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Condition: Alzheimer's
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Total 2642 results found since Jan 2013.
The role of the blood-brain barrier during neurological disease and infection
Biochem Soc Trans. 2023 Mar 17:BST20220830. doi: 10.1042/BST20220830. Online ahead of print.ABSTRACTA healthy brain is protected by the blood-brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain microenvironment and restricting pathogen and toxin entry to the brain. Dysfunction of this highly complex and regulated structure can be life threatening. BBB dysfunction is implicated in many neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis,...
Source: Biochemical Society Transactions - March 17, 2023 Category: Biochemistry Authors: Adjanie Patabendige Damir Janigro Source Type: research
Clonal Hematopoiesis of Indeterminate Potential: Current Understanding and Future Directions
This article summarizes the current knowledge about clonal hematopoiesis of indeterminate potential (CHIP), its association with cardiovascular disease (CVD), and other outcomes, pathogenesis, postulated mechanisms of various pathologies, current knowledge gaps, possible targets of intervention, and therapeutic implications.Recent FindingsRecently, a common age-related hematological entity known as CHIP has been identified as the independent risk factor for CVD. CHIP is defined as the presence of clonally expanded blood cells involving leukemogenic mutations without the evidence of malignancy. CHIP is known to increase the...
Source: Current Oncology Reports - March 16, 2023 Category: Cancer & Oncology Source Type: research
2023 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease, including prevalence and incidence, mortality and morbidity, use and costs of care, and the overall impact on family caregivers, the dementia workforce and society. The Special Report examines the patient journey from awareness of cognitive changes to potential treatment with drugs that change the underlying biology of Alzheimer's. An estimated 6.7 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060 barring the development of medical breakthroughs to prevent, slow or cure AD. Off...
Source: The Journal of Alzheimers Association - March 15, 2023 Category: Psychiatry Source Type: research
PKC ε inhibition prevents ischemia‑induced dendritic spine impairment in cultured primary neurons
In conclusion, the present study demonstrated that the PKCε/RhoA signalling pathway is a novel mechanism mediating brain ischemia-induced dendritic spine dysfunction. Developing therapeutic targets for this pathway may protect against and prevent brain ischemia-induced cognitive impairment and AD.PMID:36911376 | PMC:PMC9995843 | DOI:10.3892/etm.2023.11851
Source: Experimental and Therapeutic Medicine - March 13, 2023 Category: General Medicine Authors: Chenjie Ge Xuefeng Wang Yunhong Wang Lilei Lei Guohua Song Mincai Qian Shiliang Wang Source Type: research
Genetic Aberration Analysis of Mitochondrial Respiratory Complex I Implications in the Development of Neurological Disorders and Their Clinical Significance
Ageing Res Rev. 2023 Mar 9:101906. doi: 10.1016/j.arr.2023.101906. Online ahead of print.ABSTRACTGrowing neurological diseases pose difficult challenges for modern medicine to diagnose and manage them effectively. Many neurological disorders mainly occur due to genetic alteration in genes encoding mitochondrial proteins. Moreover, mitochondrial genes exhibit a higher rate of mutation due to the generation of Reactive oxygen species (ROS) during oxidative phosphorylation operating in their vicinity. Among the different complexes of Electron transport chain (ETC), NADH: Ubiquinone oxidoreductase (Mitochondrial complex I) is ...
Source: Ageing Research Reviews - March 11, 2023 Category: Genetics & Stem Cells Authors: Ghulam Mehdi Dar Ejaj Ahmad Asgar Ali Bhawna Mahajan Ghulam Md Ashraf Sundeep Singh Saluja Source Type: research
The effect of statins on the differentiation and function of central nervous system cells
Curr Med Chem. 2023 Mar 8. doi: 10.2174/0929867330666230308121645. Online ahead of print.ABSTRACTStatins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS), and Alzheimer's disease (AD), has received increasing attention in recent years, both within the scientific community and in the media. This review aims to provide an updated discussion on t...
Source: Current Medicinal Chemistry - March 9, 2023 Category: Chemistry Authors: Sajjad Chamani Leila Mobasheri Shadi Zerehpoosh Ali Naghizadeh Alice P McCloskey Manfredi Rizzo Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research
