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Total 2642 results found since Jan 2013.

Alzheimer's Behavioral and Psychiatric Burden in Saudi Arabia: Validation of the Saudi Version of the Neuropsychiatric Inventory
CONCLUSIONS: The SNPI is valid and reliable for assessing BPSD in Saudi AD patients. Longitudinal studies of BPSDs in Saudi specialized dementia clinics are needed.PMID:37561963 | DOI:10.1097/WAD.0000000000000563
Source: Alzheimer Disease and Associated Disorders - August 10, 2023 Category: Psychiatry Authors: Haythum O Tayeb Nadeem S Butt Roaa Khallaf Bassam Yahghmour Mohammed A Basheikh Sultan H Alamri Abrar O Baduwailan Faten Alzaben Haifa K Abdulghaffar Harold G Koenig Source Type: research

Dementia Prevalence and Risk Factors: Data From Rural Tanzania
CONCLUSIONS: The prevalence of dementia in this population is similar to a recent community-based rate in Tanzania and lower than a hospital-based rate in Senegal. This is the first time the association between visual impairment and dementia has been reported in SSA. Other associations are in keeping with previous literature.PMID:37561952 | DOI:10.1097/WAD.0000000000000564
Source: Alzheimer Disease and Associated Disorders - August 10, 2023 Category: Psychiatry Authors: Caitlin Roe Ssenku Safic Lwitiko Mwaipopo Catherine L Dotchin Joanna Klaptocz William Gray Marcyella Joseph Aimee Spector Sarah Urasa Richard W Walker Source Type: research

Where You Live Can Shape How Alzheimer ’ s Affects You
The FDA in mid-July for the first time ever approved an Alzheimer’s drug, Leqembi. The annual price-tag will run patients $26,500. The same week, the Alzheimer’s Association for the first time ever released county-level data to identify which communities are most struggling with the disease. 6.7 million Americans live with Alzheimer’s disease and 134,000 of them will die because of it each year. We’ve known these aggregate numbers for a while now, but with new data and new drugs, healthcare specialists can now better target attention and resources. [time-brightcove not-tgx=”true”] ...
Source: TIME: Health - August 7, 2023 Category: Consumer Health News Authors: Jeremy Ney Tags: Uncategorized freelance Source Type: news

The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds
Eur J Pharmacol. 2023 Aug 5:175966. doi: 10.1016/j.ejphar.2023.175966. Online ahead of print.ABSTRACTAberrant innate immunity in the brain has been implicated in the pathogenesis of several central nervous system (CNS) disorders, including Alzheimer's disease, Huntington's disease, Parkinson's disease, stroke, amyotrophic lateral sclerosis, and depression. Except for extraparenchymal CNS-associated macrophages, which predominantly afford protection against peripheral invading pathogens, it has been reported that microglia, a population of macrophage-like cells governing CNS immune defense in nearly all neurological disease...
Source: European Journal of Pharmacology - August 7, 2023 Category: Drugs & Pharmacology Authors: Hua Fan Qianqian Bai Yang Yang Xiaofei Shi Ganqin Du Junqiang Yan Jian Shi Dongmei Wang Source Type: research

NOTCH3 C201R variant causes cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) that can be confused with early-onset Alzheimer's disease
NOTCH3 is the causative gene for autosomal dominant cerebral arteriopathy with subcortical infarctions and leukoencephalopathy (CADASIL) which is associated with both stroke and dementia. When CADASIL presents primarily as dementia it can be difficult to distinguish from Alzheimer's disease (AD) at both the clinical and neuropathological levels.
Source: Journal of the Neurological Sciences - August 7, 2023 Category: Neurology Authors: Olena Korvatska, Stephanie A. Bucks, Rebecca A. Yoda, Amber Nolan, Michael O. Dorschner, Debby Tsuang, Suman Jayadev, Wendy H. Raskind, Thomas D. Bird Source Type: research

Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger associated molecular patterns (...
Source: Journal of Biomedical Science - August 7, 2023 Category: Biomedical Science Authors: Reiner Kunze, Silvia Fischer, Hugo H. Marti and Klaus T. Preissner Tags: Review Source Type: research

Development of microRNA-based therapeutics for central nervous system diseases
Eur J Pharmacol. 2023 Aug 2:175956. doi: 10.1016/j.ejphar.2023.175956. Online ahead of print.ABSTRACTMicroRNA (miRNA)-mediated gene silencing is a method of RNA interference in which a miRNA binds to messenger RNA sequences and regulates target gene expression. MiRNA-based therapeutics have shown promise in treating a variety of central nervous system diseases, as verified by results from diverse preclinical model organisms. Over the last decade, several miRNA-based therapeutics have entered clinical trials for various kinds of diseases, such as tumors, infections, and inherited diseases. However, such clinical trials for ...
Source: European Journal of Pharmacology - August 4, 2023 Category: Drugs & Pharmacology Authors: Siqi Xia Chaoran Xu Fuyi Liu Gao Chen Source Type: research

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