 alone was estimated at 48.9 million cases with 11 million resulting in mortality (Rudd et al., 2020).PMID:33650706 | DOI:10.1111/acer.14587 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - March 2, 2021 Category: Addiction Authors: Duane Jeansonne Samithamby Jeyaseelan Source Type: research

Joint Effect of Alcohol Drinking and Environmental Cadmium Exposure on Hypertension in Korean Adults: Analysis of Data from the Korea National Health and Nutrition Examination Survey, 2008 to 2013
Alcohol Clin Exp Res. 2021 Feb 26. doi: 10.1111/acer.14551. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a common disease found in 1.13 billion adults worldwide. Several animal studies have provided evidence of the joint effect of alcohol drinking and cadmium exposure on hypertension. However, no epidemiologic study has examined the association between these 2 risk factors and hypertension. Therefore, we examined the individual effects of alcohol drinking and cadmium and the joint effect of their coexposure on hypertension in the general population.METHODS: We analyzed data from 8,403 South Korean adults who h...
Source: Alcoholism, Clinical and Experimental Research - February 26, 2021 Category: Addiction Authors: Yun-Hee Choi Da-An Huh Kyong Whan Moon Source Type: research

Joint Effect of Alcohol Drinking and Environmental Cadmium Exposure on Hypertension in Korean Adults: Analysis of Data from the Korea National Health and Nutrition Examination Survey, 2008 to 2013
Alcohol Clin Exp Res. 2021 Feb 26. doi: 10.1111/acer.14551. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a common disease found in 1.13 billion adults worldwide. Several animal studies have provided evidence of the joint effect of alcohol drinking and cadmium exposure on hypertension. However, no epidemiologic study has examined the association between these 2 risk factors and hypertension. Therefore, we examined the individual effects of alcohol drinking and cadmium and the joint effect of their coexposure on hypertension in the general population.METHODS: We analyzed data from 8,403 South Korean adults who h...
Source: Alcoholism, Clinical and Experimental Research - February 26, 2021 Category: Addiction Authors: Yun-Hee Choi Da-An Huh Kyong Whan Moon Source Type: research

Joint Effect of Alcohol Drinking and Environmental Cadmium Exposure on Hypertension in Korean Adults: Analysis of Data from the Korea National Health and Nutrition Examination Survey, 2008 to 2013
Alcohol Clin Exp Res. 2021 Feb 26. doi: 10.1111/acer.14551. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a common disease found in 1.13 billion adults worldwide. Several animal studies have provided evidence of the joint effect of alcohol drinking and cadmium exposure on hypertension. However, no epidemiologic study has examined the association between these 2 risk factors and hypertension. Therefore, we examined the individual effects of alcohol drinking and cadmium and the joint effect of their coexposure on hypertension in the general population.METHODS: We analyzed data from 8,403 South Korean adults who h...
Source: Alcoholism, Clinical and Experimental Research - February 26, 2021 Category: Addiction Authors: Yun-Hee Choi Da-An Huh Kyong Whan Moon Source Type: research

Joint Effect of Alcohol Drinking and Environmental Cadmium Exposure on Hypertension in Korean Adults: Analysis of Data from the Korea National Health and Nutrition Examination Survey, 2008 to 2013
Alcohol Clin Exp Res. 2021 Feb 26. doi: 10.1111/acer.14551. Online ahead of print.ABSTRACTBACKGROUND: Hypertension is a common disease found in 1.13 billion adults worldwide. Several animal studies have provided evidence of the joint effect of alcohol drinking and cadmium exposure on hypertension. However, no epidemiologic study has examined the association between these 2 risk factors and hypertension. Therefore, we examined the individual effects of alcohol drinking and cadmium and the joint effect of their coexposure on hypertension in the general population.METHODS: We analyzed data from 8,403 South Korean adults who h...
Source: Alcoholism, Clinical and Experimental Research - February 26, 2021 Category: Addiction Authors: Yun-Hee Choi Da-An Huh Kyong Whan Moon Source Type: research

