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Condition: Alzheimer's
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Total 2642 results found since Jan 2013.
Genomics of aging: Reactive oxidation and inefficient mitochondria
This article, the fifth in the JAANP Genomics of Aging series, describes the role that mitochondrial dysfunction plays in the development of age-related diseases such as Alzheimer disease, Parkinson disease, cancer, heart disease, and stroke.PMID:37265351 | DOI:10.1097/JXX.0000000000000880
Source: Atherosclerosis - June 2, 2023 Category: Cardiology Authors: Kenneth Wysocki Beth Heuer Source Type: research
Does resveratrol improve cognition in humans? A scientometric study to an in-depth review
CONCLUSION: This study supports the hypothesis that chronic RES intake may positively affect brain function. But it has become challenging to determine the optimal dose, time and duration of RES and improve the bioavailability of RES, which many researchers need to overcome.PMID:37248634 | DOI:10.1111/cns.14276
Source: CNS Neuroscience and Therapeutics - May 30, 2023 Category: Neuroscience Authors: Wenling Tu Meiying Song Xiang Fan Source Type: research
Cerebrovascular disease lesions are additive and tied to vascular risk factors and cognitive impairment
Free Neuropathol. 2022;3:7. doi: 10.17879/freeneuropathology-2022-3792. Epub 2022 Mar 14.ABSTRACTCerebrovascular lesions are prevalent in late life and frequently co-occur but the relationship to cognitive impairment is complicated by the lack of consensus around which lesions represent hallmark pathologies for vascular impairment, particularly in the presence of Alzheimer's disease (AD). We developed an easily applicable model of cerebrovascular disease (CVD), defined as the presence of two or more lesions: moderate to severe cerebral amyloid angiopathy, moderate to severe arteriolosclerosis, infarcts (large, lacunar, or ...
Source: Atherosclerosis - May 30, 2023 Category: Cardiology Authors: John L Robinson Hayley Richardson Sharon X Xie Brian Alfaro Nicholas Loh Virginia M-Y Lee Edward B Lee John Q Trojanowski Source Type: research
Does resveratrol improve cognition in humans? A scientometric study to an in-depth review
CONCLUSION: This study supports the hypothesis that chronic RES intake may positively affect brain function. But it has become challenging to determine the optimal dose, time and duration of RES and improve the bioavailability of RES, which many researchers need to overcome.PMID:37248634 | DOI:10.1111/cns.14276
Source: CNS Neuroscience and Therapeutics - May 30, 2023 Category: Neuroscience Authors: Wenling Tu Meiying Song Xiang Fan Source Type: research
Preanalytical stability of plasma/serum brain-derived tau
DISCUSSION: BD-tau has equivalent diagnostic accuracies, but non-interchangeable absolute concentrations, in plasma versus serum. Furthermore, the analytical robustness is unaffected by batch-to-batch reagent variations.HIGHLIGHTS: Brain-derived tau (BD-tau) is a novel blood-based biomarker that quantifies tau protein of CNS origin. Effects of preanalytical handling procedures on the quality and reproducibility of BD-tau measures are unknown. In two cohorts of n = 105 participants, we compared BD-tau concentrations and diagnostic performances in paired plasma and serum samples, and evaluated impacts of batch-to-batch reage...
Source: The Journal of Alzheimers Association - May 26, 2023 Category: Psychiatry Authors: Fernando Gonzalez-Ortiz Alexandre Dias Michael Turton Rui Magalh ães Przemys ław R Kac Manuel Correia Peter Harrison Henrik Zetterberg Lu ís F Maia Kaj Blennow Thomas K Karikari Source Type: research
Association of Arterial Stiffness and Atherosclerotic Burden With Brain Structural Changes Among Japanese Men
Conclusions Among Japanese men, higher arterial stiffness was associated with lower Alzheimer disease signature volumes, whereas higher atherosclerotic burden was associated with brain vascular damage. Arterial stiffness and atherosclerotic burden may be independently associated with brain structural changes via different pathways.PMID:37232267 | DOI:10.1161/JAHA.122.028586
Source: Atherosclerosis - May 26, 2023 Category: Cardiology Authors: Nazar M Azahar Yuichiro Yano Aya Kadota Akihiko Shiino Ali H Syaifullah Naoko Miyagawa Keiko Kondo Mohammad Moniruzzaman Sayuki Torii Hiroyoshi Segawa Takashi Hisamatsu Akira Fujiyoshi Kazuhiko Nozaki Ikuo Tooyama Hirotsugu Ueshima Katsuyuki Miura SESSA R Source Type: research
Preanalytical stability of plasma/serum brain-derived tau
DISCUSSION: BD-tau has equivalent diagnostic accuracies, but non-interchangeable absolute concentrations, in plasma versus serum. Furthermore, the analytical robustness is unaffected by batch-to-batch reagent variations.HIGHLIGHTS: Brain-derived tau (BD-tau) is a novel blood-based biomarker that quantifies tau protein of CNS origin. Effects of preanalytical handling procedures on the quality and reproducibility of BD-tau measures are unknown. In two cohorts of n = 105 participants, we compared BD-tau concentrations and diagnostic performances in paired plasma and serum samples, and evaluated impacts of batch-to-batch reage...
