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Drug: Dexamethasone

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Total 197 results found since Jan 2013.

Class I Lysine Deacetylases Promote Glucocorticoid-induced Transcriptional Repression through Functional Interaction with LSD1
Publication date: Available online 16 September 2016 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Nina M. Patrick, Chanel A. Griggs, Ali L. Icenogle, Maryam M. Gilpatrick, Vineela Kadiyala, Rosa Jaime-Frias, Catharine L. Smith Small molecule inhibitors of lysine deacetylases (KDACs) are approved for clinical use in treatment of several diseases. Nuclear receptors, such as the glucocorticoid receptor (GR) use lysine acetyltransferases (KATs or HATs) and KDACs to regulate transcription through acetylation and deacetylation of protein targets such as histones. Previously we have shown that KDAC...
Source: The Journal of Steroid Biochemistry and Molecular Biology - September 16, 2016 Category: Biochemistry Source Type: research

LATE-BREAKING ABSTRACT: MUC1 downregulation induces corticosteroid resistance in asthma's in vitro and in vivo models
Conclusion: MUC1 downregulation may lack the anti-inflammatory effects of corticosteroids in Asthma.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Morell, A., Bel, E., Milara, J., Morcillo, E., Cortijo, J. Tags: 5.1 Airway Pharmacology and Treatment Source Type: research

FGF Suppresses Poldip2 Expression in Osteoblasts
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - December 4, 2016 Category: Biochemistry Authors: Sakie Katsumura, Yayoi Izu, Takayuki Yamada, Kathy Griendling, Kiyoshi Harada, Masaki Noda, Yoichi Ezura Tags: Article Source Type: research

Activation of GR but not PXR by Dexamethasone Attenuated Acetaminophen Hepatotoxicities via Fgf21 Induction.
In conclusion, via GR activation, DEX induced Fgf21 expression in mouse liver and human hepatoma cells. PMID: 28088388 [PubMed - as supplied by publisher]
Source: Toxicology - January 10, 2017 Category: Toxicology Authors: Vispute SG, Bu P, Le Y, Cheng X Tags: Toxicology Source Type: research

Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells
In conclusion, these data suggest that dexamethasone increases MKP-1 expression and th is results in the suppression of p38 MAPK signaling leading to the inhibition of cytokine production in human bronchial epithelial cells. These results point to the role of MKP-1 as an important factor in the therapeutic effects of glucocorticoids in the treatment of inflammatory lung diseases.
Source: Inflammation Research - March 14, 2017 Category: Research Source Type: research

Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice
In conclusion, our data suggest that paracrine PAI-1 is involved in GC-induced muscle wasting through the enhancement of muscle degradation in mice.
Source: Journal of Bone and Mineral Metabolism - March 19, 2017 Category: Orthopaedics Source Type: research

Vertebrate Lonesome Kinase Regulated Extracellular Matrix Protein Phosphorylation, Cell Shape, and Adhesion in Trabecular Meshwork Cells
Glaucoma, a leading cause of irreversible blindness, is commonly associated with elevated intraocular pressure (IOP) due to impaired aqueous humor (AH) drainage through the trabecular meshwork (TM). Although dysregulated production and organization of extracellular matrix (ECM) is presumed to increase resistance to AH outflow and elevate IOP by altering TM cell contractile and adhesive properties, it is not known whether regulation of ECM protein phosphorylation via the secretory vertebrate lonesome kinase (VLK) influences TM cellular characteristics. Here, we tested this possibility. Experiments carried out in this study ...
Source: Journal of Cellular Physiology - March 27, 2017 Category: Cytology Authors: Rupalatha Maddala, Nikolai P. Skiba, Ponugoti Vasantha Rao Tags: Original Research Article Source Type: research

MAPK Signaling has Stage-dependent Osteogenic Effects on Human Adipose-derived Stem Cells in vitro.
CONCLUSIONS: It is likely that MAPK signaling plays a significant role in ASC osteogenesis, affecting differentiation in kinase- and stage-specific manners. PMID: 28398098 [PubMed - as supplied by publisher]
Source: Connective Tissue Research - April 13, 2017 Category: Research Tags: Connect Tissue Res Source Type: research

Retinoic acid increases glucocorticoid receptor phosphorylation via cyclin-dependent kinase 5
Publication date: Available online 3 May 2017 Source:Molecular and Cellular Neuroscience Author(s): Julie Brossaud, Hélène Roumes, Jean-Christophe Helbling, Marie-Pierre Moisan, Véronique Pallet, Guillaume Ferreira, Essi-Fanny Biyong, Anabelle Redonnet, Jean-Benoît Corcuff Glucocorticoid receptor (GR) function is modulated by phosphorylation. As retinoic acid (RA) can activate some cytoplasmic kinases able to phosphorylate GR, we investigated whether RA could modulate GR phosphorylation in neuronal cells in a context of long-term glucocorticoid exposure. A 4-day treatment of dexamethasone (Dex) plus RA, showed that RA...
Source: Molecular and Cellular Neuroscience - May 4, 2017 Category: Neuroscience Source Type: research

