Decoding Parkinson's disease – iPSC-derived models in the OMICs era
Publication date: Available online 18 May 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Florian Krach, Marios-Evangelos Bogiongko, Beate Winner (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 19, 2020 Category: Neuroscience Source Type: research

Leptin stimulates synaptogenesis in hippocampal neurons via KLF4 and SOCS3 inhibition of STAT3 signaling
Publication date: Available online 11 May 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Gulcan Semra Sahin, Matasha Dhar, Crystal Dillon, Mingyan Zhu, Hiroko Shiina, Bradley D. Winters, Talley J. Lambert, Soren Impey, Suzanne M. Appleyard, Gary A. Wayman (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 11, 2020 Category: Neuroscience Source Type: research

Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons
Publication date: Available online 8 May 2020Source: Molecular and Cellular NeuroscienceAuthor(s): L. Galan-Acosta, C. Sierra, A. Leppert, A.N. Pouliopoulos, N. Kwon, R.L. Noel, S. Tambaro, J. Presto, P. Nilsson, E.E. Konofagou, J. Johansson (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 8, 2020 Category: Neuroscience Source Type: research

Activation and functional modulation of satellite glial cells by oxaliplatin lead to hyperexcitability of sensory neurons in vitro
Publication date: Available online 8 May 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Linda-Isabell Schmitt, Markus Leo, Andrea Kutritz, Christoph Kleinschnitz, Tim Hagenacker (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 8, 2020 Category: Neuroscience Source Type: research

LINE-1 specific nuclear organization in mice olfactory sensory neurons
Publication date: Available online 6 May 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Leonardo Fontoura Ormundo, Cleiton Fagundes Machado, Erika Demasceno Sakamoto, Viviane Simões da Silva, Lucia Armelin-Correa (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - May 6, 2020 Category: Neuroscience Source Type: research

Effects of selective inhibition of nNOS and iNOS on neuropathic pain in rats
Publication date: Available online 27 April 2020Source: Molecular and Cellular NeuroscienceAuthor(s): P.A. Rocha, A.F.B. Ferreira, J.T. Da Silva, A.S. Alves, D.O. Martins, L.R.G. Britto, M. Chacur (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 29, 2020 Category: Neuroscience Source Type: research

Short-chain fatty acids (SCFAs) alone or in combination regulate select immune functions of microglia-like cells
Publication date: Available online 22 April 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Tyler J. Wenzel, Ellen J. Gates, Athena L. Ranger, Andis Klegeris (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 23, 2020 Category: Neuroscience Source Type: research

A regulatory domain in the K2P2.1 (TREK-1) carboxyl-terminal allows for channel activation by monoterpenes
Publication date: Available online 19 April 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Eden Arazi, Galit Blecher, Noam Zilberberg (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 19, 2020 Category: Neuroscience Source Type: research

Cyclic regulation of Trpm4 expression in female vomeronasal neurons driven by ovarian sex hormones
Publication date: Available online 13 April 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Eugenia Eckstein, Martina Pyrski, Silvia Pinto, Marc Freichel, Rudi Vennekens, Frank Zufall (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 15, 2020 Category: Neuroscience Source Type: research

Spatial control of membrane traffic in neuronal dendrites
Publication date: Available online 12 April 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Megan Radler, Ayana Suber, Elias T. Spiliotis (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 13, 2020 Category: Neuroscience Source Type: research

Implications of increased S100β and Tau5 proteins in dystrophic nerves of two mdx mouse models for Duchenne muscular dystrophy
Publication date: Available online 30 March 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Vidya S. Krishnan, Annemieke Aartsma-Rus, Maurice Overzier, Cathleen Lutz, Laurent Bogdanik, Miranda D. Grounds (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 1, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: April 2020Source: Molecular and Cellular Neuroscience, Volume 104Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - April 1, 2020 Category: Neuroscience Source Type: research

Overexpression of the vesicular acetylcholine transporter disrupts cognitive performance and causes age-dependent locomotion decline in Drosophila
Publication date: Available online 23 March 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Shardae S. Showell, Yessica Martinez, Sophia Gondolfo, Sridhar Boppana, Hakeem O. Lawal (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - March 25, 2020 Category: Neuroscience Source Type: research

Hippocampal synaptic and membrane function in the DBA/2J-mdx mouse model of Duchenne muscular dystrophy
Publication date: April 2020Source: Molecular and Cellular Neuroscience, Volume 104Author(s): Riccardo Bianchi, Wouter Eilers, Federica Pellati, Lorenzo Corsi, Helen Foster, Keith Foster, Francesco Tamagnini (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - March 20, 2020 Category: Neuroscience Source Type: research

