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Total 2642 results found since Jan 2013.

Neural circuit changes in neurological disorders: Evidence from in vivo two-photon imaging
Ageing Res Rev. 2023 Apr 13;87:101933. doi: 10.1016/j.arr.2023.101933. Online ahead of print.ABSTRACTNeural circuits, such as synaptic plasticity and neural activity, are critical components of healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing procedure affecting neuronal activities. Disruption of this essential process results in diseases. Advanced microscopic applications such as two-photon laser scanning microscopy have recently been applied to understand neural circuit changes during disease since it can visualize fine structural and functional cellular activation in living anim...
Source: Ageing Research Reviews - April 15, 2023 Category: Genetics & Stem Cells Authors: Huan Xiong Fei Tang Yujie Guo Ruxiang Xu Peng Lei Source Type: research

Phytochemicals targeting lncRNAs: A novel direction for neuroprotection in neurological disorders
Biomed Pharmacother. 2023 Apr 12;162:114692. doi: 10.1016/j.biopha.2023.114692. Online ahead of print.ABSTRACTNeurological disorders with various etiologies impacting the nervous system are prevalent in clinical practice. Long non-coding RNA (lncRNA) molecules are functional RNA molecules exceeding 200 nucleotides in length that do not encode proteins, but participate in essential activities. Research indicates that lncRNAs may contribute to the pathogenesis of neurological disorders, and may be potential targets for their treatment. Phytochemicals in traditional Chinese herbal medicine (CHM) have been found to exert neuro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 14, 2023 Category: Drugs & Pharmacology Authors: Hang Zhao Lin Wang Lijuan Zhang Hongyu Zhao Source Type: research

The Potential Benefits of Quercetin for Brain Health: A Review of Anti-Inflammatory and Neuroprotective Mechanisms
Int J Mol Sci. 2023 Mar 28;24(7):6328. doi: 10.3390/ijms24076328.ABSTRACTNeuroinflammation is a critical factor in developing and progressing numerous brain diseases, including neurodegenerative diseases. Chronic or excessive neuroinflammation can lead to neurotoxicity, causing brain damage and contributing to the onset and progression of various brain diseases. Therefore, understanding neuroinflammation mechanisms and developing strategies to control them is crucial for treating brain diseases. Studies have shown that neuroinflammation plays a vital role in the progression of neurodegenerative diseases, such as Alzheimer'...
Source: Cancer Control - April 13, 2023 Category: Cancer & Oncology Authors: Ming-Chang Chiang Tsung-Yu Tsai Chieh-Ju Wang Source Type: research

Are coincidences real?
The rationalist in me knows that coincidences are inevitable, mundane, meaningless. But I can ’t deny there is something strange and magical in them, tooIn the summer of 2021, I experienced a cluster of coincidences, some of which had a distinctly supernatural feel. Here ’s how it started. I keep a journal, and record dreams if they are especially vivid or strange. It doesn’t happen often, but I logged one in which my mother’s oldest friend, a woman called Rose, made an appearance to tell me that she (Rose) had just died. She had had another stroke, she said, and that was it. Come the morning, it occurred to me tha...
Source: Guardian Unlimited Science - April 13, 2023 Category: Science Authors: Paul Broks Tags: Philosophy Neuroscience Psychology Carl Jung Albert Einstein Source Type: news

Inflammation May Be the Culprit Behind Our Deadliest Diseases
In the early days of my medical residency, I met a man whom we’ll call Jason. He arrived to our emergency room on a holiday, nonchalant yet amiable, and complained of mild chest pain. Jason was tall and trim, with a strong South Boston accent and fingertips still faintly stained from his last home-improvement project. He was only 45 years old, but he looked much younger. He didn’t smoke, barely drank alcohol, and his cholesterol levels had always been normal. No one in his family had a history of heart disease. He asked us if we could work quickly—he wanted to be home for dinner with his daughters. [time-...
Source: TIME: Health - April 11, 2023 Category: Consumer Health News Authors: Shilpa Ravella Tags: Uncategorized freelance health Source Type: news

Astrocytic Chitinase ‐3‐like Protein 1 in Neurological Diseases: Potential Roles and Future Perspectives
AbstractChitinase-3-like protein 1 (CHI3L1) is a secreted glycoprotein characterized by its ability to regulate multiple biological processes, such as the inflammatory response and gene transcriptional signaling activation. Abnormal CHI3L1 expression has been associated with multiple neurological disorders and serves as a biomarker for the early detection of several neurodegenerative diseases. Aberrant CHI3L1 expression is also reportedly associated with brain tumor migration and metastasis, as well as contributions to immune escape, playing important roles in brain tumor progression. CHI3L1 is synthesized and secreted mai...
Source: Journal of Neurochemistry - April 7, 2023 Category: Neuroscience Authors: Fei Li, An Liu, Minggao Zhao, Lanxin Luo Tags: REVIEW Source Type: research

An update on the role of Hippo signaling pathway in ischemia-associated central nervous system diseases
Biomed Pharmacother. 2023 Mar 31;162:114619. doi: 10.1016/j.biopha.2023.114619. Online ahead of print.ABSTRACTThe most frequent reason of morbidity and mortality in the world, cerebral ischemia sets off a chain of molecular and cellular pathologies that associated with some central nervous system (CNS) disorders mainly including ischemic stroke, Alzheimer's disease (AD), Parkinson's disease (PD), epilepsy and other CNS diseases. In recent times, despite significant advancements in the treatment of the pathological processes underlying various neurological illnesses, effective therapeutic approaches that are specifically ta...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 2, 2023 Category: Drugs & Pharmacology Authors: Xuan Wei Guangshan Huang Jiyong Liu Jinwen Ge Wenli Zhang Zhigang Mei Source Type: research

Acetyl-L-carnitine and Amyotrophic Lateral Sclerosis: current evidence and potential use
CONCLUSION: This narrative review aims to update the existing literature on ALCAR molecular profile, tolerability, and translational clinical potential use in neurodegeneration, focusing on ALS.PMID:36998125 | DOI:10.2174/1871527322666230330083757
Source: CNS and Neurological Disorders Drug Targets - March 31, 2023 Category: Drugs & Pharmacology Authors: Fabiola De Marchi Sakthipriyan Venkatesan Massimo Saraceno Letizia Mazzini Elena Grossini Source Type: research

Tripartite Motif Protein Family in Central Nervous System Diseases
Cell Mol Neurobiol. 2023 Mar 29. doi: 10.1007/s10571-023-01337-5. Online ahead of print.ABSTRACTTripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is widely involved in various physiological and pathological processes, such as intracellular signal transduction, cell cycle regulation, oncogenesis, and innate immune response. Central nervous system (CNS) diseases are composed of encephalopathy and spinal cord diseases, which have a high disability and mortality rate. Patients are often unable to tak...
Source: Cellular and Molecular Neurobiology - March 29, 2023 Category: Cytology Authors: Mengtian Pan Xiang Li Guangchen Xu Xinjuan Tian Yunman Li Weirong Fang Source Type: research