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Condition: Arthritis

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Total 425 results found since Jan 2013.

Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4+ T Helper Cells
Conclusions: Inhibiting Gβγ to produce these shifts in cytokine mRNA production might be beneficial for patients with autoimmune diseases such as rheumatoid arthritis (RA), Crohn’s disease (CD), psoriasis, multiple sclerosis (MS), and Hashimoto’s thyroiditis (HT), in which both IFN-γ and IL-17A are elevated. Published on None
Source: Journal of Molecular Signaling - August 21, 2015 Category: Molecular Biology Source Type: research

Histone deacetylase 1 regulates tissue destruction in rheumatoid arthritis
In this study, we have investigated the role of histone deacetylase (HDAC) enzymes in RA synovial fibroblasts (RASFs), a key cellular mediator of cartilage and bone destruction and determined effects of HDAC1 inhibition on both RASF phenotype in vitro, and joint inflammation and damage in the collagen-induced arthritis (CIA) model. Expression of HDACs 1–11 messenger ribonucleic acid (mRNA) was compared between RASFs and osteoarthritic synovial fibroblast (OASFs) using quantitative polymerase chain reaction. HDAC1 expression in RASFs was inhibited using small interfering RNA (siRNA) technology to assess effects on inv...
Source: Human Molecular Genetics - September 10, 2015 Category: Genetics & Stem Cells Authors: Hawtree, S., Muthana, M., Wilkinson, J. M., Akil, M., Wilson, A. G. Tags: ORIGINAL ARTICLES Source Type: research

Increased Expression of NAPDH Oxidase 4 in Systemic Sclerosis Dermal Fibroblasts: Regulation by Transforming Growth Factor β
ConclusionNOX‐4 expression and production were found to be constitutively elevated in SSc skin and cultured SSc dermal fibroblasts. TGFβ1 stimulated NOX‐4 expression in normal and SSc fibroblasts through PKCδ and Smad2/3 signaling pathways. A small‐molecule NOX‐4 inhibitor decreased collagen and fibronectin production by normal and SSc fibroblasts, and NOX‐4 siRNA knockdown reduced ROS and collagen production by SSc fibroblasts. These results demonstrate the involvement of NOX‐4 in SSc‐associated fibrosis and indicate NOX‐4 inhibitors as novel therapeutic approaches for SSc.
Source: Arthritis and Rheumatism - September 23, 2015 Category: Rheumatology Authors: Sonsoles Piera‐Velazquez, Alma Makul, Sergio A. Jiménez Tags: Systemic Sclerosis Source Type: research

p21 deficiency is susceptible to osteoarthritis through STAT3 phosphorylation
Conclusions: The lack of p21 has catabolic effects by regulation of aggrecan and MMP-13 expression through STAT3 phosphorylation in the cartilage tissue. p21 may function as a regulator of transcriptional factors other than the inhibitor of cell cycle progression in the cartilage tissue. Thus, the regulation of p21 may be a therapeutic strategy for the treatment of OA.
Source: Arthritis Research and Therapy - November 7, 2015 Category: Rheumatology Authors: Shinya HayashiTakaaki FujishiroShingo HashimotoNoriyuki KanzakiNobuaki ChinzeiShinsuke KiharaKoji TakayamaTomoyuki MatsumotoKotaro NishidaMasahiro KurosakaRyosuke Kuroda Source Type: research

Brief Report: Interleukin‐38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus
ConclusionThis is the first study of the function of endogenous IL‐38, and the data suggest that IL‐38 may be protective in SLE. A strong association between IL‐38 and SLE severity suggests that IL‐38 expression is driven by processes linked to SLE pathogenesis. Exploitation of the regulatory effects of IL‐38 may represent a promising therapeutic strategy in SLE.
Source: Arthritis and Rheumatism - November 25, 2015 Category: Rheumatology Authors: Ina Rudloff, Jack Godsell, Claudia A. Nold‐Petry, James Harris, Alberta Hoi, Eric F. Morand, Marcel F. Nold Tags: Systemic Lupus Erythematosus Source Type: research

GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness.
CONCLUSION: GREM1 is highly expressed in RA joints, and functions as a regulator of survival, proliferation, migration, and invasion of RA-FLS. PMID: 26834210 [PubMed - as supplied by publisher]
Source: J Rheumatol - February 1, 2016 Category: Rheumatology Authors: Han EJ, Yoo SA, Kim GM, Hwang D, Cho CS, You S, Kim WU Tags: J Rheumatol Source Type: research

PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis
Conclusions PGK1, a glycolytic enzyme catalyzing the conversion of 3-phosphoglycerate into 2-phosphoglycerate, has increased expression in synovial tissues and blood of RA, which may be involved in pro-inflammation and synovial hyperplasia of the disease.
Source: Inflammation Research - June 23, 2016 Category: Research Source Type: research

