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Condition: Septic Shock

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Total 242 results found since Jan 2013.

Passive leg raising test with minimally invasive monitoring: the way forward for guiding septic shock resuscitation?
ConclusionsThe passive leg raising maneuver in combination with real-time measurement of cardiac output changes is an easy-to-use, fast, relatively unbiased, and accurate bedside test to guide fluid management during septic shock.
Source: Journal of Intensive Care - June 8, 2017 Category: Intensive Care Source Type: research

Deriving literature-based benchmarks for surgical complications in high-income countries: a protocol for a systematic review and meta-analysis
This study of secondary data does not require ethics approval. It will be presented internationally and published in the peer-reviewed literature. Results will inform a future quality improvement tool and provide benchmarks of surgical complication rates within HICs. Trial registration International Prospective Register of Systematic Reviews (PROSPERO). Registration number CRD42016037519.
Source: BMJ Open - May 9, 2017 Category: General Medicine Authors: Brindle, M. E., Roberts, D. J., Daodu, O., Haynes, A. B., Cauley, C., Dixon, E., La Flamme, C., Bain, P., Berry, W. Tags: Open access, Health policy Protocol Source Type: research

Impact of Dobutamine in Patients With Septic Shock: A Meta-Regression Analysis
Septic shock frequently requires vasopressor agents. Conflicting evidence exists for use of inotropes in patients with septic shock. Data from English studies on human adult septic shock patients were collected. A total of 83 studies were reviewed, while 11 studies with 21 data sets including 239 patients were pooled for meta-regression analysis. For VO2, pooled difference in means (PDM) was 0.274. For cardiac index (CI), PDM was 0.783. For delivery of oxygen, PDM was −0.890. For heart rate, PDM was −0.714. For left ventricle stroke work index, PDM was 0.375. For mean arterial pressure, PDM was −0.204. For mean pulmo...
Source: American Journal of Therapeutics - May 1, 2017 Category: Drugs & Pharmacology Tags: Therapeutic Reviews Source Type: research

Cor Triatriatum and Stroke: A Case Report and Review of Literature (P3.294)
Conclusions:This is the largest review of CTS cases with associated stroke. The review showed neuroimaging results consistent with a cardioembolic mechanism. All but two of the cases made use of anticoagulation. Three cases underwent surgery. This case has the longest follow-up and the first to demonstrate failure of anti-platelet therapy and anticoagulation. The need for further investigations regarding optimal stroke prevention in this subset of patients is emphasized.Disclosure: Dr. Diestro has nothing to disclose. Dr. Espiritu has nothing to disclose. Dr. Dorotan has nothing to disclose. Dr. Regalado has nothing to dis...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Diestro, J. D., Espiritu, A., Dorotan, M. K., Regalado, J., Pascual, J. L. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Extracorporeal membrane oxygenation in critically ill neonates and children.
Abstract Extracorporeal membrane oxygenation is used as a last resort during neonatal and pediatric resuscitation in case of refractory circulatory or respiratory failure under maximum conventional therapies. Different types of ECMO can be used depending on the initial failure. The main indications for ECMO are refractory respiratory failure (acute respiratory distress syndrome, status asthmaticus, severe pneumonia, meconium aspiration syndrome, pulmonary hypertension) and refractory circulatory failure (cardiogenic shock, septic shock, refractory cardiac arrest). The main contraindications are a gestational age u...
Source: Archives de Pediatrie - April 14, 2017 Category: Pediatrics Authors: Rambaud J, Guilbert J, Guellec I, Jean S, Durandy A, Demoulin M, Amblard A, Carbajal R, Leger PL Tags: Arch Pediatr Source Type: research

Opportunities for the repurposing of PARP inhibitors for the therapy of non ‐oncological diseases
We present a preclinical and clinical action plan for the repurposing of PARP inhibitors.
Source: British Journal of Pharmacology - March 26, 2017 Category: Drugs & Pharmacology Authors: Nathan A Berger, Valerie C Besson, A Hamid Boulares, Alexander B ürkle, Alberto Chiarugi, Robert S Clark, Nicola J Curtin, Salvatore Cuzzocrea, Ted M Dawson, Valina L Dawson, György Haskó, Lucas Liaudet, Flavio Moroni, Pál Pacher, Peter Radermacher, A Tags: REVIEW ARTICLE THEMED ISSUE Source Type: research

Changes in B-type natriuretic peptide and related hemodynamic parameters following a fluid challenge in critically ill patients with severe sepsis or septic shock
Conclusions: An increase in BNP soon after a fluid challenge may have some predictive utility of a large LVEDd, which in turn can be used to independently predict the SV response to a fluid challenge.
Source: Indian Journal of Critical Care Medicine - March 8, 2017 Category: Intensive Care Authors: Shahed Omar Ahmad Ali Yahya Atiya Rudo Lufuno Mathivha Joel M Dulhunty Source Type: research

