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Condition: Alzheimer's

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Total 2642 results found since Jan 2013.

The role of the indoles in microbiota-gut-brain axis and potential therapeutic targets: A focus on human neurological and neuropsychiatric diseases
Neuropharmacology. 2023 Aug 22:109690. doi: 10.1016/j.neuropharm.2023.109690. Online ahead of print.ABSTRACTAt present, a large number of relevant studies have suggested that the changes in gut microbiota are related to the course of nervous system diseases, and the microbiota-gut-brain axis is necessary for the proper functioning of the nervous system. Indole and its derivatives, as the products of the gut microbiota metabolism of tryptophan, can be used as ligands to regulate inflammation and autoimmune response in vivo. In recent years, some studies have found that the levels of indole and its derivatives differ signifi...
Source: Neuropharmacology - August 24, 2023 Category: Drugs & Pharmacology Authors: Yi Zhou Yue Chen Hui He Meichang Peng Meiqin Zeng Haitao Sun Source Type: research

Circular RNA ciRS-7 signature as a potential biomarker for the early detection of diabetes with Alzheimer's disease: a hypothesis
Mol Biol Rep. 2023 Aug 24. doi: 10.1007/s11033-023-08729-2. Online ahead of print.ABSTRACTIn the 1970s, Circular RNAs (CircRNAs) were first discovered in RNA viruses as viroids and were initially assumed to be RNA splicing defects. The roles and topologies of these circular RNA loops were later revealed using computer analysis and RNA-sequencing. They were found to demonstrate various functions, including protein scaffolding, parental gene regulation, microRNA sponges, and RNA-protein interactions. CircRNAs play a crucial role in controlling gene expression and are essential for biological development and illness detection...
Source: Mol Biol Cell - August 24, 2023 Category: Molecular Biology Authors: Mahima Singh Ajay Guru Raghul Murugan Muthukaruppan Gopi Jesu Arockiaraj Source Type: research

Investigation of Pancreatic-beta cells Role in the Biological Process of Ageing
CONCLUSION: Aging accelerates beta cell senescence by generating premature cell senescence, which is mostly mediated by high glucose levels. Despite higher plasma glucose levels, hepatic gluconeogenesis accelerates and adipose tissue lipolysis rises, resulting in an increase in free fatty acid levels in the blood and worsening insulin resistance throughout the body.PMID:37608675 | DOI:10.2174/1871530323666230822095932
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 23, 2023 Category: Endocrinology Authors: Rishabh Chaudhary Janvi Khanna Manni Rohilla Sumeet Gupta Seema Bansal Source Type: research

Therapeutics of Extracellular Vesicles in Cardiocerebrovascular and Metabolic Diseases
Adv Exp Med Biol. 2023;1418:187-205. doi: 10.1007/978-981-99-1443-2_13.ABSTRACTExtracellular vesicles (EVs) are nanoscale membranous vesicles containing DNA, RNA, lipids, and proteins, which play versatile roles in intercellular communications. EVs are increasingly being recognized as the promising therapeutic agents for many diseases, including cardiocerebrovascular and metabolic diseases, due to their ability to deliver functional and therapeutical molecules. In this chapter, the biological characteristics and functions of EVs are briefly summarized. Importantly, the current state of applying EVs in the prevention and tr...
Source: Advances in Experimental Medicine and Biology - August 21, 2023 Category: Research Authors: Zhitao Hou Yiyan Lin Xinyu Yang Jing Chen Guoping Li Source Type: research

Development and validation of a dementia risk score in the UK Biobank and Whitehall II cohorts
Background Current dementia risk scores have had limited success in consistently identifying at-risk individuals across different ages and geographical locations. Objective We aimed to develop and validate a novel dementia risk score for a midlife UK population, using two cohorts: the UK Biobank, and UK Whitehall II study. Methods We divided the UK Biobank cohort into a training (n=176 611, 80%) and test sample (n=44 151, 20%) and used the Whitehall II cohort (n=2934) for external validation. We used the Cox LASSO regression to select the strongest predictors of incident dementia from 28 candidate predictors and then dev...
Source: Evidence-Based Mental Health - August 21, 2023 Category: Psychiatry & Psychology Authors: Anatürk, M., Patel, R., Ebmeier, K. P., Georgiopoulos, G., Newby, D., Topiwala, A., de Lange, A.-M. G., Cole, J. H., Jansen, M. G., Singh-Manoux, A., Kivimäki, M., Suri, S. Tags: Open access, Press releases Old age psychiatry Source Type: research

Risk factors for dementia in older intensive care unit (ICU) survivors
DISCUSSION: Future studies will need to examine whether interventions targeting post-ICU stroke and depression can lower dementia incidence in ICU survivors.HIGHLIGHTS: Risk factors for post-intensive care unit (ICU) dementia were distinct from those of Alzheimer's disease. Cardiovascular risk factors were not associated with dementia in older ICU survivors. Post-ICU stroke was associated with a higher risk of dementia in older ICU survivors. Post-ICU depression was associated with a higher risk of dementia in older ICU survivors.PMID:37589315 | DOI:10.1002/alz.13423
Source: The Journal of Alzheimers Association - August 17, 2023 Category: Psychiatry Authors: Sophia Wang Anthony J Perkins Rosalyn Chi Brandon A Yates Sikandar H Khan Sujuan Gao Malaz Boustani Babar A Khan Source Type: research

Detection of Ferroptosis in Models of Brain Diseases
Methods Mol Biol. 2023;2712:233-251. doi: 10.1007/978-1-0716-3433-2_21.ABSTRACTFerroptosis is a regulated form of non-apoptotic cell death driven by iron-dependent lipid peroxidation. In the past decade, ferroptosis has been reported to be involved in the pathological role in the central nervous system degenerative diseases (e.g., Alzheimer's disease, Huntington's disease, and Parkinson's disease), stroke, traumatic brain injury, and brain tumor. However, how to reliably detect and classify ferroptosis from other cell death in pathological conditions remains a great challenge, especially in primary brain cells and brain ti...
Source: Mol Biol Cell - August 14, 2023 Category: Molecular Biology Authors: Danmin Shen Fei Yang Qian Li Source Type: research

Methods to Study Inflammasome Activation in the Central Nervous System: Immunoblotting and Immunohistochemistry
Methods Mol Biol. 2023;2696:223-238. doi: 10.1007/978-1-0716-3350-2_15.ABSTRACTThe inflammasome is a multiprotein complex that is responsible for mounting an innate immune response through the activation of caspase-1 and the cleavage of interleukin-1β. This multiprotein complex plays an important role in a variety of central nervous system (CNS) diseases and conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, and traumatic brain injury, among others. Here we describe methodological procedures to carry out immunoblotting and immunohistochemical techniques used to study inflammasome sign...
Source: Molecular Medicine - August 14, 2023 Category: Molecular Biology Authors: Brianna Cyr Juan Pablo de Rivero Vaccari Source Type: research