Heme oxygenase-1 mediates anti-adipogenesis effect of raspberry ketone in 3T3-L1 cells
Conclusion : RK may exert anti-adipogenic effects through modulation of the HO-1/Wnt/beta-catenin signaling pathway. Graphical abstract
Source: Phytomedicine - May 22, 2017 Category: Drugs & Pharmacology Source Type: research

FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression.
Abstract Pyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation and a critical regulator of metabolic flexibility during the fasting to feeding transition. PDH is regulated via both PDH kinases (PDHK), and PDH phosphatases, which phosphorylate/inactivate and dephosphorylate/activate PDH, respectively. Our goal was to determine whether the transcription factor, forkhead box O1 (FoxO1) regulates PDH activity and glucose oxidation in the heart via increasing expression of Pdk4, the gene encoding PDHK4. To address this question, we differentiated H9c2 myoblasts into cardiac myocytes and modulat...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 7, 2017 Category: Physiology Authors: Gopal K, Saleme B, Al Batran R, Aburasayn H, Eshreif A, Ho KL, Ma WK, Almutairi M, Eaton F, Gandhi M, Park EA, Sutendra G, Ussher JR Tags: Am J Physiol Heart Circ Physiol Source Type: research

11 β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids.
11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids. Biochem Biophys Res Commun. 2017 Jul 08;: Authors: Zhang H, Zhou F, Pan Z, Bu X, Wang Y, Chen F Abstract The aim of the present study was to confirm the role of 11β-hydroxysteroid dehydrogenases type 2(11β-HSD-2) in steroid induced osteonecrosis of the femoral head(SANFH). We cultured mouse bone-like cells (MLO-Y4) and mouse osteoblast-like cells (MC3T3-E1). After overexpressed 11β-HSD-2 successfully, we induced cell apoptosis by dexamethasone (DXM). The level of cell apoptosis, the expres...
Source: Biochemical and Biophysical Research communications - July 8, 2017 Category: Biochemistry Authors: Zhang H, Zhou F, Pan Z, Bu X, Wang Y, Chen F Tags: Biochem Biophys Res Commun Source Type: research

Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
Publication date: Available online 10 August 2017 Source:Steroids Author(s): Wei Yang, Xiaomin Kang, Na Qin, Feng Li, Xinxin Jin, Zhengmin Ma, Zhuang Qian, Shufang Wu Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in osteoarthritis patients, which is occasionally accompanied with the serious side effects of glucocorticoids in collagen-producing tissue. Melatonin is the major hormone released from the pineal gland and its beneficial effects on cartilage has been suggested. In the present study, we investigated the protective role of melatonin on matrix degeneration in chondrocytes ind...
Source: Steroids - August 10, 2017 Category: Drugs & Pharmacology Source Type: research

Glucocorticoids regulate MiR-29c levels in vascular smooth muscle cells through transcriptional and epigenetic mechanisms
The objective of this study was to determine the underlying mechanism by which glucocorticoids (GCs) induce of miR-29c expression in vascular smooth muscle cells. Main methods QRT-PCR was used for miR-29c detection. Protein levels were determined by western blotting. Knockdown of SP1, DNMT1 and DNMT3A was achieved through transfection with their specific respective siRNAs. The effect of GCs on SP1 activity was determined by luciferase reporter assay and the methylation status in miR-29c promoter was detected by methylation specific PCR. CHIP assay was used to determine the binding ability of SP1 and glucocorticoid receptor...
Source: Life Sciences - August 12, 2017 Category: Biology Source Type: research

FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression
Pyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation and a critical regulator of metabolic flexibility during the fasting to feeding transition. PDH is regulated via both PDH kinases (PDHK) and PDH phosphatases, which phosphorylate/inactivate and dephosphorylate/activate PDH, respectively. Our goal was to determine whether the transcription factor forkhead box O1 (FoxO1) regulates PDH activity and glucose oxidation in the heart via increasing the expression of Pdk4, the gene encoding PDHK4. To address this question, we differentiated H9c2 myoblasts into cardiac myocytes and modulated FoxO1 activit...
Source: AJP: Heart and Circulatory Physiology - September 1, 2017 Category: Cardiology Authors: Gopal, K., Saleme, B., Al Batran, R., Aburasayn, H., Eshreif, A., Ho, K. L., Ma, W. K., Almutairi, M., Eaton, F., Gandhi, M., Park, E. A., Sutendra, G., Ussher, J. R. Tags: RESEARCH ARTICLE Source Type: research