A review of the role of ethanol-induced adipose tissue dysfunction in alcohol-associated liver disease
Alcohol Clin Exp Res. 2021 Sep 23. doi: 10.1111/acer.14698. Online ahead of print.ABSTRACTAlcohol-associated liver disease (AALD) encompasses a spectrum of liver diseases that includes simple steatosis, steatohepatitis, fibrosis, and cirrhosis. The adverse effects of alcohol in liver and the mechanisms by which ethanol (EtOH) promotes liver injury are well studied. Although liver is known to be the primary organ affected by EtOH exposure, alcohol's effects on other organs are also known to contribute significantly to the development of liver injury. It is becoming increasingly evident that adipose tissue (AT) is an importa...
Source: Alcoholism, Clinical and Experimental Research - September 24, 2021 Category: Addiction Authors: Thiyagarajan Gopal Weilun Ai Carol A Casey Terrence M Donohue Viswanathan Saraswathi Source Type: research

Effects of within- and between-person assessments of alcohol expectancies and valuations on use and consequences moderated by sex
CONCLUSIONS: These findings suggest that AE and valuations are dynamic, that young adults' beliefs about the effects of alcohol varied over time, and that both negative and positive AE and valuations may be important correlates of alcohol use and consequences. These findings have implications for interventions designed to challenge expectancies and valuations with the goal of reducing alcohol use and associated consequences.PMID:34533848 | DOI:10.1111/acer.14677 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 17, 2021 Category: Addiction Authors: Nicole R Schultz Scott Graupensperger Ty W Lostutter Source Type: research

Effects of within- and between-person assessments of alcohol expectancies and valuations on use and consequences moderated by sex
CONCLUSIONS: These findings suggest that AE and valuations are dynamic, that young adults' beliefs about the effects of alcohol varied over time, and that both negative and positive AE and valuations may be important correlates of alcohol use and consequences. These findings have implications for interventions designed to challenge expectancies and valuations with the goal of reducing alcohol use and associated consequences.PMID:34533848 | DOI:10.1111/acer.14677 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 17, 2021 Category: Addiction Authors: Nicole R Schultz Scott Graupensperger Ty W Lostutter Source Type: research

Effects of within- and between-person assessments of alcohol expectancies and valuations on use and consequences moderated by sex
CONCLUSIONS: These findings suggest that AE and valuations are dynamic, that young adults' beliefs about the effects of alcohol varied over time, and that both negative and positive AE and valuations may be important correlates of alcohol use and consequences. These findings have implications for interventions designed to challenge expectancies and valuations with the goal of reducing alcohol use and associated consequences.PMID:34533848 | DOI:10.1111/acer.14677 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 17, 2021 Category: Addiction Authors: Nicole R Schultz Scott Graupensperger Ty W Lostutter Source Type: research

Effects of within- and between-person assessments of alcohol expectancies and valuations on use and consequences moderated by sex
CONCLUSIONS: These findings suggest that AE and valuations are dynamic, that young adults' beliefs about the effects of alcohol varied over time, and that both negative and positive AE and valuations may be important correlates of alcohol use and consequences. These findings have implications for interventions designed to challenge expectancies and valuations with the goal of reducing alcohol use and associated consequences.PMID:34533848 | DOI:10.1111/acer.14677 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 17, 2021 Category: Addiction Authors: Nicole R Schultz Scott Graupensperger Ty W Lostutter Source Type: research

Sex-specific effect of prenatal alcohol exposure on N-Methyl-D-Aspartate Receptor function in orbitofrontal cortex pyramidal neurons of mice
CONCLUSIONS: These findings suggest that low-to-moderate PAE modulates NMDAR function in pyramidal neurons in a sex specific manner, although we did not find evidence that this is mediated by dysfunction of synaptic GluN2B subunit-containing NMDARs.PMID:34523139 | DOI:10.1111/acer.14697 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Valentina Licheri Jayapriya Chandrasekaran Clark W Bird C Fernando Valenzuela Jonathan L Brigman Source Type: research

Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus
CONCLUSIONS: Prenatal alcohol and prenatal THC exposure differentially affect parvalbumin interneuron numbers in the hippocampus, indicating that both individual and combined exposure can impact the balance of excitation and inhibition in a structure critically involved in learning and memory processes.PMID:34523142 | DOI:10.1111/acer.14708 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hannah M O Reid Taylor M Snowden Irene Shkolnikov Kristen R Breit Cristina Rodriguez Jennifer D Thomas Brian R Christie Source Type: research