Heritability of Ethanol Consumption and Pharmacokinetics in a Genetically Diverse Panel of Collaborative Cross Mouse Strains and Their Inbred Founders
CONCLUSIONS: Collectively, this research may serve as a foundation for expanded genetic study of ethanol consumption in the CC/DO and related populations; moreover, we have identified reference strains with extreme consumption phenotypes that effectively represent polygenic models of excessive ethanol use.PMID:33619752 | DOI:10.1111/acer.14582 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 23, 2021 Category: Addiction Authors: Jared R Bagley Elissa J Chesler Vivek M Philip Center for the Systems Genetics of Addiction James D Jentsch Source Type: research

Heritability of Ethanol Consumption and Pharmacokinetics in a Genetically Diverse Panel of Collaborative Cross Mouse Strains and Their Inbred Founders
CONCLUSIONS: Collectively, this research may serve as a foundation for expanded genetic study of ethanol consumption in the CC/DO and related populations; moreover, we have identified reference strains with extreme consumption phenotypes that effectively represent polygenic models of excessive ethanol use.PMID:33619752 | DOI:10.1111/acer.14582 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 23, 2021 Category: Addiction Authors: Jared R Bagley Elissa J Chesler Vivek M Philip Center for the Systems Genetics of Addiction James D Jentsch Source Type: research

Heritability of Ethanol Consumption and Pharmacokinetics in a Genetically Diverse Panel of Collaborative Cross Mouse Strains and Their Inbred Founders
CONCLUSIONS: Collectively, this research may serve as a foundation for expanded genetic study of ethanol consumption in the CC/DO and related populations; moreover, we have identified reference strains with extreme consumption phenotypes that effectively represent polygenic models of excessive ethanol use.PMID:33619752 | DOI:10.1111/acer.14582 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 23, 2021 Category: Addiction Authors: Jared R Bagley Elissa J Chesler Vivek M Philip Center for the Systems Genetics of Addiction James D Jentsch Source Type: research

Phosphatidylethanol in Whole Blood of Rhesus Monkeys Correlates with Ethanol Consumption
In this study, we measured levels of the two most abundant homologs, PEth 16:0/18:1 and 16:0/18:2, in whole blood samples from rhesus macaque monkeys that drank ethanol daily ad libitum to assess the relationship between PEth levels and recent ethanol exposure in this animal model.METHODS: Blood samples were obtained from The Monkey Alcohol Tissue Research Resource. The monkeys were first induced to consume 4% (w/v) ethanol in water from a panel attached to their home cage. Then, monkeys were allowed to drink ethanol and water ad libitum 22 hours daily for 12 months and the daily amount of ethanol each monkey consumed was ...
Source: Alcoholism, Clinical and Experimental Research - February 22, 2021 Category: Addiction Authors: Marisa Lopez-Cruzan Nicole A R Walter Jesus J Sanchez Brett C Ginsburg Wouter Koek Vanessa A Jimenez Kathleen A Grant Martin A Javors Source Type: research

Alcohol-Involved Motor Vehicle Crashes and the Size and Duration of Random Breath Testing Checkpoints
CONCLUSIONS: Sobriety checkpoints are associated with fewer alcohol-related motor vehicle crashes for around 1 week. Checkpoint size and duration do not appear to affect this relationship.PMID:33616237 | DOI:10.1111/acer.14583 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 22, 2021 Category: Addiction Authors: Christopher N Morrison Muhire Kwizera Qixuan Chen Cheneal Puljevic Charles C Branas Douglas J Wiebe Corinne Peek-Asa Kirsten M McGavin Shellee J Franssen Vy K Le Michael Keating Frances M Williams Jason Ferris Source Type: research

Association between Delay in Driving Licensure and Driving While Impaired and Riding with an Impaired Driver among Emerging Adults
Alcohol Clin Exp Res. 2021 Feb 22. doi: 10.1111/acer.14585. Online ahead of print.ABSTRACTBACKGROUND: Teens who delay driving licensure may not be subject to graduated driver licensing restrictions that are known to reduce crash risk. We explored the association of delay in licensure with driving while impaired (DWI) and riding with an impaired driver (RWI) among emerging adults.METHODS: Data from the NEXT Generation Health Study, starting with 10th grade (2009-2010), were analyzed using logistic regression. The outcome was Wave 7 (W7) self-reported DWI and RWI as dichotomous variables. The independent variable was delay i...
Source: Alcoholism, Clinical and Experimental Research - February 22, 2021 Category: Addiction Authors: Federico E Vaca Kaigang Li Denise Haynie Bruce Simons-Morton Eduardo Romano James C Fell Source Type: research

