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Condition: Arthritis

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Total 425 results found since Jan 2013.

PSORS1C1 May Be Involved in Rheumatoid Arthritis.
This study investigated whether PSORS1C1/CDSN was involved in RA. The TagSNPs rs3130983, rs3778638 and rs4959053 in the PSORS1C1/CDSN locus were shown to predict susceptibility to RA in two independent RA cohorts using a TaqMan genotyping assay and Sequenom MassARRAY. The expression of PSORS1C1/CDSN was determined with western blotting and ELISA. Cultured synovial fibroblasts from RA patients (RASF) were treated with anti-PSORS1C1 siRNA. The TaqMan genotyping assay demonstrated significant differences in the rs3130983 and rs4959053 allele frequencies (p=0.002001 and 1.74E-07, respectively) and genotype frequencies (0.01050...
Source: Immunology Letters - June 13, 2013 Category: Allergy & Immunology Authors: Sun H, Xia Y, Wang L, Wang Y, Chang X Tags: Immunol Lett Source Type: research

Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine‐Induced Cartilage Degradation
ConclusionInhibition of class I HDACs (HDAC‐1, HDAC‐2, HDAC‐3) by MS‐275 or by specific depletion of HDACs is capable of repressing cytokine‐induced metalloproteinase expression in cartilage cells and BNC explants, resulting in inhibition of cartilage resorption. These observations indicate that specific inhibition of class I HDACs is a possible therapeutic strategy in the arthritides.
Source: Arthritis and Rheumatism - July 2, 2013 Category: Rheumatology Authors: Kirsty L. Culley, Wang Hui, Matt J. Barter, Rose K. Davidson, Tracey E. Swingler, Auriane P. M. Destrument, Jenny L. Scott, Simon T. Donell, Steve Fenwick, Andrew D. Rowan, David A. Young, Ian M. Clark Tags: Osteoarthritis Source Type: research

Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications
Conclusions: Our findings strongly suggest that MICL acts as an inhibitory receptor in human neutrophils since the downregulation of MICL expression enhances MSU-induced neutrophil activation. Since MSU downregulates the expression of MICL, MICL may play a pathogenic role in gout by enhancing neutrophil effector functions. In support of this notion, colchicine counteracts the MSU-induced loss of MICL expression. Our findings thus also provide further insight into the potential molecular mechanisms behind the anti-inflammatory properties of this drug.
Source: Arthritis Research and Therapy - July 9, 2013 Category: Rheumatology Authors: Valerie GagneLouis MaroisJean-Michel LevesqueHugo GalarneauMireille LahoudIrina CaminschiPaul NaccachePhilippe TessierMaria Fernandes Source Type: research

Sphingosine 1‐Phosphate Counteracts the Effects of Interleukin‐1β in Human Chondrocytes
ConclusionIn human chondrocytes, S1P reduces the induction of catabolic genes in the presence of IL‐1β. Activation of the S1P2 receptor counteracts the detrimental phosphorylation of p38 MAPK by IL‐1β.
Source: Arthritis and Rheumatism - July 26, 2013 Category: Rheumatology Authors: Martin H. Stradner, Gerald Gruber, Hannes Angerer, Verena Huber, Daniela Setznagl, Marie‐Luise Kremser, Florentine C. Moazedi‐Fürst, Reinhard Windhager, Winfried B. Graninger Tags: Chondrocyte Biology Source Type: research

Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes
Conclusions These data suggest that AHR antagonism may represent a viable adjuvant therapeutic strategy for the amelioration of inflammation associated with RA.
Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Lahoti, T. S., John, K., Hughes, J. M., Kusnadi, A., Murray, I. A., Krishnegowda, G., Amin, S., Perdew, G. H. Tags: Immunology (including allergy), Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Epidemiology Basic and translational research Source Type: research

P2X7 Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway
ConclusionActivation of the P2X7 signaling pathway accelerates murine LN by activating the NLRP3/ASC/caspase 1 inflammasome, resulting in increased IL‐1β production and enhanced Th17 cell polarization. Thus, targeting of the P2X7/NLRP3 pathway should be considered as a novel therapeutic strategy in patients with lupus.
Source: Arthritis and Rheumatism - November 27, 2013 Category: Rheumatology Authors: Jijun Zhao, Hongyue Wang, Chao Dai, Hongyang Wang, Hui Zhang, Yuefang Huang, Shuang Wang, Felicia Gaskin, Niansheng Yang, Shu Man Fu Tags: Systemic Lupus Erythematosus Source Type: research

C/EBP homologous protein drives pro-catabolic responses in chondrocytes
IntroductionExcess C/EBP homologous protein (CHOP) expression is one feature of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress. Here, we focused on CHOP expression and function in chondrocytes. Methods: We studied human knee osteoarthritis (OA) cartilage, bovine chondrocytes cultured in alginate and subjected to sub-lethal biomechanical injury, and knee chondrocytes of human autopsy donors. We performed siRNA knockdown and transfection. Results: UPR activation was increased in human knee OA cartilage in situ, and in biomechanically injured cultured chondrocytes in vitro. In normal human chondrocyt...
Source: Arthritis Research and Therapy - December 19, 2013 Category: Rheumatology Authors: Matt HusaFreyr PeturssonMartin LotzRobert TerkeltaubRu Liu-Bryan Source Type: research

Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain
Conclusions: These results show that mechanical stress, IL-1beta and extracellular visfatin/NAMPT, all stimulated the expression and release of NGF by chondrocytes and thus suggest that the overexpression of visfatin/NAMPT and IL-1beta in OA joint and the increased mechanical loading of cartilage may mediate OA pain via the stimulation of NGF expression and release by chondrocytes.
Source: Arthritis Research and Therapy - January 20, 2014 Category: Rheumatology Authors: Emilie PecchiSabrina PriamMarjolaine GossetAudrey PigenetLaure SudreMarie-Charlotte LaiguillonFrancis BerenbaumXavier Houard Source Type: research

Cyclin‐Dependent Kinase 9 inhibition protects cartilage from the catabolic effects of pro‐inflammatory cytokines
Conclusion. CDK9 activity is required for the primary inflammatory response in chondrocytes. Flavopiridol suppresses the induction of inflammatory mediators and catabolic genes to protect cartilage from the deleterious effects of pro‐inflammatory cytokines, without impacting cell viability and functions. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - January 27, 2014 Category: Rheumatology Authors: Jasper H. N. Yik, Zi'ang Hu, Ratna Kumari, Blaine A. Christiansen, Dominik R. Haudenschild Tags: Full Length Source Type: research

Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2
Conclusion: Our results demonstrate that EPCR is overexpressed by RASF and mediates the aggressive behavior of RASF. This function of EPCR is contrary to its cytoprotective role in other settings, and is likely driven by sPLA2V.
Source: Arthritis Research and Therapy - February 5, 2014 Category: Rheumatology Authors: Meilang XueKaitlin ShenKelly McKelveyJuan LiYee-Ka ChanVicky HatzisLyn MarchChristopher LittleMichael TonkinChristopher Jackson Source Type: research

CD44 and hyaluronan promote the BMP7 signaling response in chondrocytes
Conclusion: Taken together, these investigations into the mechanisms underlying BMP7 signaling in chondrocytes reveal that while hyaluronan‐dependent pericellular matrix is critical for BMP7 signaling, expression of CD44 promotes the cellular response to lower concentrations of BMP7. © 2014 American College of Rheumatology.
Source: Arthritis and Rheumatism - February 4, 2014 Category: Rheumatology Authors: Na Luo, Warren Knudson, Emily B. Askew, Roberta Veluci, Cheryl B. Knudson Tags: Full Length Source Type: research

Role of cathepsin B in regulating migration and invasion of fibroblast‐like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
Abstract Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher expression in fibroblast‐like synoviocyte (FLS) of abnormal proliferative synovial tissues. Whether and how it affects the biological behaviors of RA‐FLS, such as migration and invasion, are poorly understood. In the present study, CB expression in synovial tissues of patients with RA and ostearthritis (OA) were measured by qPCR and immunohistochemistry (IHC), respectively. Stable depletion of endogenous CB was achieved by siRNA transfection, and decrease of CB activity was acquired ...
Source: Clinical and Experimental Immunology - April 22, 2014 Category: Allergy & Immunology Authors: Bei Tong, Bin Wan, Zhifeng Wei, Ting Wang, Peng Zhao, Yannong Dou, Zheng Lv, Yue Dai, Yufeng Xia Tags: Original Article Source Type: research

Role of cathepsin B in regulating migration and invasion of fibroblast-like synoviocytes into inflamed tissue from patients with rheumatoid arthritis.
Abstract Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher expression in fibroblast-like synoviocyte (FLS) of abnormal proliferative synovial tissues. Whether and how it affects the biological behaviors of RA-FLS, such as migration and invasion, are poorly understood. In the present study, CB expression in synovial tissues of patients with RA and ostearthritis (OA) were measured by qPCR and immunohistochemistry (IHC), respectively. Stable depletion of endogenous CB was achieved by siRNA transfection, and decrease of CB activity was acqu...
Source: Clinical and Developmental Immunology - April 22, 2014 Category: Allergy & Immunology Authors: Tong B, Wan B, Wei Z, Wang T, Zhao P, Dou Y, Lv Z, Dai Y, Xia Y Tags: Clin Exp Immunol Source Type: research

Lysine specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1beta-induced microsomal prostaglandin E synthase-1 expression in human osteoarthritic chondrocytes
Conclusion: These results indicate that H3K9 demethylation by LSD1 contributes to IL-1beta -induced mPGES-1 expression and suggest that this pathway could be a potential target for pharmacological intervention in the treatment of OA and possibly other arthritic conditions.
Source: Arthritis Research and Therapy - May 16, 2014 Category: Rheumatology Authors: Fatima El MansouriSalwa-Sarah NebbakiMohit KapoorHassan AfifJohanne Martel-PelletierJean-Pierre PelletierMohamed BenderdourHassan Fahmi Source Type: research

Cyclin‐Dependent Kinase 9 Inhibition Protects Cartilage From the Catabolic Effects of Proinflammatory Cytokines
ConclusionCDK‐9 activity is required for the primary inflammatory response in chondrocytes. Flavopiridol suppresses the induction of inflammatory mediator genes and catabolic genes to protect cartilage from the deleterious effects of proinflammatory cytokines, without affecting cell viability and functions.
Source: Arthritis and Rheumatism - May 27, 2014 Category: Rheumatology Authors: Jasper H. N. Yik, Zi'ang Hu, Ratna Kumari, Blaine A. Christiansen, Dominik R. Haudenschild Tags: Chondrocyte Biology Source Type: research