A Western diet with alcohol in drinking water model recapitulates features of alcohol-associated liver disease in mice
CONCLUSION: A simple to administer, 16-week western diet alcohol model recapitulates the inflammatory, fibrotic and gene expression aspects of human alcohol-associated steatohepatitis.PMID:34523155 | DOI:10.1111/acer.14700 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Michael Schonfeld Maura O'Neil Maria T Villar Antonio Artigues Janice Averilla Sumedha Gunewardena Steven A Weinman Irina Tikhanovich Source Type: research

How alcohol affects insulin-like growth factor-1 influences at the onset of puberty: A critical review
Alcohol Clin Exp Res. 2021 Sep 15. doi: 10.1111/acer.14711. Online ahead of print.ABSTRACTAlcohol (ALC) is capable of delaying signs associated with pubertal development in laboratory animals, as well as in humans. The normal onset of puberty is the result of a timely increase in gonadotropin-releasing hormone (GnRH) secretion, an action associated with a gradual decline in prepubertal inhibitory influences, while at the same time establishing excitatory inputs to increase release of the peptide to drive the pubertal process. In recent years, insulin like growth factor-1 (IGF-1) has emerged to play a pivotal role in prepub...
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: William L Dees Jill K Hiney Vinod K Srivastava Source Type: research

Integrative data analysis of self-efficacy in four clinical trials for alcohol use disorder
CONCLUSIONS: Alcohol self-efficacy increases following treatment and numerous evidence-based treatments are associated with significant increases in self-efficacy, which are maintained over time. Community treatment that focuses solely on addiction counseling and twelve-step support may not promote increases in self-efficacy.PMID:34523721 | DOI:10.1111/acer.14713 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Eric S Kruger Kelsey N Serier Rory A Pfund James R McKay Katie Witkiewitz Source Type: research

Exploring relationships between alcohol consumption, inflammation and brain structure in a heavy drinking sample
CONCLUSIONS: Data suggest that drinking is associated with lower GM thickness and higher WM diffusivity and that lower GM thickness is associated with higher circulating NfL. This is the first study to demonstrate an association between brain structure and NfL in a sample of heavy drinkers.PMID:34523725 | DOI:10.1111/acer.14712 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hollis C Karoly Carillon J Skrzynski Erin N Moe Angela D Bryan Kent E Hutchison Source Type: research

Cross-sectional and prospective analyses with drinking characteristics across four scores from the Self-Report of the Effects of Alcohol (SRE) questionnaire and alcohol challenges
CONCLUSIONS: Significant correlations with maximum drinks and alcohol problems were observed with prior alcohol challenges and with all SRE scores, with challenges and SRE reports seen as related but not identical LR measures. All SRE scores, including SRE-5, offered useful information.PMID:34523737 | DOI:10.1111/acer.14710 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Marc A Schuckit Tom L Smith Dennis Clarke Source Type: research

Sex-specific effect of prenatal alcohol exposure on N-Methyl-D-Aspartate Receptor function in orbitofrontal cortex pyramidal neurons of mice
CONCLUSIONS: These findings suggest that low-to-moderate PAE modulates NMDAR function in pyramidal neurons in a sex specific manner, although we did not find evidence that this is mediated by dysfunction of synaptic GluN2B subunit-containing NMDARs.PMID:34523139 | DOI:10.1111/acer.14697 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Valentina Licheri Jayapriya Chandrasekaran Clark W Bird C Fernando Valenzuela Jonathan L Brigman Source Type: research

Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus
CONCLUSIONS: Prenatal alcohol and prenatal THC exposure differentially affect parvalbumin interneuron numbers in the hippocampus, indicating that both individual and combined exposure can impact the balance of excitation and inhibition in a structure critically involved in learning and memory processes.PMID:34523142 | DOI:10.1111/acer.14708 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hannah M O Reid Taylor M Snowden Irene Shkolnikov Kristen R Breit Cristina Rodriguez Jennifer D Thomas Brian R Christie Source Type: research