Safety and efficacy of natalizumab in patients with acute ischaemic stroke (ACTION): a randomised, placebo-controlled, double-blind phase 2 trial
Publication date: March 2017 Source:The Lancet Neurology, Volume 16, Issue 3 Author(s): Jacob Elkins, Roland Veltkamp, Joan Montaner, S Claiborne Johnston, Aneesh B Singhal, Kyra Becker, Maarten G Lansberg, Weihua Tang, Ih Chang, Kumar Muralidharan, Sarah Gheuens, Lahar Mehta, Mitchell S V Elkind Background In animal models of acute ischaemic stroke, blocking of the leukocyte-endothelium adhesion by antagonism of α4 integrin reduces infarct volumes and improves outcomes. We assessed the effect of one dose of natalizumab, an antibody against the leukocyte adhesion molecule α4 integrin, in patients with acute ischaemic st...
Source: The Lancet Neurology - February 15, 2017 Category: Neurology Source Type: research

Major publications in the critical care pharmacotherapy literature in 2015.
CONCLUSION: Important recent additions to the critical care pharmacy literature include updated joint clinical practice guidelines on the management of spontaneous ICH, ACLS, and SVT. PMID: 28122702 [PubMed - as supplied by publisher]
Source: American Journal of Health-System Pharmacy : AJHP - January 24, 2017 Category: Drugs & Pharmacology Authors: Wong A, Erdman M, Hammond DA, Holt T, Holzhausen JM, Horng M, Huang LL, Jarvis J, Kram B, Kram S, Lesch C, Mercer J, Rech MA, Rivosecchi R, Stump B, Teevan C, Day S Tags: Am J Health Syst Pharm Source Type: research

Predicting Fluid Responsiveness in Acute Liver Failure: A Prospective Study.
CONCLUSIONS: PPV based on pulse contour analysis predicted fluid responsiveness in ALF. PMID: 27984249 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - December 13, 2016 Category: Anesthesiology Authors: Audimoolam VK, McPhail MJ, Willars C, Bernal W, Wendon JA, Cecconi M, Auzinger G Tags: Anesth Analg Source Type: research

Ischemic Stroke and Septic Shock After Subacute Endocarditis Caused by Haemophilus parainfluenzae: Case Report.
Abstract Haemophilus parainfluenzae, which belongs to the HACEK (Haemophilus ssp, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, and Kingella kingae) group, is a rare cause of subacute endocarditis and may lead to ischemic stroke. A 65-year-old female patient previously diagnosed with rheumatic valve disease was submitted to surgical mitral valve repair in 1996. Physical examination did not reveal any murmurs; physical examination of the lungs and abdomen was normal. The patient was admitted to hospital with progressive dyspnea, dry cough, and fever. Transesophageal echocardiog...
Source: Clin Med Res - December 8, 2016 Category: Research Authors: Menegueti MG, Machado-Viana J, Gaspar GG, Nicolini EA, Basile-Filho A, Auxiliadora-Martins M Tags: J Clin Med Res Source Type: research

A Rational Approach to Fluid Therapy in Sepsis
(Abstracted from Br J Anaesth, 116:339–349, 2016) The current standard of care for managing patients with severe sepsis and septic shock is aggressive fluid resuscitation, until a central venous pressure of greater than 8 mm Hg is achieved. The rationale behind this approach is to increase a patient’s stroke volume, which in turn improves cardiac output and organ perfusion.
Source: Survey of Anesthesiology - November 19, 2016 Category: Anesthesiology Tags: Critical Care Source Type: research

Time interval between infective endocarditis first symptoms and diagnosis: relationship to infective endocarditis characteristics, microorganisms and prognosis.
CONCLUSIONS: The time interval between IE first symptoms and diagnosis is closely related to the IE clinical presentation, patient characteristics and causative microorganism. Better prognosis reported in late-diagnosed IE may be related to a higher rate of valvular surgery. KEY MESSAGES Infective endocarditis, which time interval between first symptoms and diagnosis was less than one month, were mainly due to Staphylococcus aureus in France. Staphylococcus aureus infective endocarditis were associated with septic shock, transient ischemic attack or stroke and higher mortality rates than infective endocarditis due to other...
Source: Annals of Medicine - November 5, 2016 Category: Internal Medicine Tags: Ann Med Source Type: research

The effects of neoadjuvant therapy on morbidity and mortality of esophagectomy for esophageal cancer: American college of surgeons national surgical quality improvement program (ACS –NSQIP) 2005–2012
ConclusionsWe conclude that neoadjuvant therapy followed by esophagectomy for esophageal cancer does not have a negative impact on 30‐day mortality. Neoadjuvant therapy is associated with increased odds of PE. J. Surg. Oncol. © 2016 Wiley Periodicals, Inc.
Source: Journal of Surgical Oncology - November 3, 2016 Category: Cancer & Oncology Authors: Michel J. Sabra, Carmen Smotherman, Dale F. Kraemer, Michael S. Nussbaum, Joseph J. Tepas, Ziad T. Awad Tags: Research Article Source Type: research

Fluid responsiveness prediction using Vigileo FloTrac measured cardiac output changes during passive leg raise test
ConclusionsCO changes measured by the Vigileo ™ monitor using third-generation software during a PLR test predict fluid responsiveness in mixed medical and surgical patients withvasopressor-dependent circulatory shock.
Source: Journal of Intensive Care - October 5, 2016 Category: Intensive Care Source Type: research