Role of Candidate Gene Variants in Modulating the Risk and Severity of Alcoholic Hepatitis
CONCLUSION: The current study demonstrates that PNPLA3 and HP genetic variants increase AH risk and are associated with total bilirubin and MELD score, surrogates of AH severity.PMID:33616244 | DOI:10.1111/acer.14581 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 22, 2021 Category: Addiction Authors: James J Beaudoin Tiebing Liang Qing Tang Bubu A Banini Vijay H Shah Arun J Sanyal Naga P Chalasani Samer Gawrieh Source Type: research

Mapping Data-Driven Individualized Neurobehavioral Phenotypes in Heavy Alcohol Drinkers
CONCLUSIONS: Our results support an intercorrelated three-factor model of neurofunctional domains in alcohol use models, consistent with published findings (Kwako et al., 2019). Because childhood physical neglect was a significant predictor of all latent factors, these results also highlight the significant negative impact of childhood neglect on later addiction development.PMID:33605439 | DOI:10.1111/acer.14580 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 19, 2021 Category: Addiction Authors: Kelly S DeMartini Ralitza Gueorguieva Godfrey Pearlson Suchitra Krishnan-Sarin Alan Anticevic Lisa J Ji John H Krystal Stephanie S O'Malley Source Type: research

Antisense-Induced Downregulation of Clock Genes in the Shell Region of the Nucleus Accumbens Reduces Binge Drinking in Mice
CONCLUSIONS: Our results suggest that clock genes in the NAcSh play a crucial role in binge drinking.PMID:33606281 | DOI:10.1111/acer.14549 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 19, 2021 Category: Addiction Authors: Rishi Sharma Hunter Puckett Micaela Kemerling Meet Parikh Pradeep Sahota Mahesh Thakkar Source Type: research

Mapping Data-Driven Individualized Neurobehavioral Phenotypes in Heavy Alcohol Drinkers.
CONCLUSIONS: Our results support an intercorrelated three-factor model of neurofunctional domains in alcohol use models, consistent with published findings (Kwako et al., 2019). Because childhood physical neglect was a significant predictor of all latent factors, these results also highlight the significant negative impact of childhood neglect on later addiction development. PMID: 33605439 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 19, 2021 Category: Addiction Authors: DeMartini KS, Gueorguieva R, Pearlson G, Krishnan-Sarin S, Anticevic A, Ji LJ, Krystal JH, O'Malley SS Tags: Alcohol Clin Exp Res Source Type: research

Antisense-Induced Downregulation of Clock Genes in the Shell Region of the Nucleus Accumbens Reduces Binge Drinking in Mice.
CONCLUSIONS: Our results suggest that clock genes in the NAcSh play a crucial role in binge drinking. PMID: 33606281 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 19, 2021 Category: Addiction Authors: Sharma R, Puckett H, Kemerling M, Parikh M, Sahota P, Thakkar M Tags: Alcohol Clin Exp Res Source Type: research

Prospective Association of Digital Media Use with Alcohol Use Initiation and Progression Among Adolescents.
CONCLUSIONS: Digital media use frequency was modestly associated with increased risk of initiation and progression of alcohol use in adolescence. Additional research is needed to determine potential mechanisms for these associations. PMID: 33586788 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 15, 2021 Category: Addiction Authors: Riehm KE, Thrul J, Barrington-Trimis JL, Kelleghan A, Mojtabai R, Leventhal AM Tags: Alcohol Clin Exp Res Source Type: research