A Western diet with alcohol in drinking water model recapitulates features of alcohol-associated liver disease in mice
CONCLUSION: A simple to administer, 16-week western diet alcohol model recapitulates the inflammatory, fibrotic and gene expression aspects of human alcohol-associated steatohepatitis.PMID:34523155 | DOI:10.1111/acer.14700 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Michael Schonfeld Maura O'Neil Maria T Villar Antonio Artigues Janice Averilla Sumedha Gunewardena Steven A Weinman Irina Tikhanovich Source Type: research

How alcohol affects insulin-like growth factor-1 influences at the onset of puberty: A critical review
Alcohol Clin Exp Res. 2021 Sep 15. doi: 10.1111/acer.14711. Online ahead of print.ABSTRACTAlcohol (ALC) is capable of delaying signs associated with pubertal development in laboratory animals, as well as in humans. The normal onset of puberty is the result of a timely increase in gonadotropin-releasing hormone (GnRH) secretion, an action associated with a gradual decline in prepubertal inhibitory influences, while at the same time establishing excitatory inputs to increase release of the peptide to drive the pubertal process. In recent years, insulin like growth factor-1 (IGF-1) has emerged to play a pivotal role in prepub...
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: William L Dees Jill K Hiney Vinod K Srivastava Source Type: research

Integrative data analysis of self-efficacy in four clinical trials for alcohol use disorder
CONCLUSIONS: Alcohol self-efficacy increases following treatment and numerous evidence-based treatments are associated with significant increases in self-efficacy, which are maintained over time. Community treatment that focuses solely on addiction counseling and twelve-step support may not promote increases in self-efficacy.PMID:34523721 | DOI:10.1111/acer.14713 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Eric S Kruger Kelsey N Serier Rory A Pfund James R McKay Katie Witkiewitz Source Type: research

Exploring relationships between alcohol consumption, inflammation and brain structure in a heavy drinking sample
CONCLUSIONS: Data suggest that drinking is associated with lower GM thickness and higher WM diffusivity and that lower GM thickness is associated with higher circulating NfL. This is the first study to demonstrate an association between brain structure and NfL in a sample of heavy drinkers.PMID:34523725 | DOI:10.1111/acer.14712 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hollis C Karoly Carillon J Skrzynski Erin N Moe Angela D Bryan Kent E Hutchison Source Type: research

Cross-sectional and prospective analyses with drinking characteristics across four scores from the Self-Report of the Effects of Alcohol (SRE) questionnaire and alcohol challenges
CONCLUSIONS: Significant correlations with maximum drinks and alcohol problems were observed with prior alcohol challenges and with all SRE scores, with challenges and SRE reports seen as related but not identical LR measures. All SRE scores, including SRE-5, offered useful information.PMID:34523737 | DOI:10.1111/acer.14710 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Marc A Schuckit Tom L Smith Dennis Clarke Source Type: research

Sex-specific effect of prenatal alcohol exposure on N-Methyl-D-Aspartate Receptor function in orbitofrontal cortex pyramidal neurons of mice
CONCLUSIONS: These findings suggest that low-to-moderate PAE modulates NMDAR function in pyramidal neurons in a sex specific manner, although we did not find evidence that this is mediated by dysfunction of synaptic GluN2B subunit-containing NMDARs.PMID:34523139 | DOI:10.1111/acer.14697 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Valentina Licheri Jayapriya Chandrasekaran Clark W Bird C Fernando Valenzuela Jonathan L Brigman Source Type: research

Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus
CONCLUSIONS: Prenatal alcohol and prenatal THC exposure differentially affect parvalbumin interneuron numbers in the hippocampus, indicating that both individual and combined exposure can impact the balance of excitation and inhibition in a structure critically involved in learning and memory processes.PMID:34523142 | DOI:10.1111/acer.14708 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hannah M O Reid Taylor M Snowden Irene Shkolnikov Kristen R Breit Cristina Rodriguez Jennifer D Thomas Brian R Christie Source Type: research

A Western diet with alcohol in drinking water model recapitulates features of alcohol-associated liver disease in mice
CONCLUSION: A simple to administer, 16-week western diet alcohol model recapitulates the inflammatory, fibrotic and gene expression aspects of human alcohol-associated steatohepatitis.PMID:34523155 | DOI:10.1111/acer.14700 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Michael Schonfeld Maura O'Neil Maria T Villar Antonio Artigues Janice Averilla Sumedha Gunewardena Steven A Weinman Irina Tikhanovich Source Type: research

