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Nutrition: Iron

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Total 255 results found since Jan 2013.

Elevated CISD2 expression predicts poor diagnosis and promotes invasion and migration of prostate cancer cells.
CONCLUSIONS: The paper demonstrated that CISD2 could act as a new target for the diagnosis and treatment of PCa patients. PMID: 32633348 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - July 9, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity
AbstractPathological features of Parkinson ’s disease include the formation of Lewy bodies containing α‐synuclein and the accumulation of iron in the substantia nigra. Previous studies have suggested that iron accumulation contributes to the Parkinson’s disease pathology through reactive oxygen species production and accelerated α‐ synuclein aggregation. The current study examines the effects of commonly occurring H63D variant of the homeostatic iron regulatory (HFE) gene on α‐synuclein pathology in cell culture and animal models. H63DHFE expression in SH ‐SY5Y cells lowered endogenous α‐synuclein levels ...
Source: Journal of Neurochemistry - June 22, 2020 Category: Neuroscience Authors: Yunsung Kim, Mark C. Stahl, Xuemei Huang, James R. Connor Tags: ORIGINAL ARTICLE Source Type: research

Silencing of HIF-1 α/CD73 axis by siRNA-loaded TAT-chitosan-spion nanoparticles robustly blocks cancer cell progression.
This study suggested that TAT-TMC-TC-SPIONs can be potential nanocarrier for gene transfection in cancer therapy. Moreover, the co-silencing of CD73 and HIF-1α can be assumed as a novel anti-cancer treatment strategy with high tumor suppression potential. PMID: 32574672 [PubMed - as supplied by publisher]
Source: European Journal of Pharmacology - June 19, 2020 Category: Drugs & Pharmacology Authors: Hajizadeh F, Ardebili SM, Moornani MB, Masjedi A, Atyabi F, Kiani M, Namdar A, Karpisheh V, Izadi S, Baradaran B, Azizi G, Ghalamfarsa G, Sabz G, Yousefi M, Jadidi-Niaragh F Tags: Eur J Pharmacol Source Type: research

Surface modification of superparamagnetic iron oxide (SPION) and comparison of cytotoxicity effect of mPEG2000-PEI-SPION and mPEG750-PEI-SPION on the human embryonic carcinoma stem cell, NTERA2 cell line.
Authors: Sadeghi Z, Maleki P, Shahabi F, Bondarkhilli SAM, Masoumi M, Taheri M, Mohammadi M, Raheb J Abstract Non-viral carriers based on nanoparticles are promising vectors for drug and gene delivery into the target cells. The data provided in this article are related to research entitled "Efficiency of surface modified SPION". In this article the surface of superparamagnetic iron oxide (SPION) (core) coated with poly (ethylene glycol)-grafted polyethylenimine (mPEG-co-PEI) shell. PEI was used to increase gene transfection efficiency and poly (ethylene glycol) methyl ether was applied to reduce cytotoxicity of nan...
Source: Human Antibodies - March 4, 2020 Category: Biochemistry Tags: Hum Antibodies Source Type: research

Interaction of α-synuclein and Parkin in iron toxicity on SH-SY5Y cells: implications in the pathogenesis of Parkinson's disease.
This study has demonstrated that iron in varying concentrations (up to 400 µM) causes an increase in α-synuclein content in SH-SY5Y cells associated with mitochondrial depolarization, decreased cellular ATP content and loss of cell viability during incubation up to 96 h. Knocking-down α-synuclein expression prevents cytotoxic actions of iron, which can also be prevented by cyclosporine A (a blocker of mitochondrial permeability transition pore). These results indicate that iron cytotoxicity is mediated by α-synuclein acting on mitochondria. Likewise siRNA mediated knock-down of Parkin causes an  accumulation of  α-s...
Source: The Biochemical Journal - February 27, 2020 Category: Biochemistry Authors: Ganguly U, Banerjee A, Chakrabarti SS, Kaur U, Sen O, Cappai R, Chakrabarti S Tags: Biochem J Source Type: research

Zinc induces iron egress from intestinal Caco-2  cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption.
Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption. Biochem Biophys Res Commun. 2020 Jan 20;: Authors: Kondaiah P, Sharp PA, Pullakhandam R Abstract In previous studies we demonstrated that zinc stimulates iron uptake in intestinal Caco-2 cells via Zinc-PI3K-IRP2-DMT1 axis. In the current study we investigated the effect of zinc on basolateral iron release and characterized the associated mechanisms. In Caco-2 cells grown on permeable supports, zinc induced iron transport and expression of DMT1, HEPH mRNA and protein, but...
Source: Biochemical and Biophysical Research communications - January 19, 2020 Category: Biochemistry Authors: Kondaiah P, Sharp PA, Pullakhandam R Tags: Biochem Biophys Res Commun Source Type: research

Dihydrolipoamide dehydrogenase regulates cystine deprivation-induced ferroptosis in head and neck cancer
We examined the role of dihydrolipoamide dehydrogenase (DLD) in ferroptosis induction in head and neck cancer (HNC). The effects of cystine deprivation or sulfasalazine treatment and of DLD gene silencing/overexpression were tested on HNC cell lines and mouse tumor xenograft models. These effects were analyzed with regard to cell death, lipid reactive oxygen species (ROS) and mitochondrial iron production, mitochondrial membrane potential, mRNA/protein expression, and α-ketoglutarate dehydrogenase (KGDH)/succinate/aconitase activities. Cystine deprivation induced ferroptosis via glutaminolysis. Cystine deprivation or impo...
Source: Redox Biology - January 8, 2020 Category: Biology Source Type: research

