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Condition: Septic Shock

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Total 242 results found since Jan 2013.

Reaction in oral mucosa due to intensive therapy polypharmacy: case report
A 51-year-old white female patient hospitalized in the intensive care unit because of acute ischemic stroke who needed tracheostomy and vasoactive drugs in high dosage evolved with aspiration pneumonia and septic shock. At 30 days of hospitalization, intraoral examination revealed multiple superficial ulcers on the lips, buccal mucosa, tongue, and mouth floor, circumscribed by erythematous halo and covered by pseudomembrane with severe pain symptomatology and evolution of 15 days. Concomitantly, the patient presented bilateral conjunctivitis with erythema in the sclera and periocular region.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - December 15, 2019 Category: ENT & OMF Authors: ANDRESSA COUTINHO RIBEIRO, CLAUDIA CRISTIANE BAISEREDO DE CARVALHO, ANA FL ÁVIA SCHUELER DE ASSUMPÇÃO LEITE, ADRIANA TEREZINHA NEVES NOVELLINO ALVES, SIMONE DE QUEIROZ CHAVES LOURENÇO, JOSIANE COSTA RODRIGUES DE SÁ Source Type: research

An antibody against HK blocks Alzheimer’s disease peptide {beta}-amyloid-induced bradykinin release in human plasma Immunology and Inflammation
Bradykinin is a proinflammatory factor that mediates angioedema and inflammation in many diseases. It is a key player in some types of hereditary angioedema and is involved in septic shock, traumatic injury, Alzheimer’s disease (AD), and stroke, among others. Activation of the plasma contact system leads to elevated levels of...
Source: Proceedings of the National Academy of Sciences - November 11, 2019 Category: Science Authors: Zu-Lin Chen, Pradeep Singh, Jyen Wong, Katharina Horn, Sidney Strickland, Erin H. Norris Tags: Brief Reports Biological Sciences Source Type: research

Pneumocephalus and pneumorachis after blunt chest trauma without spinal fractures: a case report
ConclusionsThis is the first case report to describe pneumorachis and pneumocephalus following blunt trauma with pneumothorax, but no spinal or skull fractures. The mechanism that is probably involved here is a migration of air with subcutaneous emphysema and a pleural hernia into the spinal canal. However, in cases of pneumorachis or pneumocephalus, skull fractures need to be investigated as these require surgery and appropriate vaccination to prevent meningitis.
Source: Journal of Medical Case Reports - October 24, 2019 Category: General Medicine Source Type: research

A Blood Filter Fights Deadly Inflammatory Response
A new blood filtration technology may prove to be life-saving for patients whose normally healthy inflammatory response to injury or illness has gone into overdrive, resulting in fatally high levels of cytokines in their blood. In an interview with MD+DI, Dr. Phillip Chan, MD, PhD, CEO of CytoSorbents Corp., explained that inflammation, and the production of substances called cytokines that drive inflammation, are the body’s natural response to heal injury or infection. But sometimes, the inflammatory response is so severe in such conditions as sepsis and infection, burn injuries, trauma, pancreatitis, li...
Source: MDDI - October 9, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Cardiovascular Source Type: news

Weight! Weight! … Don’t Tell Me!
Weight-based, lifesaving medications are commonly used in hospitals and routinely used in emergency departments.1 Many weight-based medications are listed in the Institute for Safe Medication Practices (ISMP) high-alert medication list. According to ISMP, “high-alert medications are drugs that bear a heightened risk of causing significant patient harm when they are used in error.”2 These frequently used medications include anticoagulants (eg, heparin and enoxaparin), antibiotics for septic shock (eg, vancomycin and tobramycin), fibrinolytic agent s for stroke (eg, alteplase), and antiepileptic drugs (eg, phenytoin and fosphenytoin).
Source: Journal of Emergency Nursing: JEN - August 22, 2019 Category: Nursing Authors: Avani Bhalodia, Mona Hammam, Susan F. Paparella Tags: Danger Zone Source Type: research

Echocardiographic assessment of left ventricular systolic function in neonatal calves with naturally occurring sepsis or septic shock due to diarrhea
The objectives of this study were to evaluate the clinical value of echocardiography for monitoring left ventricular (LV) systolic function in septic calves. A prospective longitudinal study was performed using a convenience sample. Twenty septic calves and 10 healthy calves were enrolled in the study. Arterial blood pressure (BP) was measured and M-mode echocardiography performed to characterize LV systolic function; the latter included measurement of ejection fraction, EF; stroke volume, SVI and cardiac output indexed to body weight, CI; E-point of septal separation, EPSS; pre-ejection period, PEP; ejection time, LVET; r...
Source: Research in Veterinary Science - August 6, 2019 Category: Veterinary Research Source Type: research