How alcohol affects insulin-like growth factor-1 influences at the onset of puberty: A critical review
Alcohol Clin Exp Res. 2021 Sep 15. doi: 10.1111/acer.14711. Online ahead of print.ABSTRACTAlcohol (ALC) is capable of delaying signs associated with pubertal development in laboratory animals, as well as in humans. The normal onset of puberty is the result of a timely increase in gonadotropin-releasing hormone (GnRH) secretion, an action associated with a gradual decline in prepubertal inhibitory influences, while at the same time establishing excitatory inputs to increase release of the peptide to drive the pubertal process. In recent years, insulin like growth factor-1 (IGF-1) has emerged to play a pivotal role in prepub...
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: William L Dees Jill K Hiney Vinod K Srivastava Source Type: research

Integrative data analysis of self-efficacy in four clinical trials for alcohol use disorder
CONCLUSIONS: Alcohol self-efficacy increases following treatment and numerous evidence-based treatments are associated with significant increases in self-efficacy, which are maintained over time. Community treatment that focuses solely on addiction counseling and twelve-step support may not promote increases in self-efficacy.PMID:34523721 | DOI:10.1111/acer.14713 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Eric S Kruger Kelsey N Serier Rory A Pfund James R McKay Katie Witkiewitz Source Type: research

Exploring relationships between alcohol consumption, inflammation and brain structure in a heavy drinking sample
CONCLUSIONS: Data suggest that drinking is associated with lower GM thickness and higher WM diffusivity and that lower GM thickness is associated with higher circulating NfL. This is the first study to demonstrate an association between brain structure and NfL in a sample of heavy drinkers.PMID:34523725 | DOI:10.1111/acer.14712 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hollis C Karoly Carillon J Skrzynski Erin N Moe Angela D Bryan Kent E Hutchison Source Type: research

Cross-sectional and prospective analyses with drinking characteristics across four scores from the Self-Report of the Effects of Alcohol (SRE) questionnaire and alcohol challenges
CONCLUSIONS: Significant correlations with maximum drinks and alcohol problems were observed with prior alcohol challenges and with all SRE scores, with challenges and SRE reports seen as related but not identical LR measures. All SRE scores, including SRE-5, offered useful information.PMID:34523737 | DOI:10.1111/acer.14710 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Marc A Schuckit Tom L Smith Dennis Clarke Source Type: research

Sex-specific effect of prenatal alcohol exposure on N-Methyl-D-Aspartate Receptor function in orbitofrontal cortex pyramidal neurons of mice
CONCLUSIONS: These findings suggest that low-to-moderate PAE modulates NMDAR function in pyramidal neurons in a sex specific manner, although we did not find evidence that this is mediated by dysfunction of synaptic GluN2B subunit-containing NMDARs.PMID:34523139 | DOI:10.1111/acer.14697 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Valentina Licheri Jayapriya Chandrasekaran Clark W Bird C Fernando Valenzuela Jonathan L Brigman Source Type: research

Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus
CONCLUSIONS: Prenatal alcohol and prenatal THC exposure differentially affect parvalbumin interneuron numbers in the hippocampus, indicating that both individual and combined exposure can impact the balance of excitation and inhibition in a structure critically involved in learning and memory processes.PMID:34523142 | DOI:10.1111/acer.14708 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hannah M O Reid Taylor M Snowden Irene Shkolnikov Kristen R Breit Cristina Rodriguez Jennifer D Thomas Brian R Christie Source Type: research

A Western diet with alcohol in drinking water model recapitulates features of alcohol-associated liver disease in mice
CONCLUSION: A simple to administer, 16-week western diet alcohol model recapitulates the inflammatory, fibrotic and gene expression aspects of human alcohol-associated steatohepatitis.PMID:34523155 | DOI:10.1111/acer.14700 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Michael Schonfeld Maura O'Neil Maria T Villar Antonio Artigues Janice Averilla Sumedha Gunewardena Steven A Weinman Irina Tikhanovich Source Type: research

How alcohol affects insulin-like growth factor-1 influences at the onset of puberty: A critical review
Alcohol Clin Exp Res. 2021 Sep 15. doi: 10.1111/acer.14711. Online ahead of print.ABSTRACTAlcohol (ALC) is capable of delaying signs associated with pubertal development in laboratory animals, as well as in humans. The normal onset of puberty is the result of a timely increase in gonadotropin-releasing hormone (GnRH) secretion, an action associated with a gradual decline in prepubertal inhibitory influences, while at the same time establishing excitatory inputs to increase release of the peptide to drive the pubertal process. In recent years, insulin like growth factor-1 (IGF-1) has emerged to play a pivotal role in prepub...
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: William L Dees Jill K Hiney Vinod K Srivastava Source Type: research

