Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice
Publication date: Available online 2 July 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Chaitanya Chakravarthi Gali, Elham Fanaee-Danesh, Martina Zandl-Lang, Nicole Maria Albrecher, Carmen Tam-Amersdorfer, Anika Stracke, Vinay Sachdev, Florian Reichmann, Yidan Sun, Afrim Avdili, Marielies Reiter, Dagmar Kratky, Peter Holzer, Achim Lass, Karunya K. Kandimalla, Ute PanzenboeckAbstractAberrant insulin signaling constitutes an early change in Alzheimer's disease (AD). Insulin receptors (IR) and low-density lipoprotein receptor-related protein-1 (LRP-1) are expressed in brain capillary endothelial cells (BCEC) formi...
Source: Molecular and Cellular Neuroscience - July 3, 2019 Category: Neuroscience Source Type: research

Modulating proteoglycan receptor PTPσ using intracellular sigma peptide improves remyelination and functional recovery in mice with demyelinated optic chiasm
Publication date: Available online 2 July 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Parvin Niknam, Mohammad Reza Raoufy, Yaghoub Fatholahi, Mohammad JavanAbstractMultiple sclerosis (MS) is an autoimmune disease characterized by myelin and axonal damage in the central nervous system (CNS). Glial scar which is a hallmark of MS contains repair inhibitory molecules including chondroitin sulfate proteoglycans (CSPGs). CSPGs inhibit repair of damaged area through various receptors including protein tyrosine phosphatase sigma (PTPσ). In the current study we use intracellular sigma peptide (ISP), an inhibitor...
Source: Molecular and Cellular Neuroscience - July 3, 2019 Category: Neuroscience Source Type: research

Mitochondrial dynamics and transport in Alzheimer's disease
Publication date: Available online 16 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Padraig J. Flannery, Eugenia TrushinaAbstractMitochondrial dysfunction is now recognized as a contributing factor to the early pathology of multiple human conditions including neurodegenerative diseases. Mitochondria are signaling organelles with a multitude of functions ranging from energy production to a regulation of cellular metabolism, energy homeostasis, stress response, and cell fate. The success of these complex processes critically depends on the fidelity of mitochondrial dynamics that include the ability of mitoch...
Source: Molecular and Cellular Neuroscience - June 18, 2019 Category: Neuroscience Source Type: research

A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4.2 trafficking
Publication date: Available online 15 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): G. Travis Tabor, Jung M. Park, Jonathan G. Murphy, Jia-Hua Hu, Dax A. HoffmanAbstractKv4.2 voltage-gated K+ channel subunits, the primary source of the somatodendritic A-type K+ current in CA1 pyramidal neurons of the hippocampus, play important roles in regulating dendritic excitability and plasticity. To better study the trafficking and subcellular distribution of Kv4.2, we created and characterized a novel Kv4.2 construct encoding a bungarotoxin binding site in the extracellular S3–S4 linker region of the α-s...
Source: Molecular and Cellular Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research

PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking
Publication date: Available online 16 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Eva Troyano-Rodriguez, Shivani Mann, Raja Ullah, Mohiuddin AhmadAbstractAMPA-type glutamate receptors (AMPAR) are one of the principal mediators of fast excitatory synaptic transmission in the brain. These receptors associate with multiple integral membrane proteins which influence their trafficking and channel properties. Proline-rich transmembrane protein 1 (PRRT1) is a membrane protein and an understudied component of native AMPAR complexes. In order to understand the regulation of AMPARs by PRRT1, we have performed elec...
Source: Molecular and Cellular Neuroscience - June 17, 2019 Category: Neuroscience Source Type: research

Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA)
Publication date: Available online 14 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Wen-Ning Zhao, Norma K. Hylton, Jennifer Wang, Peter S. Chindavong, Begum Alural, Iren Kurtser, Aravind Subramanian, Ralph Mazitschek, Roy H. Perlis, Stephen J. HaggartyAbstractA subset of individuals with major depressive disorder (MDD) elects treatment with complementary and alternative medicines (CAMs), including the omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Previous studies in rodents suggests that DHA modulates neurodevelopmental processes, including adult neurogenesis and neuropla...
Source: Molecular and Cellular Neuroscience - June 14, 2019 Category: Neuroscience Source Type: research

