Brief Report: Interleukin‐38 Exerts Antiinflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus

ConclusionThis is the first study of the function of endogenous IL‐38, and the data suggest that IL‐38 may be protective in SLE. A strong association between IL‐38 and SLE severity suggests that IL‐38 expression is driven by processes linked to SLE pathogenesis. Exploitation of the regulatory effects of IL‐38 may represent a promising therapeutic strategy in SLE.

Source: Arthritis and Rheumatism - November 25, 2015 Category: Rheumatology Authors: Ina Rudloff, Jack Godsell, Claudia A. Nold‐Petry, James Harris, Alberta Hoi, Eric F. Morand, Marcel F. Nold Tags: Systemic Lupus Erythematosus Source Type: research