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Condition: Arthritis

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Total 425 results found since Jan 2013.

Functional role of the KCa3.1 potassium channel in synovial fibroblasts from rheumatoid arthritis patients
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Physiology - December 29, 2014 Category: Cytology Authors: Kristin Friebel, Roland Schönherr, Raimund W. Kinne, Elke Kunisch Tags: Original Research Article Source Type: research

Ras Guanine Nucleotide–Releasing Protein 4 Is Aberrantly Expressed in the Fibroblast‐like Synoviocytes of Patients With Rheumatoid Arthritis and Controls Their Proliferation
ConclusionRasGRP‐4 is aberrantly expressed in FLS and helps regulate their growth. This intracellular signaling protein is therefore a candidate target for dampening proliferative synovitis and joint destruction.
Source: Arthritis and Rheumatism - January 28, 2015 Category: Rheumatology Authors: Michihito Kono, Shinsuke Yasuda, Richard L. Stevens, Hideyuki Koide, Takashi Kurita, Yuka Shimizu, Yusaku Kanetsuka, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Tetsuya Horita, Tomohiro Shimizu, Tokifumi Majima, Takao Koike, Tatsuya Atsumi Tags: Rheumatoid Arthritis Source Type: research

CCAAT/enhancer-binding protein β promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
Conclusions: We demonstrated that C/EBPβ, especially C/EBPβ-LIP in cooperation with ATF4, is involved in osteoclast formation by regulating RANKL expression in RA-FLS. These findings suggest that C/EBPβ plays a crucial role in bone destruction in RA joints.
Source: BioMed Central - February 17, 2015 Category: Journals (General) Authors: Hidetoshi TsushimaKen OkazakiKohei IshiharaTakahiro UshijimaYukihide Iwamoto Source Type: research

CCAAT/enhancer-binding protein ß promotes receptor activator of nuclear factor-kappa-B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
Conclusions: We demonstrated that C/EBPβ, especially C/EBPβ-LIP in cooperation with ATF4, is involved in osteoclast formation by regulating RANKL expression in RA-FLS. These findings suggest that C/EBPβ plays a crucial role in bone destruction in RA joints.
Source: Arthritis Research and Therapy - February 17, 2015 Category: Rheumatology Authors: Hidetoshi TsushimaKen OkazakiKohei IshiharaTakahiro UshijimaYukihide Iwamoto Source Type: research

Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts.
Abstract Galectin-3 is a β-galactoside-binding lectin that plays an important role in the modulation of immune responses. It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order to better understand the mechanism(s) of the proinflammatory function of galectin-3 in arthritis. Galectin-3 expression in SF obtained from rheumatoid arthritis and osteoarthritis patients was inhibited by siRNA mediated gene-knockdown. Galectin-3 was also inhibited with modified citrus pec...
Source: Cytokine - February 14, 2015 Category: Molecular Biology Authors: Arad U, Madar-Balakirski N, Angel-Korman A, Amir S, Tzadok S, Segal O, Menachem A, Gold A, Elkayam O, Caspi D Tags: Cytokine Source Type: research

The Rheumatoid Arthritis Risk Gene, LBH, Regulates Growth in Fibroblast‐like Synoviocytes
Conclusion. LBH is a candidate gene for synovial pathology in RA. LBH is regulated by growth factors and modulates cell growth in primary FLS. Our data provides a novel mechanism for synovial intimal hyperplasia and joint damage in RA. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - February 23, 2015 Category: Rheumatology Authors: Anna‐Karin H. Ekwall, John W. Whitaker, Deepa Hammaker, William Bugbee, Wei Wang, Gary S. Firestein Tags: Full Length Source Type: research

Integrin-β1 regulates chondrocyte proliferation and apoptosis through the upregulation of GIT1 expression.
Abstract Chondrocytes play a critical role in the repair process of osteoarthritis, which is also known as degenerative arthritis. Integrins, as the key family of cell surface receptors, are responsible for the regulation of chondrocyte proliferation, differentiation, survival and apoptosis through the recruitment and activation of downstream adaptor proteins. Moreover, G-protein‑coupled receptor kinase interacting protein-1 (GIT1) exerts its effects on cell proliferation and migration through interaction with various cytokines. It has been previously suggested that GIT1 acts as a vital protein downstream of th...
Source: International Journal of Molecular Medicine - February 26, 2015 Category: Molecular Biology Authors: Zhang LQ, Zhao GZ, Xu XY, Fang J, Chen JM, Li JW, Gao XJ, Hao LJ, Chen YZ Tags: Int J Mol Med Source Type: research

A disintegrin and metalloprotease-10 is correlated with disease activity and mediates monocyte migration and adhesion in rheumatoid arthritis
We examined the secretion of ADAM-10 in biological fluids from patients with rheumatoid arthritis (RA) and the role it plays in monocyte migration. ADAM-10 levels were measured using enzyme-linked immunosorbent assays and immunofluorescence. To examine the role of ADAM-10 in RA synovial fluids, we studied THP-1 and monocyte chemotaxis. To determine whether ADAM-10 plays a role in cell proliferation in the RA synovium, we assayed the proliferation of ADAM-10 siRNA-transfected RA fibroblast-like synoviocytes (FLS).
Source: Translational Research - February 28, 2015 Category: Research Authors: Takeo Isozaki, Sho Ishii, Shinichiro Nishimi, Airi Nishimi, Nao Oguro, Shinya Seki, Yoko Miura, Yusuke Miwa, Koei Oh, Yoichiro Toyoshima, Masanori Nakamura, Katsunori Inagaki, Tsuyoshi Kasama Source Type: research