The corepressor CtBP2 is required for proper development of the mouse cerebral cortex
Publication date: Available online 10 March 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Esra Karaca, Xiaofei Li, Jakub Lewicki, Christina Neofytou, Nicolas Guérout, Fanie Barnabé-Heider, Ola Hermanson (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - March 12, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: March 2020Source: Molecular and Cellular Neuroscience, Volume 103Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - February 26, 2020 Category: Neuroscience Source Type: research

Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures
Publication date: Available online 12 February 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Claire A. de March, William B. Titlow, Tomoko Sengoku, Patrick Breheny, Hiroaki Matsunami, Timothy S. McClintockAbstractThe perception of odors relies on combinatorial codes consisting of odorant receptor (OR) response patterns to encode odor identity. Modulation of these patterns by odorant interactions at ORs potentially explains several olfactory phenomena: mixture suppression, unpredictable sensory outcomes, and the perception of odorant mixtures as unique objects. We determined OR response patterns to 4 odorants an...
Source: Molecular and Cellular Neuroscience - February 13, 2020 Category: Neuroscience Source Type: research

Functional heterogeneity in the pineal projection neurons of zebrafish
Publication date: Available online 3 February 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Dora Sapède, Clair Chaigne, Patrick Blader, Elise CauAbstractThe zebrafish pineal organ is a photoreceptive structure containing two main neuronal populations (photoreceptors and projections neurons). Here we describe a subpopulation of projection neurons that expresses the melanopsin gene, opn4xa. This new pineal cell type, that displays characteristics of both projection neurons and photoreceptors, share a similar dependency for BMP and Notch signalling pathways with classical non-photosensitive projection neuro...
Source: Molecular and Cellular Neuroscience - February 4, 2020 Category: Neuroscience Source Type: research

Molecular dissection of TNFR-TNFα bidirectional signaling reveals both cooperative and antagonistic interactions with p75 neurotrophic factor receptor in axon patterning
Publication date: Available online 28 January 2020Source: Molecular and Cellular NeuroscienceAuthor(s): K.D. Kuhn, K. Edamura, N. Bhatia, I. Cheng, S.A. Clark, C.V. Haynes, D.L. Heffner, F. Kabir, J. Velasquez, A.J. Spano, C.D. Deppmann, A.B. KeelerAbstractDuring neural development, complex organisms rely on progressive and regressive events whereby axons, synapses, and neurons are overproduced followed by selective elimination of a portion of these components. Tumor necrosis factor α (TNFα) together with its cognate receptor (Tumor necrosis factor receptor 1; TNFR1) have been shown to play both regressive (i.e...
Source: Molecular and Cellular Neuroscience - January 29, 2020 Category: Neuroscience Source Type: research

Smart motors and cargo steering drive kinesin-mediated selective transport
Publication date: March 2020Source: Molecular and Cellular Neuroscience, Volume 103Author(s): Alec T. Nabb, Madeline Frank, Marvin BentleyAbstractNeurons are polarized cells, with dendrites and axons that require different complements of membrane proteins to fulfill their specialized functions. Membrane proteins are synthesized in the somatodendritic domain and delivered to their target membranes via long-range vesicle transport. Most anterograde vesicle transport is mediated by kinesin motors, but it is unclear how kinesins are targeted to axons or dendrites. Two main models have been proposed to explain kinesin selectivi...
Source: Molecular and Cellular Neuroscience - January 22, 2020 Category: Neuroscience Source Type: research

Autophagy modulates Aβ accumulation and formation of aggregates in yeast
We report that GFP-Aβ42 is sequestered and is selectively transported to vacuole for degradation and that autophagy is the prominent pathway for clearance of aggregates. Next, to identify genes that selectively promote the removal of Aβ42 aggregates, we screened levels of GFP-Aβ42 and non-aggregating GFP-Aβ42 (19:34) proteins in a panel of 192 autophagy mutants lacking genes involved in regulation and initiation of the pathway, cargo selection and degradation processes. The nutrient and stress signalling genes RRD1, SNF4, GCN4 and SSE1 were identified. Deletion of these genes impaired GFP-Aβ42 clea...
Source: Molecular and Cellular Neuroscience - January 19, 2020 Category: Neuroscience Source Type: research

Editorial Board
Publication date: January 2020Source: Molecular and Cellular Neuroscience, Volume 102Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - January 16, 2020 Category: Neuroscience Source Type: research