Phosphatidylethanol as Blood Biomarker of Alcohol Consumption in Early Pregnancy: An Observational Study in 4067 Pregnant Women.
CONCLUSION: In an unselected pregnant population in Norway 1.4 % had a positive PEth sample around gestational week 12 whereas 0.4% had a positive sample around week 24. The use of PEth as an alcohol biomarker should be further investigated as a possible diagnostic tool in the antenatal setting. PMID: 33586791 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 15, 2021 Category: Addiction Authors: Finanger T, Spigset O, Gråwe RW, Andreassen TN, Løkken TN, Aamo TO, Bratt GE, Tømmervik K, Langaas VS, Finserås K, Salvesen KÅB, Skråstad RB Tags: Alcohol Clin Exp Res Source Type: research

Trends in US Alcohol Consumption Frequency During the First Wave of the SARS-CoV-2 Pandemic.
CONCLUSIONS: Drinking days increased during the first months of the COVID-19 pandemic, particularly among residents of states with lower disease burden. PMID: 33587290 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 15, 2021 Category: Addiction Authors: McKetta S, Morrison CN, Keyes KM Tags: Alcohol Clin Exp Res Source Type: research

Blood Biomarkers of Intestinal Epithelium Damage Regenerating Islet-derived Protein 3 α and Trefoil Factor 3 Are Persistently Elevated in Patients with Alcoholic Hepatitis.
CONCLUSIONS: Circulating levels of REG3α and TFF3 were highly elevated in AH patients and differentially correlated with AH disease severity, MT, and inflammation, thereby serving as potential biomarkers of MT and gut epithelial damage in AH patients. PMID: 33587293 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 15, 2021 Category: Addiction Authors: Yang J, Syed F, Xia Y, Sanyal A, Shah V, Chalasani N, Zheng X, Yu Q, Lou Y, Li W Tags: Alcohol Clin Exp Res Source Type: research

MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling.
CONCLUSIONS: MPEP lowered alcohol consumption during DID in male and female C57BL/6 mice without changes in Homer2/Erk2 expression. Locomotor activity did not mediate effects of MPEP on alcohol intake, but it did correlate with alcohol intake. Alcohol intake during DID predicted BNST Homer2 expression. These data provide support for mGlu5 regulation of alcohol consumption across sexes. PMID: 33587295 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 15, 2021 Category: Addiction Authors: Huang G, Thompson SL, Taylor JR Tags: Alcohol Clin Exp Res Source Type: research

A Validation Study of the Alcohol Related Neurodevelopmental Disorders Behavioral Checklist.
CONCLUSIONS: In an independent sample we found minimal differences between the previous data and the current validation study on measures of average total score cutoffs, scores for the 10 measures and correlations. When the two samples are combined we found robust differences in scores between children with FASD and the non-FASD controls. The sensitivity, specificity and accuracy estimates were also very high. This suggests that the ABC Screen has acceptable epidemiologic performance data to support its use as a screening tool and as an initial step in differentiating children with FASD from children who do not have FASD. ...
Source: Alcoholism, Clinical and Experimental Research - February 13, 2021 Category: Addiction Authors: Klug MG, Palme A, Kobrinsky N, Burd L Tags: Alcohol Clin Exp Res Source Type: research

Network Meta-analysis on the Mechanisms Underlying Alcohol Augmentation of COVID-19 Pathologies.
CONCLUSIONS: Our meta-analyses demonstrate that EtOH exposure may augment SARS-CoV-2-induced inflammation by altering the activity of key inflammatory mediators. Medical records of COVID-19 patients are sparse for drinking history. Our findings suggest the importance to caution against alcohol consumption, which has increased during the COVID-19 pandemic, and facilitate further investigation into how alcohol exposure may affect viral infections. PMID: 33583045 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 13, 2021 Category: Addiction Authors: Huang W, Zhou H, Hodgkinson C, Montero A, Goldman D, Chang SL Tags: Alcohol Clin Exp Res Source Type: research

