Filtered By:
Condition: Arthritis

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 425 results found since Jan 2013.

Interleukin-13 reduces bone erosion in rheumatoid arthritis by up-regulating osteoprotegerin expression in fibroblast-like synoviocytes : an in vitro and in vivo study
CONCLUSIONS: IL-13 can inhibit osteoclastogenesis by up-regulating OPG in RA-FLSs through IL-13 receptors via the STAT6 pathway, thus may ameliorate bone erosion in RA.PMID:36995338 | DOI:10.55563/clinexprheumatol/b96n1e
Source: Clinical and Experimental Rheumatology - March 30, 2023 Category: Rheumatology Authors: Ziyan Chen Zixue Cheng Zhicheng Tang Mei Li Xiaojun Tang Huayong Zhang Lingyun Sun Source Type: research

Class I HDAC inhibition modulates metalloproteinase expression and blocks cytokine‐induced cartilage degradation
Conclusions:The inhibition of class I HDACs (HDAC1, HDAC2, HDAC3) by MS‐275 or by specific depletion is capable of repressing cytokine‐induced metalloproteinase expression in cartilage cells and explants, resulting in inhibition of cartilage resorption. This indicates that specific inhibition of Class I HDACs provides a possible therapeutic strategy in the arthritides. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - April 10, 2013 Category: Rheumatology Authors: Kirsty L Culley, Wang Hui, Matt J Barter, Rose K Davidson, Tracey E Swingler, Auriane P M Destrument, Jenny L. Scott, Simon T Donell, Steve Fenwick, Andrew D Rowan, David A Young, Ian M Clark Tags: Full Length Source Type: research

Rac1 is required for matrix metalloproteinase‐13 production by chondrocytes in response to fibronectin fragments
Conclusion.Rac1 is required for Fnf induced signaling that results in increased MMP‐13 production. EGF receptor ligands, which activate Rac, can promote this effect. The presence of active Rac in OA cartilage and the ability of Rac to stimulate MMP‐13 production suggests that it could play a role in the cartilage matrix destruction seen in OA. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - March 4, 2013 Category: Rheumatology Authors: David L. Long, Jeffrey S. Willey, Richard F. Loeser Tags: Full Length Source Type: research

Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2
Conclusions Notch-1 mediates VEGF/Ang2-induced angiogenesis and EC invasion in inflammatory arthritis.
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Gao, W., Sweeney, C., Walsh, C., Rooney, P., McCormick, J., Veale, D. J., Fearon, U. Tags: Open access, Immunology (including allergy), Pathology, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Surgical diagnostic tests, Clinical diagnostic tests Basic and translational research Source Type: research

Sphingosine‐1‐phosphate counteracts interleukin‐1β in human chondrocytes
ConclusionsIn human chondrocytes, S1P reduces the induction of catabolic genes in the presence of IL‐1β. Activation of the S1P2 receptor counteracts the detrimental phosphorylation of p38MAPK by IL‐1β. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - May 10, 2013 Category: Rheumatology Authors: Martin H. Stradner, Gerald Gruber, Hannes Angerer, Verena Huber, Daniela Setznagl, Marie‐Luise Kremser, Florentine C. Fürst, Reinhard Windhager, Winfried B. Graninger Tags: Full Length Source Type: research

B cell activating factor-dependent expression of vascular endothelial growth factor in MH7A human synoviocytes stimulated with tumor necrosis factor-α
Abstract Angiogenesis in rheumatoid arthritis (RA) is one of the histological hallmarks, which is mediated by expression of vascular endothelial growth factor (VEGF) in RA synovium. VEGF expression is enhanced by TNF-α, the main pro-inflammatory cytokine in RA. B cell activating factor (BAFF) which plays a role in maturation and maintenance of B cells is also associated with autoimmune RA. Here, we investigated whether BAFF could regulate VEGF expression in TNF-α-stimulated synovium using MH7A synovial cells that are established by transfection with the SV40 T antigen. Changes in hBAFF and hVEGF were measured by...
Source: International Immunopharmacology - May 14, 2013 Category: Allergy & Immunology Authors: Lee GH, Lee J, Lee JW, Choi WS, Moon EY Tags: Int Immunopharmacol Source Type: research

Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation
Conclusion. Reduced expression of MKX is a feature of degenerated ACL in OA‐affected joints and this may be in part mediated by IL‐1β. MKX appears necessary to maintain the tissue specific cellular differentiation status and ECM production in adult human tendons and ligaments. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - May 1, 2013 Category: Rheumatology Authors: Hiroyuki Nakahara, Akihiko Hasegawa, Koji Otabe, Fumiaki Ayabe, Tetsuya Matsukawa, Naoko Onizuka, Yoshiaki Ito, Toshifumi Ozaki, Martin K. Lotz, Hiroshi Asahara Tags: Full Length Source Type: research

Rac1 Is Required for Matrix Metalloproteinase 13 Production by Chondrocytes in Response to Fibronectin Fragments
ConclusionRac1 is required for FN fragment–induced signaling that results in increased MMP‐13 production. EGF receptor ligands, which activate Rac, can promote this effect. The presence of active Rac in OA cartilage and the ability of Rac to stimulate MMP‐13 production suggest that it could play a role in the cartilage matrix destruction seen in OA.
Source: Arthritis and Rheumatism - May 30, 2013 Category: Rheumatology Authors: David L. Long, Jeffrey S. Willey, Richard F. Loeser Tags: Chondrocyte Biology Source Type: research