Integrative data analysis of self-efficacy in four clinical trials for alcohol use disorder
CONCLUSIONS: Alcohol self-efficacy increases following treatment and numerous evidence-based treatments are associated with significant increases in self-efficacy, which are maintained over time. Community treatment that focuses solely on addiction counseling and twelve-step support may not promote increases in self-efficacy.PMID:34523721 | DOI:10.1111/acer.14713 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Eric S Kruger Kelsey N Serier Rory A Pfund James R McKay Katie Witkiewitz Source Type: research

Exploring relationships between alcohol consumption, inflammation and brain structure in a heavy drinking sample
CONCLUSIONS: Data suggest that drinking is associated with lower GM thickness and higher WM diffusivity and that lower GM thickness is associated with higher circulating NfL. This is the first study to demonstrate an association between brain structure and NfL in a sample of heavy drinkers.PMID:34523725 | DOI:10.1111/acer.14712 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hollis C Karoly Carillon J Skrzynski Erin N Moe Angela D Bryan Kent E Hutchison Source Type: research

Cross-sectional and prospective analyses with drinking characteristics across four scores from the Self-Report of the Effects of Alcohol (SRE) questionnaire and alcohol challenges
CONCLUSIONS: Significant correlations with maximum drinks and alcohol problems were observed with prior alcohol challenges and with all SRE scores, with challenges and SRE reports seen as related but not identical LR measures. All SRE scores, including SRE-5, offered useful information.PMID:34523737 | DOI:10.1111/acer.14710 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Marc A Schuckit Tom L Smith Dennis Clarke Source Type: research

Sex-specific effect of prenatal alcohol exposure on N-Methyl-D-Aspartate Receptor function in orbitofrontal cortex pyramidal neurons of mice
CONCLUSIONS: These findings suggest that low-to-moderate PAE modulates NMDAR function in pyramidal neurons in a sex specific manner, although we did not find evidence that this is mediated by dysfunction of synaptic GluN2B subunit-containing NMDARs.PMID:34523139 | DOI:10.1111/acer.14697 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Valentina Licheri Jayapriya Chandrasekaran Clark W Bird C Fernando Valenzuela Jonathan L Brigman Source Type: research

Prenatal alcohol and cannabis exposure can have opposing and region-specific effects on parvalbumin interneuron numbers in the hippocampus
CONCLUSIONS: Prenatal alcohol and prenatal THC exposure differentially affect parvalbumin interneuron numbers in the hippocampus, indicating that both individual and combined exposure can impact the balance of excitation and inhibition in a structure critically involved in learning and memory processes.PMID:34523142 | DOI:10.1111/acer.14708 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hannah M O Reid Taylor M Snowden Irene Shkolnikov Kristen R Breit Cristina Rodriguez Jennifer D Thomas Brian R Christie Source Type: research

A Western diet with alcohol in drinking water model recapitulates features of alcohol-associated liver disease in mice
CONCLUSION: A simple to administer, 16-week western diet alcohol model recapitulates the inflammatory, fibrotic and gene expression aspects of human alcohol-associated steatohepatitis.PMID:34523155 | DOI:10.1111/acer.14700 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Michael Schonfeld Maura O'Neil Maria T Villar Antonio Artigues Janice Averilla Sumedha Gunewardena Steven A Weinman Irina Tikhanovich Source Type: research

How alcohol affects insulin-like growth factor-1 influences at the onset of puberty: A critical review
Alcohol Clin Exp Res. 2021 Sep 15. doi: 10.1111/acer.14711. Online ahead of print.ABSTRACTAlcohol (ALC) is capable of delaying signs associated with pubertal development in laboratory animals, as well as in humans. The normal onset of puberty is the result of a timely increase in gonadotropin-releasing hormone (GnRH) secretion, an action associated with a gradual decline in prepubertal inhibitory influences, while at the same time establishing excitatory inputs to increase release of the peptide to drive the pubertal process. In recent years, insulin like growth factor-1 (IGF-1) has emerged to play a pivotal role in prepub...
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: William L Dees Jill K Hiney Vinod K Srivastava Source Type: research

