Sphingosine 1‐Phosphate Counteracts the Effects of Interleukin‐1β in Human Chondrocytes

ConclusionIn human chondrocytes, S1P reduces the induction of catabolic genes in the presence of IL‐1β. Activation of the S1P2 receptor counteracts the detrimental phosphorylation of p38 MAPK by IL‐1β.

Source: Arthritis and Rheumatism - July 26, 2013 Category: Rheumatology Authors: Martin H. Stradner, Gerald Gruber, Hannes Angerer, Verena Huber, Daniela Setznagl, Marie‐Luise Kremser, Florentine C. Moazedi‐Fürst, Reinhard Windhager, Winfried B. Graninger Tags: Chondrocyte Biology Source Type: research