“A contemporary description of staphylococcus aureus prosthetic valve endocarditis. Differences according to the time elapsed from surgery”
Staphylococcus aureus prosthetic valve endocarditis (SAPVE) has a poor prognosis. There are no large series that accurately describe this entity. This is a retrospective observational study on a prospective cohort from 3 Spanish reference hospitals for cardiac surgery, including 78 definitive episodes of left SAPVE between 1996 and 2016. Fifty percent had a Charlson Index score>5; 53% were health care-related. Twenty percent did not present fever. Complications at diagnosis included: severe heart failure (HF, 29%), septic shock (SS, 17.9%), central nervous system abnormalities (19%), septic metastasis (4%). Hemorrhagic s...
Source: Medicine - August 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Prevalence, risk factors and outcomes of patients coming from the community with sepsis due to multidrug resistant bacteria
ConclusionIn light of the prevalence and impact of MDR bacteria causing sepsis in patients coming from the community, physicians should consider ESBL coverage when starting an empiric antibiotic therapy in patients with specific risk factors, especially in the presence of septic shock.
Source: Multidisciplinary Respiratory Medicine - July 4, 2019 Category: Respiratory Medicine Source Type: research

Are Patients Who Undergo THA for Infection at Higher Risk for 30-day Complications?
CONCLUSIONS: Patients undergoing revision THA for infection undergo reoperation and experience major complications more frequently in a 30-day episode of care than patients undergoing aseptic revision THA. Without risk adjustment to existing alternative payment and quality reporting models, providers may experience a disincentive to care for patients with infected THAs, who may face difficulties with access to care. LEVEL OF EVIDENCE: Level III, therapeutic study. PMID: 31268424 [PubMed - in process]
Source: Clinical Orthopaedics and Related Research - June 30, 2019 Category: Orthopaedics Authors: Boniello AJ, Lieber AM, Courtney PM Tags: Clin Orthop Relat Res Source Type: research

Beyond Triage and Resuscitation: Optimizing Care for the Critically Ill Emergency Department Patient
During my last shift in the emergency department (ED), I assumed care at sign-out of an intubated patient with an acute asthma exacerbation as well as a patient with cardiogenic pulmonary edema who was receiving noninvasive ventilation. Shortly thereafter, prehospital personnel brought us a patient with respiratory failure due to emphysema who needed to be intubated, followed by a patient having an acute stroke who would receive thrombolytics, followed by a patient with hypotension who would later require pressors for septic shock.
Source: Emergency Medicine Clinics of North America - June 29, 2019 Category: Emergency Medicine Authors: Amal Mattu Tags: Foreword Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Boerhaave’s syndrome: a case report of damage control approach
ConclusionPrompt diagnosis with thoracic drainage and a damage control treatment plan might lead to good prognosis for patients with this rare and potentially fatal condition.
Source: International Journal of Surgery Case Reports - April 20, 2019 Category: Surgery Source Type: research

Pentraxin 3 in Cardiovascular Disease
Giuseppe Ristagno1*, Francesca Fumagalli1, Barbara Bottazzi2, Alberto Mantovani2,3,4, Davide Olivari1, Deborah Novelli1 and Roberto Latini1 1Department of Cardiovascular Research, Mario Negri Institute for Pharmacological Research IRCCS, Milan, Italy 2Humanitas Clinical and Research Center-IRCCS, Milan, Italy 3Humanitas University, Milan, Italy 4The William Harvey Research Institute, Queen Mary University of London, London, United Kingdom The long pentraxin PTX3 is a member of the pentraxin family produced locally by stromal and myeloid cells in response to proinflammatory signals and microbial moieties. The p...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier
We examined a possible protective effect of OX-A against LPS-induced ROS formation and microglia activation. To mimic in vitro the connection between gut and brain and to study the putative effect on the cortical microglia, we used a co-culture of Caco-2 cells and primary cortical microglia with Caco-2 cells placed at the apical side of a transwell and primary cortical microglia at the basolateral side. All treatments used to study the apical vs. basal connection were applied to the apical compartment. We used DHR (10 μM, 20 min), a cell-permeable fluorogenic probe useful for the detection of ROS formation, to dete...
Source: Frontiers in Endocrinology - April 9, 2019 Category: Endocrinology Source Type: research

A Study of Convulsive Status Epilepticus Cases in Indonesia
Publication date: Available online 14 March 2019Source: Epilepsy & Behavior Case ReportsAuthor(s): Machlusil Husna, K. Shahdevi Nandar, Risma Karlina Prabawati, Siti NurlaelaAbstractStatus epilepticus (SE) is a serious health issue in developing countries, with high morbidity and mortality rates of 3%–46%. There are two types of SE, convulsive status epilepticus (CSE) and non-convulsive status epilepticus. The most common type, CSE, is easy to detect but, in several cases, the patients are diagnosed too late to be properly treated and hospitalized. The present study therefore investigated the clinical manifestations of C...
Source: Epilepsy and Behavior Case Reports - March 16, 2019 Category: Neurology Source Type: research