Integrative data analysis of self-efficacy in four clinical trials for alcohol use disorder
CONCLUSIONS: Alcohol self-efficacy increases following treatment and numerous evidence-based treatments are associated with significant increases in self-efficacy, which are maintained over time. Community treatment that focuses solely on addiction counseling and twelve-step support may not promote increases in self-efficacy.PMID:34523721 | DOI:10.1111/acer.14713 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Eric S Kruger Kelsey N Serier Rory A Pfund James R McKay Katie Witkiewitz Source Type: research

Exploring relationships between alcohol consumption, inflammation and brain structure in a heavy drinking sample
CONCLUSIONS: Data suggest that drinking is associated with lower GM thickness and higher WM diffusivity and that lower GM thickness is associated with higher circulating NfL. This is the first study to demonstrate an association between brain structure and NfL in a sample of heavy drinkers.PMID:34523725 | DOI:10.1111/acer.14712 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Hollis C Karoly Carillon J Skrzynski Erin N Moe Angela D Bryan Kent E Hutchison Source Type: research

Cross-sectional and prospective analyses with drinking characteristics across four scores from the Self-Report of the Effects of Alcohol (SRE) questionnaire and alcohol challenges
CONCLUSIONS: Significant correlations with maximum drinks and alcohol problems were observed with prior alcohol challenges and with all SRE scores, with challenges and SRE reports seen as related but not identical LR measures. All SRE scores, including SRE-5, offered useful information.PMID:34523737 | DOI:10.1111/acer.14710 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 15, 2021 Category: Addiction Authors: Marc A Schuckit Tom L Smith Dennis Clarke Source Type: research

Patient and provider factors associated with receipt and delivery of brief interventions for unhealthy alcohol use in primary care
CONCLUSIONS: These findings point to characteristics that can be targeted to improve universal receipt of brief intervention.PMID:34486124 | DOI:10.1111/acer.14702 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Yun Lu Felicia W Chi Sujaya Parthasarathy Vanessa A Palzes Andrea H Kline-Simon Verena E Metz Constance Weisner Derek D Satre Cynthia I Campbell Joseph Elson Thekla B Ross Sameer V Awsare Stacy A Sterling Source Type: research

Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring
CONCLUSIONS: We did not find evidence for a causal effect of fetal alcohol exposure on risk of ADHD symptoms in offspring. The results may be affected by limited power to detect small effects and outcome assessment.PMID:34486127 | DOI:10.1111/acer.14692 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Elis Haan Hannah M Sallis Eivind Ystrom P ål Rasmus Njølstad Ole A Andreassen Ted Reichborn-Kjennerud Marcus R Munaf ò Alexandra Havdahl Luisa Zuccolo Source Type: research

Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
Alcohol Clin Exp Res. 2021 Sep 5. doi: 10.1111/acer.14694. Online ahead of print.ABSTRACTAlcohol is one of the most widely used recreational substances worldwide, with drinking frequently initiated during adolescence. The developmental state of the adolescent brain makes it vulnerable to initiating alcohol use, often in high doses, and particularly susceptible to alcohol-induced brain changes. Microglia, the brain parenchymal macrophages, have been implicated in mediating some of these effects, though the role that these cells play in the progression from alcohol drinking to dependence remains unclear. Microglia are unique...
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Jennifer K Melbourne Cassie M Chandler Catherine E Van Doorn Michael T Bardo James R Pauly Hui Peng Kimberly Nixon Source Type: research

Multiparametric magnetic resonance imaging/magnetic resonance elastography assesses progression and regression of steatosis, inflammation, and fibrosis in alcohol-associated liver disease
Alcohol Clin Exp Res. 2021 Sep 5. doi: 10.1111/acer.14699. Online ahead of print.ABSTRACTBACKGROUND: Magnetic resonance imaging (MRI) and MRI-based elastography (MRE) are the most promising noninvasive techniques in assessing liver diseases. The purpose of this study was to evaluate an advanced multiparametric imaging method for staging disease and assessing treatment response in realistic preclinical ALD models.METHODS: We utilized four different preclinical mouse models in our study: Model 1-mice were fed a fast-food diet and fructose water for 48 weeks to induce nonalcoholic fatty liver disease; Model 2-mice were fed ch...
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Jingbiao Chen Rosa Martin-Mateos Jiahui Li Ziying Yin Jie Chen Xin Lu Kevin J Glaser Taofic Mounajjed Hiroaki Yashiro Jenifer Siegelman Christopher T Winkelmann Jin Wang Richard L Ehman Vijay H Shah Meng Yin Source Type: research

