PARP9 enhances infiltration of mononuclear cells in pSS through IFIT1 ‐mediated upregulation of CXCL10
ConclusionThis study is the first to implicate PARP9 as a regulator of infiltration of mononuclear cells in pSS progression and reveal that PARP9 increased CXCL10 expression through upregulating IFIT1 which is mediated by phosphorylation of STAT1. PARP9 might therefore be a novel therapeutic target for pSS.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Qingqing Tian,
Han Zhao,
Hanzhi Ling,
Li Sun,
Chipeng Xiao,
Guoyu Yin,
Xiaobing Wang,
Gan Wu,
Chenglin Yang,
Mu Chen,
Shengwei Jin,
Xinyu Yang,
Jianguang Wang Tags: FULL LENGTH Source Type: research