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Condition: Arthritis
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Total 425 results found since Jan 2013.
PARP9 enhances infiltration of mononuclear cells in pSS through IFIT1 ‐mediated upregulation of CXCL10
ConclusionThis study is the first to implicate PARP9 as a regulator of infiltration of mononuclear cells in pSS progression and reveal that PARP9 increased CXCL10 expression through upregulating IFIT1 which is mediated by phosphorylation of STAT1. PARP9 might therefore be a novel therapeutic target for pSS.
Source: Arthritis and Rheumatology - December 25, 2019 Category: Rheumatology Authors: Qingqing Tian,
Han Zhao,
Hanzhi Ling,
Li Sun,
Chipeng Xiao,
Guoyu Yin,
Xiaobing Wang,
Gan Wu,
Chenglin Yang,
Mu Chen,
Shengwei Jin,
Xinyu Yang,
Jianguang Wang Tags: FULL LENGTH Source Type: research
Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D
The complement system plays an important role in the pathogenesis of rheumatoid arthritis (RA). Besides driving lectin pathway (LP) activation, the mannan-binding lectin (MBL)-associated serine proteases (MASPs) also play a key role in regulating the alternative pathway (AP). We evaluated the effects of N-acetylgalactosamine (GalNAc)-conjugated MASP-1 and MASP-2 duplexes in vitro and in mice with and without arthritis to examine whether knockdown of MASP-1 and MASP-2 expression affects the development of arthritis. GalNAc-siRNAs for MASP-1 and MASP-2 demonstrated robust silencing of MASP-1 or MASP-2 at pM concentrations in...
Source: Frontiers in Immunology - February 20, 2020 Category: Allergy & Immunology Source Type: research
Poly(ADP ‐Ribose) Polymerase Enhances Infiltration of Mononuclear Cells in Primary Sjögren's Syndrome Through Interferon‐Induced Protein With Tetratricopeptide Repeats 1–Mediated Up‐Regulation of CXCL10
ConclusionThis study is the first to implicate PARP ‐9 as a regulator of infiltration of mononuclear cells in primary SS progression and to reveal that PARP‐9 increases CXCL10 expression through up‐regulating IFIT‐1, which is mediated by the phosphorylation of STAT1. PARP‐9 might therefore be a novel therapeutic target for primary SS.
Source: Arthritis and Rheumatology - May 1, 2020 Category: Rheumatology Authors: Qingqing Tian,
Han Zhao,
Hanzhi Ling,
Li Sun,
Chipeng Xiao,
Guoyu Yin,
Xiaobing Wang,
Gan Wu,
Chenglin Yang,
Mu Chen,
Shengwei Jin,
Xinyu Yang,
Jianguang Wang Tags: Original Article Source Type: research
Sinomenine inhibited Interleukin-1 β-induced matrix metalloproteinases levels via SOCS3 up-regulation in SW1353 cells.
Sinomenine inhibited Interleukin-1β-induced matrix metalloproteinases levels via SOCS3 up-regulation in SW1353 cells.
Biol Pharm Bull. 2020 Sep 02;:
Authors: Qi W, Gu Y, Wang Z, Fan W
Abstract
Matrix metalloproteinases (MMPs) are required for collagen degradation which play a key pathological role in arthritis progression. Herein, the effect of sinomenine (SN) on Interleukin 1 beta (IL-1β)-induced MMPs production and its underlying mechanism were explored in SW1353 cells. The MTT assay showed that 200 and 400 µM SN significantly inhibited SW1353 cell proliferation, thus the lower dose of SN (25-100...
Source: Biological and Pharmaceutical Bulletin - September 1, 2020 Category: Drugs & Pharmacology Authors: Qi W, Gu Y, Wang Z, Fan W Tags: Biol Pharm Bull Source Type: research
Guanylate Binding Protein 5 (GBP5) regulates synovial fibroblast mediated inflammation and tissue destruction in rheumatoid arthritis
ConclusionExpressed by RASFs in response to cytokine stimulation, GBP5 has potential to restore cellular homeostasis and blunt inflammation and tissue destruction in RA.
Source: Arthritis and Rheumatology - December 5, 2020 Category: Rheumatology Authors: Mahamudul Haque,
Anil K. Singh,
Madhu M. Ouseph,
Salahuddin Ahmed Tags: Full Length Source Type: research
Knockdown of nrf2 Exacerbates TNF- α-Induced Proliferation and Invasion of Rheumatoid Arthritis Fibroblast-Like Synoviocytes through Activating JNK Pathway.
In conclusion, nrf2 is overexpressed in synovial tissues of RA patients, which may be promoted by TNF-α and ROS levels. Activation of nrf2 may suppress TNF-α-induced proliferation, invasion, and MMPs expression in RA-FLS by inhibiting JNK activation, indicating that nrf2 plays a protective role in relieving the severity of synovitis in RA. Our results might provide novel insights into the treatment of RA.
PMID: 33426091 [PubMed - in process]
Source: Journal of Immunology Research - January 13, 2021 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Regulation of Synovial Inflammation and Tissue Destruction by Guanylate Binding Protein 5 in Synovial Fibroblasts From Patients With Rheumatoid Arthritis and Rats With Adjuvant ‐Induced Arthritis
ConclusionExpressed by RASFs in response to cytokine stimulation, GBP ‐5 has potential to restore cellular homeostasis and blunt inflammation and tissue destruction in RA.