CD147 induces up-regulation of vascular endothelial growth factor in U937-derived foam cells through PI3K/AKT pathway.
Abstract Intraplaque angiogenesis has been recognized as an important risk factor for the rupture of advanced atherosclerotic plaques in recent years. CD147, also called Extracellular Matrix Metalloproteinase Inducer, has been found the ability to promote angiogenesis in many pathological conditions such as cancer diseases and rheumatoid arthritis via the up-regulation of vascular endothelial growth factor (VEGF), a critical mediator of angiogenesis. We investigated whether CD147 would also induce the up-regulation of VEGF in the foam cells formation process and explored the probable signaling pathway. The results...
Source: Archives of Biochemistry and Biophysics - September 8, 2016 Category: Biochemistry Authors: Zong J, Li Y, Du D, Liu Y, Yin Y Tags: Arch Biochem Biophys Source Type: research

Nanoparticle injections show promise as treatment for osteoarthritis
This study is interesting, as it showed that these nanoparticles could reduce inflammation caused by joint injuries in mice. It's not yet clear from the study whether these nanoparticles will be effective once osteoarthritis has developed in the joint, so we would be interested to learn more and see how the research progresses."
Source: Arthritis Research UK - October 2, 2016 Category: Rheumatology Source Type: news

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis
Conclusions Macrophage response to MTX is polarisation-dependent and determined by the TS-p53 axis. CCL20 and LIF constitute novel macrophage markers for MTX responsiveness in vitro.
Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Municio, C., Soler Palacios, B., Estrada-Capetillo, L., Benguria, A., Dopazo, A., Garcia-Lorenzo, E., Fernandez-Arroyo, S., Joven, J., Miranda-Carus, M. E., Gonzalez-Alvaro, I., Puig-Kröger, A. Tags: Immunology (including allergy), Inflammation, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast-like synoviocytes in rheumatoid arthritis.
Abstract To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and invasion of fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA). FLSs were separated from synovial tissues (STs) from patients with RA and osteoarthritis (OA). An inhibitor of PRMT5 (EPZ015666) and short interference RNA (siRNA) against PRMT5 were used to inhibit PRMT5 expression. The standard of protein was measured by Western blot or immunofluorescence. The excretion and genetic expression of inflammatory factors were, respectively, estimated by enz...
Source: J Cell Mol Med - November 16, 2016 Category: Molecular Biology Authors: Chen D, Zeng S, Huang M, Xu H, Liang L, Yang X Tags: J Cell Mol Med Source Type: research

Roles of 1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > and Vitamin D Receptor in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus by Regulating the Activation of CD4 < sup > + < /sup > T Cells and the PKC δ/ERK Signaling Pathway
Conclusion:Our study provide evidence that 1,25(OH)2D3 and VDR could inhibit the activation of CD4+ T cells and suppress the immune response of SLE and RA through inhibiting PKC δ/ERK pathway and promoting DNA methylation of CD11a, CD70 and CD40L.Cell Physiol Biochem 2016;40:743-756
Source: Cellular Physiology and Biochemistry - December 2, 2016 Category: Cytology Source Type: research

Hypoxia-Induced Fibroblast Growth Factor 11 Stimulates Osteoclast-Mediated Resorption of Bone
This study suggests FGF11 as a novel factor driving pathological bone resorption in osteolytic disease and as a potential target for the development of new anti-resorptive therapeutic agents.
Source: Calcified Tissue International - January 17, 2017 Category: Orthopaedics Source Type: research

Inhibition of 6 ‐phosphofructo‐2‐kinase suppresses fibroblast‐like synoviocytes‐ mediated synovial inflammation and joint destruction in rheumatoid arthritis
Conclusion And ImplicationsElevated PFKFB3 expression might contribute to synovial inflammation and aggressive behaviors of RA FLSs, suggesting a novel strategy of targeting PFKFB3 to prevent synovial inflammation and joint destruction in RA.
Source: British Journal of Pharmacology - February 27, 2017 Category: Drugs & Pharmacology Authors: Yaoyao Zou, Shan Zeng, Mingcheng Huang, Qian Qiu, Youjun Xiao, Maohua Shi, Zhongping Zhan, Liuqin Liang, Xiuyan Yang, Hanshi Xu Tags: RESEARCH PAPER Source Type: research

Role of Fibulin 3 in Aging ‐Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage
ConclusionFibulin 3 is specifically expressed in the SZ of articular cartilage and its expression is reduced in aging and OA. Fibulin 3 regulates differentiation of adult progenitor cells, and its aging‐related decline is an early event in the pathogenesis of OA. Preventing aging‐associated loss of fibulin 3 or restoring it to normal levels in SZ chondrocytes has the potential to delay or prevent the onset of OA.
Source: Arthritis and Rheumatism - February 26, 2017 Category: Rheumatology Authors: Akihiko Hasegawa, Tomo Yonezawa, Noboru Taniguchi, Koji Otabe, Yukio Akasaki, Tetsuya Matsukawa, Masahiko Saito, Masashi Neo, Lihua Y. Marmorstein, Martin K. Lotz Tags: Osteoarthritis Source Type: research