Multifunctional hybrid nanoparticles as magnetic delivery systems for siRNA targeting the HER2 gene in breast cancer cells
In this study, we prepared a magnetic hybrid nanostructure composed of iron oxide nanoparticles coated with caffeic acid and stabilized by layers of calcium phosphate and PEG-polyanion block copolymer for incorporation of siRNA. Transmission electron microscopy images showed monodisperse, neutrally charged compact spheres sized <100 nm. Dynamic light scattering and nanoparticle tracking analysis revealed that the nanostructure had an average hydrodynamic diameter of 130 nm. Nanoparticle suspensions remained stable over 42 days of storage at 4 and 25 °C. Unloaded caffeic acid–magnetic calcium phosphate (Caf-MCaP)...
Source: Materials Science and Engineering: C - December 26, 2019 Category: Materials Science Source Type: research

Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine ‑functionalized magnetic iron oxide nanoparticles on LX‑2 cells.
Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine‑functionalized magnetic iron oxide nanoparticles on LX‑2 cells. Mol Med Rep. 2019 Nov 20;: Authors: Yu Q, Xiong X, Zhao L, Xu T, Wang Q Abstract Connective tissue growth factor (CTGF) is a possible key determinant of progressive fibrosis. Nanotechnology has been considered as a potential tool for developing novel drug delivery systems for various diseases, including liver fibrosis. The present study aimed to investigate the potential antifibrotic activity of CTGF small interfering RNA (si...
Source: Molecular Medicine Reports - November 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Site-specific intestinal DMT1 silencing to mitigate iron absorption using pH-sensitive multi-compartmental nanoparticulate oral delivery system
We report a novel pH-sensitive multi-compartmental nanoparticulate (MCP) oral delivery system that encapsulates siRNA for silencing the divalent metal transporter 1 (DMT1) gene, a primary iron transporter highly expressed in the intestine. The gelatin nanoparticles-coated with Eudragit® L100–55 are able to protect siRNA from intracellular degradation and allow for sustained release of siRNA in the cytosol. When orally-administered, Eudragit® L100–55 based MCPs containing DMT1 siRNA/gelatin NPs specifically and significantly decreased the expression of DMT1 mRNA in the duodenum, which consequently decreased intestinal...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - October 16, 2019 Category: Nanotechnology Source Type: research

Magnetic nanocarriers for the specific delivery of siRNA: contribution of breast cancer cells active targeting for down-regulation efficiency
In conclusion, TS-MSN are promising nanocarriers for the specific and efficient delivery of siRNA to HER2-overexpressing breast cancer cells.Graphical abstract
Source: International Journal of Pharmaceutics - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism
The absorption of iron is influenced by numerous dietary and physiological factors. We have previously demonstrated that zinc treatment of intestinal cells increases iron absorption via induction of the apical membrane iron transporter divalent metal ion transporter-1 (DMT1). To better understand the mechanisms of zinc-induced iron absorption, we have studied the effect of zinc on iron uptake, iron transporter and iron regulatory protein (IRP 1 and 2) expression and the impact of the PI3K pathway in differentiated Caco-2 cells, an intestinal cell culture model. We found that zinc induces DMT1 protein and mRNA expression. Z...
Source: Biochemical Journal - June 10, 2019 Category: Biochemistry Authors: Kondaiah, P., Aslam, M. F., Mashurabad, P. C., Sharp, P. A., Pullakhandam, R. Tags: Research Articles Source Type: research

Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury
Conclusion: We demonstrate a protective role of hepcidin in endotoxin- and peritonitis-induced pathologies and AKI, exerted through anti-inflammatory effects, and antibacterial property. Macrophage H-ferritin plays an important role in hepcidin-mediated protection against endotoxin-induced inflammation. We uncover a novel prophylactic and therapeutic role of hepcidin in sepsis-associated bacteremia, AKI and mortality.
Source: Frontiers in Pharmacology - June 5, 2019 Category: Drugs & Pharmacology Source Type: research

Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism.
Abstract The absorption of dietary iron is influenced by numerous dietary and physiological factors. We have previously demonstrated that zinc treatment of intestinal cells increases iron absorption via induction of the apical membrane iron transporter divalent metal iron transporter-1 (DMT1). To better understand the mechanisms of zinc-induced iron absorption we have studied the effect of zinc on iron uptake, iron transporter and iron regulatory protein (IRP 1 and 2) expression and the impact of thePI3K pathway in differentiated Caco-2 cells, an intestinal cell culture model. We found that zinc induces DMT1 prote...
Source: The Biochemical Journal - May 14, 2019 Category: Biochemistry Authors: Kondaiah P, Aslam MF, Mashurabad P, Sharp PA, Pullakhandam R Tags: Biochem J Source Type: research

TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages.
In conclusion, alterations of labile heme levels in macrophages following TLR4 stimulation play a crucial role in BACH1-mediated regulation of HO-1 expression. PMID: 31026585 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - April 22, 2019 Category: Biology Authors: Sudan K, Vijayan V, Madyaningrana K, Gueler F, Igarashi K, Foresti R, Motterlini R, Immenschuh S Tags: Free Radic Biol Med Source Type: research