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Condition: Septic Shock

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Total 242 results found since Jan 2013.

Addition of terlipressin to norepinephrine in septic shock and effect of renal perfusion: a pilot study
CONCLUSIONS: Terlipressin improves renal perfusion, increases stroke volume, and decreases norepinephrine dose and heart rates in patients with septic shock.PMID:35856162 | PMC:PMC9307113 | DOI:10.1080/0886022X.2022.2095286
Source: Renal Failure - July 20, 2022 Category: Urology & Nephrology Authors: Jinlong Wang Mengjuan Shi Lili Huang Qing Li Shanshan Meng Jingyuan Xu Ming Xue Jianfeng Xie Songqiao Liu Yingzi Huang Source Type: research

Benefits of esmolol in adults with sepsis and septic shock: An updated meta-analysis of randomized controlled trials
Conclusions: Esmolol treatment may be safe and effective in decreasing 28-day mortality, controlling heart rate, and providing cardioprotective function, but has no effect on lung injury in patients with sepsis or septic shock after early fluid resuscitation. Improvement in cardiac function may be related to changes in serum inflammatory mediators. No significant adverse effects on tissue perfusion and oxygen utilization were observed.
Source: Current Awareness Service for Health (CASH) - July 15, 2022 Category: Consumer Health News Source Type: news

A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era*
CONCLUSIONS: Maintenance-only fluid therapy normalized clinical and myocardial perturbations in shock without compromising cardiac or hemodynamic function whereas fluid-bolus management of WHO shock resulted in high fatality. Troponin and lactate biomarkers of cardiac dysfunction could be promising outcome predictors in pediatric septic shock in resource-limited settings.
Source: Pediatric Critical Care Medicine - July 1, 2022 Category: Pediatrics Tags: Feature Articles Source Type: research

The impact of hypoalbuminemia on postoperative outcomes after outpatient surgery: a national analysis of the NSQIP database
CONCLUSIONS: Hypoalbuminemia is associated with major complications and death in outpatient surgery. Since hypoalbuminemia is a potential modifiable intervention, future clinical trials to evaluate the impact of optimizing preoperative albumin levels before outpatient surgery are warranted.PMID:35761062 | DOI:10.1007/s12630-022-02280-7
Source: Canadian Journal of Anaesthesia - June 27, 2022 Category: Anesthesiology Authors: Sean Curran Patricia Apruzzese Mark C Kendall Gildasio De Oliveira Source Type: research

Characteristics of hemodynamic parameters after fluid resuscitation and vasoactive drugs administration in pediatric shock: A prospective observational study
CONCLUSIONS: Most pediatric shock patients were hypodynamic. Even when the CI was normal, the preload, inotropy, and afterload may still be abnormal. It represented the inotropy as a key to hemodynamic.PMID:35495407 | PMC:PMC9052134 | DOI:10.1016/j.amsu.2022.103521
Source: Annals of Medicine - May 2, 2022 Category: Internal Medicine Authors: Saptadi Yuliarto Antonius H Pudjiadi Abdul Latief Source Type: research

RANKL Impairs the TLR4 Pathway by Increasing TRAF6 and RANK Interaction in Macrophages
In this study, we investigated the crosstalk between RANK and TLR4 pathways in macrophages stimulated with both RANKL and LPS to unveil the role of OPG in inflammatory processes. We found that RANKL inhibits TLR4 activation by binding to RANK, promoting the binding between TRAF6 and RANK, lowering TLR4 activation and the expression of proinflammatory mediators. Furthermore, high OPG levels aggravate inflammation by inhibiting RANKL. Our findings elect RANKL as a candidate for drug development as a way to mitigate the impact of obesity-induced inflammation in patients.PMID:35463988 | PMC:PMC9019442 | DOI:10.1155/2022/7740079
Source: Biomed Res - April 25, 2022 Category: Research Authors: Ryerson Fonseca Mota Paulo Henrique Cavalcanti de Ara újo Maria Eduarda Ramos Cezine Fl ávia Sayuri Matsuo Rodrigo Jair Morandi Metzner Carlos Alberto Oliveira de Biagi Junior Kamila Chagas Peronni Hiroki Hayashi Munehisa Shimamura Hironori Nakagami Mar Source Type: research

Esmolol response in septic shock patients in relation to vascular waterfall phenomenon measured by critical closure pressure and mean systemic filling pressure: a prospective observational study
ConclusionPatients with septic shock whose heart rate is greater than 95 beats/min after hemodynamic optimization were treated with esmolol, which could effectively control heart rate and reduce CI, as well as improve Pcc and increase the difference between Pcc and Pmsf (known as “vascular waterfall” phenomenon), without affecting MAP, CVP, Pmsf and arteriovenous vascular resistance, and improve the balance of oxygen supply and demand in the body.
Source: Journal of Intensive Care - January 4, 2022 Category: Intensive Care Source Type: research