Identification of C‐terminal Hsp70‐interacting protein as a mediator of tumour necrosis factor action in osteoblast differentiation by targeting osterix for degradation
Abstract In patients with inflammatory arthritis, tumour necrosis factor (TNF)‐α are overproduced in inflamed joints. This leads to local erosion of cartilage and bone, periarticular osteopenia, as well as osteoporosis. But less is known regarding the molecular mechanisms that mediate the effect of TNF‐α on osteoblast function. The purpose of this study was to test that C terminus of Hsc70‐interacting protein (CHIP) has a specific role in suppressing the osteogenic activity of osteoblasts under inflammatory conditions. C2C12, MC3T3‐E1 and HEK293T cell lines were cultured and cotransfected with related plasmids. A...
Source: Journal of Cellular and Molecular Medicine - March 26, 2015 Category: Molecular Biology Authors: Jianmin Xie, Jieruo Gu Tags: Original Article Source Type: research

Identification of C-terminal Hsp70-interacting protein as a mediator of tumour necrosis factor action in osteoblast differentiation by targeting osterix for degradation.
Abstract In patients with inflammatory arthritis, tumour necrosis factor (TNF)-α are overproduced in inflamed joints. This leads to local erosion of cartilage and bone, periarticular osteopenia, as well as osteoporosis. But less is known regarding the molecular mechanisms that mediate the effect of TNF-α on osteoblast function. The purpose of this study was to test that C terminus of Hsc70-interacting protein (CHIP) has a specific role in suppressing the osteogenic activity of osteoblasts under inflammatory conditions. C2C12, MC3T3-E1 and HEK293T cell lines were cultured and cotransfected with related plasmids. ...
Source: J Cell Mol Med - March 26, 2015 Category: Molecular Biology Authors: Xie J, Gu J Tags: J Cell Mol Med Source Type: research

Critical role of eukaryotic elongation factor 1 alpha 1 (EEF1A1) in avian reovirus sigma-C-induced apoptosis and inhibition of viral growth
We report here the identification of eukaryotic elongation factor 1 alpha 1 (EEF1A1) as the interacting partner of σC. We found that σC-induced apoptosis in DF-1 cells could be completely abolished by knockdown of EEF1A1 by siRNA. Furthermore, knockdown of EEF1A1 markedly reduced ARV-induced apoptosis associated with decreased caspase-9 and -3 activation and cytochrome C release, leading to increased ARV growth in host cells. Thus, EEF1A1 plays a critical role in σC-induced apoptosis and inhibition of viral growth.
Source: Archives of Virology - April 10, 2015 Category: Virology Source Type: research

MicroRNA‐9 promotes IL‐6 expression by inhibiting MCPIP1 expression in IL‐1β‐stimulated human chondrocytes
Conclusions. These studies implicate miR‐9‐mediated suppression of MCPIP1 in OA pathogenesis via upregulation of IL‐6 expression in IL‐1β‐stimulated human OA chondrocytes. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - April 27, 2015 Category: Rheumatology Authors: Mohammad S Makki, Abdul Haseeb, Tariq M Haqqi Tags: Full Length Source Type: research

Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism
Conclusions: Cadherin-11 undergoes ectodomain shedding followed by regulated intramembrane proteolysis in synovial fibroblasts, triggered by a novel sheddase that generates extracelluar cadherin-11 fragments. Cadherin-11 fragments were enriched in RA synovial fluid, suggesting they may be a marker of synovial burden and may function to modify cadherin-11 interactions between synovial fibroblasts.
Source: Arthritis Research and Therapy - May 15, 2015 Category: Rheumatology Authors: Erika NossGerald WattsDavide ZoccoTracy KellerMalcolm WhitmanCarl BlobelDavid LeeMichael Brenner Source Type: research

Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells
Conclusion. The Shh signalling pathway plays a role in regulating endothelial cell apoptosis in a Smo-dependent manner.
Source: Rheumatology - May 19, 2015 Category: Rheumatology Authors: Zhu, S.-l., Luo, M.-q., Peng, W.-x., Li, Q.-x., Feng, Z.-y., Li, Z.-x., Wang, M.-x., Feng, X.-x., Liu, F., Huang, J.-l. Tags: Rheumatoid Arthritis BASIC SCIENCE Source Type: research

Anti-Citrullinated Protein Antibodies Induce Macrophage Subset Disequilibrium in RA Patients
Abstract We used samples from rheumatoid arthritis (RA) patients to examine whether Anti-citrullinated protein antibodies (ACPAs) alter macrophage subset distribution and promote RA development. Macrophage subset distributions and interferon regulatory factor 4 (IRF4) and IRF5 expressions were analyzed. ACPAs were purified by affinity column. After RA and osteoarthritis (OA) patients’ macrophages were cocultured with ACPAs, macrophage subsets and IRF4 and IRF5 expressions were measured. Small interfering RNAs (siRNAs) were transfected into ACPA-activated cells to suppress IRF4 or IRF5. Fluorescence-activated cel...
Source: Inflammation - June 11, 2015 Category: Allergy & Immunology Source Type: research