BDNF elevates the axonal levels of hnRNPs Q and R in cultured rat cortical neurons
Publication date: Available online 14 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Hui-Wen Chung, Ju-Chen Weng, Chih-En King, Chih-Fan Chuang, Wei-Yuan Chow, Yen-Chung ChangAbstractLocal translation plays important roles in the maintenance and various functions of axons, and dysfunctions of local translation in axons are implicated in various neurological diseases. Heterogeneous nuclear ribonucleoproteins (hnRNPs) are RNA binding proteins with multiple functions in RNA metabolism. Here, we identified 20 hnRNPs in the axons of cultured rat cortical neurons by interrogating published axon mass spectrometric...
Source: Molecular and Cellular Neuroscience - June 14, 2019 Category: Neuroscience Source Type: research

Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration
Publication date: Available online 12 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Glen Acosta, Nicholas Race, Seth Herr, Joseph Fernandez, Jonathan Tang, Edmond Rogers, Riyi ShiAbstractSurvivors of blast-induced traumatic brain injury (bTBI) have increased susceptibility to Parkinson's disease (PD), characterized by α-synuclein aggregation and the progressive degeneration of nigrostriatal dopaminergic neurons. Using an established bTBI rat model, we evaluated the changes of α-synuclein and tyrosine hydroxylase (TH), known hallmarks of PD, and acrolein, a reactive aldehyde and marker of oxidat...
Source: Molecular and Cellular Neuroscience - June 14, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: June 2019Source: Molecular and Cellular Neuroscience, Volume 97Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - June 12, 2019 Category: Neuroscience Source Type: research

mir-234 controls neuropeptide release at the Caenorhabditis elegans neuromuscular junction
Publication date: Available online 12 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Goda Snieckute, Oguzhan Baltaci, Haowen Liu, Lei Li, Zhitao Hu, Roger PocockAbstractmiR-137 is a highly conserved microRNA (miRNA) that is associated with the control of brain function and the etiology of psychiatric disorders including schizophrenia and bipolar disorder. The Caenorhabditis elegans genome encodes a single miR-137 ortholog called mir-234, the function of which is unknown. Here we show that mir-234 is expressed in a subset of sensory, motor and interneurons in C. elegans. Using a mir-234 deletion strain, we s...
Source: Molecular and Cellular Neuroscience - June 12, 2019 Category: Neuroscience Source Type: research

1H NMR profiling of the 6-OHDA parkinsonian rat brain reveals metabolic alterations and signs of recovery after N-acetylcysteine treatment
Publication date: Available online 12 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Ana Virel, Ilona Dudka, Rutger Laterveer, Sara af BjerkénAbstractParkinson's disease is the second most common neurodegenerative disease caused by degeneration of dopamine neurons in the substantia nigra. The origin and causes of dopamine neurodegeneration in Parkinson's disease are not well understood but oxidative stress may play an important role in its onset. Much effort has been dedicated to find biomarkers indicative of oxidative stress and neurodegenerative processes in parkinsonian brains. By using 1H NMR (nu...
Source: Molecular and Cellular Neuroscience - June 12, 2019 Category: Neuroscience Source Type: research

Embryonic and postnatal development of mouse olfactory tubercle
Publication date: Available online 11 June 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Eduardo Martin-Lopez, Christine Xu, Teresa Liberia, Sarah J. Meller, Charles A. GreerAbstractThe olfactory tubercle (OT) is located in the ventral-medial region of the brain where it receives primary input from olfactory bulb (OB) projection neurons and processes olfactory behaviors related to motivation, hedonics of smell and sexual encounters. The OT is part of the dopamine reward system that shares characteristics with the striatum. Together with the nucleus accumbens, the OT has been referred to as the “ventral st...
Source: Molecular and Cellular Neuroscience - June 11, 2019 Category: Neuroscience Source Type: research

Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene
Publication date: Available online 31 May 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Toshihiko Shirafuji, Haruo Shimazaki, Tatsuhiro Miyagi, Takehiko Ueyama, Naoko Adachi, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio SakaiAbstractSpinocerebellar ataxia type 14 (SCA14) is an autosomal dominant neurodegenerative disorder characterized by cerebellar ataxia with myoclonus, dystonia, spasticity, and rigidity. Although missense mutations and a deletion mutation have been found in the protein kinase C gamma (PRKCG) gene encoding protein kinase C γ (PKCγ) in SCA14 families, a nonsense mutation has not...
Source: Molecular and Cellular Neuroscience - June 1, 2019 Category: Neuroscience Source Type: research

Disease signatures: Biomarkers/indicators of neurodegeneration
Publication date: Available online 25 May 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Henrik Zetterberg, Mathias Bähr (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 26, 2019 Category: Neuroscience Source Type: research

Hippocampal sub-regional differences in the microRNA response to forebrain ischemia
The objective of the present study was to assess and compare post-injury miRNA profiles between CA1 and DG using a rat model of forebrain ischemia. CA1 and DG sub-regions were dissected from rat hippocampi following 10 min of forebrain ischemia at three time points (3 h, 24 h, and 72 h) and at baseline. Pronounced differences between CA1 and DG were observed for several select miRNAs, including miR-181a-5p, a known regulator of cerebral ischemic injury. We complexed fluorescent in situ hybridization with immunohistochemistry to observe cell-type specific and temporal differences in mir-181a-5p expression between CA...
Source: Molecular and Cellular Neuroscience - May 23, 2019 Category: Neuroscience Source Type: research

Exposing immature hippocampal neurons to excitotoxins reveals distinct transcriptome and protein regulation with induction of common survival signaling pathways
Publication date: Available online 11 May 2019Source: Molecular and Cellular NeuroscienceAuthor(s): L.K. Friedman, N. Osei-tutu, B. ZhangAbstractEarly life traumas lead to neuroprotection by preconditioning mechanisms. To determine which genes and pathways are most likely involved in specific adaptive effects, immature hippocampal cultures were exposed to a single high dose of glutamate (250 μM), NMDA (100 μM), or KA (300 μM) for 48 h (5–7 DIV) based on our prior “two hit” in vitro model of preconditioning. Transcriptome profiling and immunocytochemistry of gene candidates were performed ...
Source: Molecular and Cellular Neuroscience - May 12, 2019 Category: Neuroscience Source Type: research

Loss of EPAC2 alters dendritic spine morphology and inhibitory synapse density
In this study we sought to further understand the cellular consequences of knocking out Epac2 on the development of neuronal and synaptic structure and organization of cortical neurons. Using primary cortical neurons generated from Epac2+/+ or Epac2−/− mice, we confirm that EPAC2 is required for cAMP-dependent spine shrinkage. Neurons from Epac2−/− mice also displayed increased synaptic expression of GluA2/3-containing AMPA receptors, as well as of the adhesion protein N-cadherin. Intriguingly, analysis of excitatory and inhibitory synaptic proteins revealed that loss of EPAC2 resulted in altered ex...
Source: Molecular and Cellular Neuroscience - May 4, 2019 Category: Neuroscience Source Type: research

Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration
Publication date: Available online 24 April 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Maria Gomez, Doris GermainAbstractThe mitochondrial unfolded protein response (UPRmt) is rapidly gaining attention. While the CHOP (ATF4/5) axis of the UPRmt was the first to be described, other axes have subsequently been reported. Validation of this complex pathway in C. elegans has been extensively studied. However, validation of the UPRmt in mouse models of disease known to implicate mitochondrial reprogramming or dysfunction, such as cancer and neurodegeneration, respectively, is only beginning to emerge. This review ...
Source: Molecular and Cellular Neuroscience - April 24, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: April 2019Source: Molecular and Cellular Neuroscience, Volume 96Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 18, 2019 Category: Neuroscience Source Type: research