Source: Arthritis and Rheumatology - April 20, 2021 Category: Rheumatology Authors: Mahamudul Haque,
Anil K. Singh,
Madhu M. Ouseph,
Salahuddin Ahmed Tags: Original Article Source Type: research
Variants on the UBE2L3 ‐YDJC autoimmune disease risk haplotype increase UBE2L3 gene expression by modulating CTCF and YY1 binding
ConclusionTheUBE2L3-YDJC autoimmune risk haplotype increasesUBE2L3 expression through strengthening a YY1-mediated interaction between theUBE2L3 andYDJC promoters.
Source: Arthritis and Rheumatology - July 21, 2021 Category: Rheumatology Authors: Jaanam Gopalakrishnan,
Kandice L. Tessneer,
Yao Fu,
Satish Pasula,
Richard C. Pelikan,
Jennifer A. Kelly,
Graham B. Wiley,
Patrick M. Gaffney Tags: FULL LENGTH Source Type: research
Sinomenine increases adenosine A < sub > 2A < /sub > receptor and inhibits NF- κB to inhibit arthritis in adjuvant-induced-arthritis rats and fibroblast-like synoviocytes through α7nAChR
J Leukoc Biol. 2021 Aug 23. doi: 10.1002/JLB.3MA0121-024RRRR. Online ahead of print.ABSTRACTSinomenine (SIN) is a clinical drug for treating rheumatoid arthritis (RA) in China. Our previous study found SIN inhibited inflammation via alpha7 nicotinic acetylcholine receptor (α7nAChR) in macrophages in vitro. Adenosine receptor A2A has anti-inflammatory and immunosuppressive function. However, the mechanisms of SIN acting on α7nAChR and the effect on adenosine A2A receptor (A2A R) in RA are not clear. In the present study, the effects of SIN on adjuvant-induced-arthritis (AIA) rats in vivo and on fibroblast-like synoviocyte...
Source: Journal of Leukocyte Biology - August 23, 2021 Category: Hematology Authors: Lang Yi Junyu Ke Jiayan Liu Huili Lai Yanjun Lv Chong Peng Yingkun Zhi Qun Du Liang Liu Peixun Wang Hua Zhou Yan Dong Source Type: research
Yi Shen Juan Bi Pill Regulates the Bone Immune Microenvironment via the JAK2/STAT3 Signaling Pathway in Vitro
This study provides a new strategy for regulating the bone immune microenvironment in RA with traditional Chinese medicine.
Source: Frontiers in Pharmacology - December 14, 2021 Category: Drugs & Pharmacology Source Type: research
Variants on the UBE2L3/YDJC Autoimmune Disease Risk Haplotype Increase UBE2L3 Expression by Modulating CCCTC ‐Binding Factor and YY1 Binding
ConclusionTheUBE2L3/YDJC autoimmune risk haplotype increasesUBE2L3 expression through strengthening a YY1-mediated interaction between theUBE2L3 andYDJC promoters.
Source: Arthritis and Rheumatology - December 14, 2021 Category: Rheumatology Authors: Jaanam Gopalakrishnan,
Kandice L. Tessneer,
Yao Fu,
Satish Pasula,
Richard C. Pelikan,
Jennifer A. Kelly,
Graham B. Wiley,
Patrick M. Gaffney Tags: Full Length Source Type: research
Increased eEF2K Promotes Glycolysis and Aggressive Behaviors of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis
CONCLUSION: eEF2K inhibition suppressed glycolysis and aggressive behaviors of RA FLS, which indicated that targeting eEF2K may be a new strategy for the treatment of RA.PMID:35300214 | PMC:PMC8922331 | DOI:10.2147/JIR.S337620
Source: Cell Research - March 18, 2022 Category: Cytology Authors: Dongying Chen Xiaoyan Cai Hui Ouyang Shiwen Yuan Xiaodong Wang Lian Lin Zhiqing Chen Mingcheng Huang Source Type: research
Valdecoxib attenuates lipid-induced hepatic steatosis through autophagy-mediated suppression of endoplasmic reticulum stress
This study investigated the effects of VAL on lipid accumulation and lipogenesis in human primary hepatocytes. Treatment with VAL suppressed lipid accumulation and expressions of lipogenic genes, such as processed sterol regulatory element binding proteins (SREBP1) and stearoyl-CoA desaturase-1 (SCD1) in palmitate-treated hepatocytes. Furthermore, VAL ameliorated dose-dependently palmitate-induced ER stress markers. Treatment of hepatocytes with VAL increased AMPK phosphorylation and SIRT6 expression. siRNA-mediated suppression of AMPK or SIRT6 abolished the effects of VAL on lipid accumulation, lipogenesis, and endoplasmi...
Source: Biochemical Pharmacology - March 31, 2022 Category: Drugs & Pharmacology Authors: Seung Yeon Park Wonjun Cho A M Abd El-Aty Ahmet Hacimuftuoglu Ji Hoon Jeong Tae Woo Jung Source Type: research