Ecological Momentary Assessment of Alcohol Consumption and Its Concordance with Transdermal Alcohol Detection and Timeline Follow-Back Self-report Among Adults Experiencing Homelessness.
CONCLUSIONS: This is the first study to examine concordance of alcohol use estimates using EMA, SCRAM, and TLFB methods in adults experiencing homelessness. EMA is a valid approach to quantifying alcohol use, especially given its relatively low cost, low participant burden, and ease of use. Furthermore, any stigma associated with wearing the SCRAM or reporting alcohol use in person may be attenuated by using EMA, which may be appealing for use in studies of stigmatized and underserved populations. PMID: 33583057 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 13, 2021 Category: Addiction Authors: Mun EY, Li X, Businelle MS, Hébert ET, Tan Z, Barnett NP, Walters ST Tags: Alcohol Clin Exp Res Source Type: research

Carnitine in Alcohol Use Disorders: A Scoping Review.
CONCLUSIONS: The increase in plasma carnitine in alcoholic cirrhosis may be related to disordered fatty acid metabolism and oxidative stress that occurs in AUD. The multiple possible therapeutic effects carnitine could have for ethanol metabolism and the early evidence available for carnitine supplementation as a treatment for AUDs provide a foundation for future randomized control trials for the use of carnitine in AUD. PMID: 33576525 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 12, 2021 Category: Addiction Authors: Bota AB, Simmons JG, DiBattista A, Wilson K Tags: Alcohol Clin Exp Res Source Type: research

An Experimental Test of the Relationship between Electronic Nicotine Delivery System Use and Alcohol Consumption.
CONCLUSIONS: Overall, ENDS use did not increase alcohol use; however, the data suggest that ENDS puffs might act as a prime for beer sips or that these two behaviors are linked through habit. Research should more fully measure and compare global and event-level data on ENDS and alcohol use as they might show disparate patterns of relationships. PMID: 33547653 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 6, 2021 Category: Addiction Authors: Hershberger AR, Studebaker A, Whitt ZT, Fillmore M, Kahler CW, Cyders MA Tags: Alcohol Clin Exp Res Source Type: research

Estimated Prevalence of Harmful Alcohol Consumption in Pregnant and Non-pregnant Women in Saxony-Anhalt (North-East Germany) Using Biomarkers.
CONCLUSION: Estimated prevalence rates differ greatly with respect to the biomarkers and cut-offs used. The isolated measurement of CDT/%CDT might result in an overestimation of harmful alcohol consumption during pregnancy. PMID: 33547677 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 6, 2021 Category: Addiction Authors: Adler J, Rissmann A, Kropf S, Mohnicke K, Taneva E, Ansorge T, Zenker M, Wex T Tags: Alcohol Clin Exp Res Source Type: research

Do Social Cognition Deficits Recover in Alcohol-Dependent Patients With Abstinence?
CONCLUSIONS: Our findings indicate no natural recovery of social cognition impairments in ADP during an intermediate to long-term period of abstinence (2+ months), the usual active treatment phase. Research aimed at developing interventions that focus on the improvement of social cognition deficits (e.g., social cognition training) and determining whether they benefit short- and long-term clinical outcomes in AUD seems warranted. PMID: 33523497 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - February 1, 2021 Category: Addiction Authors: Rupp CI, Junker D, Kemmler G, Mangweth-Matzek B, Derntl B Tags: Alcohol Clin Exp Res Source Type: research

Delineating Developmental Periods in Adulthood Suggests Age-Related Shifts in the Correlates of Alcohol Use and Problems.
CONCLUSIONS: These findings highlight the importance of sensation seeking and lack of planning with regard to adult alcohol use, particularly in a college environment. There was also a strong link between the rates of change in alcohol behavior and enhancement expectancies across all waves. This study supports the utility of exploratory LGMs for delineating developmental periods of alcohol behavior, which are characterized by different processes. PMID: 33512731 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 29, 2021 Category: Addiction Authors: Ellingson JM, Littlefield AK, Wood PK, Sher KJ Tags: Alcohol Clin Exp Res Source Type: research