Klotho deficiency affects the spine morphology and network synchronization of neurons
Publication date: Available online 13 April 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Hai T. Vo, Mary L. Phillips, Jeremy H. Herskowitz, Gwendalyn D. KingAbstractKlotho-deficient mice rapidly develop cognitive impairment and show some evidence of the onset of neurodegeneration. However, it is impossible to investigate the long-term consequences on the brain because of the dramatic shortening of lifespan caused by systemic klotho deficiency. As klotho expression is downregulated with advancing organismal age, understanding the mechanisms of klotho action is important for developing novel strategies to suppor...
Source: Molecular and Cellular Neuroscience - April 15, 2019 Category: Neuroscience Source Type: research

An FTLD-associated SQSTM1 variant impacts Nrf2 and NF-κB signalling and is associated with reduced phosphorylation of p62
Publication date: Available online 4 April 2019Source: Molecular and Cellular NeuroscienceAuthor(s): A. Foster, D. Scott, R. Layfield, S.L. ReaAbstractElevated oxidative stress has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). In response to oxidative stress, the Nrf2 transcription factor activates protective antioxidant genes. A critical regulator of Nrf2 is the inhibitory protein Keap1, which mediates Nrf2 degradation. In response to cellular stress an interaction between Keap1 and SQSTM1/p62 (p62), a signalling adaptor protein, allows for increas...
Source: Molecular and Cellular Neuroscience - April 5, 2019 Category: Neuroscience Source Type: research

Modulation of Cav2.3 channels by unconjugated bilirubin (UCB) – Candidate mechanism for UCB-induced neuromodulation and neurotoxicity
Publication date: Available online 12 March 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Walid Albanna, Jan Niklas Lüke, Gerrit Alexander Schubert, Maxine Dibué-Adjei, Konstantin Kotliar, Jürgen Hescheler, Hans Clusmann, Hans-Jakob Steiger, Daniel Hänggi, Marcel A. Kamp, Toni Schneider, Felix NeumaierAbstractElevated levels of unbound unconjugated bilirubin (UCB) can lead to bilirubin encephalopathy and kernicterus. In spite of a large number of studies demonstrating UCB-induced changes in central neurotransmission, it is still unclear whether these effects involve alterations in the func...
Source: Molecular and Cellular Neuroscience - March 14, 2019 Category: Neuroscience Source Type: research

Small molecules as therapeutic drugs for Alzheimer's disease
This article discusses advantages and disadvantages of small molecules, their ability to mitigate Aβ induced damage, and ability to ameliorate synaptic dysfunction and cognitive loss. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - March 12, 2019 Category: Neuroscience Source Type: research

Growth and excitability at synapsin II deficient hippocampal neurons
Publication date: Available online 9 March 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Heidi Matos, Raymond Quiles, Rodrigo Andrade, Maria BykhovskaiaAbstractSynapsins are neuronal phosphoproteins that fine-tune synaptic transmission and suppress seizure activity. Synapsin II (SynII) deletion produces epileptic seizures and overexcitability in neuronal networks. Early studies in primary neuronal cultures have shown that SynII deletion results in a delay in synapse formation. More recent studies at hippocampal slices have revealed increased spontaneous activity in SynII knockout (SynII(−)) mice. To recon...
Source: Molecular and Cellular Neuroscience - March 10, 2019 Category: Neuroscience Source Type: research

Fluid and imaging biomarkers for Huntington's disease
Publication date: Available online 23 February 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Paul Zeun, Rachael I. Scahill, Sarah J. Tabrizi, Edward J. WildAbstractHuntington's disease is a chronic progressive neurodegenerative condition for which there is no disease-modifying treatment. The known genetic cause of Huntington's disease makes it possible to identify individuals destined to develop the disease and instigate treatments before the onset of symptoms. Multiple trials are already underway that target the cause of HD, yet clinical measures are often insensitive to change over typical clinical trial dura...
Source: Molecular and Cellular Neuroscience - February 25, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: March 2019Source: Molecular and Cellular Neuroscience, Volume 95Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - February 22, 2019 Category: Neuroscience Source Type: research