Identification of MAGUK scaffold proteins as intracellular binding partners of synaptic adhesion protein Slitrk2
Publication date: Available online 8 January 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Connor Loomis, Aliyah Stephens, Remi Janicot, Usman Baqai, Laura Drebushenko, Jennifer RoundAbstractSynaptic adhesion proteins play a critical role in the formation and maintenance of synapses in the developing nervous system. Errors in synaptic adhesion constitute the molecular basis of many neuropsychiatric disorders, including schizophrenia, bipolar disorder, Tourette syndrome, and autism. Slit- and Trk-like proteins (Slitrks) are a family of leucine-rich repeat containing transmembrane proteins that promote synaptogen...
Source: Molecular and Cellular Neuroscience - January 8, 2020 Category: Neuroscience Source Type: research

Δ9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons
Publication date: Available online 7 January 2020Source: Molecular and Cellular NeuroscienceAuthor(s): Carole Shum, Lucia Dutan, Emily Annuario, Katherine Warre-Cornish, Samuel E. Taylor, Ruth D. Taylor, Laura C. Andreae, Noel J. Buckley, Jack Price, Sagnik Bhattacharyya, Deepak P. SrivastavaAbstractEndocannabinoids regulate different aspects of neurodevelopment. In utero exposure to the exogenous psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC), has been linked with abnormal cortical development in animal models. However, much less is known about the actions of endocannabinoids in human neurons. Here ...
Source: Molecular and Cellular Neuroscience - January 7, 2020 Category: Neuroscience Source Type: research

Deficits in developmental neurogenesis and dendritic spine maturation in mice lacking the serine protease inhibitor neuroserpin
Publication date: Available online 2 December 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Melanie Hermann, Rebecca Reumann, Katrin Schostak, Dilara Kement, Mathias Gelderblom, Christian Bernreuther, Renato Frischknecht, Angela Schipanski, Sergej Marik, Susanne Krasemann, Diego Sepulveda-Falla, Michaela Schweizer, Tim Magnus, Markus Glatzel, Giovanna GalliciottiAbstractNeuroserpin is a serine protease inhibitor of the nervous system required for normal synaptic plasticity and regulating cognitive, emotional and social behavior in mice. The high expression level of neuroserpin detected at late stages of nervous...
Source: Molecular and Cellular Neuroscience - December 2, 2019 Category: Neuroscience Source Type: research

Macrophage migration inhibitory factor and its binding partner HTRA1 are expressed by olfactory ensheathing cells
Publication date: Available online 30 November 2019Source: Molecular and Cellular NeuroscienceAuthor(s): A.A. Wright, M. Todorovic, M. Murtaza, J.A. St John, J.A. EkbergAbstractMacrophage migration inhibitory factor (MIF) is an important regulator of innate immunity with key roles in neural regeneration and responses to pathogens, amongst a multitude of other functions. The expression of MIF and its binding partners has been characterised throughout the nervous system, with one key exception: the primary olfactory nervous system. Here, we showed in young mice (postnatal day 10) that MIF is expressed in the olfactory nerve ...
Source: Molecular and Cellular Neuroscience - December 1, 2019 Category: Neuroscience Source Type: research

Cerebrospinal fluid and serum glycosphingolipid biomarkers in canine globoid cell leukodystrophy (Krabbe Disease)
This study identified several biomarkers which may be useful in the development of therapeutics for GLD. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - December 1, 2019 Category: Neuroscience Source Type: research

SNAP-25 phosphorylation at Ser187 is not involved in Ca2+ or phorbolester-dependent potentiation of synaptic release
In conclusion, our results indicate that phosphorylation of Ser-187 in SNAP-25 is not involved in modulation of synaptic release by Ca2+ or phorbol esters. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - December 1, 2019 Category: Neuroscience Source Type: research

Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses
Publication date: Available online 23 November 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Jennifer J. O'Brien, James P. O'Callaghan, Diane B. Miller, Suman Chalgeri, Lawrence P. Wennogle, Robert E. Davis, Gretchen L. Snyder, Joseph P. HendrickAbstractA novel, potent, and highly specific inhibitor of calcium-calmodulin-dependent phosphodiesterases (PDE) of the PDE1 family, ITI-214, was used to investigate the role of PDE1 in inflammatory responses. ITI-214 dose-dependently suppressed lipopolysaccharide (LPS)-induced gene expression of pro-inflammatory cytokines in an immortalized murine microglial cell line, ...
Source: Molecular and Cellular Neuroscience - November 25, 2019 Category: Neuroscience Source Type: research

