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Nutrition: Iron
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Total 255 results found since Jan 2013.
Activation of p62-NRF2 Axis Protects against Doxorubicin-Induced Ferroptosis in Cardiomyocytes: A Novel Role and Molecular Mechanism of Resveratrol
This study showed that DOX decreased cell viability, increased iron accumulation and lipid peroxidation in H9c2 cells; however, these effects were reversed by RSV and ferroptosis inhibitor ferrostatin-1 (Fer-1) pre-treatment. Additionally, RSV significantly increased the cell viability of H9c2 cells treated with ferroptosis inducers Erastin (Era) and RSL3. Mechanistically, RSV inhibited mitochondrial reactive oxygen species (mtROS) overproduction and upregulated the p62-NRF2/HO-1 pathway. RSV-induced NRF2 activation was partially dependent on p62, and the selective inhibition of p62 (using p62-siRNA interference) or NRF2 (...
Source: The American Journal of Chinese Medicine - October 30, 2022 Category: Complementary Medicine Authors: Wei Yu Chunjuan Chen Chenxi Xu De Xie Qiang Wang Weidong Liu Hairong Zhao Furong He Bingyang Chen Yuemei Xi Yunbo Yan Linqian Yu Jidong Cheng Source Type: research
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia-reperfusion injury
CONCLUSIONS: USP7 inhibition attenuated I/R-induced renal injury by inhibiting ferroptosis through decreasing ubiquitination of TBK1 and promoting DNMT1-mediated methylation of FMR1.PMID:36264362 | DOI:10.1007/s00011-022-01648-1
Source: Cell Research - October 20, 2022 Category: Cytology Authors: Boqing Dong Chenguang Ding Heli Xiang Jin Zheng Xiao Li Wujun Xue Yang Li Source Type: research
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia –reperfusion injury
ConclusionsUSP7 inhibition attenuated I/R-induced renal injury by inhibiting ferroptosis through decreasing ubiquitination of TBK1 and promoting DNMT1-mediated methylation of FMR1.
Source: Inflammation Research - October 20, 2022 Category: Research Source Type: research
Heme oxygenase-1 modulates ferroptosis by fine-tuning levels of intracellular iron and reactive oxygen species of macrophages in response to Bacillus Calmette-Guerin infection
Macrophages are the host cells and the frontline defense against Mycobacterium tuberculosis (Mtb) infection, and the form of death of infected macrophages plays a pivotal role in the outcome of Mtb infections. Ferroptosis, a programmed necrotic cell death induced by overwhelming lipid peroxidation, was confirmed as one of the mechanisms of Mtb spread following infection and the pathogenesis of tuberculosis (TB). However, the mechanism underlying the macrophage ferroptosis induced by Mtb infection has not yet been fully understood. In the present study, transcriptome analysis revealed the upregulation of heme oxygenase-1 (H...
Source: Frontiers in cellular and infection microbiology - September 23, 2022 Category: Microbiology Source Type: research
5 ‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis
Oncol Rep. 2022 Oct;48(4):186. doi: 10.3892/or.2022.8401. Epub 2022 Sep 9.ABSTRACTIron is an essential nutrient that facilitates cell proliferation and growth, and it can contribute to tumor growth. Although iron chelators have shown great potential in preclinical cancer models, they can cause adverse side‑effects. The aim of the present study was to determine whether treatment with 5‑aminolevurinic acid (5‑ALA) has antitumor effects in bladder cancer, by reduction of mitochondrial iron without using an iron chelator, through activation of heme synthesis. T24 and MGH‑U3 cells were treated with 5‑ALA. Ferrochelata...
Source: Oncology Reports - September 9, 2022 Category: Cancer & Oncology Authors: Yasushi Nakai Yoshihiro Tatsumi Shunta Hori Yosuke Morizawa Kota Iida Kenta Onishi Makito Miyake Yuki Oda Takuya Owari Tomomi Fujii Sayuri Onishi Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
Theranostic silk sericin/SPION nanoparticles for targeted delivery of ROR1 siRNA: Synthesis, characterization, diagnosis and anticancer effect on triple-negative breast cancer
In conclusion, the prepared delivery system could be considered a potential therapeutic strategy for treating TNBC.PMID:36084874 | DOI:10.1016/j.ijbiomac.2022.09.020
Source: International Journal of Biological Macromolecules - September 9, 2022 Category: Biochemistry Authors: Armina Shirangi Fatemeh Mottaghitalab Sajad Dinarvand Fatemeh Atyabi Source Type: research
5 ‑Aminolevurinic acid inhibits the proliferation of bladder cancer cells by activating heme synthesis
Oncol Rep. 2022 Oct;48(4):186. doi: 10.3892/or.2022.8401. Epub 2022 Sep 9.ABSTRACTIron is an essential nutrient that facilitates cell proliferation and growth, and it can contribute to tumor growth. Although iron chelators have shown great potential in preclinical cancer models, they can cause adverse side‑effects. The aim of the present study was to determine whether treatment with 5‑aminolevurinic acid (5‑ALA) has antitumor effects in bladder cancer, by reduction of mitochondrial iron without using an iron chelator, through activation of heme synthesis. T24 and MGH‑U3 cells were treated with 5‑ALA. Ferrochelata...
Source: Oncology Reports - September 9, 2022 Category: Cancer & Oncology Authors: Yasushi Nakai Yoshihiro Tatsumi Shunta Hori Yosuke Morizawa Kota Iida Kenta Onishi Makito Miyake Yuki Oda Takuya Owari Tomomi Fujii Sayuri Onishi Nobumichi Tanaka Kiyohide Fujimoto Source Type: research
Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3 β/Nrf2 axis
In conclusion, Dex protects hearts against MIRI-induced ferroptosis via activation of Nrf2 through AMPK/GSK-3β signaling pathway.PMID:35988428 | DOI:10.1016/j.biopha.2022.113572
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 21, 2022 Category: Drugs & Pharmacology Authors: Zhuoran Wang Mengran Yao Leyu Jiang Lingyan Wang Yuqiao Yang Quan Wang Xi Qian Yu Zhao Jinqiao Qian Source Type: research
Zinc induces hephaestin expression via a PI3K-CDX2 dependent mechanism to regulate iron transport in intestinal Caco-2 cells
Biochem Biophys Res Commun. 2022 Jul 30;626:1-7. doi: 10.1016/j.bbrc.2022.07.053. Online ahead of print.ABSTRACTZinc stimulates intestinal iron absorption via induction of divalent metal ion transporter (DMT1) and hephaestin (HEPH). While the increase in DMT1 is mediated via a PI3K/IPR2 axis, the mechanisms of Zn-induced HEPH expression downstream of PI3K remain elusive. In the current study we probed the role of Caudal-related homeobox transcription factor-2 (CDX2) on Zn-induced HEPH expression. Zn treatment of Caco-2 cells increased CDX2 phosphorylation and HEPH protein and mRNA expression. siRNA-silencing of CDX2 inhibi...
Source: Biochemical and Biophysical Research communications - August 13, 2022 Category: Biochemistry Authors: Hanuma Naik Ramavath Purna Chandra Mashurabad Puneeta Singh Yaduvanshi Shobi Veleri Paul A Sharp Raghu Pullakhandam Source Type: research