Synaptic vesicle protein 2A as a potential biomarker in synaptopathies
Publication date: Available online 20 February 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Kerstin Heurling, Nicholas J. Ashton, Antoine Leuzy, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Jonas Eriksson, Mark Lubberink, Michael SchöllAbstractMeasuring synaptic density in vivo using positron emission tomography (PET) imaging-based biomarkers targeting the synaptic vesicle protein 2A (SV2A) has received much attention recently due to its potential research and clinical applications in synaptopathies, including neurodegenerative and psychiatric diseases. Fluid-based biomarkers in proteinopathies have...
Source: Molecular and Cellular Neuroscience - February 21, 2019 Category: Neuroscience Source Type: research

Taxifolin protects neurons against ischemic injury in vitro via the activation of antioxidant systems and signal transduction pathways of GABAergic neurons
Publication date: Available online 15 February 2019Source: Molecular and Cellular NeuroscienceAuthor(s): M.V. Turovskaya, S.G. Gaidin, V.N. Mal'tseva, V.P. Zinchenko, E.A. TurovskyAbstractCerebral blood flow disturbances lead to the massive death of brain cells. The death of>80% of cells is observed in hippocampal cell cultures after 40 min of oxygen and glucose deprivation (ischemia-like conditions, OGD). However, there are some populations of GABAergic neurons which are characterized by increased vulnerability to oxygen-glucose deprivation conditions. Using fluorescent microscopy, immunocytochemical assay, vitality ...
Source: Molecular and Cellular Neuroscience - February 17, 2019 Category: Neuroscience Source Type: research

Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy
Publication date: Available online 13 February 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Mariana Oliveira Mendes, Alexandra Isabel Rosa, Andreia Neves Carvalho, Maria João Nunes, Pedro Dionísio, Elsa Rodrigues, Daniela Costa, Sara Duarte-Silva, Patrícia Maciel, Cecília Maria Pereira Rodrigues, Maria João Gama, Margarida Castro-CaldasAbstractParkinson's disease (PD) is a progressive neurological disorder, mainly characterized by the progressive loss of dopaminergic neurons in the Substantia nigra pars compacta (SNpc) and by the presence of intracellular inclusions, known as...
Source: Molecular and Cellular Neuroscience - February 14, 2019 Category: Neuroscience Source Type: research

CPEB1 is overexpressed in neurons derived from Down syndrome IPSCs and in the hippocampus of the mouse model Ts1Cje
Publication date: Available online 11 February 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Juan José Casañas, Macarena González-Corrales, Jesús David Urbano-Gámez, Alexandra Alves-Sampaio, José Antonio Troca-Marín, María Luz MontesinosAbstractTrisomy 21, also known as Down syndrome (DS), is the most frequent genetic cause of intellectual impairment. In mouse models of DS, deficits in hippocampal synaptic plasticity have been observed, in conjunction with alterations to local dendritic translation that are likely to influence plasticity, learning and memo...
Source: Molecular and Cellular Neuroscience - February 12, 2019 Category: Neuroscience Source Type: research

Sympathomimetics regulate neuromuscular junction transmission through TRPV1, P/Q- and N-type Ca2+ channels
Publication date: Available online 11 February 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Anna Zaia Carolina Rodrigues, Zhong-Min Wang, María Laura Messi, Osvaldo DelbonoAbstractIncreasing evidence indicates that, first, the sympathetic nervous system interacts extensively with both vasculature and skeletal muscle fibers near neuromuscular junctions (NMJs) and, second, its neurotransmitter, noradrenaline, influences myofiber molecular composition and function and motor innervation. Since sympathomimetic agents have been reported to improve NMJ transmission, we examined whether two in clinical use, sal...
Source: Molecular and Cellular Neuroscience - February 12, 2019 Category: Neuroscience Source Type: research