Source: The Journal of Alzheimers Association - May 26, 2023 Category: Psychiatry Authors: Fernando Gonzalez-Ortiz Alexandre Dias Michael Turton Rui Magalh ães Przemys ław R Kac Manuel Correia Peter Harrison Henrik Zetterberg Lu ís F Maia Kaj Blennow Thomas K Karikari Source Type: research
Brain health and mental health: Common vascular risk factors and practical implications
Alzheimers Dement. 2023 May 22. doi: 10.1002/alz.13153. Online ahead of print.ABSTRACTThe pandemic dramatized the close links among cognitive, mental, and social health; a change in one reflects others. This realization offers the opportunity to bridge the artificial separation of brain and mental health, as brain disorders have behavioral consequences and behavioral disorders affect the brain. The leading causes of mortality and disability, namely stroke, heart disease, and dementia, share the same risk and protective factors. It is emerging that bipolar disorders, obsessive compulsive disorders, and some depressions shar...
Source: The Journal of Alzheimers Association - May 22, 2023 Category: Psychiatry Authors: Vladimir Hachinski Ennapadam Krishnamoorthy Levent Kuey Laurence J Kirmayer Source Type: research
Natural killer cells in aging and age-related diseases
Neurobiol Dis. 2023 May 18:106156. doi: 10.1016/j.nbd.2023.106156. Online ahead of print.ABSTRACTAging leads to escalated systemic inflammation. As the sentinel of immune system, natural killer (NK) cells are early responders that sense cues and signals from target organs and swiftly orchestrate local inflammation upon their arrival. Emerging evidence indicates a profound role of NK cells in the initiation and evolution of neuroinflammation in aging and age-related diseases. Here we discuss recent advances in NK cell biology and the organ-specific features of NK cells in normal brain aging, Alzheimer's disease, Parkinson's...
Source: Neurobiology of Disease - May 20, 2023 Category: Neurology Authors: Caiyun Qi Qiang Liu Source Type: research
Acrolein: formation, health hazards and its controlling by dietary polyphenols
Crit Rev Food Sci Nutr. 2023 May 19:1-14. doi: 10.1080/10408398.2023.2214625. Online ahead of print.ABSTRACTAcrolein, a highly reactive toxic aldehyde, is a common dietary and environmental contaminant which can also be generated endogenously. Exposure to acrolein has been positively associated with some pathological conditions, such as atherosclerosis, diabetes mellitus, stroke, and Alzheimer's disease. At the cellular level, acrolein induces various harmful effects, particularly protein adduction and oxidative damages. Polyphenols are a group of secondary plant metabolites ubiquitously presented in fruits, vegetables, an...
Source: Atherosclerosis - May 19, 2023 Category: Cardiology Authors: Yue Zhou Wendy Jin Qingli Wu Qian Zhou Source Type: research
Is dietary choline intake related to dementia and Alzheimer's disease risks? Results from the Framingham Heart Study
CONCLUSIONS: Low choline intake was associated with increased risks of incident dementia and AD.PMID:37208066 | PMC:PMC9630864 | DOI:10.1093/ajcn/nqac193
Source: The American Journal of Clinical Nutrition - May 19, 2023 Category: Nutrition Authors: Jing Yuan Xue Liu Chunyu Liu Alvin Fa Ang Joseph Massaro Sherral A Devine Sanford H Auerbach Jan Krzysztof Blusztajn Rhoda Au Paul F Jacques Source Type: research
