Online Abstract Translations
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Abstract Translations Source Type: research

Bereaved Caregiver Perspectives on the End of Life in Pediatric Patients With Ventricular Assist Devices
CONCLUSIONS: Bereaved families’ perspectives provide insight into quality decision-making for major interventions and end-of-life care in pediatric patients with chronic illness who face decisions regarding technology dependence. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Brief Reports Source Type: research

Outcomes of Critically Ill Children With Acute Lymphoblastic Leukemia and Cytokine Release Syndrome Due to Chimeric Antigen Receptor T Cell Therapy: US, Multicenter PICU, Cohort Database Study
CONCLUSIONS: PICU patients with CRS frequently received a high level of support, and the majority survived their PICU stay and hospitalization. Additional multicenter investigations of severe CRS are necessary to inform evidence-based practice. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Brief Reports Source Type: research

Proton Pump Inhibitor Use and Associated Infectious Complications in the PICU: Propensity Score Matching Analysis
CONCLUSIONS: This study highlights the prevalent use of PPIs in the PICU, and the potential association between PPIs and nine-fold greater odds of NI is not excluded. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Brief Reports Source Type: research

Routine Perioperative Esmolol After Infant Tetralogy of Fallot Repair: Single-Center Retrospective Study of Hemodynamics
CONCLUSIONS: In this infant cohort, our experience is that the routine use of postoperative esmolol is associated with good cardiac output with minimal requirement for vasoactive support in most patients. We believe optimal postoperative management of infant TOF repair requires a meticulous multidisciplinary approach, which in our experience is enhanced with routine postoperative esmolol treatment. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research

Pediatric Reference Change Value Optimized for Acute Kidney Injury: Multicenter Retrospective Study in China
OBJECTIVES: The standard definition of pediatric acute kidney injury (AKI) is evolving, especially for critically ill in the PICU. We sought to validate the application of the Pediatric Reference Change Value Optimized for Acute Kidney Injury in Children (pROCK) criteria in critically ill children. DESIGN: Multicenter retrospective study. SETTING: Six PICUs in mainland China. PATIENTS: One thousand six hundred seventy-eight hospitalized children admitted to the PICU with at least two creatinine values within 7 days. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: AKI was diagnosed...
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Decreases in Nephrotoxic Pain Medications Are Not Associated With Increased Opioid Utilization in Critically Ill Children
CONCLUSIONS: The NINJA intervention was efficaciously implemented in our single-center PICU. Nephrotoxic exposure is a modifiable factor that did not inadvertently increase exposure to opioids and benzodiazepines. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock
CONCLUSIONS: This article is the first to describe increased MDSCs in children with septic shock, along with an association between early increase in MDSCs and adverse OD outcomes in this population. It remains unclear if MDSCs play a causative role in sepsis-induced immune suppression in children. Additional studies are warranted to establish MDSC as a potential therapeutic target. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Hemostasis Proteins in Invasive Meningococcal and Nonmeningococcal Infections: A Prospective Multicenter Study
OBJECTIVES: We aimed to describe the variation of hemostasis proteins in children with bacterial infections due to different pathogens (Neisseria meningitidis, Streptococcus pneumoniae, Staphylococcus aureus, and group A streptococcus [GAS]) and to study hemostasis proteins in relation to mortality. DESIGN: Preplanned analysis in prospective cohort study. SETTING: Hospitals in five European countries (Austria, The Netherlands, Spain, Switzerland, and the United Kingdom). PATIENTS: Admitted children (2012–2016) with community-acquired infections due to meningococci (n = 83), pneumococci (n = 64), ...
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Risk Stratifying Febrile Children in the Emergency Department: An Ongoing Challenge*
No abstract available (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Editorial Source Type: research

Commentary on the First-Line Support for Assistance in Breathing in Children Trials on Noninvasive Respiratory Support: Taking a Closer Look
Noninvasive respiratory support modalities such as high-flow nasal cannula (HFNC) therapy and continuous positive airway pressure (CPAP) are used frequently in pediatric critical care to support acutely ill children with respiratory failure (step-up management) and children following extubation (step-down management). Although there are several observational studies and database analyses comparing the efficacy of HFNC and CPAP, and a few small randomized clinical trials (RCTs), until recently, there were no large RCTs comparing the two modalities in a mixed group of critically ill children. In the first half of 2022, resul...
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: PCCM Trials Source Type: research

Commentary on High-Flow Nasal Cannula and Continuous Positive Airway Pressure Practices After the First-Line Support for Assistance in Breathing in Children Trials
Continuous positive airway pressure (CPAP) and heated humidified high-flow nasal cannula (HFNC) are commonly used to treat children admitted to the PICU who require more respiratory support than simple oxygen therapy. Much has been published on these two treatment modalities over the past decade, both in Pediatric Critical Care Medicine (PCCM) and elsewhere. The majority of these studies are observational analyses of clinical, administrative, or quality improvement datasets and, therefore, are only able to establish associations between exposure to treatment and outcomes, not causation. None of the initial randomized clini...
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: PCCM Trials Source Type: research

The United Kingdom Paediatric Critical Care Society Study Group: The 20-Year Journey Toward Pragmatic, Randomized Clinical Trials
Over the past two decades, pediatric intensive care research networks have been formed across North America, Europe, Asia, and Australia/New Zealand. The U.K. Paediatric Critical Care Society Study Group (PCCS-SG) has over a 20-year tradition of fostering collaborative research, leading to the design and successful conduct of randomized clinical trials (RCTs). To date, the PCCS-SG network has delivered 13 different multicenter RCTs, covering a spectrum of study designs, methodologies, and scale. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Mini Symposium Source Type: research

Pediatric Acute Lung Injury and Sepsis Investigators (PALISI): Evolution of an Investigator-Initiated Research Network
The Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network originated over 20 years ago to foster research to optimize the care of critically ill infants and children. Over this period, PALISI has seen two major evolutions: formalization of our network infrastructure and a broadening of our clinical research focus. First, the network is unique in that its activities and meetings are funded by subscriptions from members who now comprise a multidisciplinary group of investigators from over 90 PICUs all over the United States (US) and Canada, with collaborations across the globe. In 2020, the network converted ...
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Mini Symposium Source Type: research

Evolution of the Collaborative Pediatric Critical Care Research Network
This article describes the history of CPCCRN, discusses its financial and organizational structure, illustrates how funds were efficiently used to carry out studies, and describes CPCCRN public use datasets and future directions, concluding with the development of the PeRsonalizEd Immunomodulation in PediatriC SepsIS-InducEd MODS study. (Source: Pediatric Critical Care Medicine)
Source: Pediatric Critical Care Medicine - December 1, 2022 Category: Pediatrics Tags: Mini Symposium Source Type: research