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Drug: Dexamethasone
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Total 197 results found since Jan 2013.
Abstract 3964: NVP-BEZ235 enhances dexamethasone-induced BIM expression and apoptosis in models of T-ALL with PTEN dysfunction and increased PI3K/AKT activity
Introduction: Glucocorticoid (GC) resistance presents a major challenge in pediatric acute lymphoblastic leukemia (ALL) treatment. Increased activation of the PI3K/AKT pathway, which may occur following loss of PTEN function, may be a possible mechanism of GC resistance. We therefore investigated the effects of inhibiting the PI3K/AKT pathway with the dual PI3K/mTOR inhibitor NVP-BEZ235 on the enhancement of dexamethasone activity in in vitro and in vivo models of ALL and the role the PI3K/AKT pathway plays in resistance to GCs.
Methods: Cytotoxicity of NVP-BEZ235, dexamethasone, and the combination were evaluated using DI...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Hall, C., Kang, M. Tags: Tumor Biology Source Type: research
Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
CONCLUSION: IL-37 inhibits CpG-ODN-mediated inflammatory responses through regulation of a TRAF6-NF-κB pathway in human macrophages.PMID:34672136 | DOI:10.3349/ymj.2021.62.11.1023
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seong-Kyu Kim Jung-Yoon Choe Ki-Yeun Park Source Type: research
