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Total 2642 results found since Jan 2013.

Neutrophil Extracellular Traps in Cerebral Ischemia/Reperfusion Injury: Friend and Foe
Curr Neuropharmacol. 2023 Mar 8. doi: 10.2174/1570159X21666230308090351. Online ahead of print.ABSTRACTCerebral ischemic injury, one of the leading causes of morbidity and mortality worldwide, triggers various central nervous system (CNS) diseases, including acute ischemic stroke (AIS) and chronic ischemia-induced Alzheimer's disease (AD). Currently, targeted therapies are urgently needed to address neurological disorders caused by cerebral ischemia/reperfusion injury (CI/RI), and the emergence of Neutrophil extracellular traps (NETs) may be able to relieve the pressure. Neutrophils are precursors to brain injury following...
Source: Current Neuropharmacology - March 9, 2023 Category: Drugs & Pharmacology Authors: Haoyue Luo Hanjing Guo Yue Zhou Rui Fang Wenli Zhang Zhigang Mei Source Type: research

The effect of statins on the differentiation and function of central nervous system cells
Curr Med Chem. 2023 Mar 8. doi: 10.2174/0929867330666230308121645. Online ahead of print.ABSTRACTStatins (3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) reduce plasma cholesterol and improve endothelium-dependent vasodilation, inflammation, and oxidative stress. The effect of statins on the central nervous system (CNS), particularly on cognition and neurological disorders such as cerebral ischemic stroke, multiple sclerosis (MS), and Alzheimer's disease (AD), has received increasing attention in recent years, both within the scientific community and in the media. This review aims to provide an updated discussion on t...
Source: Current Medicinal Chemistry - March 9, 2023 Category: Chemistry Authors: Sajjad Chamani Leila Mobasheri Shadi Zerehpoosh Ali Naghizadeh Alice P McCloskey Manfredi Rizzo Tannaz Jamialahmadi Amirhossein Sahebkar Source Type: research

Neuroglobin Facilitates Neuronal Oxygenation through Tropic Migration under Hypoxia or Anemia in Rat: How Does the Brain Breathe?
AbstractThe discovery of neuroglobin (Ngb), a brain- or neuron-specific member of the hemoglobin family, has revolutionized our understanding of brain oxygen metabolism. Currently, how Ngb plays such a role remains far from clear. Here, we report a novel mechanism by which Ngb might facilitate neuronal oxygenation upon hypoxia or anemia. We found that Ngb was present in, co-localized to, and co-migrated with mitochondria in the cell body and neurites of neurons. Hypoxia induced a sudden and prominent migration of Ngb towards the cytoplasmic membrane (CM) or cell surface in living neurons, and this was accompanied by the mi...
Source: Neuroscience Bulletin - March 8, 2023 Category: Neuroscience Source Type: research

Future-proofing the Profession: Physiotherapists ’ Perceptions of their Current and Emerging Role
This qualitative report is important and reflects the deeper thinking that is needed about the directions of physiotherapy as a leading established health profession [1]. As a profession we have shown less reflexivity and responsiveness to epidemiologic trends since the end of World War 2, over 70 years ago. Given the progressive increase in prevalence of chronic lifestyle-related non-communicable diseases since World War 2, namely, heart disease, cancer, hypertension, stroke, diabetes, obesity, renal disease, autoimmune diseases, and Alzheimer ’s disease and that non-invasive interventions are typically superior to drug...
Source: Physiotherapy - March 7, 2023 Category: Physiotherapy Authors: Elizabeth Dean Tags: Letter to the Editor Source Type: research

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer ’s disease mouse model and proteomics analysis
The pathophysiology of Alzheimer’s disease (AD) is multifactorial with characteristic extracellular accumulation of amyloid-beta (Aβ) and intraneuronal aggregation of hyperphosphorylated tau in the brain. Development of disease-modifying treatment for AD has been challenging. Recent studies suggest that deleterious alterations in neurovascular cells happens in parallel with Aβ accumulation, inducing tau pathology and necroptosis. Therefore, therapies targeting cellular Aβ and tau pathologies may provide a more effective strategy of disease intervention. Tetramethylpyrazine nitrone (TBN) is a nitrone derivative of tetr...
Source: Frontiers in Pharmacology - March 6, 2023 Category: Drugs & Pharmacology Source Type: research

Cognitive trajectories and incident dementia after a cardiovascular event in older adults
DISCUSSION: Findings highlight the importance of monitoring cognition after a CVD event.PMID:36856152 | DOI:10.1002/alz.13006
Source: The Journal of Alzheimers Association - March 1, 2023 Category: Psychiatry Authors: Swarna Vishwanath Ingrid Hopper Rory Wolfe Galina Polekhina Christopher M Reid Andrew M Tonkin Anne M Murray Raj C Shah Elsdon Storey Robyn L Woods John McNeil Suzanne G Orchard Mark R Nelson Claire J Steves Joanne Ryan Source Type: research

Association between seropositivity for toxocariasis and cognitive functioning in older adults: an analysis of cross-sectional data from the US National Health and Nutrition Examination Survey (NHANES), 2011-2014
Conclusions In our study, seropositive toxocariasis was independently and significantly associated with worse working memory, sustained attention, processing speed and global cognition in older adults. If this association is causal, public health measures to prevent human toxocariasis might help protect older adults’ cognitive function.
Source: BMJ Open - March 1, 2023 Category: General Medicine Authors: Song, G., Yang, C., Qu, Z., Lin, X., Liu, M., Wang, Y. Tags: Open access, Epidemiology Source Type: research

Inflammatory Bowel Disease and Neurodegenerative Diseases
Gut Liver. 2023 Feb 27. doi: 10.5009/gnl220523. Online ahead of print.ABSTRACTA growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new discoveries stem from an improved understanding of the gut-microbiome-brain axis: specifically, the ability of the intestinal microbiota to modulate inflammation and regulate neuromodulatory compounds. Clinical retrospective studies incorporating large sample sizes and population-based cohorts have demonstrated and c...
Source: Gut and Liver - February 27, 2023 Category: Gastroenterology Authors: Jin Sun Kim Mu-Hong Chen Hohui E Wang Ching-Liang Lu Yen-Po Wang Bing Zhang Source Type: research

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