Alcohol use disorder severity moderates clinical response to varenicline
CONCLUSIONS: Treatment response to varenicline may be maximized among individuals with less-severe AUD presentation, as determined by both reductions in drinking outcomes and improvements in psychosocial functioning.PMID:34486130 | DOI:10.1111/acer.14674 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Suzanna Donato ReJoyce Green Lara A Ray Source Type: research

Trehalose activates hepatic transcription factor EB (TFEB) but fails to ameliorate alcohol-impaired TFEB and liver injury in mice
CONCLUSIONS: Trehalose fails to improve the impaired TFEB induced by Gao-binge alcohol and does not protect against alcohol-induced liver injury.PMID:34486131 | DOI:10.1111/acer.14695 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Xiaojuan Chao Shaogui Wang Ling Yang Hong-Min Ni Wen-Xing Ding Source Type: research

COVID-19 pandemic and methanol poisoning outbreak in Iranian children and adolescents: A data linkage study
Alcohol Clin Exp Res. 2021 Sep 6. doi: 10.1111/acer.14680. Online ahead of print.ABSTRACTBACKGROUND: During the first wave of COVID-19, many Iranians were poisoned by ingesting hand sanitizers and/or alcoholic beverages to avoid viral infection. To assess whether the COVID-19 pandemic resulted in an increased prevalence of accidental hand sanitizer/alcoholic beverage exposure in children and adolescents, we compared pediatric hospitalization rates during COVID-19 and the previous year. For poisoning admissions during COVID-19, we also evaluated the cause by age and clinical outcomes.METHODS: This retrospective data linkage...
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Seyed Amirhosein Mahdavi Ali-Asghar Kolahi Maryam Akhgari Farzad Gheshlaghi Narges Gholami Mohammad Moshiri Neda Mohtasham Sara Ebrahimi Pardis Ziaeefar Rebecca McDonald Basak Tas Amir Mohammad Kazemifar Alireza Amirabadizadeh Mohammadreza Ghadirzadeh Far Source Type: research

Patient and provider factors associated with receipt and delivery of brief interventions for unhealthy alcohol use in primary care
CONCLUSIONS: These findings point to characteristics that can be targeted to improve universal receipt of brief intervention.PMID:34486124 | DOI:10.1111/acer.14702 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Yun Lu Felicia W Chi Sujaya Parthasarathy Vanessa A Palzes Andrea H Kline-Simon Verena E Metz Constance Weisner Derek D Satre Cynthia I Campbell Joseph Elson Thekla B Ross Sameer V Awsare Stacy A Sterling Source Type: research

Maternal and offspring genetic risk score analyses of fetal alcohol exposure and attention-deficit hyperactivity disorder risk in offspring
CONCLUSIONS: We did not find evidence for a causal effect of fetal alcohol exposure on risk of ADHD symptoms in offspring. The results may be affected by limited power to detect small effects and outcome assessment.PMID:34486127 | DOI:10.1111/acer.14692 (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Elis Haan Hannah M Sallis Eivind Ystrom P ål Rasmus Njølstad Ole A Andreassen Ted Reichborn-Kjennerud Marcus R Munaf ò Alexandra Havdahl Luisa Zuccolo Source Type: research

Primed for addiction: A critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking
Alcohol Clin Exp Res. 2021 Sep 5. doi: 10.1111/acer.14694. Online ahead of print.ABSTRACTAlcohol is one of the most widely used recreational substances worldwide, with drinking frequently initiated during adolescence. The developmental state of the adolescent brain makes it vulnerable to initiating alcohol use, often in high doses, and particularly susceptible to alcohol-induced brain changes. Microglia, the brain parenchymal macrophages, have been implicated in mediating some of these effects, though the role that these cells play in the progression from alcohol drinking to dependence remains unclear. Microglia are unique...
Source: Alcoholism, Clinical and Experimental Research - September 6, 2021 Category: Addiction Authors: Jennifer K Melbourne Cassie M Chandler Catherine E Van Doorn Michael T Bardo James R Pauly Hui Peng Kimberly Nixon Source Type: research