Resilience to Hazardous Drinking among Never-Deployed Male United States Army Reserve and National Guard Soldiers.
Abstract BACKGROUND: Negative emotions related to never having been deployed are associated with an increased risk of hazardous drinking among United States Army Reserve/National Guard (USAR/NG) soldiers. Resiliency factors are known to buffer the effects of combat on hazardous drinking among service members who have been deployed, but it is not known if these factors are protective for never-deployed service members, or which domains of hazardous drinking might be affected. Therefore, we examined the effects of a range of resiliency factors (i.e., marital satisfaction, psychological hardiness, intrinsic religiosi...
Source: Alcoholism, Clinical and Experimental Research - January 27, 2021 Category: Addiction Authors: Hoopsick RA, Homish DL, Vest BM, Bartone PT, Homish GG Tags: Alcohol Clin Exp Res Source Type: research

Stability of Post-Treatment Reductions in World Health Organization (WHO) Drinking Risk Levels and Post-Treatment Functioning in Older Adults with DSM-5 Alcohol Use Disorder: Secondary Data Analysis of the Elderly-Study.
CONCLUSIONS: Maintaining reductions in WHO risk levels appears achievable for older adults seeking treatment for AUD. The small effect on reduction of AUD symptoms and improvement of quality of life indicate that these reductions should not be applied as the only treatment goal. PMID: 33496964 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 26, 2021 Category: Addiction Authors: Mejldal A, Andersen K, Behrendt S, Bilberg R, Bogenschutz M, Braun-Michl B, Bühringer G, Søgaard Nielsen A Tags: Alcohol Clin Exp Res Source Type: research

Three Weeks of Binge Alcohol Drinking Generates Increased Alcohol Front-loading and Robust Compulsive-Like Alcohol Drinking in Male and Female C57BL/6J Mice.
CONCLUSIONS: These data suggest that compulsive-like QuA drinking can be robustly achieved following three weeks DID and male and female C57BL/6J mice do not differ in compulsive-like alcohol drinking. PMID: 33496972 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 26, 2021 Category: Addiction Authors: Bauer MR, McVey MM, Boehm SL Tags: Alcohol Clin Exp Res Source Type: research

Ascending Pattern of Alcohol Use and Underage Drinking in Asia: A Commentary on the Article by Assanangkornchai and Vichitkunakorn (2020).
Abstract According to a 2018 World Health Organization (WHO) report, nearly half (43 %) of the world's population (15 years and older) had consumed alcohol within the last 12 months. The report, based on data until 2016, revealed that 26.5 % of 15-19-year-olds and 40.7 % of 20-24-year-olds had consumed alcohol. In Southeast Asia, 21.1 % and 34.3 % of 15-19- and 20-24- year-olds, respectively, had reduced their drinking habits. This was in sharp contrast to the global trend whereby there was a marked decline in individuals' drinking habits within the same period in the American and European regions (World Health Or...
Source: Alcoholism, Clinical and Experimental Research - January 24, 2021 Category: Addiction Authors: Siste K, Sen LT Tags: Alcohol Clin Exp Res Source Type: research

Distinct Whole-Body Movements in Response to Alcohol and Sexual Content in Alcohol Use Disorder.
a S Abstract BACKGROUND: Spontaneous motor responses of approach and avoidance toward stimuli are important in characterizing psychopathological conditions, including alcohol use disorder (AUD). However, divergent results have been reported, possibly due to confounded parameters (i.e. using a symbolic versus a sensorimotor task, implementation of approach-avoidance as a measure versus a manipulation). METHOD: We studied whole body/posturometric changes by using a sensorimotor measure relying on embodied cognition principles to assess forward (approach) and backward (avoidance) spontaneous leaning movements. O...
Source: Alcoholism, Clinical and Experimental Research - January 24, 2021 Category: Addiction Authors: Noël X, Dubuson M, Rougier M, Lelard T, Mouras H, Kornreich C, Wyckmans F, Pereira M, Chatard A, Jaafari N, Campanella S Tags: Alcohol Clin Exp Res Source Type: research

Alterations in Insulin Levels in Adults with Prenatal Alcohol Exposure.
Abstract OBJECTIVE: Evidence suggests that prenatal alcohol exposure (PAE) may adversely impact insulin production and signaling but there is limited information on the range of these effects and their future health consequences. METHOD: A prospective cohort of predominantly African American individuals identified while in utero and followed into adulthood were used to evaluate differences in various indicators of diabetes, including fasting plasma glucose, hemoglobin A1c, and insulin levels. The homoeostatic model assessment of insulin resistance (HOMA-IR) was also computed. Body mass index (BMI) was calcula...
Source: Alcoholism, Clinical and Experimental Research - January 24, 2021 Category: Addiction Authors: Kable JA, Mehta PK, Coles CD Tags: Alcohol Clin Exp Res Source Type: research

