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Condition: Alzheimer's
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Total 2642 results found since Jan 2013.
Microfluidic 'brain-on chip' systems to supplement neurological practice: development, applications and considerations
Regen Med. 2023 Apr 26. doi: 10.2217/rme-2022-0212. Online ahead of print.ABSTRACTAmong the greatest general challenges in bioengineering is to mimic human physiology. Advanced efforts in tissue engineering have led to sophisticated 'brain-on-chip' (BoC) microfluidic devices that can mimic structural and functional aspects of brain tissue. BoC may be used to understand the biochemical pathways of neurolgical pathologies and assess promising therapeutic agents for facilitating regenerative medicine. We evaluated the potential of microfluidic BoC devices in various neurological pathologies, such as Alzheimer's, glioblastoma,...
Source: Regenerative Medicine - May 1, 2023 Category: Genetics & Stem Cells Authors: Ryan Jarrah Karim Rizwan Nathani Shaan Bhandarkar Chibuze S Ezeudu Ryan T Nguyen Abrham Amare Usama A Aljameey Sabrina I Jarrah Archis R Bhandarkar Brian Fiani Source Type: research
Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF- κB/NLRP3 signaling pathway
In this study, lipopolysaccharide (LPS) was used to establish an inflammation model, and the therapeutic effect of TP-5 was evaluated. Behavioral tests showed that TP-5 treatment could improve the performance of LPS-treated mice in the open field and pole test, but not hanging wire test. TP-5 also attenuated neuronal lesions in the brains of LPS-treated mice. TP-5 reduced cytotoxicity and morphological changes in activated microglia. Label-free quantitative analysis indicated that the expression of multiple proteins and the activation of associated signaling pathways were altered by TP-5. Moreover, TP-5 could inhibit LPS-i...
Source: International Immunopharmacology - April 30, 2023 Category: Allergy & Immunology Authors: Si-Jia Peng Ya Feng Xuan Li Xi-Xi Wang Yu Wang Bu-Tian Zhou Ye Liu Te Liu Yun-Cheng Wu Source Type: research
Comparison of genetic and health risk factors for mild cognitive impairment and Alzheimer's disease between Hispanic and non-Hispanic white participants
DISCUSSION: APOEε2 may not be protective for AD in Hispanic participants and Hispanic participants with depression may face a higher risk for AD.HIGHLIGHTS: GAAIN allows for discovery of data sets to use in secondary analyses. APOEε2 was not protective for AD in Hispanic participants. APOEε4 was associated with fewer MCI cases in Hispanic participants. Depression was associated with more AD cases in Hispanic participants.PMID:37104247 | DOI:10.1002/alz.13110
Source: The Journal of Alzheimers Association - April 27, 2023 Category: Psychiatry Authors: Cally Xiao Ioannis Pappas Leon M Aksman Sid E O'Bryant Arthur W Toga Health and Aging Brain Study (HABS-HD) Study Team, Alzheimer's Disease Neuroimaging Initiative Source Type: research
Biogen Earnings Beat Expectations, but All Eyes Are on Alzheimer ’s Drug
The company said it was dropping a number of drug-development initiatives, including two stroke drugs.
Source: Reuters: Health - April 25, 2023 Category: Consumer Health News Source Type: news
Toll ‐like receptors in pathogenesis of neurodegenerative diseases and their therapeutic potential
AbstractToll-like receptors (TLRs) are a family of pattern-recognition receptors triggered by pathogen-derived and tissue-damage-related ligands. TLRs were previously believed to only be expressed in immune cells. However, it is now confirmed that they are ubiquitously expressed in cells within the body including neurons, astrocytes, and microglia of the central nervous system (CNS). Activation of TLRs is capable of inducing immunologic and inflammatory responses to injury or infection of CNS. This response is self-limiting that usually resolves once the infection has been eradicated or the tissue damage has been repaire...
Source: Immunity, Inflammation and Disease - April 19, 2023 Category: Allergy & Immunology Authors: Yosef Tsegaye Dabi,
Abayomi O. Ajagbe,
Sisay T. Degechisa Tags: REVIEW ARTICLE Source Type: research
Clinical diagnostic utility of transcranial magnetic stimulation in neurological disorders. Updated report of an IFCN committee
Clin Neurophysiol. 2023 Mar 29;150:131-175. doi: 10.1016/j.clinph.2023.03.010. Online ahead of print.ABSTRACTThe review provides a comprehensive update (previous report: Chen R, Cros D, Curra A, Di Lazzaro V, Lefaucheur JP, Magistris MR, et al. The clinical diagnostic utility of transcranial magnetic stimulation: report of an IFCN committee. Clin Neurophysiol 2008;119(3):504-32) on clinical diagnostic utility of transcranial magnetic stimulation (TMS) in neurological diseases. Most TMS measures rely on stimulation of motor cortex and recording of motor evoked potentials. Paired-pulse TMS techniques, incorporating conventio...
Source: Clinical Neurophysiology - April 17, 2023 Category: Neurology Authors: Steve Vucic Kai-Hsiang Stanley Chen Matthew C Kiernan Mark Hallett David H Benninger Vincenzo Di Lazzaro Paolo M Rossini Alberto Benussi Alfredo Berardelli Antonio Curr à Sandro M Krieg Jean-Pascal Lefaucheur Yew Long Lo Richard A Macdonell Marcello Mass Source Type: research
Neural Circuit Changes in Neurological Disorders: Evidence from in vivo Two-photon Imaging
Ageing Res Rev. 2023 Apr 13:101933. doi: 10.1016/j.arr.2023.101933. Online ahead of print.ABSTRACTNeural circuits, such as synaptic plasticity and neural activity, are critical components of healthy brain function. The consequent dynamic remodeling of neural circuits is an ongoing procedure affecting neuronal activities. Disruption of this essential process results in diseases. Advanced microscopic applications such as two-photon laser scanning microscopy have recently been applied to understand neural circuit changes during disease since it can visualize fine structural and functional cellular activation in living animals...
Source: Ageing Research Reviews - April 15, 2023 Category: Genetics & Stem Cells Authors: Huan Xiong Fei Tang Yujie Guo Ruxiang Xu Peng Lei Source Type: research