APP depletion alters selective pre- and post-synaptic proteins
Publication date: Available online 11 February 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Isak Martinsson, Estibaliz Capetillo-Zarate, Mathilde Faideau, Katarina Willén, Noemi Esteras, Susanne Frykman, Lars O. Tjernberg, Gunnar K. GourasAbstractThe normal role of Alzheimer's disease (AD)-linked amyloid precursor protein (APP) in the brain remains incompletely understood. Previous studies have reported that lack of APP has detrimental effects on spines and electrophysiological parameters. APP has been described to be important in synaptic pruning during development. The effect of APP knockout on mature...
Source: Molecular and Cellular Neuroscience - February 12, 2019 Category: Neuroscience Source Type: research

Interleukin-16 inhibits sodium channel function and GluA1 phosphorylation via CD4- and CD9-independent mechanisms to reduce hippocampal neuronal excitability and synaptic activity
We examined the mechanisms underlying these effects, with rIL-16 reducing GluA1 S831 phosphorylation and inhibiting Na+ channel function. Taken together, these data suggest that IL-16 reduces neuronal excitability and synaptic activity via multiple mechanisms and adds further evidence that alternative receptors may exist for IL-16. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - February 7, 2019 Category: Neuroscience Source Type: research

Stem cells in animal models of Huntington disease: A systematic review
Publication date: Available online 24 January 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Gabriela Delevati Colpo, Erin Furr Stimming, Antonio Lucio TeixeiraAbstractHuntington's disease (HD) is an autosomal-dominant neurodegenerative disorder encoding a mutant form of the huntingtin protein (HTT). HD is pathologically characterized by loss of neurons in the striatum and cortex, which leads to progressive motor dysfunction, cognitive decline and behavioral symptoms. Stem cell-based therapy has emerged as a feasible therapeutic approach for the treatment of neurodegenerative diseases and may be effective in all...
Source: Molecular and Cellular Neuroscience - January 24, 2019 Category: Neuroscience Source Type: research

Norepinephrine control of ventromedial hypothalamic nucleus glucoregulatory neurotransmitter expression in the female rat: Role of monocarboxylate transporter function
Publication date: Available online 17 January 2019Source: Molecular and Cellular NeuroscienceAuthor(s): A.S.M. Hasan Mahmood, Santosh K. Mandal, Khaggeswar Bheemanapally, Mostafa M.H. Ibrahim, K.P. BriskiAbstractThe ventromedial hypothalamic nucleus (VMN) is a critical component of the neural circuitry that regulates glucostasis. Astrocyte glycogen is a vital reserve of glucose and its oxidizable metabolite L-lactate. In hypoglycemic female rats, estradiol-dependent augmentation of VMN glycogen phosphorylase (GP) protein requires hindbrain catecholamine input. The research here investigated the premise that norepinephrine ...
Source: Molecular and Cellular Neuroscience - January 18, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: January 2019Source: Molecular and Cellular Neuroscience, Volume 94Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - January 8, 2019 Category: Neuroscience Source Type: research

Alteration of parvalbumin expression and perineuronal nets formation in the cerebral cortex of aged mice
This study suggests that the RSG of aged mice is in an abnormal activated state. RSG function abnormality may be part of the cognitive decline mechanism. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - January 3, 2019 Category: Neuroscience Source Type: research

siRNA-mediated knockdown of B3GALT4 decreases GM1 ganglioside expression and enhances vulnerability for neurodegeneration
Publication date: Available online 3 January 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Megha Verma, Jay S. SchneiderAbstractReduced levels of brain gangliosides GD1a, GD1b, GT1b and to a lesser extent GM1 have been found in substantia nigra (SN) from Parkinson's disease (PD) patients, along with decreased gene expression for key enzymes (B3Galt4, St3gal2) involved in synthesis of these gangliosides. Based on these observations, the present study examined the extent to which decreased expression of B3GALT4 mRNA and resulting decreased levels of GM1 ganglioside in dopaminergic cells may increase the vulnerabi...
Source: Molecular and Cellular Neuroscience - January 3, 2019 Category: Neuroscience Source Type: research

Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease
Publication date: Available online 28 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Ha-Lim Song, Atanas Vladimirov Demirev, Na-Young Kim, Dong-Hou Kim, Seung-Yong YoonAbstractThe number of neurofibrillary tangles containing abnormal hyperphosphorylated tau protein correlates with the degree of dementia in Alzheimer's disease (AD). In addition, autophagosome accumulation and disturbance of autophagy, the process by which toxic aggregate proteins are degraded in the cytosol, are also found in AD models. These indicate that regulation of the autophagy-lysosome system may be a potential therapeutic target ...
Source: Molecular and Cellular Neuroscience - December 28, 2018 Category: Neuroscience Source Type: research

Impairment of chaperone-mediated autophagy affects neuronal homeostasis through altered expression of DJ-1 and CRMP-2 proteins
In this study, we have manipulated CMA function through alterations of LAMP2A abundance of utilizing primary rat cortical neurons, to identify potential changes to the neuronal proteome occurring prior to actual toxic effects. We have identified a list of proteins with significant,>2-fold change in abundance following our manipulations, of which PARK7/DJ-1 – an anti-oxidant implicated in hereditary forms of Parkinson's Disease (PD), and DPYSL2/CRMP-2 – a microtubule-binding phosphoprotein involved in schizophrenia pathogenesis – were both found to have measurable effects on neuronal homeostasis and phe...
Source: Molecular and Cellular Neuroscience - December 15, 2018 Category: Neuroscience Source Type: research

Cerebrospinal fluid biomarker for Parkinson's disease: An overview
In conclusion, technical advancements in the field already yielded promising results, but further multicenter trials with well-defined cohorts, standardized protocols and integrated data analysis of different modalities are needed before successful translation into routine clinical application. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - December 10, 2018 Category: Neuroscience Source Type: research

Fluid and PET biomarkers for amyloid pathology in Alzheimer's disease
Publication date: Available online 8 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Ann D. Cohen, Susan M. Landau, Beth E. Snitz, William E. Klunk, Kaj Blennow, Henrik ZetterbergAbstractAlzheimer's disease (AD) is characterized by amyloid plaques and tau pathology (neurofibrillary tangles and neuropil threads). Amyloid plaques are primarily composed of aggregated and oligomeric β-amyloid (Aβ) peptides ending at position 42 (Aβ42). The development of fluid and PET biomarkers for Alzheimer's disease (AD), has allowed for detection of Aβ pathology in vivo and marks a major advancement i...
Source: Molecular and Cellular Neuroscience - December 8, 2018 Category: Neuroscience Source Type: research

Biomarkers for tau pathology
Publication date: Available online 7 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Michael Schöll, Anne Maass, Niklas Mattsson, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, William JagustAbstractThe aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80% of all dementia disorders, the most common neurodegenerative disorders. These so-called tauopathies are hitherto not curable and their diagnosis, especially at early disease stages, has traditionally proven difficult. A keystone in the diagnosis of tauopathies was the develo...
Source: Molecular and Cellular Neuroscience - December 7, 2018 Category: Neuroscience Source Type: research

Melanocortin 4 receptor activation protects striatal neurons and glial cells from 3-nitropropionic acid toxicity
Publication date: Available online 4 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Julieta Saba, Lila Carniglia, Delia Ramírez, Juan Turati, Mercedes Imsen, Daniela Durand, Mercedes Lasaga, Carla CarusoAbstractα-Melanocyte stimulating hormone (α-MSH) is a melanocortin which exerts potent anti-inflammatory and anti-apoptotic effects. Melanocortin 4 receptors (MC4R) are abundantly expressed in the brain and we previously demonstrated that [Nle(4), D-Phe(7)]melanocyte-stimulating hormone (NDP-MSH), an α-MSH analogue, increased expression of brain derived-neurotrophic factor (BDNF)...
Source: Molecular and Cellular Neuroscience - December 5, 2018 Category: Neuroscience Source Type: research