Cerebrospinal fluid biomarkers in patients with alcohol use disorder and persistent cognitive impairment.
CONCLUSIONS: This study revealed a high prevalence of AD in alcohol-dependent patients with persistent cognitive deficits and several anomalies in other CSF profiles. Thus, it seems important to consider AD as a frequent differential diagnosis and to use CSF biomarkers in the evaluation of alcohol-related cognitive impairments in addition to imaging and neuropsychological testing. PMID: 33486797 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 24, 2021 Category: Addiction Authors: Azuar J, Bouaziz-Amar E, Cognat E, Dumurgier J, Clergue-Duval V, Barré T, Amami J, Hispard E, Bellivier F, Paquet C, Vorspan F, Questel F Tags: Alcohol Clin Exp Res Source Type: research

Impact of Caffeine on Ethanol Induced Stimulation and Sensitization: Changes in ERK and DARPP-32 Phosphorylation in Nucleus Accumbens.
CONCLUSIONS: The present results demonstrated that, after the first administration, caffeine potentiated the stimulating actions of ethanol, but did not counteract its suppressant and ataxic effects. Moreover, our results show that caffeine has reduced activating effects in ethanol sensitized animals. PMID: 33471948 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 20, 2021 Category: Addiction Authors: Porru S, López-Cruz L, Carratalá-Ros C, Salamone JD, Acquas E, Correa M Tags: Alcohol Clin Exp Res Source Type: research

Association of the Fatty Acid Amide Hydrolase C385A Polymorphism with Alcohol Use Severity and Coping Motives in Heavy-drinking Youth.
CONCLUSIONS: These findings extend previous studies by suggesting that reduced endocannabinoid metabolism may be related to heavier use of alcohol in youth, prior to the onset of chronic drinking problems. Furthermore, differences in negative reinforcement-related drinking might account in part for this association. PMID: 33460184 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 18, 2021 Category: Addiction Authors: Best LM, Wardell JD, Tyndale RF, McPhee MD, Le Foll B, Kish SJ, Boileau I, Hendershot CS Tags: Alcohol Clin Exp Res Source Type: research

Sex-Dependent Alcohol Instrumentalization Goals in Non-Addicted Alcohol Consumers versus Patients with Alcohol Use Disorder: Longitudinal Change and Outcome Prediction.
CONCLUSIONS: We identified cross-sectional and intraindividual differences in instrumentalization goals supporting the assumption that the onset of an AUD coincides with a shift of instrumentalization goals from a pro-social instrumentalization towards the self-management of aversive mental states. PMID: 33449373 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 15, 2021 Category: Addiction Authors: Müller CP, Mühle C, Kornhuber J, Lenz B Tags: Alcohol Clin Exp Res Source Type: research

The Effects of Anger on Alcohol Demand and Subjective Alcohol Craving.
Abstract BACKGROUND: Anger and anger-related traits have been related to alcohol use in both cross-sectional and prospective studies. However, only a small number of studies have experimentally manipulated anger to examine whether the manipulation of anger influences alcohol craving or the relative reinforcing value of alcohol. METHODS: Participants (N = 231) recruited through Amazon's MTurk were randomly assigned to a provocation condition or a neutral condition prior to completing both the Alcohol Purchase Task and a self-report measure of alcohol craving. Linear regression analyses were conducted...
Source: Alcoholism, Clinical and Experimental Research - January 14, 2021 Category: Addiction Authors: Ellis JD, Grekin ER Tags: Alcohol Clin Exp Res Source Type: research

