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Condition: Alzheimer's
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Total 2642 results found since Jan 2013.
Acrolein: formation, health hazards and its controlling by dietary polyphenols
Crit Rev Food Sci Nutr. 2023 May 19:1-14. doi: 10.1080/10408398.2023.2214625. Online ahead of print.ABSTRACTAcrolein, a highly reactive toxic aldehyde, is a common dietary and environmental contaminant which can also be generated endogenously. Exposure to acrolein has been positively associated with some pathological conditions, such as atherosclerosis, diabetes mellitus, stroke, and Alzheimer's disease. At the cellular level, acrolein induces various harmful effects, particularly protein adduction and oxidative damages. Polyphenols are a group of secondary plant metabolites ubiquitously presented in fruits, vegetables, an...
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Yue Zhou Wendy Jin Qingli Wu Qian Zhou Source Type: research
Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study
CONCLUSIONS: Low choline intake was associated with increased risks of incident dementia and AD.PMID:37208066 | PMC:PMC9630864 | DOI:10.1093/ajcn/nqac193
Source: The American Journal of Clinical Nutrition - May 19, 2023 Category: Nutrition Authors: Jing Yuan Xue Liu Chunyu Liu Alvin Fa Ang Joseph Massaro Sherral A Devine Sanford H Auerbach Jan Krzysztof Blusztajn Rhoda Au Paul F Jacques Source Type: research
Combining Mendelian randomization and network deconvolution for inference of causal networks with GWAS summary data
by Zhaotong Lin, Haoran Xue, Wei Pan
Mendelian randomization (MR) has been increasingly applied for causal inference with observational data by using genetic variants as instrumental variables (IVs). However, the current practice of MR has been largely restricted to investigating thetotal causal effect between two traits, while it would be useful to infer thedirect causal effect between any two of many traits (by accounting for indirect or mediating effects through other traits). For this purpose we propose a two-step approach: we first apply an extended MR method to infer (i.e. both estimate and test) a causal network of...
Source: PLoS Genetics - May 18, 2023 Category: Genetics & Stem Cells Authors: Zhaotong Lin Source Type: research
Roche ’s BTK inhibitor fenebrutinib significantly reduced brain lesions in people with relapsing forms of multiple sclerosis
Fenebrutinib is an investigational, potent and highly selective oralBruton ’s tyrosine kinase (BTK) inhibitor, the only reversible BTK inhibitor currently in Phase III multiple sclerosis (MS) trialsPhase II study met its primary and secondary endpoints by reducing the total number of new gadolinium-enhancing T1 brain lesions and significantly reducing the total number of new or enlarging T2 brain lesions compared to placeboThe safety profile offenebrutinib was consistent with previous and ongoing clinical trials across more than 2,400 people to dateBasel, 17 May 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today p...
Source: Roche Media News - May 17, 2023 Category: Pharmaceuticals Source Type: news
Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
Biomedicines. 2023 Mar 23;11(4):994. doi: 10.3390/biomedicines11040994.ABSTRACTAccumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer's disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, ...
Source: Cancer Control - May 16, 2023 Category: Cancer & Oncology Authors: William B Grant Fatme Al Anouti Barbara J Boucher Hana M A Fakhoury Meis Moukayed Stefan Pilz Nasser M Al-Daghri Source Type: research
Snoring could raise your risk of Alzheimer's disease and stroke, study suggests
New research suggests that a lack of deep sleep could make you more prone to Alzheimer's disease and stroke, with snoring playing a role.
Source: Daily Express - Health - May 12, 2023 Category: Consumer Health News Source Type: news
Prevalent stroke, age of its onset, and post-stroke lifestyle in relation to dementia: A prospective cohort study
DISCUSSION: Stroke onset in earlier life stage predicted a higher risk for dementia, but a favorable post-stroke lifestyle may protect against dementia.PMID:37157186 | DOI:10.1002/alz.13122
Source: The Journal of Alzheimers Association - May 9, 2023 Category: Psychiatry Authors: Wansi Zhong Hui Chen Xiaoxian Gong Lusha Tong Xin Xu Geng Zong Changzheng Yuan Min Lou Source Type: research
Microfluidic 'brain-on chip' systems to supplement neurological practice: development, applications and considerations
Regen Med. 2023 Apr 26. doi: 10.2217/rme-2022-0212. Online ahead of print.ABSTRACTAmong the greatest general challenges in bioengineering is to mimic human physiology. Advanced efforts in tissue engineering have led to sophisticated 'brain-on-chip' (BoC) microfluidic devices that can mimic structural and functional aspects of brain tissue. BoC may be used to understand the biochemical pathways of neurolgical pathologies and assess promising therapeutic agents for facilitating regenerative medicine. We evaluated the potential of microfluidic BoC devices in various neurological pathologies, such as Alzheimer's, glioblastoma,...
Source: Regenerative Medicine - May 1, 2023 Category: Genetics & Stem Cells Authors: Ryan Jarrah Karim Rizwan Nathani Shaan Bhandarkar Chibuze S Ezeudu Ryan T Nguyen Abrham Amare Usama A Aljameey Sabrina I Jarrah Archis R Bhandarkar Brian Fiani Source Type: research