Review: Fluid biomarkers in the human prion diseases
Publication date: Available online 4 December 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Andrew G.B. Thompson, Simon H. MeadAbstractThe human prion diseases are a diverse set of often rapidly progressive neurodegenerative conditions associated with abnormal forms of the prion protein. We review work to establish diagnostic biomarkers and assays that might fill other important roles, particularly those that could assist the planning and interpretation of clinical trials. The field now benefits from highly sensitive and specific diagnostic biomarkers using cerebrospinal fluid: detecting by-products of rapid ne...
Source: Molecular and Cellular Neuroscience - December 5, 2018 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2018Source: Molecular and Cellular Neuroscience, Volume 93Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - November 17, 2018 Category: Neuroscience Source Type: research

Cyclo(His-Pro) inhibits NLRP3 inflammasome cascade in ALS microglial cells
In this study we used hSOD1(G93A) microglial cells to investigate the effects of the antioxidant and anti-inflammatory cyclic dipeptide (His-Pro) on LPS-induced inflammasome activation. We found that cyclo(His-Pro) inhibits NLRP3 inflammasome activation by reducing protein nitration via reduction in NO and ROS levels, indicative of lower peroxynitrite generation by LPS. Low levels in peroxynitrite are related to NF-κB inhibition responsible for iNOS down-regulation and NO dampening. On the other hand, cyclo(His-Pro)-mediated ROS attenuation, not linked to Nrf2 activation in this cellular model, is ascribed to increas...
Source: Molecular and Cellular Neuroscience - November 14, 2018 Category: Neuroscience Source Type: research

Interaction of nectin-2α with the auxiliary protein of the voltage-gated A-type K+ channel Kv4.2 dipeptidyl aminopeptidase-like protein at the boundary between the adjacent somata of clustered cholinergic neurons in the medial habenula
Publication date: Available online 5 November 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Hajime Shiotani, Muneaki Miyata, Kiyohito Mizutani, Shujie Wang, Akira Mizoguchi, Hideki Mochizuki, Kenji Mandai, Yoshimi TakaiAbstractThe medial habenula (MHb) receives septal inputs and sends efferents to the interpeduncular nucleus and is implicated in stress, depression, memory, and nicotine withdrawal syndrome. We previously showed by immunofluorescence microscopy that the cell adhesion molecule nectin-2α is expressed in the cholinergic neurons in the developing and adult mouse MHbs and localized at the bounda...
Source: Molecular and Cellular Neuroscience - November 6, 2018 Category: Neuroscience Source Type: research

Biomarkers for diseases with TDP-43 pathology
Publication date: Available online 3 November 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Petra Steinacker, Peggy Barschke, Markus OttoAbstractThe discovery that aggregated transactive response DNA-binding protein 43 kDa (TDP-43) is the major component of pathological ubiquitinated inclusions in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) caused seminal progress in the unveiling of the genetic bases and molecular characteristics of these now so-called TDP-43 proteinopathies. Substantial increase in the knowledge of clinic-pathological coherencies, especially for FTLD var...
Source: Molecular and Cellular Neuroscience - November 4, 2018 Category: Neuroscience Source Type: research

Strain differences in hippocampal synaptic dysfunction in the TgCRND8 mouse model of Alzheimer's disease: Implications for improving translational capacity
Publication date: Available online 4 November 2018Source: Molecular and Cellular NeuroscienceAuthor(s): Wanda M. Snow, Kensuke Oikawa, Jelena Djordjevic, Benedict C. AlbensiAbstractIn Alzheimer's disease (AD), characterized by cognitive deterioration, synaptic alterations are frequently reported. The TgCRND8 model, in which mice develop AD-like amyloid β plaque formation, has been used to investigate the effects of amyloidosis on synaptic function. Background strain impacts the behavioral and neuropathological phenotype of mice in this model, but whether this extends to synaptic function is unknown. We investigated th...
Source: Molecular and Cellular Neuroscience - November 4, 2018 Category: Neuroscience Source Type: research