Role of Fibulin 3 in Aging ‐Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage

ConclusionFibulin 3 is specifically expressed in the SZ of articular cartilage and its expression is reduced in aging and OA. Fibulin 3 regulates differentiation of adult progenitor cells, and its aging‐related decline is an early event in the pathogenesis of OA. Preventing aging‐associated loss of fibulin 3 or restoring it to normal levels in SZ chondrocytes has the potential to delay or prevent the onset of OA.

Source: Arthritis and Rheumatism - February 26, 2017 Category: Rheumatology Authors: Akihiko Hasegawa, Tomo Yonezawa, Noboru Taniguchi, Koji Otabe, Yukio Akasaki, Tetsuya Matsukawa, Masahiko Saito, Masashi Neo, Lihua Y. Marmorstein, Martin K. Lotz Tags: Osteoarthritis Source Type: research