Stroke RSS Page 8

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Condition: Alzheimer's

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Total 2642 results found since Jan 2013.

Sex differences in cognitive impairment after focal ischemia in middle-aged rats and the effect of iv miR-20a-3p treatment
Neurobiol Aging. 2023 May 5;129:168-177. doi: 10.1016/j.neurobiolaging.2023.05.001. Online ahead of print.ABSTRACTStroke is a major cause of death and disability worldwide and is also a leading cause of vascular dementia and Alzheimer's disease, with older women experiencing accelerated decline. Our previous studies show that intravenous (iv) injections of miR-20a-3p, a small noncoding RNA (miRNA) delivered after stroke improves acute stroke outcomes in middle-aged male and female rats. The present study tested whether mir-20a-3p treatment would also ameliorate stroke-induced cognitive decline in the chronic phase. Acyclic...
Source: Neurobiology of Aging - June 19, 2023 Category: Geriatrics Authors: Dayalan Sampath Taylor E Branyan Kylee G Markowsky Rithvik Gunda Nadia Samiya Andre Obenaus Farida Sohrabji Source Type: research

Hyperglycemia Aggravates the Cerebral Ischemia Injury via Protein O-GlcNAcylation
CONCLUSION: Overall, our study indicates a critical role for O-GlcNAcylation in that hyperglycemia aggravates cerebral ischemia injury. O-GlcNAcylation may be a potential therapeutic drug for ischemic stroke associated with AD.PMID:37334605 | DOI:10.3233/JAD-230264
Source: Atherosclerosis - June 19, 2023 Category: Cardiology Authors: Jing Zhu Xin Ji Ruirui Shi Tianqi He Su-Ying Chen Ruochen Cong Bosheng He Su Liu Hui Xu Jin-Hua Gu Source Type: research

Neutrophil Extracellular Traps in Cerebral Ischemia/Reperfusion Injury: Friend and Foe
Curr Neuropharmacol. 2023 Jun 16. doi: 10.2174/1570159X21666230616114255. Online ahead of print.ABSTRACTCerebral ischemic injury, one of the leading causes of morbidity and mortality worldwide, triggers various central nervous system (CNS) diseases, including acute ischemic stroke (AIS) and chronic ischemia-induced Alzheimer's disease (AD). Currently, targeted therapies are urgently needed to address neurological disorders caused by cerebral ischemia/reperfusion injury (CI/RI), and the emergence of neutrophil extracellular traps (NETs) may be able to relieve the pressure. Neutrophils are precursors to brain injury followin...
Source: Current Neuropharmacology - June 16, 2023 Category: Drugs & Pharmacology Authors: Haoyue Luo Hanjing Guo Yue Zhou Rui Fang Wenli Zhang Zhigang Mei Source Type: research

Are Periodontitis, Stroke, and Alzheimer ' s Disease Linked? Are Periodontitis, Stroke, and Alzheimer ' s Disease Linked?
A new report provides the latest scientific evidence for the association between these outcomes, as well as practical recommendations.Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - June 15, 2023 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news

Association of brain microbleeds with risk factors, cognition, and MRI markers in MESA
DISCUSSION: Results suggest differing associations for lobar versus deep locations. Sensitive microbleed quantification will facilitate future longitudinal studies of their potential role as an early indicator of vascular pathology.PMID:37289978 | DOI:10.1002/alz.13346
Source: The Journal of Alzheimers Association - June 8, 2023 Category: Psychiatry Authors: Paul N Jensen Tanweer Rashid Jeffrey B Ware Yuhan Cui Colleen M Sitlani Thomas R Austin W T Longstreth Alain G Bertoni Elizabeth Mamourian R Nick Bryan Ilya M Nasrallah Mohamad Habes Susan R Heckbert Source Type: research

A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke
In this study, we identified a novel phenotype of macrophage-like B cells in brain-infiltrating immune cells expressing a high level of CD45. Macrophage-like B cells characterized by co-expression of B-cell and macrophage markers, showed stronger phagocytic and chemotactic functions compared with other B cells and showed upregulated expression of phagocytosis-related genes. Gene Ontology analysis found that the expression of genes associated with phagocytosis, including phagosome- and lysosome-related genes, was upregulated in macrophage-like B cells. The phagocytic activity of macrophage-like B cells was verified by immun...
Source: Cell Research - June 7, 2023 Category: Cytology Authors: Rui Wang Huaming Li Chenhan Ling Xiaotao Zhang Jianan Lu Weimin Luan Jianmin Zhang Ligen Shi Source Type: research

Mesenchymal stem cells (MSCs) and MSC ‐derived exosomes in animal models of central nervous system diseases: Targeting the NLRP3 inflammasome
AbstractThe NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome is a multimeric protein complex that is engaged in the innate immune system and plays a vital role in inflammatory reactions. Activation of the NLRP3 inflammasome and subsequent release of proinflammatory cytokines can be triggered by microbial infection or cellular injury. The NLRP3 inflammasome has been implicated in the pathogenesis of many disorders affecting the central nervous system (CNS), ranging from stroke, traumatic brain injury, and spinal cord injury to Alzheimer's disease, Parkinson's disease, epilepsy, multiple sclerosis, and ...
Source: IUBMB Life - June 7, 2023 Category: Research Authors: Shahrzad Nazari, Seyed Mahmoud Pourmand, Elahe Motevaseli, Gholamreza Hassanzadeh Tags: CRITICAL REVIEW Source Type: research

Genomics of aging: Reactive oxidation and inefficient mitochondria
This article, the fifth in the JAANP Genomics of Aging series, describes the role that mitochondrial dysfunction plays in the development of age-related diseases such as Alzheimer disease, Parkinson disease, cancer, heart disease, and stroke.PMID:37265351 | DOI:10.1097/JXX.0000000000000880
Source: Atherosclerosis - June 2, 2023 Category: Cardiology Authors: Kenneth Wysocki Beth Heuer Source Type: research

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