Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis

Conclusions
Macrophage response to MTX is polarisation-dependent and determined by the TS-p53 axis. CCL20 and LIF constitute novel macrophage markers for MTX responsiveness in vitro.

Source: Annals of the Rheumatic Diseases - November 9, 2016 Category: Rheumatology Authors: Municio, C., Soler Palacios, B., Estrada-Capetillo, L., Benguria, A., Dopazo, A., Garcia-Lorenzo, E., Fernandez-Arroyo, S., Joven, J., Miranda-Carus, M. E., Gonzalez-Alvaro, I., Puig-Kröger, A. Tags: Immunology (including allergy), Inflammation, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research