Mitochondrial dysfunction in neurons in Friedreich's ataxia
Publication date: Available online 23 November 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Anna Stepanova, Jordi MagranéAbstractFriedreich's ataxia is a multisystemic genetic disorder within the family of mitochondrial diseases that is characterized by reduced levels of the essential mitochondrial protein frataxin. Based on clinical evidence, the peripheral nervous system is affected early, neuronal dysfunction progresses towards the central nervous system, and other organs (such as heart and pancreas) are affected later. However, little attention has been given to the specific aspects of mitochondria ...
Source: Molecular and Cellular Neuroscience - November 25, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: December 2019Source: Molecular and Cellular Neuroscience, Volume 101Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - November 24, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: October 2019Source: Molecular and Cellular Neuroscience, Volume 100Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - November 20, 2019 Category: Neuroscience Source Type: research

Overexpression of human wtTDP-43 causes impairment in hippocampal plasticity and behavioral deficits in CAMKII-tTa transgenic mouse model
ConclusionsOverall, our findings suggest the significant vulnerability of hippocampal neurons toward elevated wtTDP-43 levels possibly via PCP-4 and GluR-dependent calcium signaling pathways. Further, we report that wtTDP-43 expression induced selective CA2 subfield degeneration, contributing to the deterioration of the hippocampal-dependent cognitive phenotype. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - November 7, 2019 Category: Neuroscience Source Type: research

Glial mitochondrial function and dysfunction in health and neurodegeneration
Publication date: Available online 31 October 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Kevin McAvoy, Hibiki KawamataAbstractMitochondria play essential metabolic roles in neural cells. Mitochondrial dysfunction has profound effects on the brain. In primary mitochondrial diseases, mutations that impair specific oxidative phosphorylation (OXPHOS) proteins or OXPHOS assembly factors lead to isolated biochemical defects and a heterogeneous group of clinical phenotypes, including mitochondrial encephalopathies. A broader defect of OXPHOS function, due to mutations in proteins involved in mitochondrial DNA maint...
Source: Molecular and Cellular Neuroscience - November 2, 2019 Category: Neuroscience Source Type: research

Hippocampal stimulation promotes intracellular Tip60 dynamics with concomitant genome reorganization and synaptic gene activation
Publication date: Available online 1 November 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Ashley Karnay, Bhanu Chandra Karisetty, Mariah Beaver, Felice ElefantAbstractGenomic reorganizations mediating the engagement of target genes to transcription factories (TFs), characterized as specialized nuclear subcompartments enriched in hyperphosphorylated RNA polymerase II (RNAPII) and transcriptional regulators, act as an important layer of control in coordinating efficient gene transcription. However, their presence in hippocampal neurons and potential role in activity-dependent coregulation of genes within the br...
Source: Molecular and Cellular Neuroscience - November 2, 2019 Category: Neuroscience Source Type: research

Fibroblast growth Factor-21 promotes ketone body utilization in neurons through activation of AMP-dependent kinase
Publication date: Available online 29 October 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Yurika Katsu-Jiménez, Alfredo Giménez-CassinaAbstractEnergy supply to the brain is essential to ensure correct neuronal function, and glucose is the main fuel utilized by neurons. In metabolically challenging situations when glucose availability is restricted, brain cells may switch to alternative carbon substrates. This ensures energy supply to preserve the functions of the central nervous system. In this regard, ketone bodies, a by-product of fat metabolism, play a key role. They can replace glucose as th...
Source: Molecular and Cellular Neuroscience - October 30, 2019 Category: Neuroscience Source Type: research

Role of GPCR signaling and calcium dysregulation in Alzheimer's disease
Publication date: Available online 23 October 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Sushma, Amal Chandra MondalAbstractAlzheimer's disease (AD), a late onset neurodegenerative disorder is characterized by the loss of memory, disordered cognitive function, caused by accumulation of amyloid-β (Aβ) peptide and neurofibrillary tangles (NFTs) in the neocortex and hippocampal brain area. Extensive research has been done on the findings of the disease etiology or pathological causes of aggregation of Aβ and hyperphosphorylation of tau protein without much promising results. Recently, calcium dys...
Source: Molecular and Cellular Neuroscience - October 24, 2019 Category: Neuroscience Source Type: research

Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates
In this study, the effect on α-syn aggregate clearance of ginkgolic acid (GA), a natural compound extracted from Ginkgo biloba leaves that inhibits SUMOylation amongst other pathways, was assessed in SH-SY5Y neuroblastoma cells and rat primary cortical neurons. Depolarization of SH-SY5Y neuroblastoma cells and rat primary cortical neurons with KCl was used to induce α-syn aggregate formation. Cells pre-treated with either GA or the related compound, anacardic acid, revealed a significant decrease in intracytoplasmic aggregates immunopositive for α-syn and SUMO-1. An increased frequency of autophagosomes w...
Source: Molecular and Cellular Neuroscience - October 24, 2019 Category: Neuroscience Source Type: research

CBP and p300 coactivators contribute to the maintenance of Isl1 expression by the Onecut transcription factors in embryonic spinal motor neurons
Publication date: Available online 21 October 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Mathilde Toch, Frédéric ClotmanAbstractOnecut transcription factors are required to maintain Islet1 (Isl1) expression in developing spinal motor neurons (MNs), and this process is critical for proper MN differentiation. However, the mechanisms whereby OC stimulate Isl1 expression remain unknown. CREB-binding protein (CBP) and p300 paralogs are transcriptional coactivators that interact with OC proteins in hepatic cells. In the embryonic spinal cord, CBP and p300 play key roles in neurogenesis and MN differe...
Source: Molecular and Cellular Neuroscience - October 22, 2019 Category: Neuroscience Source Type: research

L-type Ca2+ channels and charybdotoxin-sensitive Ca2+-activated K+ channels are required for reduction of GABAergic activity induced by β2-adrenoceptor in the prefrontal cortex
Publication date: Available online 20 October 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Wei-Ke Deng, Xing Wang, Hou-Cheng Zhou, Fei LuoAbstractWhereas β2-adrenoceptor (β2-AR) has been reported to reduce GABAergic activity in the prefrontal cortex (PFC), the underlying cellular and molecular mechanisms have not been completely determined. Here, we showed that β2-AR agonist Clenbuterol (Clen) decreased GABAergic transmission onto PFC layer V/VI pyramidal neurons via a presynaptic mechanism without altering postsynaptic GABA receptors. Clen decreased the action potential firing rate but increase...
Source: Molecular and Cellular Neuroscience - October 21, 2019 Category: Neuroscience Source Type: research

Crosstalk between Nrf2 signaling and mitochondrial function in Parkinson's disease
Publication date: Available online 20 October 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Navneet Ammal Kaidery, Manuj Ahuja, Bobby ThomasAbstractSearch for a definitive cure for neurodegenerative disorders like Parkinson's disease (PD) has met with little success. Mitochondrial dysfunction and elevated oxidative stress precede characteristic loss of dopamine-producing neurons from the midbrain in PD. The majority of PD cases are classified as sporadic (sPD) with an unknown etiology, whereas mutations in a handful of genes cause monogenic form called familial (fPD). Both sPD and fPD is characterized by protei...
Source: Molecular and Cellular Neuroscience - October 21, 2019 Category: Neuroscience Source Type: research

The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice
Publication date: Available online 12 September 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Melissa L. Young, James L. FranklinAbstractOxidative stress, likely stemming from dysfunctional mitochondria, occurs before major cognitive deficits and neuropathologies become apparent in Alzheimer's disease (AD) patients and in mouse models of the disease. We previously reported that treating 2- to 7-month-old 3xTg-AD mice with the mitochondria-targeted antioxidant MitoQ (mitoquinone mesylate: [10-(4,5-Dimethoxy-2-methyl-3,6-dioxo-1,4-cyclohexadien-1-yl)decyl](triphenyl)phosphonium methanesulfonate), a period when AD...
Source: Molecular and Cellular Neuroscience - September 12, 2019 Category: Neuroscience Source Type: research

Editorial Board
Publication date: September 2019Source: Molecular and Cellular Neuroscience, Volume 99Author(s): (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - September 10, 2019 Category: Neuroscience Source Type: research

Edaravone protects primary-cultured rat cortical neurons from ketamine-induced apoptosis via reducing oxidative stress and activating PI3K/Akt signal pathway
Publication date: Available online 7 September 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Qianqian Li, Zhengguo Qiu, Yang Lu, Pan Lu, Jieqiong Wen, Kui Wang, Xijuan Zhao, Rong Li, Hong Zhang, Yan Zhang, Pengyu Jia, Pei Fan, Yuanyuan Zhang, Shuyue Zhang, Haixia Lv, Xinlin Chen, Yong Liu, Pengbo ZhangAbstractKetamine caused neuroapoptosis in the development of rat brain, in which oxidative stress play an important role. Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, exerts neuroprotective effects in many neurological disease models. Here we investigated whether edaravone protects pr...
Source: Molecular and Cellular Neuroscience - September 9, 2019 Category: Neuroscience Source Type: research

