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Condition: Alzheimer's

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Total 2642 results found since Jan 2013.

IJERPH, Vol. 20, Pages 5290: Cognitive Performance Deficits Are Associated with Clinically Significant Depression Symptoms in Older US Adults
nos Accumulating research has described cognitive impairment in adults with depression, however, few studies have focused on this relationship during older adulthood. Our cross-sectional study investigated the association between cognitive function performance and clinically significant depression symptoms in older adults. We analysed the data from the 2011 to 2014 National Health and Nutrition Examination Survey on older (aged 60 years and above) US adults. Cognitive function was assessed as a composite score and on a test-by-test basis based on the Consortium to Establish a Registry for Alzheimer’s Dise...
Source: International Journal of Environmental Research and Public Health - March 28, 2023 Category: Environmental Health Authors: Orestis Delardas Panagiotis Giannos Tags: Brief Report Source Type: research

Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)
Int J Mol Med. 2023 Apr;51(4):35. doi: 10.3892/ijmm.2023.5238. Epub 2023 Mar 24.ABSTRACTThe inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis‑associated speck‑like protein (ASC) and pro‑caspase‑1, is by far the most extensively studied and well‑characterized inflammasome. A variety of stimuli can activate the NLRP3 inflammasome. When activated, the NLRP3 protein recruits the adaptor ASC protein and activates pro‑caspase‑1, resulting in inflammatory cytokine maturation and secreti...
Source: International Journal of Molecular Medicine - March 24, 2023 Category: Molecular Biology Authors: Xiaolu Zhang Ziyu Wang Yujia Zheng Qun Yu Miao Zeng Liding Bai Lin Yang Maojuan Guo Xijuan Jiang Jiali Gan Source Type: research

Association of vascular and degenerative brain pathologies and past medical history from the National Alzheimer's Coordinating Center Database
We examined the following PMH: transient ischemic attack (TIA), stroke, traumatic brain injury, seizures, hypertension, cardiovascular events, hypercholesterolemia, B12 deficiency, diabetes mellitus, and thyroid disease. We dichotomized the following neuropathologies: atherosclerosis, arteriolosclerosis, cerebral amyloid angiopathy (CAA), Alzheimer disease neuropathology (ADNP), Lewy bodies (LB), hippocampal sclerosis, frontotemporal lobar degeneration (FTLD), and TAR DNA-binding protein-43 (TDP-43). Separate logistic regression models assessed the relationship between the outcome of individual neuropathologies and all PMH...
Source: Atherosclerosis - March 22, 2023 Category: Cardiology Authors: Kiana A Scambray Hannah L Nguyen S Ahmad Sajjadi Source Type: research

The forkhead box O3 (FOXO3): a key player in the regulation of ischemia and reperfusion injury
This study is a comprehensive review of the expression of FOXO3 under ischemia and reperfusion (IR) and the molecular mechanisms of its regulation and function. We found that the expression level of FOXO3 under ischemia and IR is tissue-specific. Specifically, the expression level of FOXO3 is increased in the lung and intestinal epithelial cells after IR. However, FOXO3 is downregulated in the kidney after IR and in the skeletal muscles following ischemia. Interestingly, both increased and decreased FOXO3 expression have been reported in the brain, liver, and heart following IR. Nevertheless, these contribute to stimulatin...
Source: Cellular and Molecular Life Sciences : CMLS - March 20, 2023 Category: Cytology Authors: Moussa Omorou Yiwei Huang Meng Gao Chenxi Mu Weijing Xu Yuchun Han Hui Xu Source Type: research

The role of the blood-brain barrier during neurological disease and infection
Biochem Soc Trans. 2023 Mar 17:BST20220830. doi: 10.1042/BST20220830. Online ahead of print.ABSTRACTA healthy brain is protected by the blood-brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain microenvironment and restricting pathogen and toxin entry to the brain. Dysfunction of this highly complex and regulated structure can be life threatening. BBB dysfunction is implicated in many neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis,...
Source: Biochemical Society Transactions - March 17, 2023 Category: Biochemistry Authors: Adjanie Patabendige Damir Janigro Source Type: research