The Effectiveness of Alcohol Impact Areas in Reducing Crime in Washington Neighborhoods.
CONCLUSIONS: Findings suggest that malt liquor policies such as AIAs may be one of a number of tools local officials can use to reduce alcohol-related crime in cities, especially less-serious crime. PMID: 33443773 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 14, 2021 Category: Addiction Authors: Jones-Webb R, Joshi S, Erickson D, McKee P, Nelson T, Toomey T Tags: Alcohol Clin Exp Res Source Type: research

Validity and Reliability of Executive Function Measures in Children with Heavy Prenatal Alcohol Exposure: Correspondence Between Multiple Raters and Laboratory Measures.
CONCLUSION: Findings from this study indicate that behavior ratings can be used to supplement laboratory measures but may not be measuring cognitive abilities regardless of whether a clinical diagnosis is present. A multi-method approach should be used when measuring skills in this domain. This was one of the first studies to examine cross-informant agreement in a sample of children with prenatal alcohol exposure. Further research is necessary to understand why inter-rater agreement differed for children with prenatal alcohol exposure and those with ADHD. PMID: 33433001 [PubMed - as supplied by publisher] (Source: Alc...
Source: Alcoholism, Clinical and Experimental Research - January 12, 2021 Category: Addiction Authors: Bernes GA, Villodas M, Coles CD, Kable JA, May PA, Kalberg WO, Sowell ER, Jones KL, Riley EP, Mattson SN, CIFASD Tags: Alcohol Clin Exp Res Source Type: research

Increased Synaptic Strength and mGlu2/3 Receptor Plasticity on Mouse Prefrontal Cortex Intra-telencephalic Pyramidal Cells Following Intermittent Access to Ethanol.
CONCLUSIONS: Together, these studies provide insight into the specific PFC neurocircuits altered by voluntary drinking. In addition, these findings provide additional rationale for developing compounds that potentiate mGlu2 and/or mGlu3 receptor function as potential treatments for AUD. PMID: 33434325 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 12, 2021 Category: Addiction Authors: Joffe ME, Winder DG, Conn PJ Tags: Alcohol Clin Exp Res Source Type: research

Early Identification of Alcohol Use Disorder Patients at Risk of Developing Korsakoff's Syndrome.
CONCLUSIONS: These findings suggest that BEARNI is a relevant tool to detect severe memory impairments, thus making early identification of AUD patients at high risk of developing KS possible. PMID: 33432596 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 11, 2021 Category: Addiction Authors: Ritz L, Laniepce A, Cabé N, Lannuzel C, Boudehent C, Urso L, Segobin S, Vabret F, Beaunieux H, Pitel AL Tags: Alcohol Clin Exp Res Source Type: research

You Didn't Drink during Pregnancy, Did You?
CONCLUSIONS: Self-reported quantity of alcohol use varies greatly based on type of questions asked. Brief targeted questions about maximum number of drinks in 24 hours and total number of drinks at the most recent drinking episode provide much higher estimates of alcohol use and thus might be less affected by self-reporting bias. PMID: 33393695 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - January 4, 2021 Category: Addiction Authors: Bakhireva LN, Leeman L, Roberts M, Rodriguez DE, Jacobson SW Tags: Alcohol Clin Exp Res Source Type: research

Ethanol Exposure Attenuates Immune Response in Sepsis via Sirtuin 2 Expression.
CONCLUSION: Ethanol exposure decreases survival and reduces the inflammatory response to sepsis via increased SIRT2 expression. SIRT2 is a potential therapeutic target in ethanol with sepsis. PMID: 33368409 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - December 23, 2020 Category: Addiction Authors: Gandhirajan A, Roychowdhury S, Kibler C, Bauer SR, Nagy LE, Vachharajani V Tags: Alcohol Clin Exp Res Source Type: research

Housing Condition Differentially Impacts Escalation of Alcohol Intake, Relapse-Like Drinking, Anxiety-Like Behavior, and Stress History Effects by Sex.
CONCLUSIONS: Together, these findings suggest that paired housing differentially contributes to behavior in male and female rats, blunting alcohol intake in females and unmasking stress history effects on anxiety-like behavior in males. PMID: 33351976 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - December 22, 2020 Category: Addiction Authors: Moench KM, Logrip ML Tags: Alcohol Clin Exp Res Source Type: research