Mechanism of mitochondrial complex I damage in brain ischemia/reperfusion injury. A hypothesis
Publication date: Available online 5 September 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Vadim Ten, Alexander GalkinAbstractThe purpose of this review is to integrate available data on the effect of brain ischemia/reperfusion (I/R) on mitochondrial complex I. Complex I is a key component of the mitochondrial respiratory chain and it is the only enzyme responsible for regenerating NAD+ for the maintenance of energy metabolism. The vulnerability of brain complex I to I/R injury has been observed in multiple animal models, but the mechanisms of enzyme damage have not been studied. This review summarizes old an...
Source: Molecular and Cellular Neuroscience - September 6, 2019 Category: Neuroscience Source Type: research

A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum
Publication date: Available online 3 September 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Yuko Yamakage, Michinao Kato, Aya Hongo, Himari Ogino, Keisuke Ishii, Takumi Ishizuka, Takana Kamei, Hitomi Tsuiji, Tomomi Miyamoto, Hisashi Oishi, Takao Kohno, Mitsuharu HattoriAbstractReelin plays important roles in regulating neuronal development, modulating synaptic function, and counteracting amyloid β toxicity. A specific proteolytic cleavage (N-t cleavage) of Reelin abolishes its biological activity. We recently identified ADAMTS-3 (a disintegrin and metalloproteinase with thrombospondin motifs 3) as the maj...
Source: Molecular and Cellular Neuroscience - September 3, 2019 Category: Neuroscience Source Type: research

Role of fast inhibitory synaptic transmission in neonatal respiratory rhythmogenesis and pattern formation
Publication date: Available online 28 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Michael George Zaki Ghali, Sarah BeshayAbstractSeveral studies have investigated the general role of chloride-based neurotransmission (GABAA and glycinergic signaling) in respiratory rhythmogenesis and pattern formation. In several brain regions, developmental alterations in these signaling pathways have been shown to be mediated by changes in cation-chloride cotransporter (CC) expression. For instance, CC expression changes over the neonatal period in medullary respiratory nuclei and other brain/spinal cord regions in a ...
Source: Molecular and Cellular Neuroscience - August 30, 2019 Category: Neuroscience Source Type: research

Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila
Publication date: Available online 28 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Nisha, Prerna Aggarwal, Surajit SarkarAbstractNeurogenesis is driven by spatially and temporally regulated proliferation of neuronal progenitor cells that generates enormous number of assorted neurons to drive the complex behavior of an organism. Drosophila nervous system provides an advantageous model for identification and elucidation of the functional significance of the novel gene(s) involved in neurogenesis. The present study attempts to investigate the role(s) of globin1 (glob1) in the development and maintenance of...
Source: Molecular and Cellular Neuroscience - August 30, 2019 Category: Neuroscience Source Type: research

PlexinD1 and Sema3E determine laminar positioning of heterotopically projecting callosal neurons
In this study, we showed that the axon guidance receptor PlexinD1 is expressed by a large proportion of heterotopically projecting CPNs in layer 5A of the primary somatosensory (S1) and motor (M1) areas. Retrograde tracing of M1 CPNs projecting to the contralateral striatum revealed the presence of ectopic neurons aberrantly located in layers 2/3 of Plxnd1 and Sema3e mutant cortices. These results showed that Sema3E/PlexinD1 signalling controls the laminar distribution of heterotopically projecting CPNs. (Source: Molecular and Cellular Neuroscience)
Source: Molecular and Cellular Neuroscience - August 25, 2019 Category: Neuroscience Source Type: research

TDP-43 proteinopathy and mitochondrial abnormalities in neurodegeneration
Publication date: Available online 21 August 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Ju Gao, Luwen Wang, Tingxiang Yan, George Perry, Xinglong WangAbstractGenetic mutations in TAR DNA-binding protein 43 (TDP-43) cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Importantly, TDP-43 proteinopathy, characterized by aberrant phosphorylation, ubiquitination, cleavage or nuclear depletion of TDP-43 in neurons and glial cells, is a common prominent pathological feature of various major neurodegenerative diseases including ALS, FTD, and Alzheimer's disease (AD). Although the pathomechan...
Source: Molecular and Cellular Neuroscience - August 22, 2019 Category: Neuroscience Source Type: research