Suppression of cytokine production by glucocorticoids is mediated by MKP-1 in human lung epithelial cells

In conclusion, these data suggest that dexamethasone increases MKP-1 expression and th is results in the suppression of p38 MAPK signaling leading to the inhibition of cytokine production in human bronchial epithelial cells. These results point to the role of MKP-1 as an important factor in the therapeutic effects of glucocorticoids in the treatment of inflammatory lung diseases.
Source: Inflammation Research - Category: Research Source Type: research